Commentaries
Apremilast in Psoriasis
Apremilast en psoriasis
A. Pérez Ferriols
Servicio de Dermatología, Hospital General Universitario, Valencia, Spain
Read
3504
Timeswas read the article
1528
Total PDF
1976
Total HTML
Share statistics
array:24 [ "pii" => "S1578219020300147" "issn" => "15782190" "doi" => "10.1016/j.adengl.2019.11.005" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "2275" "copyright" => "AEDV" "copyrightAnyo" => "2019" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2020;111:87" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S0001731019303771" "issn" => "00017310" "doi" => "10.1016/j.ad.2019.11.001" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "2275" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2020;111:87" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 37 "formatos" => array:2 [ "HTML" => 19 "PDF" => 18 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Comentario editorial</span>" "titulo" => "Apremilast en psoriasis" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "87" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Apremilast in Psoriasis" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Pérez Ferriols" "autores" => array:1 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Pérez Ferriols" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219020300147" "doi" => "10.1016/j.adengl.2019.11.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020300147?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731019303771?idApp=UINPBA000044" "url" => "/00017310/0000011100000002/v2_202009190635/S0001731019303771/v2_202009190635/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S1578219020300135" "issn" => "15782190" "doi" => "10.1016/j.adengl.2019.03.029" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "2193" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2020;111:87-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>" "titulo" => "Early Syphilis: New Diagnostic Approaches in a Changing Scenario" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "87" "paginaFinal" => "88" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Sífilis precoz: nuevas aproximaciones diagnósticas para un escenario cambiante" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "T. Toledo Pastrana" "autores" => array:1 [ 0 => array:2 [ "nombre" => "T." "apellidos" => "Toledo Pastrana" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731019301279" "doi" => "10.1016/j.ad.2019.03.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731019301279?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020300135?idApp=UINPBA000044" "url" => "/15782190/0000011100000002/v1_202004140647/S1578219020300135/v1_202004140647/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>" "titulo" => "Apremilast in Psoriasis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "87" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "A. Pérez Ferriols" "autores" => array:1 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Pérez Ferriols" "email" => array:1 [ 0 => "perez_ampferr@gva.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario, Valencia, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Apremilast en psoriasis" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The authors present the results of a Delphi study conducted in Spain on the use of apremilast in psoriasis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Apremilast is a “small-molecule” oral phosphodiesterase 4 inhibitor that according to its summary of product characteristics is indicated for the treatment of psoriatic arthritis and chronic moderate to severe plaque psoriasis. The position of apremilast in the current arsenal of treatments for psoriasis has been influenced by several factors. First, its limited effectiveness compared with other alternatives; second its adverse effects, which in many cases require withdrawal of treatment due to poor tolerability; and last but not least, its cost, which is similar to that of the most effective biologic drugs available and higher than that of other biosimilars.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The authors, all experts in psoriasis, chose 5 points of interest to analyze using a Delphi questionnaire. After reviewing each point based on the existing literature, the panel concluded that apremilast might be a treatment option for patients with a different profile to that studied in the clinical trials. They highlight the need for a consensus-based definition of moderate psoriasis, which is where apremilast could possibly be positioned as a treatment option preceding biologic therapy. Finally, they stress the need for more scientific evidence from clinical trials and real-world studies to verify the opinions expressed in this study.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Pérez Ferriols A. Apremilast en psoriasis. Actas Dermosifiliogr. 2020;111:87.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Reference" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:1 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio Delphi para el uso de apremilast en psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.M. Carrascosa" 1 => "I. Belinchón" 2 => "R. Rivera" 3 => "M. Ara" 4 => "M. Bustinduy" 5 => "P. Herranz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifilogr" "fecha" => "2020" "volumen" => "111" "paginaInicial" => "115" "paginaFinal" => "134" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011100000002/v1_202004140647/S1578219020300147/v1_202004140647/en/main.assets" "Apartado" => array:4 [ "identificador" => "66476" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Commentaries" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011100000002/v1_202004140647/S1578219020300147/v1_202004140647/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020300147?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 11 | 19 |
| 2024 October | 53 | 52 | 105 |
| 2024 September | 53 | 22 | 75 |
| 2024 August | 82 | 57 | 139 |
| 2024 July | 49 | 34 | 83 |
| 2024 June | 56 | 21 | 77 |
| 2024 May | 66 | 22 | 88 |
| 2024 April | 61 | 26 | 87 |
| 2024 March | 57 | 28 | 85 |
| 2024 February | 47 | 25 | 72 |
| 2024 January | 53 | 33 | 86 |
| 2023 December | 40 | 14 | 54 |
| 2023 November | 61 | 29 | 90 |
| 2023 October | 45 | 12 | 57 |
| 2023 September | 34 | 35 | 69 |
| 2023 August | 33 | 9 | 42 |
| 2023 July | 31 | 30 | 61 |
| 2023 June | 40 | 25 | 65 |
| 2023 May | 35 | 20 | 55 |
| 2023 April | 25 | 20 | 45 |
| 2023 March | 30 | 28 | 58 |
| 2023 February | 38 | 22 | 60 |
| 2023 January | 22 | 25 | 47 |
| 2022 December | 37 | 41 | 78 |
| 2022 November | 20 | 29 | 49 |
| 2022 October | 25 | 15 | 40 |
| 2022 September | 21 | 50 | 71 |
| 2022 August | 26 | 32 | 58 |
| 2022 July | 28 | 38 | 66 |
| 2022 June | 19 | 29 | 48 |
| 2022 May | 26 | 31 | 57 |
| 2022 April | 31 | 24 | 55 |
| 2022 March | 27 | 40 | 67 |
| 2022 February | 23 | 21 | 44 |
| 2022 January | 20 | 26 | 46 |
| 2021 December | 24 | 56 | 80 |
| 2021 November | 24 | 34 | 58 |
| 2021 October | 43 | 52 | 95 |
| 2021 September | 18 | 36 | 54 |
| 2021 August | 19 | 28 | 47 |
| 2021 July | 21 | 20 | 41 |
| 2021 June | 21 | 22 | 43 |
| 2021 May | 37 | 44 | 81 |
| 2021 April | 71 | 44 | 115 |
| 2021 March | 36 | 28 | 64 |
| 2021 February | 31 | 21 | 52 |
| 2021 January | 29 | 16 | 45 |
| 2020 December | 27 | 19 | 46 |
| 2020 November | 19 | 10 | 29 |
| 2020 October | 15 | 7 | 22 |
| 2020 September | 30 | 14 | 44 |
| 2020 August | 28 | 14 | 42 |
| 2020 July | 11 | 7 | 18 |
| 2020 June | 18 | 22 | 40 |
| 2020 May | 42 | 18 | 60 |
| 2020 April | 76 | 26 | 102 |
| 2020 March | 10 | 12 | 22 |
| 2020 February | 4 | 2 | 6 |
Show all
