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Piel de tronco inferior, cadera y glúteo derecho con placas de superficie mamelonada, induradas al tacto, sin alteraciones del color ni pérdida de folículos pilosos.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. Kaplan, C. Bolte, I. Sazunic, X. Wortsman" "autores" => array:4 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Kaplan" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Bolte" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Sazunic" ] 3 => array:2 [ "nombre" => "X." 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A, Macrophages with amastigotes of <span class="elsevierStyleItalic">Leishmania major</span> (Riu's stain, magnification,<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>400). B, Greater magnification (Riu's stain, magnification,<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1000).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Sainz-Gaspar, E. Rosón, J. Llovo, H. Vázquez-Veiga" "autores" => array:4 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Sainz-Gaspar" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Rosón" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Llovo" ] 3 => array:2 [ "nombre" => "H." "apellidos" => "Vázquez-Veiga" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018302497" "doi" => "10.1016/j.ad.2018.02.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018302497?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300423?idApp=UINPBA000044" "url" => "/15782190/0000011000000003/v1_201904030645/S1578219019300423/v1_201904030645/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S157821901930054X" "issn" => "15782190" "doi" => "10.1016/j.adengl.2019.02.015" "estado" => "S300" "fechaPublicacion" => "2019-04-01" "aid" => "1987" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2019;110:244-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4 "formatos" => array:2 [ "EPUB" => 1 "HTML" => 3 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "An Analysis of Drug Survival, Effectiveness, and Safety in Moderate to Severe Psoriasis Treated With Ustekinumab: An Observational Study of 69 Patients in Routine Clinical Practice" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "244" "paginaFinal" => "246" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Análisis de supervivencia, eficacia y seguridad en psoriasis moderada–grave tratada con ustekinumab. Estudio observacional de 69 pacientes en la práctica clínica habitual" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2258 "Ancho" => 2500 "Tamanyo" => 215575 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan-Meier analysis of treatment survival (duration in months, 8.3 years of follow-up).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Salgüero Fernández, M. Hospital Gil, M. Sigüenza Sanz, G. Roustan Gullón" "autores" => array:4 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Salgüero Fernández" ] 1 => array:2 [ "nombre" => "M." 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Kaplan, C. Bolte, I. Sazunic, X. Wortsman" "autores" => array:4 [ 0 => array:4 [ "nombre" => "V." "apellidos" => "Kaplan" "email" => array:1 [ 0 => "vierakaplan@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Bolte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "I." "apellidos" => "Sazunic" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "X." "apellidos" => "Wortsman" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología, Universidad de Chile, Santiago, Chile" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Dermatología, Clínica Las Condes, Santiago, Chile" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Clínica Las Condes, Santiago, Chile" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Instituto de Investigación y Diagnóstico por Imágenes en Piel y Tejidos Blandos, Las Condes, Santiago, Chile" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Morfología ecográfica de síndrome de Stiff cutáneo con correlación clínica e histológica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 422 "Ancho" => 750 "Tamanyo" => 26919 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image. Skin of the lower trunk, hip, and right buttock, with plaques with a mammillated surface, indurated to touch, with no changes in color or hair follicle loss.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Stiff skin syndrome is a sclerodermoid disease, observed more frequently in children, with involvement of the pelvic, scapular, and thigh regions. It is associated with prominent fibrosis of the skin layers without the inflammatory component of scleroderma or morphea.