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Geographic Tongue: What a Dermatologist Should Know
Lengua geográfica: ¿qué es lo que un dermatólogo debería saber?
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Ogueta, M.P. Ramírez, C.O. Jiménez, M.M. Cifuentes" "autores" => array:4 [ 0 => array:4 [ "nombre" => "I.C." "apellidos" => "Ogueta" "email" => array:1 [ 0 => "iaogueta@uc.cl" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.P." "apellidos" => "Ramírez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C.O." "apellidos" => "Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M.M." "apellidos" => "Cifuentes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lengua geográfica: ¿qué es lo que un dermatólogo debería saber?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 708 "Ancho" => 650 "Tamanyo" => 62011 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Erythematous plaques with a well-defined whitish margin on the dorsal of the tongue.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Geographic tongue, also known as benign migratory glossitis, is a benign chronic inflammatory condition of the tongue. It is characterized by erythematous lesions with filiform papillae atrophy, surrounded by white limited areas in the dorsal and lateral aspects of the tongue, producing a map-like aspect. This lesions change in size and shape with time, and are characterized by periods of exacerbation and remission without scaring.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Prevalence in general population ranges from 1% to 2,5%.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">2</span></a> Studies show a greater incidence in children between ages 4 and 5,<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">3</span></a> and adults under 30 years.<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">1,4,5</span></a> It tends to appear more in women than men, in a ratio of 1,5:1.<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">4–6</span></a> Benign migratory glossitis is a condition to which many associations have been established, leading to the formulation of different theories about its possible etiology.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Etiology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Although the cause of geographic tongue is still unknown, most patients report family history of the condition, suggesting then a possible genetic predisposition. Prevalence of this condition among parents and siblings of these patients is significantly higher than general population. A study of Redman et al<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">7</span></a> in students of the University of Minnesota who suffered from geographic tongue analyzed family history, showing that prevalence of first-degree relatives with geographic tongue was significantly higher than in the control group (14.1% vs 4%). In relation to the studies about this condition's heritage, a polygenetic inheritance model has been proposed.<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">7,8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">On the other hand, different factors and related diseases have been described to be related to this condition, such as allergies, hormonal alterations, pregnancy, juvenile diabetes, Reiter syndrome, psoriasis,<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">9</span></a> Down syndrome, nutritional deficiencies, lichen planus, and also some drugs such as oral contraceptives, lithium an antihypertensives.<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">1,10,11</span></a> An inverse relation has been observed with smoking..<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">5,11</span></a> Some of the main conditions that have been related with geographic tongue are named in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Psoriasis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Psoriasis is a chronic inflammatory skin disease, which can also compromise joints. Its cause is multifactorial, redounding in a pro-inflammatory environment that produces a defect in the normal cycle of epidermis, with alterations in the proliferation and differentiation of keratinocytes, associated with inflammatory changes.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Presence of oral lesions in psoriasis is uncommon and controversial.<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">12</span></a> Oral manifestations such as geographic tongue and fissured tongue are highly non-specific. Some reports suggest that approximately 10% of patients would have geographic tongue, turning it the most common oral manifestation in these patients.<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">13</span></a> This studies are based on the observation of elemental lesions, the histological similarity of both conditions and the presence of a common genetic marker HLA-Cw6.<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">13–16</span></a> Gonzaga et al showed a strong association between the presence of HLA-Cw6 in psoriasis with geographic tongue, identifying this antigen in a 59.1% of patients with psoriasis and in a 43.8% of patients with benign migratory glossitis, while only a 12.6% was observed in the control group. As a consequence, the presence of geographic tongue has been planted as an authentic oral manifestation of psoriasis.<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">16</span></a> However, other investigations have suggested that the association cannot be established properly,<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">17</span></a> given there is a non-negligible percentage of healthy patients with migratory glossitis.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">18</span></a> An study performed by Picciani et al. has proposed that only some patients with suggestive tongue lesions would have true oral psoriasis, while the rest corresponds only to a primary geographic tongue.<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">19</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Geographic tongue has been described as an early manifestation of psoriasis, with late evolution into the fissured variant, which could be permanent and/or concomitant with geographic tongue up to a 34.5% of affected patients.