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emollients&#44; and systemic corticosteroids &#40;0&#46;5-1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41;&#44; with which she achieved a partial response&#46; She received treatment at another center with ciclosporin 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#44; which had to be suspended because of hypertension that was difficult to control despite the addition of amlodipine 20<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46; Successive treatment with azathioprine 50<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; methotrexate 15<span class="elsevierStyleHsp" style=""></span>mg&#47;wk&#44; and mycophenolate mofetil 1&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;d had to be suspended because of gastrointestinal intolerance to the first 2 drugs and lack of response to the third&#46; Treatment with narrowband UV-B was not considered&#44; because the patient was unable to attend the sessions&#46; During the switch to mycophenolate mofetil&#44; the clinical expression of AD varied&#44; with intense edema and erythema on the face and neck &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Therefore&#44; the initial diagnosis proposed was head and neck dermatitis&#46; We carried out a prick test with inhaled allergens from the standard series&#46; The results were positive for <span class="elsevierStyleItalic">Alternaria</span> species&#44; <span class="elsevierStyleItalic">Cladosporium</span> species&#44; and cat dander and negative for gastrointestinal allergens&#44; latex&#44; and <span class="elsevierStyleItalic">Anisakis</span> species&#46; The evaluation was completed with prick testing to <span class="elsevierStyleItalic">Malassezia</span> species and <span class="elsevierStyleItalic">Candida</span> species&#46; The results were positive for the former and negative for the latter &#40;tested with 20 healthy controls in the last 2 cases&#41;&#46; Histopathology was consistent with AD&#46; Treatment was started with itraconazole 100<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h for 1 month&#44; which was tapered until 5 months of treatment had been completed&#46; The patient&#39;s lesions improved considerably &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The prevalence of adult AD ranges from 0&#46;3&#37; to 14&#37;&#44; with the most widely accepted range being that of 1&#37;-3&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> In adults&#44; pruriginous eczema affecting the face&#44; neck&#44; and upper thorax is known as head and neck dermatitis&#46; It is associated with intense pruritus and a major alteration of the patient&#39;s quality of life&#46; Curiously&#44; the activity of AD at other sites is usually minimal or moderate&#46; In terms of etiology and pathology&#44; it has been associated with hypersensitivity &#40;but not overgrowth&#41; caused by different subspecies of the lipophilic mold <span class="elsevierStyleItalic">Malassezia</span> &#40;<span class="elsevierStyleItalic">Malassezia furfur&#44; Malassezia restricta&#44; Malassezia sympodialis</span>&#44; and <span class="elsevierStyleItalic">Malassezia globosa</span>&#41;&#46; Increased colonization by <span class="elsevierStyleItalic">Malassezia</span> species of specific areas of the body has been observed in pubertal patients and young adults&#46; In this case&#44; the areas affected were the same as those affected in head and neck dermatitis&#44; compared with healthy skin and compared with healthy persons&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The host immune response to <span class="elsevierStyleItalic">Malassezia</span> species was assessed using prick testing&#44; determination of specific IgE&#44; and patch testing&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Most studies have not simultaneously compared the response to <span class="elsevierStyleItalic">Candida</span> species&#44; staphylococci&#44; streptococci&#44; and <span class="elsevierStyleItalic">Trichophyton</span> species&#46; In the immune response&#44; it seems that stimulation of B lymphocytes plays a more important role than delayed T lymphocyte&#8211;mediated hypersensitivity&#46; Similarly&#44; some studies correlate the severity of head and neck dermatitis with specific IgE levels to <span class="elsevierStyleItalic">Malassezia</span> species&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> This hypersensitivity is greater in patients with allergic rhinoconjunctivitis or asthma&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> as observed in the present case&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">With respect to therapy&#44; there is no well-defined protocol to enable a suitable approach to this condition&#46; Outcome with topical antifungal agents does not seem to be satisfactory&#46; Systemic therapy has focused on the use of ketoconazole 200<span class="elsevierStyleHsp" style=""></span>mg&#47;d or itraconazole 100-400<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and it is necessary to wait a month before results appear in most patients&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Series that present a more extensive cohort of patients<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> apply different itraconazole schedules over periods ranging from 7 days to 2 months&#46; It seems reasonable to initiate treatment at 100-200<span class="elsevierStyleHsp" style=""></span>mg&#47;d and to evaluate the effect of therapy at 1 month in order to reduce to a minimum therapeutic dose that could be used over a longer period&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> The main reported adverse effects were flushing and headache&#44; which resolved after interruption of treatment and enabled treatment to be reintroduced&#46; Routine laboratory testing is not necessary in the absence of baseline liver disease or of associated contraindications&#46; Case reports have shown that the condition can be controlled and therapy can subsequently be combined with other immunosuppressants&#44; such as azathioprine&#44; thus leading to a successful outcome&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letters
Dermatitis of the Face and Neck: Response to Itraconazole
Dermatitis de cara y cuello. Respuesta a itraconazol
R. Ruiz-Villaverde, D. Sánchez-Cano
Corresponding author
ismenios@hotmail.com

Corresponding author.
