array:24 [
  "pii" => "S157821901930054X"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2019.02.015"
  "estado" => "S300"
  "fechaPublicacion" => "2019-04-01"
  "aid" => "1987"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2019;110:244-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4
    "formatos" => array:2 [
      "EPUB" => 1
      "HTML" => 3
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731018302515"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2018.02.019"
      "estado" => "S300"
      "fechaPublicacion" => "2019-04-01"
      "aid" => "1987"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2019;110:244-6"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 153
        "formatos" => array:2 [
          "HTML" => 98
          "PDF" => 55
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "An&#225;lisis de supervivencia&#44; eficacia y seguridad en psoriasis moderada&#8211;grave tratada con ustekinumab&#46; Estudio observacional de 69 pacientes en la pr&#225;ctica cl&#237;nica habitual"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "244"
            "paginaFinal" => "246"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "An analysis of Drug Survival&#44; Effectiveness&#44; and Safety in Moderate to Severe Psoriasis Treated With Ustekinumab&#58; An Observational Study of 69 Patients in Routine Clinical Practice"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2258
                "Ancho" => 2500
                "Tamanyo" => 226394
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis de supervivencia Kaplan-Meier &#40;tiempo en meses&#44; 8&#44;3 a&#241;os de seguimiento&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "I&#46; Salg&#252;ero Fern&#225;ndez, M&#46; Hospital Gil, M&#46; Sig&#252;enza Sanz, G&#46; Roustan Gull&#243;n"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Salg&#252;ero Fern&#225;ndez"
              ]
              1 => array:2 [
                "nombre" => "M&#46; Hospital"
                "apellidos" => "Gil"
              ]
              2 => array:2 [
                "nombre" => "M&#46; Sig&#252;enza"
                "apellidos" => "Sanz"
              ]
              3 => array:2 [
                "nombre" => "G&#46; Roustan"
                "apellidos" => "Gull&#243;n"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S157821901930054X"
          "doi" => "10.1016/j.adengl.2019.02.015"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901930054X?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018302515?idApp=UINPBA000044"
      "url" => "/00017310/0000011000000003/v1_201904030618/S0001731018302515/v1_201904030618/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219019300551"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2019.02.016"
    "estado" => "S300"
    "fechaPublicacion" => "2019-04-01"
    "aid" => "1986"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2019;110:247-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7
      "formatos" => array:3 [
        "EPUB" => 1
        "HTML" => 4
        "PDF" => 2
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Ultrasound Morphology of Stiff Skin Syndrome with Clinical and Histological Correlation"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "247"
          "paginaFinal" => "248"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Morfolog&#237;a ecogr&#225;fica de s&#237;ndrome de Stiff cut&#225;neo con correlaci&#243;n cl&#237;nica e histol&#243;gica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 422
              "Ancho" => 750
              "Tamanyo" => 26919
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image&#46; Skin of the lower trunk&#44; hip&#44; and right buttock&#44; with plaques with a mammillated surface&#44; indurated to touch&#44; with no changes in color or hair follicle loss&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "V&#46; Kaplan, C&#46; Bolte, I&#46; Sazunic, X&#46; Wortsman"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Kaplan"
            ]
            1 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Bolte"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Sazunic"
            ]
            3 => array:2 [
              "nombre" => "X&#46;"
              "apellidos" => "Wortsman"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731018302503"
        "doi" => "10.1016/j.ad.2017.12.016"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018302503?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300551?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000003/v1_201904030645/S1578219019300551/v1_201904030645/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219019300526"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2019.02.013"
    "estado" => "S300"
    "fechaPublicacion" => "2019-04-01"
    "aid" => "2036"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2019;110:243-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 8
      "formatos" => array:3 [
        "EPUB" => 2
        "HTML" => 4
        "PDF" => 2
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Allergic Contact Dermatitis to Kojic Acid"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "243"
          "paginaFinal" => "244"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Dermatitis al&#233;rgica de contacto al &#225;cido k&#243;jico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 599
              "Ancho" => 900
              "Tamanyo" => 86635
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Eczematous lesions at the application sites of the skin lightening product&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Tejera-Vaquerizo, J&#46; Garc&#237;a-Gav&#237;n"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tejera-Vaquerizo"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Garc&#237;a-Gav&#237;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731018303557"
        "doi" => "10.1016/j.ad.2018.03.021"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018303557?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300526?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000003/v1_201904030645/S1578219019300526/v1_201904030645/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "An Analysis of Drug Survival&#44; Effectiveness&#44; and Safety in Moderate to Severe Psoriasis Treated With Ustekinumab&#58; An Observational Study of 69 Patients in Routine Clinical Practice"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "244"
