Case and Research Letters
Spontaneous Regression of Medium-Sized Congenital Melanocytic Nevi: Report of 3 New Cases
Regresión espontánea de tres nevus melanocíticos congénitos medianos
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B) Seguimiento: obsérvese pérdida progresiva de pigmento a predominio folicular. C) Detalle: atrofia folicular. Obsérvese vellos sin pigmento.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Alperovich, M.J. Fiandrino, R. Asial, M.C. Boente" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Alperovich" ] 1 => array:2 [ "nombre" => "M.J." "apellidos" => "Fiandrino" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Asial" ] 3 => array:2 [ "nombre" => "M.C." "apellidos" => "Boente" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219019301398" "doi" => "10.1016/j.adengl.2019.04.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019301398?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018304277?idApp=UINPBA000044" "url" => "/00017310/0000011000000005/v1_201906020639/S0001731018304277/v1_201906020639/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S157821901930037X" "issn" => "15782190" "doi" => "10.1016/j.adengl.2019.02.005" "estado" => "S300" "fechaPublicacion" => "2019-06-01" "aid" => "2133" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2019;110:417-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2 "PDF" => 2 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Multiple Eruptive Dermatofibromas in a Patient Treated With Brentuximab Vedotin" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "417" "paginaFinal" => "418" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatofibromas eruptivos múltiples en una paciente tratada con brentuximab vedotin" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 446 "Ancho" => 1000 "Tamanyo" => 102105 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multiple dermatofibromas. Histologic examination showing a cellular proliferation of spindled cells in the dermis, with overlying epidermal acanthosis (2a, H&E stain, x 40). Higher magnification shows that the spindle cells entrap normal dermal collagen bundles (2b, H&E stain, x 200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Giavedoni, A. Combalia, R. Pigem, J.M. Mascaró" "autores" => array:4 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Giavedoni" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Combalia" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Pigem" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Mascaró" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018305799" "doi" => "10.1016/j.ad.2018.05.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018305799?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901930037X?idApp=UINPBA000044" "url" => "/15782190/0000011000000005/v1_201906050857/S157821901930037X/v1_201906050857/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219019301404" "issn" => "15782190" "doi" => "10.1016/j.adengl.2019.04.015" "estado" => "S300" "fechaPublicacion" => "2019-06-01" "aid" => "2062" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2019;110:412-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Severe and Lethal Presentation of Folliculotropic Mycosis Fungoides" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "412" "paginaFinal" => "414" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Micosis fungoide foliculotropa de presentación grave y letal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1179 "Ancho" => 2086 "Tamanyo" => 613613 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histopathology images. Immune staining with hematoxylin–eosin shows a hyperplasic perifollicular epidermis with infiltration of the follicular epithelium by numerous lymphocytes, some of which are atypical. Immune staining and immunophenotyping of these lymphocytes shows CD3<span class="elsevierStyleSup">+</span>, with partial loss of CD2 and CD7, and a CD4:CD8 ratio of 4:1.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Uribe-Bojanini, C. Santa-Vélez, X. Rueda-Cadena, S.D. Morales" "autores" => array:4 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Uribe-Bojanini" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Santa-Vélez" ] 2 => array:2 [ "nombre" => "X." "apellidos" => "Rueda-Cadena" ] 3 => array:2 [ "nombre" => "S.D." "apellidos" => "Morales" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018304289" "doi" => "10.1016/j.ad.2018.02.027" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018304289?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019301404?idApp=UINPBA000044" "url" => "/15782190/0000011000000005/v1_201906050857/S1578219019301404/v1_201906050857/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Spontaneous Regression of Medium-Sized Congenital Melanocytic Nevi: Report of 3 New Cases" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "414" "paginaFinal" => "416" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R. Alperovich, M.J. Fiandrino, R. Asial, M.C. Boente" "autores" => array:4 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "Alperovich" "email" => array:1 [ 0 => "ruthalperovich@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.J." "apellidos" => "Fiandrino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "R." "apellidos" => "Asial" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M.C." "apellidos" => "Boente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Dermatología, Hospital del Niño Jesús, Tucumán, Argentina" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centro Integral de Dermatología, Tucumán, Argentina" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Regresión espontánea de tres nevus melanocíticos congénitos medianos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1068 "Ancho" => 2092 "Tamanyo" => 189783 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A, Medium CMN with small areas of regression. B, Follow-Up: note the progressive loss of pigmentation to follicular predominance. C. Detail of follicular atrophy. Note the unpigmented hairs. gr3.