Case and Research Letters
Histioid Leprosy a Rare Variant: First Report in Ecuador
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Nódulos eritematovioláceos con distribución centrofacial sobre la frente y las mejillas. B. Varios nódulos en forma de cúpula de consistencia firme y parches en el tronco. C. Histiocitos fusiformes con tendencia a la nodularidad (H-E x40). D. Bacilos ácido-alcohol resistentes intracitoplasmáticos en macrófagos (Ziehl-Neelsen X100).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.J. Dávila-Rodríguez, C. Rosero, S. Tello, S. Yanchapaxi" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.J." "apellidos" => "Dávila-Rodríguez" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Rosero" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Tello" ] 3 => array:2 [ "nombre" => "S." 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B, Detail of the same image showing granulomas composed of palisaded histiocytes (arrow) arranged around a central eosinophilic zone corresponding to fibrin (asterisk) (hematoxylin-eosin, original magnification ×100).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P.J. Álvarez-Chinchilla, I. Poveda Montoyo, F. Illán, J. Bañuls Roca" "autores" => array:4 [ 0 => array:2 [ "nombre" => "P.J." "apellidos" => "Álvarez-Chinchilla" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Poveda Montoyo" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Illán" ] 3 => array:2 [ "nombre" => "J." 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Dávila-Rodríguez, C Rosero, S Tello, S Yanchapaxi" "autores" => array:4 [ 0 => array:4 [ "nombre" => "J.J." "apellidos" => "Dávila-Rodríguez" "email" => array:1 [ 0 => "dr.davila.dermato@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C" "apellidos" => "Rosero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "S" "apellidos" => "Tello" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "S" "apellidos" => "Yanchapaxi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología, Universidad Central del Ecuador, Quito, Ecuador" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Docente de Calderón, Quito, Ecuador" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Patología, Hospital Axxis, Quito, Ecuador" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1308 "Ancho" => 1500 "Tamanyo" => 328007 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A. Nódulos eritematovioláceos con distribución centrofacial sobre la frente y las mejillas. B. Varios nódulos en forma de cúpula de consistencia firme y parches en el tronco. C. Histiocitos fusiformes con tendencia a la nodularidad (H-E x40). D. Bacilos ácido-alcohol resistentes intracitoplasmáticos en macrófagos (Ziehl-Neelsen X100).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">To the Editor:</p><p id="par0010" class="elsevierStylePara elsevierViewall">Histioid leprosy (HL) is a rare variant of lepromatous leprosy with characteristic clinical, histopathological, bacteriological and immunological findings.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> We report the first documented cases of HL in Ecuador.</p><p id="par0015" class="elsevierStylePara elsevierViewall">A 44 years-old male with a history of lepromatous leprosy successfully treated 2 years ago with complete WHO multidrug therapy (MDT) scheme, with improvement in clinical features and negative bacilloscopy. However, during the treatment and subsequent medical follow-up the patient presented erythema nodosum leprosum that was treated successfully with thalidomide in another hospital. In the last 6 months the patient presented generalized erythematous-violaceous nodules, hiperpigmented macules and patchs on the face, trunk and limbs that respect palms, soles and mucosa, with malaise, paresthesias in upper limbs and thickening of ulnar nerves (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A, B). Bacilloscopy was positive in the ear ++, elbow + and knee +. The histopathological study shows fusiform histiocytes with a tendency to nodularity and identifies acid-alcohol resistant bacilli intracytoplasmic in macrophages, compatible with histoid leprosy (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C, D). The patient is being treated with MDT and we added minocycline 100 mg with good clinical response by decreased size and disappearance of some nodules at the third month.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The second case is a 52 years-old male with no relevant personal history who presents asymptomatic generalized skin color nodules, mainly localized in trunk and proximal limbs (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A, B). The bacilloscopy was positive in the ear ++, elbow ++ and knee +. The biopsy shows a thinned epidermis with a Grenz zone and diffuse dermal proliferation of epithelioid-vacuolated histiocytes with fusiform cells and moderate lymphocytic infiltrate. Virchow historiocytes are also around the nerves (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>C). Wade-Fite stain shows globus and isolated acid resistant bacilli, which confirms the diagnosis of histioid leprosy (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>D). The patient is being treated with WHO MDT.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">By 2003 leprosy had been eliminated from 117 countries, but the disease continues to present a public health problem in 17 countries.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It remains an enigmatic form of leprosy mostly reported from India, Brasil, Birmania and constitutes 1,2-3,5% of all leprosy cases, with male predominance in age range of 20-50 years; however, studies regarding this form of disease are very rare.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a> HL has been reported generally to manifest in patients after long-term dapsone monotherapy, irregular or inadequate therapy, there are also reports of disease developing as relapse after successful treatment.