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Clinically, it is manifest as areas of indurated skin, typically presenting without any alterations in coloration and occasionally with hypertrichosis, hyperpigmentation, subcutaneous nodules on the hands, lordosis on bending at the hip or knees, or prominent abdomen.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Diagnosis and monitoring of this syndrome represents a clinical challenge, as induration may resemble morphea. Moreover, clinical follow-up may not indicate the true extent of involvement, and monitoring with serial biopsies in children would be invasive and not very practical.</p><p id="par0015" class="elsevierStylePara elsevierViewall">In recent years, applications of ultrasound in dermatology have increased tremendously,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> and so far, the ultrasound pattern for Stiff skin syndrome has not been reported.</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Case history.</span> A 4<span class="elsevierStyleHsp" style=""></span>year old girl, with allergy to cow milk protein and with no family history of relevance, attended the clinic due to thickening and progressive stiffness of the skin of the trunk, hips, right buttock, and left leg from when she was 2 months old. She had no limitations to joint movements.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The physical examination highlighted indurated skin on the hips, lumbar region, and right buttock, with raised and irregular nodular areas without erythema, edema, local heat, or hypertrichosis. (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Blood work up and C reactive protein were normal, and antinuclear antibodies, anti-DNA, and anti-ENA were negative.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Color Doppler echotomography of the hips and right buttock was performed (Logic E9, General Electric Health Systems; Wakesha, WI; compact linear transducer of 8-18<span class="elsevierStyleHsp" style=""></span>MHz), using the dermatological prototype,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> which showed focal regions of thickening and decreased dermal echogenicity, with preserved hair follicles. Nodules or defined cysts were not observed. The thickness of the dermis varied between 1.5 and 3.8<span class="elsevierStyleHsp" style=""></span>mm and was greatest in the right hip. Foci of calcium deposits were not observed either inside or outside these areas. Subcutaneous adipose tissue showed a homogeneous echostructure, with unchanged thickness and prominent hyperechogenic fibrous septa. There were no signs of hypervascularization and musculotendinous planes maintained their normal morphology (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). With these ultrasound findings, active morphea was ruled out. The findings were consistent with stiff skin syndrome.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Pathology study showed a thin orthokeratotic epidermis with preservation of the dermoepidermal junction and thickening of the dermis with denser thick collagen fibers, particularly in the lower part of the reticular dermis. Thickened septa were observed in the adipose panniculus. Alcian blue staining showed increased interstitial mucin in the dermis and septa of the adipose panniculus (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Considering the clinical, ultrasound, and histological findings, diagnosis of stiff skin syndrome was made.</p><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Discussion.</span> Stiff skin syndrome is a disorder whose pathogenesis was unknown until recently.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> The main hypotheses consider a primary anomaly of the fascia with increased production of collagen VI and congenital abnormalities of fibroblasts that lead to a noninflammatory dermis due to defective synthesis of mucopolysaccharides.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In recent years, color Doppler ultrasound has gained increasing importance in dermatology, in view of its high definition when simultaneously visualizing cutaneous layers, underlying planes, and vascularization.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">6–8</span></a> To the best of our knowledge, this would be the first case in which the ultrasound morphology of this entity is described. The ultrasound signs of stiff skin syndrome are dermal thickening and reduced echogenicity, prominent fibrous septa in the hypodermis, preserved hair follicle morphology, and absence of regional hypervascularization. The most important differential diagnosis is with active morphea, in which inflammatory involvement of the dermal and epidermal layers would be observed, decreased dermal echogenicity, areas of increased subcutaneous echogenicity, and signs of dermal-hypodermal hypervascularization, with loss of hair follicle definition.