<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">5,20,21</span></a> Given the strong family history among parents and twins, both lesions could correspond to a polygenetic inheritance pattern.<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">22</span></a> On the other hand, the fissured form has been described in pustular psoriasis,<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">23,24</span></a> establishing a probable relationship with the severity of the disease.<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">21,23,24</span></a> Recent studies have shown that mutations in the gene IL36RN are associated with geographic tongue, being the latter the main cause of generalized pustular psoriasis.<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">25</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Allergies</span><p id="par0040" class="elsevierStylePara elsevierViewall">Studies have linked the presence of allergies with geographic tongue. It has been reported that patients with personal or family history of asthma, eczema, allergic rhinitis and higher levels of immunoglobulin E are more prone to have geographic tongue when compared to people without the mentioned diseases.<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">6,26</span></a> Miloglu et al determined that 24.1% of patients with geographic tongue had concomitantly an atopic or allergic disease.<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">5</span></a> Likewise, the study of Marks et al<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">6</span></a> shows personal or family history of these diseases in 86% of the studied patients, while in the control group was only up to 37%.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">There is a relationship between geographic tongue and seborreic dermatitis, with some subtypes of bronchitis in children.<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">27</span></a> Furthermore, a study in patients with cow's milk allergy by Mclendon and Jaeger<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">28</span></a> showed that a significant proportion of these patients present benign migratory glossitis.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Atopic dermatitis</span><p id="par0050" class="elsevierStylePara elsevierViewall">Atopic dermatitis is a relapsing chronic inflammatory skin disease associated with other atopic diseases such as allergic rhinitis and asthma.<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">29</span></a> In developed countries its prevalence has increased in the last 30 years, affecting 15-30% of children and 2-10% of adults.<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">30</span></a> It is characterized by periods of exacerbation and remission, presenting erythematous, highly pruritic, scaly and scabby plaques, evolving into lichenified plates secondary to scratching.<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">31</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Clinical manifestations vary with age and its etiopathogenesis responds to multiple mechanisms, hence 2 mainly hypothesis have been proposed: On the one hand, the primary defect would be an immunological alteration that causes an IgE-mediated sensitization, with a dysfunction of the epithelial barrier secondary to local inflammation; and on the other, there would be an intrinsic defect in the epithelial cells that leads to a dysfunction of the skin barrier.<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">32</span></a> However, recent studies have proposed environmental allergens as a key triggering factor, proposing a new concept of pathogenesis (“from the outside in”).</p><p id="par0060" class="elsevierStylePara elsevierViewall">Regarding its association with geographic tongue, studies have reported that patients with a personal or family history of atopy are more likely to have benign migratory glossitis.<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">6,31</span></a> This association may respond to the existence of psychosomatic factors, which contribute to both pathologies.<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">33</span></a> Furthermore, good response has been seen with the use of topical Tacrolimus in patients with symptomatic migratory glossitis, which is widely used in the treatment of atopic patients.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">34</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Vitamin D</span><p id="par0065" class="elsevierStylePara elsevierViewall">There is no consistent evidence to establish a direct relationship between vitamin D deficiency and migratory glossitis. However, in 2016 a meta-analysis was performed establishing a possible role of vitamin D in improving the symptoms of atopic dermatitis.<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">35</span></a> Thus, it is possible to assume that vitamin D supplementation could help diminish severe symptoms of atopic dermatitis and, consequently, symptomatic glossitis.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Celiac disease</span><p id="par0070" class="elsevierStylePara elsevierViewall">Celiac disease is an autoimmune disease that produces chronic inflammation of the small intestine's mucosa due to gluten intolerance.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">36</span></a> There are genetic markers such as HLA DQ2 or HLA DQ8,<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">37</span></a> that are present in more than 95% of patients with this disease, compared to 40% in the general population. Clinically, it presents with malabsorption and malnutrition, diarrhea, anorexia, constipation, vomiting and abdominal distension.<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">38</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Celiac disease may compromise oral cavity. The most frequent and best-documented oral manifestations are recurrent aphthous stomatitis and dental enamel defects,<a class="elsevierStyleCrossRefs" href="#bib0460"><span class="elsevierStyleSup">39,40</span></a> however, geographic tongue may constitute a possible oral manifestation of celiac disease.