        "paginaFinal" => "246"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "I&#46; Salg&#252;ero Fern&#225;ndez, M&#46; Hospital Gil, M&#46; Sig&#252;enza Sanz, G&#46; Roustan Gull&#243;n"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "I&#46;"
            "apellidos" => "Salg&#252;ero Fern&#225;ndez"
            "email" => array:1 [
              0 => "irenebsf&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Hospital Gil"
          ]
          2 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Sig&#252;enza Sanz"
          ]
          3 => array:2 [
            "nombre" => "G&#46;"
            "apellidos" => "Roustan Gull&#243;n"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Dermatolog&#237;a&#44; Hospital Universitario Puerta de Hierro&#44; Majadahonda&#44; Madrid"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "An&#225;lisis de supervivencia&#44; eficacia y seguridad en psoriasis moderada&#8211;grave tratada con ustekinumab&#46; Estudio observacional de 69 pacientes en la pr&#225;ctica cl&#237;nica habitual"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2258
            "Ancho" => 2500
            "Tamanyo" => 215575
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan-Meier analysis of treatment survival &#40;duration in months&#44; 8&#46;3 years of follow-up&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Psoriasis is a chronic disease with a prevalence of between 1&#37; and 3&#37;&#46; Its clinical manifestations and associated comorbidities have a considerable impact on affected patients&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">While the advent of biologic therapy has greatly improved the control of moderate to severe psoriasis&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> the treatment of this disease is still complicated&#46; We have data on the patients who participated in clinical trials of biologic drugs&#44; but these cases are often unlike those we encounter in clinical practice&#44; as shown by a study of data from the Spanish BIOBADADERM registry&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> That study&#44; which analyzed data from 1042 patients on systemic therapy &#40;classic and biologic&#41;&#44; reported that 30&#37; of those patients would have been excluded from clinical trials&#46; The patients who would not have been eligible for inclusion in a clinical trial had a higher risk of developing severe adverse reactions to systemic treatment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Since we consider that it is important to report data on patients being treated in routine clinical practice&#44; we designed a study to evaluate the efficacy&#44; safety&#44; and survival of treatment with ustekinumab in our hospital&#46; We studied patients with moderate to severe psoriasis who started treatment with ustekinumab in our specialized psoriasis clinic between 1 January 2010 and 30 April 2017&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The characteristics of the patients included in the study are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Patients weighing 100&#160;kg or less started treatment with an initial dose of ustekinumab 45<span class="elsevierStyleHsp" style=""></span>mg followed by a second dose at 4 weeks and then 45<span class="elsevierStyleHsp" style=""></span>mg every 12 weeks for at least 12 months&#46; At 1 year&#44; treatment optimization was considered&#44; taking into account the efficacy achieved&#46; In 2 patients who weighed over 100<span class="elsevierStyleHsp" style=""></span>kg&#44; a dose of 90<span class="elsevierStyleHsp" style=""></span>mg was administered initially followed by another at 4 weeks and 90<span class="elsevierStyleHsp" style=""></span>mg every 12 weeks thereafter&#46; Informed consent was obtained from all of the patients before start of treatment&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Treatment survival was calculated as the number of days a patient continued on ustekinumab during follow-up&#46; The longest interval between two injections of the drug considered not to constitute loss to follow-up or treatment interruption was 180 days&#46; We performed 2 analyses&#58; one of the dataset as a whole and the other differentiating between patients who had previously received biologic therapy &#40;naive&#41; and those who had not &#40;non-naive&#41;&#46; The data was analyzed using the Kaplan-Meier method&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Treatment resulted in an improvement from the mean baseline Psoriasis Area and Severity Index &#40;PASI&#41; of 13&#46;3 to a final mean PASI score of 3&#46;5&#44; which represents an 83&#37; reduction in absolute PASI&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The treatment survival rate at the end of the 8&#46;3 years of follow-up was 75&#46;3&#37;&#44; and the rate was higher in the group of patients who had not previously been treated with a biologic agent than in the non-naive group &#40;80&#37; vs 60&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> includes the patients who continued on ustekinumab and those in whom treatment was withdrawn&#46; In this series&#44; 6 patients reported adverse events&#44; most of which were considered to be mild and did not lead to cessation of treatment&#46; Treatment was withdrawn due to an adverse event in 2 patients&#58; one who presented with infectious spondylodiscitis and another who developed severe palmoplantar pustulosis&#46; A patient who developed psoriatic arthritis 3 months after starting ustekinumab continued on treatment&#44; achieving a good response in terms of both skin lesions and joint involvement&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Tuberculin skin test conversion occurred in 12 patients&#44; who were prescribed 6 to 9 months of treatment with isoniazid&#46; No cases of active tuberculosis were recorded&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Several recent studies&#44; including the PSOLAR<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> and BABDIR<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> studies&#44; have collected data on the survival of biologic therapy in clinical practice&#46; The findings of the Spanish ORBIT<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> study&#8212;based on data from 427 patients collected over a 4-year period&#8212;highlight the efficacy and safety of long-term biologic therapy&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The