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In the future, it will be necessary to compare ultrasound images of this disease with those from other types of hamartomatous lesions, and connective tissue lesions, which are often observed in children. Perhaps some cases diagnosed clinically as hamartomas might correspond to or be associated with this entity.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Another potential use for ultrasound in this condition would be to select the biopsy site, as this method of diagnosis through imaging can delimit the regions of greatest involvement and define the depth of the lesions and their proximity to structures of risk such as large blood vessels and nerves.</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion, color Doppler ultrasound can be used for the diagnosis of Stiff skin syndrome.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-09-07" "fechaAceptado" => "2017-12-04" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Kaplan V, Bolte C, Sazunic I, Wortsman X. Ultrasound Morphology of Stiff Skin Syndrome with Clinical and Histological Correlation. Actas Dermosifiliogr. 2019;110:247–248.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 422 "Ancho" => 750 "Tamanyo" => 26919 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image. Skin of the lower trunk, hip, and right buttock, with plaques with a mammillated surface, indurated to touch, with no changes in color or hair follicle loss.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 730 "Ancho" => 2500 "Tamanyo" => 174444 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Ultrasound. A, The grey scale (longitudinal axis; right hip) showing thickening and decreased dermal echogenicity (*) with preserved hair follicles (arrow heads). B, Color Doppler (longitudinal axis; right hip) shows absence of dermal or hypodermal hypervascularization. Note the prominent fibrous septa (arrows) in the hypodermis (A and B).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1248 "Ancho" => 2084 "Tamanyo" => 671272 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histology. A, Hematoxylin-eosin staining, ×20: reticular dermis with bands of thickened and dense collagen, without any inflammatory infiltrate. B, Alcian blue staining, ×200: increased mucin in the connective tissue.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stiff skin syndrome in a newborn infant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.P. Halverstam" 1 => "S.E. Mercer" 2 => "I. Harwayne-Gidansky" 3 => "L. Geller" 4 => "R.G. Phelps" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2012.05478.x" "Revista" => array:7 [ "tituloSerie" => "Int J Dermatol." 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Year/Month | Html | Total | |
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2024 November | 13 | 8 | 21 |
2024 October | 89 | 49 | 138 |
2024 September | 86 | 21 | 107 |
2024 August | 105 | 48 | 153 |
2024 July | 103 | 37 | 140 |
2024 June | 85 | 37 | 122 |
2024 May | 95 | 44 | 139 |
2024 April | 106 | 24 | 130 |
2024 March | 84 | 29 | 113 |
2024 February | 85 | 42 | 127 |
2024 January | 91 | 37 | 128 |
2023 December | 59 | 18 | 77 |
2023 November | 93 | 25 | 118 |
2023 October | 83 | 13 | 96 |
2023 September | 74 | 35 | 109 |
2023 August | 62 | 14 | 76 |
2023 July | 61 | 29 | 90 |
2023 June | 78 | 27 | 105 |
2023 May | 82 | 22 | 104 |
2023 April | 60 | 27 | 87 |
2023 March | 89 | 18 | 107 |
2023 February | 53 | 24 | 77 |
2023 January | 37 | 44 | 81 |
2022 December | 66 | 31 | 97 |
2022 November | 59 | 34 | 93 |
2022 October | 34 | 31 | 65 |
2022 September | 34 | 40 | 74 |
2022 August | 34 | 45 | 79 |
2022 July | 25 | 49 | 74 |
2022 June | 18 | 18 | 36 |
2022 May | 54 | 24 | 78 |
2022 April | 50 | 31 | 81 |
2022 March | 46 | 59 | 105 |
2022 February | 71 | 24 | 95 |
2022 January | 83 | 25 | 108 |
2021 December | 68 | 35 | 103 |
2021 November | 104 | 42 | 146 |
2021 October | 54 | 58 | 112 |
2021 September | 39 | 30 | 69 |
2021 August | 40 | 21 | 61 |
2021 July | 36 | 18 | 54 |
2021 June | 43 | 30 | 73 |
2021 May | 44 | 37 | 81 |
2021 April | 98 | 47 | 145 |
2021 March | 56 | 20 | 76 |
2021 February | 49 | 19 | 68 |
2021 January | 43 | 9 | 52 |
2020 December | 45 | 13 | 58 |
2020 November | 21 | 16 | 37 |
2020 October | 18 | 19 | 37 |
2020 September | 23 | 10 | 33 |
2020 August | 16 | 23 | 39 |
2020 July | 19 | 12 | 31 |
2020 June | 29 | 26 | 55 |
2020 May | 22 | 14 | 36 |
2020 April | 18 | 13 | 31 |
2020 March | 14 | 4 | 18 |
2020 February | 2 | 0 | 2 |
2019 June | 1 | 0 | 1 |
2019 May | 2 | 1 | 3 |
2019 April | 1 | 1 | 2 |