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Estudio retrospectivo de las características epidemiológicas y clínicas. Utilidad de la ecografía en el diagnóstico" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1651 "Ancho" => 759 "Tamanyo" => 136948 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Significant increase in volume on the dorsal aspect of both feet of patient 1. B, Color Doppler ultrasound (18-MHz probe) in patient 1 reveals a small anechoic pseudocyst with posterior reinforcement, no increase in vascularization, and a snowstorm-like pattern.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Morgado-Carrasco, X. 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"apellidos" => "Giavedoni" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731020300776" "doi" => "10.1016/j.ad.2018.12.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020300776?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020301414?idApp=UINPBA000044" "url" => "/15782190/0000011100000005/v3_202012020957/S1578219020301414/v3_202012020957/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Bilateral Segmental Neurofibromatosis on the Lower Limbs" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "432" "paginaFinal" => "433" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "R. Fornons-Servent, A. Talavera-Belmonte, A. Bauer-Alonso, J. Marcoval" "autores" => array:4 [ 0 => array:3 [ "nombre" => "R." "apellidos" => "Fornons-Servent" "email" => array:1 [ 0 => "rfornons@bellvitgehospital.cat" ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Talavera-Belmonte" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Bauer-Alonso" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Marcoval" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servei de Dermatologia, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Neurofibromatosis segmentaria bilateral en extremidades inferiores" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 506 "Ancho" => 755 "Tamanyo" => 59583 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Skin-colored papules and nodules compatible with neurofibromas on the soles of both feet.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Segmental neurofibromatosis (NF) is a rare entity characterized by neurofibromas, with or without the presence of café au lait spots, distributed in either 1 or, less frequently, 2 or more dermatomes.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 55-year-old woman with no personal or family history of interest was seen at our dermatology department for multiple skin-colored papules and nodules (3–15<span class="elsevierStyleHsp" style=""></span>mm in diameter) with an elastic consistency that had appeared 10 years earlier and were located exclusively in the distal areas of the legs and on the feet (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>). Café au lait spots, axillary freckles, and plexiform neurofibroma lesions were absent. Two of the lesions were excised and subsequent histology confirmed the clinical suspicion of neurofibroma (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The patient was diagnosed with bilateral segmental NF. Ocular, neurological, and visceral involvement were ruled out. The patient was monitored for 10 years, during which no new lesions appeared in other areas of the body.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Segmental NF is 10 to 20 times less frequent than classical type I NF.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a> It is caused by somatic mosaicism due to a postzygotic mutation in the <span class="elsevierStyleItalic">NF1</span> gene. Therefore, all cases are sporadic by definition. Some familial cases have been described, and can be explained by somatic and gonadal involvement due to mosaicism, although there are also some cases of vertical transmission of segmental NF that this mechanism cannot adequately explain. Depending on whether the mutation occurs before or after tissue differentiation, the clinical phenotype of mosaicism can be generalized or localized, respectively.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1–6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">NF was first classified in 1982, and divided into 8 subtypes, of which type 5 corresponded to segmental NF, defined by the presence of pigmentation disorders (including café au lait spots or axillary freckles) or of neurofibromas located in a single unilateral segment of the body without crossing the midline, without a family history of NF and without systemic involvement or extracutaneous lesions.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,7</span></a> Because not all patients with segmental involvement corresponded to the description of type 5 NF, in 1987 Roth et al proposed a classification system for segmental NF consisting of 4 categories: true segmental NF; localized NF with deep involvement; hereditary segmental NF; and bilateral segmental NF.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,2,7</span></a> Yet another classification system describes 4 types of segmental NF according to the corresponding lesions: pigmentation disorders only; neurofibromas only; pigmentation disorders with neurofibromas; and isolated plexiform neurofibromas.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Bilateral segmental NF is an uncommon form of segmental NF, first described by Gammel in 1931.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> In their series of 82 cases of segmental NF, Hager et al<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> found that the most frequent clinical presentation was isolated unilateral neurofibromas occupying dermatomes (predominantly in the cervical region, with decreasing frequency in the thoracic, lumbar, and sacral regions), and observed bilateral involvement in 5 cases.</p><p id="par0030" class="elsevierStylePara elsevierViewall">A review of 15 published cases of bilateral segmental NF suggests that the most frequent clinical presentation is the exclusive presence of bilateral neurofibromas without pigmented lesions affecting the lumbar region, scalp, chest wall, chest, upper extremities, and infraorbital region.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> We have not found any published cases of bilateral segmental involvement of the lower extremities.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Diagnosis of segmental NF requires a physical examination to evaluate other cutaneous manifestations of the disease and rule out generalized involvement, and an ophthalmological examination to rule out the presence of Lisch nodules.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,3</span></a> Clinically, the disease course is similar to that of type I NF, with progressive development of pigmentation disorders and plexiform neurofibromas in childhood and neurofibromas in adulthood.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,5,6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Interestingly, segmental NF is twice as common in women than men, and the right side of the body is more commonly affected than the left.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3,9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">There are no specific guidelines for the treatment and follow-up of segmental NF and there is some controversy as to whether segmental NF is associated with an increase in comorbidities typical of type I NF.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> However, patients should know that the absence of generalized type I NF implies a low risk of disease-related complications.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,2,6</span></a> Given that mosaicism can also affect the germline, genetic counseling should be considered for affected individuals.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,9</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Fornons-Servent R, Talavera-Belmonte A, Bauer-Alonso A, Marcoval J. Neurofibromatosis segmentaria bilateral en extremidades inferiores. Actas Dermosifiliogr. 2020;111:432–433.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 537 "Ancho" => 805 "Tamanyo" => 79353 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Skin-colored papules and nodules compatible with neurofibromas on the front of the legs and on the feet.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 506 "Ancho" => 755 "Tamanyo" => 59583 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Skin-colored papules and nodules compatible with neurofibromas on the soles of both feet.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 409 "Ancho" => 1255 "Tamanyo" => 195166 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A, Proliferation of spindle cells in the dermis with Grenz zone (hematoxylin-eosin, original magnification ×5.85). 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Year/Month | Html | Total | |
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2024 November | 9 | 9 | 18 |
2024 October | 85 | 30 | 115 |
2024 September | 95 | 27 | 122 |
2024 August | 127 | 56 | 183 |
2024 July | 95 | 39 | 134 |
2024 June | 112 | 40 | 152 |
2024 May | 90 | 42 | 132 |
2024 April | 111 | 21 | 132 |
2024 March | 110 | 27 | 137 |
2024 February | 102 | 31 | 133 |
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2023 December | 106 | 18 | 124 |
2023 November | 121 | 39 | 160 |
2023 October | 102 | 44 | 146 |
2023 September | 75 | 32 | 107 |
2023 August | 65 | 23 | 88 |
2023 July | 88 | 37 | 125 |
2023 June | 79 | 22 | 101 |
2023 May | 74 | 18 | 92 |
2023 April | 56 | 18 | 74 |
2023 March | 81 | 25 | 106 |
2023 February | 52 | 27 | 79 |
2023 January | 73 | 26 | 99 |
2022 December | 75 | 31 | 106 |
2022 November | 43 | 31 | 74 |
2022 October | 87 | 34 | 121 |
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2022 August | 80 | 40 | 120 |
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2022 June | 41 | 34 | 75 |
2022 May | 113 | 43 | 156 |
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2022 March | 69 | 53 | 122 |
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