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Congenital melanocytic nevi (CMN) are genetically determined benign proliferations of cells that arise from the neural crest and which are present from birth or the first weeks of life.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1–3</span></a> They may remain unchanged or present a dynamic course.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,3</span></a> Regression is a rare process that causes progressive loss of pigment and may occur in different ways.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1–5</span></a> It is frequently associated with the formation of distant achromic lesions.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,4</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case 1</span><p id="par0010" class="elsevierStylePara elsevierViewall">An 8-year-old boy was examined for changes in CMN lesions, which had appeared on his left leg 3 years earlier. These changes began with a halo and subsequent disappearance of pigment on the surface and of the hair covering the lesion. At the same time, the patient developed distant achromic lesions (in the region of the right iliac fossa and in the occipital region of the scalp) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A-<span class="elsevierStyleSmallCaps">C</span>). Topical treatment was instated with mometasone furoate for 3 weeks, followed by tacrolimus 0.1% ointment, and repigmentation was achieved by sectors of both the nevus (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D) and the distant achromic lesions, though without changes to the poliosis.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Case 2</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 5-year-old girl was examined due to changes in CMN lesions, which had appeared a month earlier. Physical examination revealed a brown lesion measuring 9<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>cm; the lesion was brown with a whitish central area, a corrugated surface, and a fibrous appearance, and had white hairs on the surface (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). At the same time, an achromic macule appeared on the upper left eyelid. Treatment was instated with tacrolimus 0.03% ointment for both lesions. The patient did not return.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case 3</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 5-year-old girl was examined due to progressive depigmentation of her CMN lesions; this process had begun with a halo and gradual reduction of the pigment on the surface of the halo. At the same time, the patient developed achromic lesions on the upper eyelids. In the following years, she developed areas of fibrosis and follicular atrophy inside the CMN lesions. Treatment with pimecrolimus 1% was instated for the distant achromic lesions and no repigmentation was observed (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A-C).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">In all of the patients, histology revealed nevus cells and a predominantly lymphocytic inflammatory infiltrate in the deep dermis. Replacement of the nevus cells with fibrous tissue was observed in Cases 2 and 3 (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B).</p><p id="par0030" class="elsevierStylePara elsevierViewall">In all 3 cases, dermatoscopy revealed perifollicular hyperpigmentation, a blue-gray pigment associated with the deep component, globules, and pink areas without structures.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">CMN are classified by size into small (less than 1.5<span class="elsevierStyleHsp" style=""></span>cm), medium (1.5 to 10<span class="elsevierStyleHsp" style=""></span>cm), large (10 to 20<span class="elsevierStyleHsp" style=""></span>cm), and giant (greater than 20<span class="elsevierStyleHsp" style=""></span>cm). They may be located on any part of the skin surface and may appear in isolation or as part of more complex syndromes.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Torrelo et al.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> suggest that nevi reflect mosaicisms and show that they follow certain skin patterns and phenotypic characteristics. Postzygotic mutations of the H-Ras gene have also been shown in these nevi.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3,6,7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The course of CMN is variable and they may remain stable throughout life, increase in size, change color and thickness, become more hairy, become malignant, and even regress.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,3,4</span></a> To date, multiple forms have been reported in which these nevi show signs of regression.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,2,4,5</span></a> The most frequent form starts with a halo phenomenon that spontaneously regresses from the periphery to the center. Another more frequent form lacks this halo phenomenon.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> In exceptional cases, regression occurs by means fibrosis of the lesions.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The halo phenomenon is an area of depigmentation that may occur around CMN and other entities.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> It affects 1% of the general population and incidence is higher in patients with pediatric vitiligo.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,8</span></a> There are many theories regarding its pathophysiology, including cellular and/or humoral immune responses to nevus cells or melanocytic nevi, which may present associated antigens or nonspecific abnormalities, even leading to cross-reactivity with distant melanocytes.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> The latter would explain the appearance of distant achromic lesions. Drakensjö et al.