treatment survival rate in this series was high &#40;76&#46;3&#37; at 100 months&#41;&#46; The 83&#37; decline in absolute PASI score was similar to results reported by other authors in the literature&#46; Puig et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a> in a 3-year study of 67 patients receiving ustekinumab&#44; reported a PASI 75 response at 1 year in 86&#37; of the patients&#46; Also of interest is the study by Molina-Leyva et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> of 30 patients treated with ustekinumab&#44; in which the PASI 75 response at 1 year was 81&#46;5&#37;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In the present series&#44; we should note that the baseline PASI was probably underestimated because none of the patients underwent a washout period before start of treatment with ustekinumab&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Withdrawal of treatment due to lack of efficacy &#40;both primary and secondary treatment failure&#41; was 13&#37;&#46; This low percentage may be due to the practice in our clinic of having a &#8220;watch and wait&#8221; period before deciding on loss of efficacy or withdrawal of treatment and to our patient&#39;s high degree of satisfaction with the efficacy achieved&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the literature we reviewed&#44; we found no cases of paradoxical psoriatic reactions associated with the use of IL-23 inhibitors&#46; By contrast&#44; their use as an alternative treatment for such reactions is reported&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> We did&#44; however&#44; find a report of a case in which paradoxical psoriasis worsened following treatment with ustekinumab&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">9</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The limitations of this study include its retrospective design and the use of the treatment survival rate as a measure of treatment success because this endpoint does not provide any information on how patients were included or take into account cases in which treatment was discontinued because the lesions had cleared&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">Irene Salg&#252;ero has participated in clinical trials and has been invited to give papers by Janssen&#44; Abbvie&#44; and Novartis&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
        ]
        1 => array:1 [
          "titulo" => "R&#233;f&#233;rences"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Salg&#252;ero Fern&#225;ndez I&#44; Gil MH&#44; Sanz MS&#44; Gull&#243;n GR&#46; An&#225;lisis de supervivencia&#44; eficacia y seguridad en psoriasis moderada&#8211;grave tratada con ustekinumab&#46; Estudio observacional de 69 pacientes en la pr&#225;ctica cl&#237;nica habitual&#46; Actas Dermosifiliogr&#46; 2019&#59;110&#58;244&#8211;246&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2258
            "Ancho" => 2500
            "Tamanyo" => 215575
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan-Meier analysis of treatment survival &#40;duration in months&#44; 8&#46;3 years of follow-up&#41;&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total number of patients n&#61;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Women&#44; 31&#46;88&#37; &#40;21&#41;&#59; Men&#44; 69&#46;57&#37; &#40;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Naive patients&#44; 39&#37; &#40;28&#41;&#59; Non-naive patients&#44; 61&#37; &#40;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#37; patients &#61; 1 prior biologic&#44; 34&#46;78&#37;&#59; &#62; 1 prior biologic&#44; 23&#46;18&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">Mean</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">Median</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age on starting ustekinumab&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Baseline PASI score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Final PASI score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Number of prior biologic therapies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of follow-up&#44; mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Patients Still on Therapy and Reasons for Withdrawal</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Number</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#37;</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Patients still on UST&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Withdrawal due to adverse events&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Withdrawal due to lack of efficacy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Withdrawal due to good response&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Withdrawal because patient was lost to follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2003845.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patient Characteristics&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "R&#233;f&#233;rences"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accumulated disability in the life course&#58; the scar of psoriasis in the patient&#39;s life"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Ros"
                            1 => "L&#46; Puig"
                            2 => "J&#46;M&#46; Carrascosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2013.02.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2014 Mar"
                        "volumen" => "105"
                        "paginaInicial" => "128"
                        "paginaFinal" => "134"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23668623"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of serious adverse events associated with biologic and nonbiologic psoriasis systemic therapy&#58; patients ineligible vs eligible for randomized controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Garcia-Doval"
                            1 => "G&#46; Carretero"
                            2 => "F&#46; Vanaclocha"
                            3 => "C&#46; Ferrandiz"
                            4 => "E&#46; Daud&#233;n"
                            5 => "J&#46;L&#46; S&#225;nchez-Carazo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2011.2768"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol&#46;"
                        "fecha" => "2012 Apr"
                        "volumen" => "148"
                        "paginaInicial" => "463"