<a class="elsevierStyleCrossRefs" href="#bib0470"><span class="elsevierStyleSup">41–43</span></a> Cigic et al conducted a study in patients with geographic tongue and no history of celiac disease. This study showed a 15% incidence of celiac disease in these patients, with diagnosis confirmed by duodenal biopsy. All patients had a genetic marker present (HLA DQ2 or HLADQ8).<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">38</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Although more studies are still required, the clinical examination of the oral cavity could serve as a diagnostic tool in patients with celiac disease, especially in atypical forms, which would help prevent associated complications.<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">38</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Nutritional deficiencies</span><p id="par0085" class="elsevierStylePara elsevierViewall">Since there is a relationship between iron and B complex vitamins deficiency with generalized glossitis with papillary atrophy, a possible association between geographic tongue and nutritional deficiencies has been proposed. This type of glossitis can be confused with geographic tongue, especially when the apex and lateral borders are compromised.<a class="elsevierStyleCrossRefs" href="#bib0485"><span class="elsevierStyleSup">44,45</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">A study was conducted by the University of Minnesota in 42 patients with geographic tongue, in which no patient showed signs of nutritional deficiencies. Moreover, there was no trend towards improvement among the ten patients who received a high dose of multivitamins and minerals when compared with the control group.<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">45</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In a study performed in elderly patients suffering from lingual abnormalities, including geographic tongue, it was found that treatment with multivitamins for 6 months did not significantly influence these conditions.<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">46</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Infections</span><p id="par0100" class="elsevierStylePara elsevierViewall">Due to the inflammatory nature of the lesions, some bacterial and fungal infections were thought to be related with geographic tongue. However, no associated microorganism was consistently found.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">34</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Syndromes and geographical language<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">33</span></a></span><p id="par0105" class="elsevierStylePara elsevierViewall">Some of the syndromes described are Reiter syndrome,<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">47</span></a> Robinow syndrome,<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">48</span></a> fetal hydantoin syndrome and Down syndrome. Regarding the latter, a study conducted on mucocutaneous alterations in these patients established a possible association with lingual alterations, given that 28% of these patients had fissured tongue and 4% had a geographical tongue.<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">49</span></a></p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Diagnosis</span><p id="par0110" class="elsevierStylePara elsevierViewall">The diagnosis of benign migratory glossitis is essentially clinical. Laboratory tests are usually normal and, in general terms, lesion biopsy is not required given the benign nature of the disease.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">1</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Clinically, erythematous plaques can be observed in absence of filiform papillae, with a well-defined whitish margin (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and a mixture of neutrophils and keratin.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">10</span></a> These lesions are found mainly in the dorsal and lateral regions of the tongue, have a migratory pattern, and can change size, shape and location within minutes to hours (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). They present periods of exacerbation and remission, without complications or sequelae.<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">50</span></a> There may be compromise of other areas of the oral mucosa such as soft palate, buccal mucosa, floor of the mouth, gums and uvula, however these are rare to be present.<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">33</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">In most cases it presents as an asymptomatic disease, with few reports of stomatodynia and/or foreign body sensation.</p><p id="par0125" class="elsevierStylePara elsevierViewall">Differential diagnoses to be consider include: oral candidiasis, oral lichen planus, lupus erythematous, trauma and adverse drug reaction. In children, atrophic candidiasis, local trauma and severe neutropenia should be ruled out.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">1</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Treatment</span><p id="par0130" class="elsevierStylePara elsevierViewall">Due to its benign nature and mainly asymptomatic course, patients with geographic tongue do not usually receive treatment.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">1</span></a> In cases of symptoms, such as pain and/or burning sensation, the use of mouthwashes with local anesthetic, topical corticosteroids and/or sucralfate can be considered.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">10</span></a> There are case reports with symptomatic glossitis that have presented an optimal response to the use of topical tacrolimus,<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">34</span></a> even in pediatric patients, and when given over a short period of time.<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">51</span></a> However, in severe and persistent cases, the use of oral ciclosporin has been described as the main effective treatment.