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However, de-novo cases of HL have also been encountered, as our second case.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The etiopathogenesis of this entity is not clear, but has been suggested to represent a hyperactive expression of multibacillary leprosy in an effort to restrict or focalize the disease.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The interplay of genetic factors, immune response and treatment received in a given patient seems to influence the manifestations of HL.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> According to Sehgal et al. probably some groups of histiocytes work different from others, this would explain why a combination of ordinary lepromas and histoid nodules can be found in the same patients.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The most accepted theory is that proposed by Civatte, who pointed out that the histiocyte grows slowly and begins to produce large amounts of collagen under an unknown stimulus. This hyperplasia produces an inflammatory process that subsequently results in the formation of a nodule.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Clinically the histoid lesions appear as smooth, shiny, erythematous or coppery color, dome-shaped, nontender soft to firm nodules which may be superficial or subcutaneous and plaques appearing on otherwise normal looking skin.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The localization is usually on the posterior and lateral aspects of the arms, buttocks, thighs, dorsum of the hands, lower part of the back, and over the bony prominences, especially over the elbows and knees. Lesions vary in size and consistency, usually of 1.5-3 cm.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Mendiratta et al. and Nair and Nanda Kumar have reported frequencies of erythema nodosum leprosum (ENL) among HL cases of 40%, 27% and 24% respectively.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,9</span></a> It has been proposed that ENL probably occurs in patients during the transition to manifest HL,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> as our first case.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The instant confirmation of histoid leproma is made with smears test, which has a specificity of 100% and a sensitivity of 50%, and can be obtained from nasal mucosa, an ear lobe or skin lesions.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Histopathological findings are unique, epidermis may be normal or atrophic with a Grenz zone. The leproma consists of fusiform histiocytes arranged in a whorled, criss-cross, or storiform pattern.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Within the histiocytes, plenty of acid fast bacillus can be found. They are longer than the normal bacilli, are uniform in length and are arranged in parallel bundles along the long axis of the spindle histiocytes with or without globus formation.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In addition the factor XIIIa positive is characteristic and the loss of S100 expression.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">It has been treated on the lines of multibacillary leprosy with the recommended WHO MDT.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Researchers have also managed initially by giving the range of motion therapy, with rifampicin 600 mg, ofloxacin 400 mg, and minocycline 200 mg, which is followed by MDT.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">To conclude, it is important to recognize atypical leprosy presentations to continue the surveillance for new cases, since early diagnosis and complete treatment are important to achieve our goal of eliminating leprosy. Furthermore, continuous medical follow-up must be done after a multidrug therapy in order to detect these rare variants.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-01-23" "fechaAceptado" => "2018-09-09" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Dávila-Rodríguez J.J., Rosero C., Tello S., Yanchapaxi S. Lepra histioide, una variante rara: primer reporte en Ecuador. Actas Dermo-Sifiliográficas. 2019;110:867–869.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1308 "Ancho" => 1500 "Tamanyo" => 328007 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A. Nódulos eritematovioláceos con distribución centrofacial sobre la frente y las mejillas. B. Varios nódulos en forma de cúpula de consistencia firme y parches en el tronco. C. Histiocitos fusiformes con tendencia a la nodularidad (H-E x40). D. Bacilos ácido-alcohol resistentes intracitoplasmáticos en macrófagos (Ziehl-Neelsen X100).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2230 "Ancho" => 2500 "Tamanyo" => 848556 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A y B. Nódulos color piel en el tronco y antebrazos. C. Atrofia epidérmica, zona de Grenz, y acúmulo circunscrito de histiocitos fusiformes en la dermis (H-E x40). D. Globus y bacilos ácido resistentes aislados (Wade-Fite stain x100).