                        "paginaFinal" => "470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22508869"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Drug survival of biologic therapy in a large&#44; disease-based registry of patients with psoriasis&#58; results from the Psoriasis Longitudinal Assessment and Registry &#40;PSOLAR&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Menter"
                            1 => "K&#46;A&#46; Papp"
                            2 => "M&#46; Gooderham"
                            3 => "D&#46;M&#46; Pariser"
                            4 => "M&#46; Augustin"
                            5 => "F&#46;A&#46; Kerdel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.13611"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2016 Jul"
                        "volumen" => "30"
                        "paginaInicial" => "1148"
                        "paginaFinal" => "1158"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27027388"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential drug survival of biologic therapies for the treatment of psoriasis&#58; A prospective observational cohort study from the British Association of Dermatologists Biologic Interventions Register &#40;BADBIR&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;B&#46; Warren"
                            1 => "C&#46;H&#46; Smith"
                            2 => "Z&#46;Z&#46;N&#46; Yiu"
                            3 => "D&#46;M&#46; Ashcroft"
                            4 => "J&#46;N&#46;W&#46;N&#46; Barker"
                            5 => "A&#46;D&#46; Burden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2015.208"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol&#46;"
                        "fecha" => "2015 Nov"
                        "volumen" => "135"
                        "paginaInicial" => "2632"
                        "paginaFinal" => "2640"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26053050"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ORBIT &#40;Outcome and Retention Rate of Biologic Treatments for Psoriasis&#41;&#58; A retrospective observational study on biologic drug survival in daily practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Vilarrasa"
                            1 => "J&#46; Notario"
                            2 => "X&#46; Bordas"
                            3 => "A&#46; L&#243;pez-Ferrer"
                            4 => "I&#46;J&#46; Gich"
                            5 => "L&#46; Puig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2016.01.037"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2016 Jun"
                        "volumen" => "74"
                        "paginaInicial" => "1066"
                        "paginaFinal" => "1072"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27004803"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term efficacy&#44; safety and drug survival of ustekinumab in a Spanish cohort of patients with moderate to severe plaque psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Puig"
                            1 => "V&#46; Ruiz-Salas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000366499"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology&#46;"
                        "fecha" => "2015"
                        "volumen" => "230"
                        "paginaInicial" => "46"
                        "paginaFinal" => "54"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25572820"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety and effectiveness of ustekinumab for treatment of moderate to severe psoriasis&#58; a prospective study in a clinical setting"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Molina-Leyva"
                            1 => "H&#46; Husein-Elahmed"
                            2 => "R&#46; Naranjo-Sintes"
                            3 => "J&#46;C&#46; Ruiz-Carrascosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Drugs Dermatol&#46;"
                        "fecha" => "2014 Aug"
                        "volumen" => "13"
                        "paginaInicial" => "971"
                        "paginaFinal" => "974"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of systemic therapies for moderate-to-severe psoriasis&#58; a systematic review and meta-analysis of long-term treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46;C&#46; Lucka"
                            1 => "D&#46; Pathirana"
                            2 => "A&#46; Sammain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2012.04492.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2012"
                        "volumen" => "26"
                        "paginaInicial" => "1331"
                        "paginaFinal" => "1344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22404617"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0022202X16310442"
                          "estado" => "S300"
                          "issn" => "0022202X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasiform eruption and worsening of pustulosis palmoplantaris after treatment with two anti-TNF-&#945; inhibitors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;A&#46; Bogaards"
                            1 => "M&#46;A&#46; de Rie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s13555-016-0151-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "followed by successful treatment with ustekinumab&#46; Dermatol Ther &#40;Heidelb&#41;&#46;"
                        "fecha" => "2016 Dec"
                        "volumen" => "6"
                        "paginaInicial" => "683"
                        "paginaFinal" => "688"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27783331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000011000000003/v1_201904030645/S157821901930054X/v1_201904030645/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000003/v1_201904030645/S157821901930054X/v1_201904030645/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901930054X?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case and Research Letters
An Analysis of Drug Survival, Effectiveness, and Safety in Moderate to Severe Psoriasis Treated With Ustekinumab: An Observational Study of 69 Patients in Routine Clinical Practice
Análisis de supervivencia, eficacia y seguridad en psoriasis moderada–grave tratada con ustekinumab. Estudio observacional de 69 pacientes en la práctica clínica habitual
I. Salgüero Fernández
Corresponding author
irenebsf@hotmail.com

Corresponding author.