<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">52</span></a> It is recommended to avoid irritating agents that exacerbate injuries, such as spiced and acid foods, and maintaining a good oral hygiene, with toothpastes free of dyes and preservatives.<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">53</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">A general approach to patients with geographic tongue is proposed in <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusions</span><p id="par0140" class="elsevierStylePara elsevierViewall">The geographical tongue or “migratory glossitis” is a benign and chronic inflammatory condition of the tongue, with no known cause. The diagnosis is made essentially with clinical resources, with characteristic findings on physical examination. It usually does not require treatment, given its benign condition and asymptomatic course.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Although there are no studies that aim at geographic tongue associations with certain pathologies and/or clinical conditions, it is possible to highlight some important aspects of these. First place, a considerable number of studies support the relationship between geographical tongue and psoriasis, showing a histological similarity and a common genetic marker. In this context, it is important to perform a thorough physical examination of patients with psoriasis in search of oral lesions, which if present, can constitute a marker of severity. In the same way, in patients with migratory glossitis, it is advisable to investigate in search of cutaneous lesions suggestive of psoriasis.</p><p id="par0150" class="elsevierStylePara elsevierViewall">Regarding the existing relationship between allergies or atopy and geographical tongue, it could be useful to consider therapies that are beneficial in atopic patients for the treatment of symptomatic glossitis, such as the use of topical tacrolimus. Along these lines, a possible association between atopic patients and hypovitaminosis D has been proposed, so it has been suggested that supplementation with vitamin D could reduce its symptoms. However, there are no studies that demonstrate this relationship with migratory glossitis. New lines of research are required to establish possible causality and relationship with severity of the lingual manifestations, as well to offer other treatment alternatives to patients with symptomatic and persistent migratory glossitis.</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of Interest</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1199765" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1118208" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1199766" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1118209" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Etiology" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Psoriasis" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Allergies" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Atopic dermatitis" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Vitamin D" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Celiac disease" ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "Nutritional deficiencies" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Infections" ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Syndromes and geographical language" ] ] ] 6 => array:2 [ "identificador" => "sec0055" "titulo" => "Diagnosis" ] 7 => array:2 [ "identificador" => "sec0060" "titulo" => "Treatment" ] 8 => array:2 [ "identificador" => "sec0065" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0070" "titulo" => "Conflicts of Interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-06-07" "fechaAceptado" => "2018-10-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1118208" "palabras" => array:4 [ 0 => "Bening migratory glossitis" 1 => "Inflammation" 2 => "Psoriasis" 3 => "Atopia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1118209" "palabras" => array:4 [ 0 => "Glositis migratoria benigna" 1 => "Inflamación" 2 => "Psoriasis" 3 => "Atopia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Geographic tongue, also known as benign migratory glossitis, is a benign chronic inflammatory condition of the tongue. It is characterized by erythematous lesions with filiform papillae atrophy, surrounded by white limited areas in the dorsal and lateral aspects of the tongue, producing a map-like aspect. This lesions change in size and shape with time, and are characterized by periods of exacerbation and remission without scaring. The cause is unknown, but multiple associations have been described, which will be discussed below.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La lengua geográfica, también conocida como glositis migratoria benigna, es una condición inflamatoria crónica benigna de la lengua. Se caracteriza por presentar lesiones eritematosas asociadas a una atrofia de papilas, las que están rodeadas por áreas blanquecinas bien delimitadas y localizadas predominantemente en la cara lateral y dorsal de la lengua, lo que da una imagen que recuerda un mapa geográfico. Estas lesiones pueden variar tanto de tamaño como de forma durante su evolución; además, presentan periodos de exacerbación y remisión sin dejar lesiones cicatriciales residuales. La causa de esta entidad sigue siendo desconocida, sin embargo, múltiples asociaciones se han descrito, las que son comentadas a continuación.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ogueta IC, Ramírez MP, Jiménez CO, Cifuentes MM. Lengua geográfica: ¿qué es lo que un dermatólogo debería saber?. Actas Dermosifiliogr. 2019;110:341–346.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 757 "Ancho" => 650 "Tamanyo" => 72530 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Erythematous plaques in absence of filiform papillae.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 708 "Ancho" => 650 "Tamanyo" => 62011 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Erythematous plaques with a well-defined whitish margin on the dorsal of the tongue.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 3096 "Ancho" => 2500 "Tamanyo" => 394150 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A proposed general approach to patients witch suspected geographic tongue.