, D. López-Delgado
Unidad de Dermatología Médico-Quirúrgica y Venereología, Complejo Hospitalario de Granada, Granada, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 36-year-old woman with a personal history of seasonal rhinitis and atopic dermatitis &#40;AD&#41; dating from childhood&#46; She consulted for worsening of AD accompanied by severe lesions caused by scratching on the trunk and limbs&#46; The initial physical examination revealed a SCORAD severity score of 47 and major involvement of the skinfolds and trunk&#46; The results of a laboratory workup were normal&#44; with an immunoglobulin &#40;Ig&#41; E level<span class="elsevierStyleHsp" style=""></span>of<span class="elsevierStyleHsp" style=""></span>240<span class="elsevierStyleHsp" style=""></span>IU &#40;N<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100<span class="elsevierStyleHsp" style=""></span>IU&#41;&#46; Before consulting&#44; the patient had received various topical corticosteroids&#44; emollients&#44; and systemic corticosteroids &#40;0&#46;5-1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41;&#44; with which she achieved a partial response&#46; She received treatment at another center with ciclosporin 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#44; which had to be suspended because of hypertension that was difficult to control despite the addition of amlodipine 20<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46; Successive treatment with azathioprine 50<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; methotrexate 15<span class="elsevierStyleHsp" style=""></span>mg&#47;wk&#44; and mycophenolate mofetil 1&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;d had to be suspended because of gastrointestinal intolerance to the first 2 drugs and lack of response to the third&#46; Treatment with narrowband UV-B was not considered&#44; because the patient was unable to attend the sessions&#46; During the switch to mycophenolate mofetil&#44; the clinical expression of AD varied&#44; with intense edema and erythema on the face and neck &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Therefore&#44; the initial diagnosis proposed was head and neck dermatitis&#46; We carried out a prick test with inhaled allergens from the standard series&#46; The results were positive for <span class="elsevierStyleItalic">Alternaria</span> species&#44; <span class="elsevierStyleItalic">Cladosporium</span> species&#44; and cat dander and negative for gastrointestinal allergens&#44; latex&#44; and <span class="elsevierStyleItalic">Anisakis</span> species&#46; The evaluation was completed with prick testing to <span class="elsevierStyleItalic">Malassezia</span> species and <span class="elsevierStyleItalic">Candida</span> species&#46; The results were positive for the former and negative for the latter &#40;tested with 20 healthy controls in the last 2 cases&#41;&#46; Histopathology was consistent with AD&#46; Treatment was started with itraconazole 100<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h for 1 month&#44; which was tapered until 5 months of treatment had been completed&#46; The patient&#39;s lesions improved considerably &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The prevalence of adult AD ranges from 0&#46;3&#37; to 14&#37;&#44; with the most widely accepted range being that of 1&#37;-3&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> In adults&#44; pruriginous eczema affecting the face&#44; neck&#44; and upper thorax is known as head and neck dermatitis&#46; It is associated with intense pruritus and a major alteration of the patient&#39;s quality of life&#46; Curiously&#44; the activity of AD at other sites is usually minimal or moderate&#46; In terms of etiology and pathology&#44; it has been associated with hypersensitivity &#40;but not overgrowth&#41; caused by different subspecies of the lipophilic mold <span class="elsevierStyleItalic">Malassezia</span> &#40;<span class="elsevierStyleItalic">Malassezia furfur&#44; Malassezia restricta&#44; Malassezia sympodialis</span>&#44; and <span class="elsevierStyleItalic">Malassezia globosa</span>&#41;&#46; Increased colonization by <span class="elsevierStyleItalic">Malassezia</span> species of specific areas of the body has been observed in pubertal patients and young adults&#46; In this case&#44; the areas affected were the same as those affected in head and neck dermatitis&#44; compared with healthy skin and compared with healthy persons&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The host immune response to <span class="elsevierStyleItalic">Malassezia</span> species was assessed using prick testing&#44; determination of specific IgE&#44; and patch testing&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Most studies have not simultaneously compared the response to <span class="elsevierStyleItalic">Candida</span> species&#44; staphylococci&#44; streptococci&#44; and <span class="elsevierStyleItalic">Trichophyton</span> species&#46; In the immune response&#44; it seems that stimulation of B lymphocytes plays a more important role than delayed T lymphocyte&#8211;mediated hypersensitivity&#46; Similarly&#44; some studies correlate the severity of head and neck dermatitis with specific IgE levels to <span class="elsevierStyleItalic">Malassezia</span> species&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> This hypersensitivity is greater in patients with allergic rhinoconjunctivitis or asthma&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> as observed in the present case&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">With respect to therapy&#44; there is no well-defined protocol to enable a suitable approach to this condition&#46; Outcome with topical antifungal agents does not seem to be satisfactory&#46; Systemic therapy has focused on the use of ketoconazole 200<span class="elsevierStyleHsp" style=""></span>mg&#47;d or itraconazole 100-400<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and it is necessary to wait a month before results appear in most patients&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Series that present a more extensive cohort of patients<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> apply different itraconazole schedules over periods ranging from 7 days to 2 months&#46; It seems reasonable to initiate treatment at 100-200<span class="elsevierStyleHsp" style=""></span>mg&#47;d and to evaluate the effect of therapy at 1 month in order to reduce to a minimum therapeutic dose that could be used over a longer period&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> The main reported adverse effects were flushing and headache&#44; which resolved after interruption of treatment and enabled treatment to be reintroduced&#46; Routine laboratory testing is not necessary in the absence of baseline liver disease or of associated contraindications&#46; Case reports have shown that the condition can be controlled and therapy can subsequently be combined with other immunosuppressants&#44; such as azathioprine&#44; thus leading to a successful outcome&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Article information
ISSN: 15782190
Original language: English
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