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Both gluteus maximus muscles showed hypodense areas measuring approximately 6<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>cm&#44; and signs of myositis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Two skin biopsies were performed&#44; 1 of which was sent for histopathology study &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; and the other for microbiology culture&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">What is your diagnosis&#63;</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Diagnosis and Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">The microbiology culture was negative&#46; Histology revealed multiple empty cystic areas in the dermis and hypodermis&#44; surrounded by an inflammatory histiocyte infiltrate&#46; The study also revealed abundant foam cells and multinucleate giant cells &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">When questioned again&#44; the patient admitted that he had undergone injections with mineral oil 2 years earlier in the buttocks on up to 30 occasions&#44; for esthetic purposes&#46; A year later&#44; he began to present the symptoms described above&#46; In light of this information&#44; foreign body granuloma was diagnosed and treatment with 40<span class="elsevierStyleHsp" style=""></span>mg per day of prednisone was prescribed&#59; a complete clinical response was achieved&#46; The patient was then discharged with a descending dose of prednisone over 2 weeks&#46; Because he continued to present intermittent episodes&#44; minocycline was prescribed at a dosage of 100<span class="elsevierStyleHsp" style=""></span>mg per day&#44; 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image&#44; owing to cystic spaces that replace the normal subcutaneous cell tissue&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Complications following the injection of liquid chemical products will present in a period of time that may vary from months to years&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Adverse effects&#44; such as infection and ulceration&#44; are often seen within 18&#46;5 months after the paraffin injections&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> With regard to treatment&#44; complete surgical excision is the best option for preventing recurrence<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#59; however&#44; complete excision is often not possible&#46; Macrolides and tetracyclines have been shown to produce good results where infection is suspected&#44; 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Case for Diagnosis
Recurrent Buttock Cellulitis in a Young Man
Celulitis glútea de repetición en un varón joven
D. Morgado-Carrasco
Corresponding author
morgadodaniel8@gmail.com

Corresponding author.
, P. Giavedoni, J.M. Mascaró
Servicio de Dermatología, Hospital Clínic de Barcelona, Barcelona, España
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and nodules in the gluteal and sacral region&#44; showing marked asymmetry between the 2 buttocks &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Palpation also revealed swollen lymph glands measuring approximately between 1 and 2&#46;5<span class="elsevierStyleHsp" style=""></span>cm&#46; Blood tests revealed leukocytosis with neutrophilia and raised C-reactive protein &#40;CRP&#41; levels &#40;13&#46;65<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; Despite attempts to puncture the nodules&#44; it was not possible to obtain material for study&#46; The patient was admitted to the infectious disease unit and empirical intravenous antibiotic treatment was instated with ceftriaxone and clindamycin&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A pelvic CT scan revealed diffuse bilateral thickening in the superficial and deep soft tissue&#44; which corresponded to radiologic signs of cellulitis and fasciitis&#46; Both gluteus maximus muscles showed hypodense areas measuring approximately 6<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>cm&#44; and signs of myositis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Two skin biopsies were performed&#44; 1 of which was sent for histopathology study &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; and the other for microbiology culture&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">What is your diagnosis&#63;</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Diagnosis and Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">The microbiology culture was negative&#46; Histology revealed multiple empty cystic areas in the dermis and hypodermis&#44; surrounded by an inflammatory histiocyte infiltrate&#46; The study also revealed abundant foam cells and multinucleate giant cells &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">When questioned again&#44; the patient admitted that he had undergone injections with mineral oil 2 years earlier in the buttocks on up to 30 occasions&#44; for esthetic purposes&#46; A year later&#44; he began to present the symptoms described above&#46; In light of this information&#44; foreign body granuloma was diagnosed and treatment with 40<span class="elsevierStyleHsp" style=""></span>mg per day of prednisone was prescribed&#59; a complete clinical response was achieved&#46; The patient was then discharged with a descending dose of prednisone over 2 weeks&#46; Because he continued to present intermittent episodes&#44; minocycline was prescribed at a dosage of 100<span class="elsevierStyleHsp" style=""></span>mg per day&#44; with no clinical improvement&#46; Alopurinol was later prescribed but was poorly tolerated by the patient and it was therefore decided to change to 400<span class="elsevierStyleHsp" style=""></span>mg per day of hydroxychloroquine&#59; however&#44; the episodes persisted&#46; The patient has since been undergoing intermittent pulse corticosteroid therapy with prednisone and has remained asymptomatic&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The popularity of injectable fillers has increased markedly in recent decades&#46; The materials used include a wide variety of nonauthorized products&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2</span></a> Mineral oil &#40;petrolatum&#41; has been used for cosmetic purposes to perform injections of permanent dermal filler&#46; This filler has even been used to increase muscle volume<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> and penis size&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;4</span></a> The cosmetic results immediately after injections of petrolatum tend to be satisfactory&#59; however&#44; the long-term complications are disastrous&#46; For this reason&#44; petrolatum is not currently considered legal for use as a filler&#46; Furthermore&#44; it is not generally administered by medical personnel and is most frequently self-injected&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The adverse effects of injections of fillers include arterial occlusion&#44; tissue necrosis&#44; embolism&#44; infections&#44; hypersensitivity reactions&#44; migration of the injected material&#44; and even death&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> The formation of sclerosing lipogranuloma or paraffinoma&#44; a granulomatous reaction associated with intense fibrosis&#44; is a frequent complication secondary to injection of mineral oil&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;4</span></a> Histology often shows a &#8220;Swiss cheese&#8221; image&#44; owing to cystic spaces that replace the normal subcutaneous cell tissue&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Complications following the injection of liquid chemical products will present in a period of time that may vary from months to years&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Adverse effects&#44; such as infection and ulceration&#44; are often seen within 18&#46;5 months after the paraffin injections&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> With regard to treatment&#44; complete surgical excision is the best option for preventing recurrence<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#59; however&#44; complete excision is often not possible&#46; Macrolides and tetracyclines have been shown to produce good results where infection is suspected&#44; partly owing to their anti-inflammatory action&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> Oral or intralesional corticosteroids can be used to reduce granulomatous immune reactions&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;5</span></a> Other therapeutic alternatives include tacrolimus&#44; etanercept&#44; and alopurinol&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Although most medical professionals no longer inject unauthorized products&#44; unqualified personnel continue to expose themselves and third parties to severe complications&#46; It is therefore very important to take this entity into consideration as a possible diagnosis&#44; as most patients will be reluctant to admit to having undergone these procedures&#46; It should also be remembered that the adverse effects caused by injecting this material may appear after a long period of latency&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Article information
ISSN: 15782190
Original language: English
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2022 November 222 32 254
2022 October 188 22 210
2022 September 139 36 175
2022 August 85 29 114
2022 July 63 36 99
2022 June 48 29 77
2022 May 212 47 259
2022 April 244 37 281
2022 March 241 52 293
2022 February 198 43 241
2022 January 175 30 205
2021 December 193 40 233
2021 November 153 35 188
2021 October 190 49 239
2021 September 144 41 185
2021 August 142 24 166
2021 July 114 23 137
2021 June 111 24 135
2021 May 124 42 166
2021 April 306 87 393
2021 March 153 25 178
2021 February 104 30 134
2021 January 118 21 139
2020 December 127 12 139
2020 November 100 22 122
2020 October 88 18 106
2020 September 79 12 91
2020 August 47 9 56
2020 July 29 7 36
2020 June 28 14 42
2020 May 26 15 41
2020 April 58 28 86
2020 March 24 12 36
2020 February 1 1 2
2019 September 1 2 3
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Idiomas
Actas Dermo-Sifiliográficas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?