, M. Hospital Gil, M. Sigüenza Sanz, G. Roustan Gullón
Dermatología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid
Read
4265
Times
was read the article
1737
Total PDF
2528
Total HTML
Share statistics
 array:24 [
  "pii" => "S157821901930054X"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2019.02.015"
  "estado" => "S300"
  "fechaPublicacion" => "2019-04-01"
  "aid" => "1987"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2019;110:244-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4
    "formatos" => array:2 [
      "EPUB" => 1
      "HTML" => 3
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731018302515"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2018.02.019"
      "estado" => "S300"
      "fechaPublicacion" => "2019-04-01"
      "aid" => "1987"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2019;110:244-6"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 153
        "formatos" => array:2 [
          "HTML" => 98
          "PDF" => 55
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "An&#225;lisis de supervivencia&#44; eficacia y seguridad en psoriasis moderada&#8211;grave tratada con ustekinumab&#46; Estudio observacional de 69 pacientes en la pr&#225;ctica cl&#237;nica habitual"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "244"
            "paginaFinal" => "246"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "An analysis of Drug Survival&#44; Effectiveness&#44; and Safety in Moderate to Severe Psoriasis Treated With Ustekinumab&#58; An Observational Study of 69 Patients in Routine Clinical Practice"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2258
                "Ancho" => 2500
                "Tamanyo" => 226394
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis de supervivencia Kaplan-Meier &#40;tiempo en meses&#44; 8&#44;3 a&#241;os de seguimiento&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "I&#46; Salg&#252;ero Fern&#225;ndez, M&#46; Hospital Gil, M&#46; Sig&#252;enza Sanz, G&#46; Roustan Gull&#243;n"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Salg&#252;ero Fern&#225;ndez"
              ]
              1 => array:2 [
                "nombre" => "M&#46; Hospital"
                "apellidos" => "Gil"
              ]
              2 => array:2 [
                "nombre" => "M&#46; Sig&#252;enza"
                "apellidos" => "Sanz"
              ]
              3 => array:2 [
                "nombre" => "G&#46; Roustan"
                "apellidos" => "Gull&#243;n"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S157821901930054X"
          "doi" => "10.1016/j.adengl.2019.02.015"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901930054X?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018302515?idApp=UINPBA000044"
      "url" => "/00017310/0000011000000003/v1_201904030618/S0001731018302515/v1_201904030618/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219019300551"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2019.02.016"
    "estado" => "S300"
    "fechaPublicacion" => "2019-04-01"
    "aid" => "1986"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2019;110:247-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7
      "formatos" => array:3 [
        "EPUB" => 1
        "HTML" => 4
        "PDF" => 2
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Ultrasound Morphology of Stiff Skin Syndrome with Clinical and Histological Correlation"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "247"
          "paginaFinal" => "248"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Morfolog&#237;a ecogr&#225;fica de s&#237;ndrome de Stiff cut&#225;neo con correlaci&#243;n cl&#237;nica e histol&#243;gica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 422
              "Ancho" => 750
              "Tamanyo" => 26919
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image&#46; Skin of the lower trunk&#44; hip&#44; and right buttock&#44; with plaques with a mammillated surface&#44; indurated to touch&#44; with no changes in color or hair follicle loss&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "V&#46; Kaplan, C&#46; Bolte, I&#46; Sazunic, X&#46; Wortsman"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Kaplan"
            ]
            1 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Bolte"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Sazunic"
            ]
            3 => array:2 [
              "nombre" => "X&#46;"
              "apellidos" => "Wortsman"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731018302503"
        "doi" => "10.1016/j.ad.2017.12.016"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018302503?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300551?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000003/v1_201904030645/S1578219019300551/v1_201904030645/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219019300526"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2019.02.013"
    "estado" => "S300"
    "fechaPublicacion" => "2019-04-01"
    "aid" => "2036"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2019;110:243-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 8
      "formatos" => array:3 [
        "EPUB" => 2
        "HTML" => 4
        "PDF" => 2
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Allergic Contact Dermatitis to Kojic Acid"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "243"
          "paginaFinal" => "244"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Dermatitis al&#233;rgica de contacto al &#225;cido k&#243;jico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 599
              "Ancho" => 900
              "Tamanyo" => 86635
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Eczematous lesions at the application sites of the skin lightening product&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Tejera-Vaquerizo, J&#46; Garc&#237;a-Gav&#237;n"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tejera-Vaquerizo"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Garc&#237;a-Gav&#237;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731018303557"
        "doi" => "10.1016/j.ad.2018.03.021"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018303557?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300526?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000003/v1_201904030645/S1578219019300526/v1_201904030645/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "An Analysis of Drug Survival&#44; Effectiveness&#44; and Safety in Moderate to Severe Psoriasis Treated With Ustekinumab&#58; An Observational Study of 69 Patients in Routine Clinical Practice"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "244"