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A clinical and histopathological study of histoid leprosy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Nair" 1 => "G. Nanda Kumar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2013" "volumen" => "52" "paginaInicial" => "580" "paginaFinal" => "586" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An update: Definition, pathogenesis, classification, diagnosis, and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Eichelmann" 1 => "S. González" 2 => "J. Salas" 3 => "Ocampo J. Leprosy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.adengl.2012.03.028" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2013" "volumen" => "104" "paginaInicial" => "554" "paginaFinal" => "563" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23870850" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histoid leprosy: the impact of the entity on the postglobal leprosy elimination era" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Sehgal" 1 => "G. Srivastava" 2 => "N. Singh" 3 => "P. Prasad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2009.03992.x" "Revista" => array:7 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2009" "volumen" => "48" "numero" => "6" "paginaInicial" => "603" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19538369" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hansen lepromatoso histioide. Características clínicas y epidemiológicas en pacientes de la cátedra de dermatología del hospital de clínicas. Facultad de ciencias médicas de la Universidad Nacional. Asunción. Paraguay" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "T. Moreno" 1 => "S. Mancia" 2 => "B. Di Martino" 3 => "M. Rodriguez" 4 => "O. Knopfelmacher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Fontilles Rev Leprol." "fecha" => "2013" "volumen" => "29" "paginaInicial" => "109" "paginaFinal" => "111" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histoid leprosy: review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.K. Gupta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ijd.12799" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2015" "volumen" => "54" "paginaInicial" => "1283" "paginaFinal" => "1288" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26094829" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lepra histioide o de Wade. Presentación de un caso clínico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Albrecht" 1 => "V. Leban" 2 => "M. Guardati" 3 => "J. Iribas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Argent Dermatol" "fecha" => "2018" "volumen" => "99" "paginaInicial" => "1" "paginaFinal" => "10" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "De novo histoid leprosy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Kantaria" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Indian Dermatol Online J" "fecha" => "2014" "volumen" => "5" "numero" => "4" "paginaInicial" => "556" "paginaFinal" => "558" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lepromatous leprosy of histoid type" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Annigeri" 1 => "S. Metgud" 2 => "J. Patil" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Indian J Med Microbiol" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "70" "paginaFinal" => "71" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A nine-year clinicoepidemiological study of histoid Hansen in India" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V. Mendiratta" 1 => "A. Jain" 2 => "R. Chander" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3855/jidc.1190" "Revista" => array:6 [ "tituloSerie" => "J Infect Dev Ctries" "fecha" => "2011" "volumen" => "5" "paginaInicial" => "128" "paginaFinal" => "131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21389593" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pruritic lesions during pregnancy: an unusual presentation of a rare variant of multibacillary leprosy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Sánchez" 1 => "M. Albízuri" 2 => "T. González" 3 => "E. Sendagorta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2015.08.010" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2016" "volumen" => "107" "paginaInicial" => "352" "paginaFinal" => "354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26739118" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011000000010/v1_201912080808/S1578219019302793/v1_201912080808/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000010/v1_201912080808/S1578219019302793/v1_201912080808/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019302793?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 10 | 10 | 20 |
| 2024 October | 80 | 49 | 129 |
| 2024 September | 74 | 32 | 106 |
| 2024 August | 118 | 80 | 198 |
| 2024 July | 91 | 29 | 120 |
| 2024 June | 86 | 46 | 132 |
| 2024 May | 93 | 46 | 139 |
| 2024 April | 77 | 34 | 111 |
| 2024 March | 64 | 35 | 99 |
| 2024 February | 51 | 38 | 89 |
| 2024 January | 47 | 36 | 83 |
| 2023 December | 47 | 20 | 67 |
| 2023 November | 56 | 28 | 84 |
| 2023 October | 79 | 25 | 104 |
| 2023 September | 75 | 33 | 108 |
| 2023 August | 63 | 28 | 91 |
| 2023 July | 64 | 35 | 99 |
| 2023 June | 51 | 19 | 70 |
| 2023 May | 66 | 25 | 91 |
| 2023 April | 39 | 23 | 62 |
| 2023 March | 59 | 24 | 83 |
| 2023 February | 49 | 18 | 67 |
| 2023 January | 30 | 25 | 55 |
| 2022 December | 52 | 36 | 88 |
| 2022 November | 31 | 28 | 59 |
| 2022 October | 45 | 30 | 75 |
| 2022 September | 55 | 41 | 96 |
| 2022 August | 47 | 52 | 99 |
| 2022 July | 42 | 40 | 82 |
| 2022 June | 26 | 32 | 58 |
| 2022 May | 49 | 38 | 87 |
| 2022 April | 46 | 37 | 83 |
| 2022 March | 38 | 49 | 87 |
| 2022 February | 50 | 24 | 74 |
| 2022 January | 78 | 40 | 118 |
| 2021 December | 47 | 33 | 80 |
| 2021 November | 52 | 45 | 97 |
| 2021 October | 47 | 49 | 96 |
| 2021 September | 38 | 45 | 83 |
| 2021 August | 51 | 26 | 77 |
| 2021 July | 27 | 22 | 49 |
| 2021 June | 33 | 24 | 57 |
| 2021 May | 33 | 34 | 67 |
| 2021 April | 74 | 92 | 166 |
| 2021 March | 65 | 30 | 95 |
| 2021 February | 43 | 24 | 67 |
| 2021 January | 34 | 14 | 48 |
| 2020 December | 37 | 17 | 54 |
| 2020 November | 18 | 17 | 35 |
| 2020 October | 27 | 13 | 40 |
| 2020 September | 28 | 12 | 40 |
| 2020 August | 19 | 25 | 44 |
| 2020 July | 19 | 13 | 32 |
| 2020 June | 15 | 24 | 39 |
| 2020 May | 20 | 10 | 30 |
| 2020 April | 29 | 11 | 40 |
| 2020 March | 32 | 5 | 37 |
| 2020 February | 8 | 5 | 13 |
| 2020 January | 1 | 2 | 3 |
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