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> believed that nevus cells remained in the dermis despite the regression.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Both vitiligo and the halo phenomenon share immunologic mechanisms and it has been shown that, when both are present, they are associated with some subtypes of the human leukocyte antigen HLA complex.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,8</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Regression of CMN without the halo phenomenon is very rare and alternative regression mechanisms have been proposed, such as reduced melanin synthesis and/or nevus cell apoptosis. In Case 2, the CMN regressed without a prior halo phenomenon but with distant achromic lesions.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Regression by means of fibrosis has been reported very rarely and the underlying mechanism is unknown. One variant of this form of regression by fibrosis, described by Ruiz-Maldonado et al.,<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> is desmoplastic nevus. In that case, the authors proposed the immune system as a trigger.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9,10</span></a> Histology shows replacement of nevus cells with connective tissue, and the most salient clinical finding is induration of the lesion. The principal differential diagnosis is malignant transformation and clinical and histologic follow-up is therefore essential.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9,10</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The immune response to neoplastic cells would act concomitantly against the melanocytic nevus cells. Although an association has been described between the halo phenomenon and melanoma, it is rarely associated with CMN.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">We believe that these clinical cases are of interest as they provide examples of the different forms of regression. Knowledge of this process will make it possible to anticipate the potential development of vitiligo and follow-up with therefore allow for dearly diagnosis and treatment. Case 2 is notable, as regression occurred without a prior halo phenomenon, despite the appearance of distant achromic lesions, suggesting that the immune system played an important role in the process.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of Interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case 1" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Case 2" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Case 3" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of Interest" ] 5 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-10-24" "fechaAceptado" => "2018-03-24" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Alperovich R, Fiandrino MJ, Asial R, Boente MC. Spontaneous Regression of Medium-Sized Congenital Melanocytic Nevi: Report of 3 New Cases. Actas Dermosifiliogr. 2019;110:414–416.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 582 "Ancho" => 2083 "Tamanyo" => 135206 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, CMN showing loss of pigment and persistence of pigment in the central area. B, Achromic macule in the right iliac fossa. C, Occipital poliosis. D, Areas of repigmentation of the CMN 4 months after treatment. gr1.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1129 "Ancho" => 1500 "Tamanyo" => 242874 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, CMN with blackish-brown coloring and a whitish central area with a fibrotic appearance. Note the white hairs in this area. B, Histology: areas of collagen homogeneization (<span class="elsevierStyleBold">></span>) in the deep dermis, involving adnexa, surrounded by nevus cells and an inflammatory infiltrate (*). gr2.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1068 "Ancho" => 2092 "Tamanyo" => 189783 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A, Medium CMN with small areas of regression. B, Follow-Up: note the progressive loss of pigmentation to follicular predominance. C. Detail of follicular atrophy. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 17 | 10 | 27 |
| 2024 October | 116 | 44 | 160 |
| 2024 September | 192 | 26 | 218 |
| 2024 August | 136 | 51 | 187 |
| 2024 July | 106 | 42 | 148 |
| 2024 June | 90 | 41 | 131 |
| 2024 May | 105 | 36 | 141 |
| 2024 April | 95 | 24 | 119 |
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| 2024 February | 133 | 34 | 167 |
| 2024 January | 109 | 32 | 141 |
| 2023 December | 92 | 34 | 126 |
| 2023 November | 98 | 50 | 148 |
| 2023 October | 103 | 35 | 138 |
| 2023 September | 99 | 36 | 135 |
| 2023 August | 67 | 23 | 90 |
| 2023 July | 104 | 58 | 162 |
| 2023 June | 84 | 44 | 128 |
| 2023 May | 78 | 41 | 119 |
| 2023 April | 72 | 25 | 97 |
| 2023 March | 96 | 27 | 123 |
| 2023 February | 80 | 32 | 112 |
| 2023 January | 55 | 20 | 75 |
| 2022 December | 61 | 48 | 109 |
| 2022 November | 42 | 36 | 78 |
| 2022 October | 55 | 34 | 89 |
| 2022 September | 40 | 51 | 91 |
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| 2022 June | 36 | 22 | 58 |
| 2022 May | 93 | 36 | 129 |
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| 2022 January | 109 | 32 | 141 |
| 2021 December | 83 | 34 | 117 |
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| 2021 October | 90 | 61 | 151 |
| 2021 September | 78 | 43 | 121 |
| 2021 August | 96 | 22 | 118 |
| 2021 July | 77 | 14 | 91 |
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| 2021 May | 64 | 37 | 101 |
| 2021 April | 114 | 75 | 189 |
| 2021 March | 73 | 21 | 94 |
| 2021 February | 69 | 16 | 85 |
| 2021 January | 32 | 18 | 50 |
| 2020 December | 29 | 8 | 37 |
| 2020 November | 15 | 15 | 30 |
| 2020 October | 18 | 14 | 32 |
| 2020 September | 41 | 6 | 47 |
| 2020 August | 24 | 10 | 34 |
| 2020 July | 24 | 13 | 37 |
| 2020 June | 41 | 20 | 61 |
| 2020 May | 29 | 10 | 39 |
| 2020 April | 11 | 10 | 21 |
| 2020 March | 14 | 4 | 18 |
| 2020 February | 2 | 0 | 2 |
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