        "paginaFinal" => "246"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "I&#46; Salg&#252;ero Fern&#225;ndez, M&#46; Hospital Gil, M&#46; Sig&#252;enza Sanz, G&#46; Roustan Gull&#243;n"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "I&#46;"
            "apellidos" => "Salg&#252;ero Fern&#225;ndez"
            "email" => array:1 [
              0 => "irenebsf&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Hospital Gil"
          ]
          2 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Sig&#252;enza Sanz"
          ]
          3 => array:2 [
            "nombre" => "G&#46;"
            "apellidos" => "Roustan Gull&#243;n"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Dermatolog&#237;a&#44; Hospital Universitario Puerta de Hierro&#44; Majadahonda&#44; Madrid"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "An&#225;lisis de supervivencia&#44; eficacia y seguridad en psoriasis moderada&#8211;grave tratada con ustekinumab&#46; Estudio observacional de 69 pacientes en la pr&#225;ctica cl&#237;nica habitual"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2258
            "Ancho" => 2500
            "Tamanyo" => 215575
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan-Meier analysis of treatment survival &#40;duration in months&#44; 8&#46;3 years of follow-up&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Psoriasis is a chronic disease with a prevalence of between 1&#37; and 3&#37;&#46; Its clinical manifestations and associated comorbidities have a considerable impact on affected patients&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">While the advent of biologic therapy has greatly improved the control of moderate to severe psoriasis&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> the treatment of this disease is still complicated&#46; We have data on the patients who participated in clinical trials of biologic drugs&#44; but these cases are often unlike those we encounter in clinical practice&#44; as shown by a study of data from the Spanish BIOBADADERM registry&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> That study&#44; which analyzed data from 1042 patients on systemic therapy &#40;classic and biologic&#41;&#44; reported that 30&#37; of those patients would have been excluded from clinical trials&#46; The patients who would not have been eligible for inclusion in a clinical trial had a higher risk of developing severe adverse reactions to systemic treatment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Since we consider that it is important to report data on patients being treated in routine clinical practice&#44; we designed a study to evaluate the efficacy&#44; safety&#44; and survival of treatment with ustekinumab in our hospital&#46; We studied patients with moderate to severe psoriasis who started treatment with ustekinumab in our specialized psoriasis clinic between 1 January 2010 and 30 April 2017&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The characteristics of the patients included in the study are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Patients weighing 100&#160;kg or less started treatment with an initial dose of ustekinumab 45<span class="elsevierStyleHsp" style=""></span>mg followed by a second dose at 4 weeks and then 45<span class="elsevierStyleHsp" style=""></span>mg every 12 weeks for at least 12 months&#46; At 1 year&#44; treatment optimization was considered&#44; taking into account the efficacy achieved&#46; In 2 patients who weighed over 100<span class="elsevierStyleHsp" style=""></span>kg&#44; a dose of 90<span class="elsevierStyleHsp" style=""></span>mg was administered initially followed by another at 4 weeks and 90<span class="elsevierStyleHsp" style=""></span>mg every 12 weeks thereafter&#46; Informed consent was obtained from all of the patients before start of treatment&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Treatment survival was calculated as the number of days a patient continued on ustekinumab during follow-up&#46; The longest interval between two injections of the drug considered not to constitute loss to follow-up or treatment interruption was 180 days&#46; We performed 2 analyses&#58; one of the dataset as a whole and the other differentiating between patients who had previously received biologic therapy &#40;naive&#41; and those who had not &#40;non-naive&#41;&#46; The data was analyzed using the Kaplan-Meier method&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Treatment resulted in an improvement from the mean baseline Psoriasis Area and Severity Index &#40;PASI&#41; of 13&#46;3 to a final mean PASI score of 3&#46;5&#44; which represents an 83&#37; reduction in absolute PASI&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The treatment survival rate at the end of the 8&#46;3 years of follow-up was 75&#46;3&#37;&#44; and the rate was higher in the group of patients who had not previously been treated with a biologic agent than in the non-naive group &#40;80&#37; vs 60&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> includes the patients who continued on ustekinumab and those in whom treatment was withdrawn&#46; In this series&#44; 6 patients reported adverse events&#44; most of which were considered to be mild and did not lead to cessation of treatment&#46; Treatment was withdrawn due to an adverse event in 2 patients&#58; one who presented with infectious spondylodiscitis and another who developed severe palmoplantar pustulosis&#46; A patient who developed psoriatic arthritis 3 months after starting ustekinumab continued on treatment&#44; achieving a good response in terms of both skin lesions and joint involvement&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Tuberculin skin test conversion occurred in 12 patients&#44; who were prescribed 6 to 9 months of treatment with isoniazid&#46; No cases of active tuberculosis were recorded&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Several recent studies&#44; including the PSOLAR<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> and BABDIR<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> studies&#44; have collected data on the survival of biologic therapy in clinical practice&#46; The findings of the Spanish ORBIT<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> study&#8212;based on data from 427 patients collected over a 4-year period&#8212;highlight the efficacy and safety of long-term biologic therapy&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The treatment survival rate in this series was high &#40;76&#46;3&#37; at 100 months&#41;&#46; The 83&#37; decline in absolute PASI score was similar to results reported by other authors in the literature&#46; Puig et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a> in a 3-year study of 67 patients receiving