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Psoriasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Reiter syndrome \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Allergies \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Lichen planus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Atopic dermatitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Drugs: Oral contraceptives, lithium, antihypertensives \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Nutritional deficiencies \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Genetic syndromes: Robinow syndrome, Down syndrome \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Infections \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Hormonal conditions: pregnancy among others \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Celiac disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2049319.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Conditions that have been frequently associated with geographic tongue.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:53 [ 0 => array:3 [ "identificador" => "bib0270" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benign migratory glossitis or geographic tongue: An enigmatic oral lesion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Assimakopoulos" 1 => "G. Patrikakos" 2 => "C. Fotika" 3 => "M. Elisaf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Med" "fecha" => "2002" "volumen" => "113" "paginaInicial" => "5" "paginaFinal" => "751" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0275" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prevalence of oral mucosal lesions in a population in Ljubljana, Slovenia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Kovac-Kovacic" 1 => "U. Skaleric" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Oral Pathol Med" "fecha" => "2000" "volumen" => "29" "paginaInicial" => "331" "paginaFinal" => "335" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10947249" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0280" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of the most common oral mucosal diseases in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.R. Rioboo-Crespo" 1 => "P. Planells-del Pozo" 2 => "R. Rioboo-García" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Oral Patol Oral Cir Bucal" "fecha" => "2005" "volumen" => "10" "paginaInicial" => "376" "paginaFinal" => "387" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0285" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Geographic tongue: Clinical characteristics of 188 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Jainkittivong" 1 => "R.P. Langlais" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Contemp Dent Pract" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "123" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15719084" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0290" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prevalence and risk factors associated with benign migratory glossitis lesions in 7619 Turkish dental outpatients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O. Miloğlu" 1 => "M. Göregen" 2 => "H.M. Akgül" 3 => "H. Acemoğlu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tripleo.2008.10.015" "Revista" => array:6 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod" "fecha" => "2009" "volumen" => "107" "paginaInicial" => "e29" "paginaFinal" => "e33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19138635" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0295" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Geographic tongue —a manifestation of atopy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Marks" 1 => "M.J. Simons" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1979" "volumen" => "101" "paginaInicial" => "159" "paginaFinal" => "162" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/486322" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0300" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hereditary component in the etiology of benign migratory glossitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.S. Redman" 1 => "B.L. Shapiro" 2 => "R.J. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 113 | 100 | 213 |
| 2024 October | 774 | 566 | 1340 |
| 2024 September | 428 | 436 | 864 |
| 2024 August | 459 | 468 | 927 |
| 2024 July | 433 | 317 | 750 |
| 2024 June | 352 | 291 | 643 |
| 2024 May | 310 | 367 | 677 |
| 2024 April | 240 | 247 | 487 |
| 2024 March | 291 | 251 | 542 |
| 2024 February | 476 | 216 | 692 |
| 2024 January | 572 | 224 | 796 |
| 2023 December | 758 | 191 | 949 |
| 2023 November | 982 | 205 | 1187 |
| 2023 October | 1298 | 196 | 1494 |
| 2023 September | 1334 | 172 | 1506 |
| 2023 August | 1126 | 153 | 1279 |
| 2023 July | 1066 | 174 | 1240 |
| 2023 June | 884 | 133 | 1017 |
| 2023 May | 689 | 146 | 835 |
| 2023 April | 440 | 98 | 538 |
| 2023 March | 428 | 75 | 503 |
| 2023 February | 361 | 75 | 436 |
| 2023 January | 467 | 79 | 546 |
| 2022 December | 400 | 90 | 490 |
| 2022 November | 224 | 108 | 332 |
| 2022 October | 194 | 104 | 298 |
| 2022 September | 199 | 85 | 284 |
| 2022 August | 202 | 87 | 289 |
| 2022 July | 170 | 98 | 268 |
| 2022 June | 203 | 111 | 314 |
| 2022 May | 1172 | 140 | 1312 |
| 2022 April | 1769 | 84 | 1853 |
| 2022 March | 1846 | 149 | 1995 |
| 2022 February | 1826 | 89 | 1915 |
| 2022 January | 2509 | 111 | 2620 |
| 2021 December | 1969 | 67 | 2036 |
| 2021 November | 2022 | 83 | 2105 |
| 2021 October | 3037 | 97 | 3134 |
| 2021 September | 2409 | 68 | 2477 |
| 2021 August | 481 | 69 | 550 |
| 2021 July | 371 | 39 | 410 |
| 2021 June | 717 | 49 | 766 |
| 2021 May | 566 | 72 | 638 |
| 2021 April | 980 | 152 | 1132 |
| 2021 March | 579 | 79 | 658 |
| 2021 February | 463 | 51 | 514 |
| 2021 January | 477 | 49 | 526 |
| 2020 December | 342 | 49 | 391 |
| 2020 November | 250 | 36 | 286 |
| 2020 October | 198 | 30 | 228 |
| 2020 September | 191 | 30 | 221 |
| 2020 August | 196 | 39 | 235 |
| 2020 July | 143 | 27 | 170 |
| 2020 June | 113 | 51 | 164 |
| 2020 May | 172 | 34 | 206 |
| 2020 April | 54 | 26 | 80 |
| 2020 March | 20 | 10 | 30 |
| 2020 February | 2 | 0 | 2 |
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