ustekinumab&#44; reported a PASI 75 response at 1 year in 86&#37; of the patients&#46; Also of interest is the study by Molina-Leyva et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> of 30 patients treated with ustekinumab&#44; in which the PASI 75 response at 1 year was 81&#46;5&#37;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In the present series&#44; we should note that the baseline PASI was probably underestimated because none of the patients underwent a washout period before start of treatment with ustekinumab&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Withdrawal of treatment due to lack of efficacy &#40;both primary and secondary treatment failure&#41; was 13&#37;&#46; This low percentage may be due to the practice in our clinic of having a &#8220;watch and wait&#8221; period before deciding on loss of efficacy or withdrawal of treatment and to our patient&#39;s high degree of satisfaction with the efficacy achieved&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the literature we reviewed&#44; we found no cases of paradoxical psoriatic reactions associated with the use of IL-23 inhibitors&#46; By contrast&#44; their use as an alternative treatment for such reactions is reported&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> We did&#44; however&#44; find a report of a case in which paradoxical psoriasis worsened following treatment with ustekinumab&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">9</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The limitations of this study include its retrospective design and the use of the treatment survival rate as a measure of treatment success because this endpoint does not provide any information on how patients were included or take into account cases in which treatment was discontinued because the lesions had cleared&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">Irene Salg&#252;ero has participated in clinical trials and has been invited to give papers by Janssen&#44; Abbvie&#44; and Novartis&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
        ]
        1 => array:1 [
          "titulo" => "R&#233;f&#233;rences"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Salg&#252;ero Fern&#225;ndez I&#44; Gil MH&#44; Sanz MS&#44; Gull&#243;n GR&#46; An&#225;lisis de supervivencia&#44; eficacia y seguridad en psoriasis moderada&#8211;grave tratada con ustekinumab&#46; Estudio observacional de 69 pacientes en la pr&#225;ctica cl&#237;nica habitual&#46; Actas Dermosifiliogr&#46; 2019&#59;110&#58;244&#8211;246&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2258
            "Ancho" => 2500
            "Tamanyo" => 215575
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kaplan-Meier analysis of treatment survival &#40;duration in months&#44; 8&#46;3 years of follow-up&#41;&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total number of patients n&#61;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Women&#44; 31&#46;88&#37; &#40;21&#41;&#59; Men&#44; 69&#46;57&#37; &#40;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Naive patients&#44; 39&#37; &#40;28&#41;&#59; Non-naive patients&#44; 61&#37; &#40;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#37; patients &#61; 1 prior biologic&#44; 34&#46;78&#37;&#59; &#62; 1 prior biologic&#44; 23&#46;18&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">Mean</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">Median</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age on starting ustekinumab&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Baseline PASI score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Final PASI score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Number of prior biologic therapies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of follow-up&#44; mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Patients Still on Therapy and Reasons for Withdrawal</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Number</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#37;</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Patients still on UST&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Withdrawal due to adverse events&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Withdrawal due to lack of efficacy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Withdrawal due to good response&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Withdrawal because patient was lost to follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2003845.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patient Characteristics&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "R&#233;f&#233;rences"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accumulated disability in the life course&#58; the scar of psoriasis in the patient&#39;s life"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Ros"
                            1 => "L&#46; Puig"
                            2 => "J&#46;M&#46; Carrascosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2013.02.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2014 Mar"
                        "volumen" => "105"
                        "paginaInicial" => "128"
                        "paginaFinal" => "134"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23668623"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of serious adverse events associated with biologic and nonbiologic psoriasis systemic therapy&#58; patients ineligible vs eligible for randomized controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Garcia-Doval"
                            1 => "G&#46; Carretero"
                            2 => "F&#46; Vanaclocha"
                            3 => "C&#46; Ferrandiz"
                            4 => "E&#46; Daud&#233;n"
                            5 => "J&#46;L&#46; S&#225;nchez-Carazo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2011.2768"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol&#46;"
                        "fecha" => "2012 Apr"
                        "volumen" => "148"
                        "paginaInicial" => "463"
                        "paginaFinal" => "470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22508869"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Drug survival of biologic therapy in a large&#44; disease-based registry of patients with psoriasis&#58; results from the Psoriasis Longitudinal Assessment and Registry &#40;PSOLAR&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Menter"
                            1 => "K&#46;A&#46; Papp"
                            2 => "M&#46; Gooderham"
                            3 => "D&#46;M&#46; Pariser"
                            4 => "M&#46; Augustin"
                            5 => "F&#46;A&#46; Kerdel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.13611"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2016 Jul"
                        "volumen" => "30"
                        "paginaInicial" => "1148"
                        "paginaFinal" => "1158"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27027388"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential drug survival of biologic therapies for the treatment of psoriasis&#58; A prospective observational cohort study from the British Association of Dermatologists Biologic Interventions Register &#40;BADBIR&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;B&#46; Warren"
                            1 => "C&#46;H&#46; Smith"
                            2 => "Z&#46;Z&#46;N&#46; Yiu"
                            3 => "D&#46;M&#46; Ashcroft"
                            4 => "J&#46;N&#46;W&#46;N&#46; Barker"
                            5 => "A&#46;D&#46; Burden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2015.208"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol&#46;"
                        "fecha" => "2015 Nov"
                        "volumen" => "135"
                        "paginaInicial" => "2632"
                        "paginaFinal" => "2640"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26053050"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ORBIT &#40;Outcome and Retention Rate of Biologic Treatments for Psoriasis&#41;&#58; A retrospective observational study on biologic drug survival in daily practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Vilarrasa"
                            1 => "J&#46; Notario"
                            2 => "X&#46; Bordas"
                            3 => "A&#46; L&#243;pez-Ferrer"
                            4 => "I&#46;J&#46; Gich"
                            5 => "L&#46; Puig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2016.01.037"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2016 Jun"
                        "volumen" => "74"
                        "paginaInicial" => "1066"
                        "paginaFinal" => "1072"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27004803"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term efficacy&#44; safety and drug survival of ustekinumab in a Spanish cohort of patients with moderate to severe plaque psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Puig"
                            1 => "V&#46; Ruiz-Salas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000366499"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology&#46;"
                        "fecha" => "2015"
                        "volumen" => "230"
                        "paginaInicial" => "46"
                        "paginaFinal" => "54"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25572820"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety and effectiveness of ustekinumab for treatment of moderate to severe psoriasis&#58; a prospective study in a clinical setting"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Molina-Leyva"
                            1 => "H&#46; Husein-Elahmed"
                            2 => "R&#46; Naranjo-Sintes"
                            3 => "J&#46;C&#46; Ruiz-Carrascosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Drugs Dermatol&#46;"
                        "fecha" => "2014 Aug"
                        "volumen" => "13"
                        "paginaInicial" => "971"
                        "paginaFinal" => "974"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of systemic therapies for moderate-to-severe psoriasis&#58; a systematic review and meta-analysis of long-term treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46;C&#46; Lucka"
                            1 => "D&#46; Pathirana"
                            2 => "A&#46; Sammain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2012.04492.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2012"
                        "volumen" => "26"
                        "paginaInicial" => "1331"
                        "paginaFinal" => "1344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22404617"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0022202X16310442"
                          "estado" => "S300"
                          "issn" => "0022202X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasiform eruption and worsening of pustulosis palmoplantaris after treatment with two anti-TNF-&#945; inhibitors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;A&#46; Bogaards"
                            1 => "M&#46;A&#46; de Rie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s13555-016-0151-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "followed by successful treatment with ustekinumab&#46; Dermatol Ther &#40;Heidelb&#41;&#46;"
                        "fecha" => "2016 Dec"
                        "volumen" => "6"
                        "paginaInicial" => "683"
                        "paginaFinal" => "688"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27783331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000011000000003/v1_201904030645/S157821901930054X/v1_201904030645/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000003/v1_201904030645/S157821901930054X/v1_201904030645/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901930054X?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 10 9 19
2024 October 58 49 107
2024 September 69 34 103
2024 August 87 65 152
2024 July 65 43 108
2024 June 70 38 108
2024 May 57 41 98
2024 April 65 29 94
2024 March 64 44 108
2024 February 47 42 89
2024 January 54 41 95
2023 December 60 21 81
2023 November 63 34 97
2023 October 65 22 87
2023 September 51 38 89
2023 August 47 25 72
2023 July 44 32 76
2023 June 54 25 79
2023 May 53 23 76
2023 April 25 21 46
2023 March 45 23 68
2023 February 36 25 61
2023 January 33 34 67
2022 December 56 41 97
2022 November 32 34 66
2022 October 30 29 59
2022 September 20 38 58
2022 August 23 55 78
2022 July 22 43 65
2022 June 21 38 59
2022 May 37 41 78
2022 April 73 44 117
2022 March 76 55 131
2022 February 84 24 108
2022 January 67 47 114
2021 December 46 45 91
2021 November 51 34 85
2021 October 41 52 93
2021 September 34 36 70
2021 August 32 23 55
2021 July 53 12 65
2021 June 47 28 75
2021 May 32 40 72
2021 April 76 31 107
2021 March 35 21 56
2021 February 48 18 66
2021 January 38 14 52
2020 December 20 9 29
2020 November 20 18 38
2020 October 19 11 30
2020 September 20 9 29
2020 August 26 22 48
2020 July 18 13 31
2020 June 30 23 53
2020 May 32 12 44
2020 April 19 13 32
2020 March 21 6 27
2020 February 4 0 4
2019 May 2 0 2
2019 April 1 0 1
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?