Case for Diagnosis
Fast-growing Tumor of the Eyelid
Tumor de rápido crecimiento en el párpado
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Morales-Cardona, C. Rodríguez-Zakzuk, A. Téllez-Lozada" "autores" => array:3 [ 0 => array:4 [ "nombre" => "C.A." "apellidos" => "Morales-Cardona" "email" => array:1 [ 0 => "camiderm@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Rodríguez-Zakzuk" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Téllez-Lozada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Hospital Universitario Centro Dermatológico Federico Lleras Acosta E.S.E., Bogotá, D.C., Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Fundación Universitaria Sanitas, Bogotá, D.C., Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tumor de rápido crecimiento en el párpado" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1283 "Ancho" => 1167 "Tamanyo" => 264708 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 24-year-old woman with no relevant past history presented with a fast-growing, asymptomatic nodular lesion on the left lower eyelid that had first appeared 5 months earlier. The patient reported no history of manipulation or trauma in the affected area. However, she did report an episode of pain, redness, and edema on the left cheek a month earlier, which was resolved with an oral antibiotic.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination revealed a 2.5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1.5<span class="elsevierStyleHsp" style=""></span>cm multilobulated, erythematous nodule with yellowish-white areas that was firm on palpation and had a smooth, friable surface, a few telangiectasias, hematic crusts, and an ulcerated central depression (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histologic examination revealed a dermal lesion composed of basaloid cells and ghost cells, with foci of calcification surrounded by fibrous stroma without atypia (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis?</span></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0020" class="elsevierStylePara elsevierViewall">Perforating pilomatrixoma.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course</span><p id="par0025" class="elsevierStylePara elsevierViewall">Complete excision of the lesion was carried out under local anesthesia. No recurrence of the lesion was observed during a 6-month follow-up period (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0030" class="elsevierStylePara elsevierViewall">Pilomatrixoma, a benign tumor of the hair follicle matrix, is among the most common skin neoplasms in children and young adults.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> It is more common in women and usually appears on the head and neck, where it manifests as a single subcutaneous nodule measuring 0.5-2<span class="elsevierStyleHsp" style=""></span>cm in diameter that is firm on palpation, with blood vessels and discoloration of the overlying skin.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> The perforating presentation is extremely rare and fast-growing; it is characterized by the elimination of the content of the tumor, with or without ulceration, depending on the depth of the lesion.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Diagnosis is confirmed by histologic examination, which shows basophilic cells, and, in the perforating variant, ossification and transepidermal elimination.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Pilomatrixoma is usually confused with other lesions such as epidermoid cyst, keratoacanthoma, molluscum contagiosum, foreign body granuloma, juvenile xanthogranuloma, sebaceous carcinoma, matrical carcinoma, dermatofibrosarcoma protuberans, and amelanotic melanoma, and preoperative diagnosis is correct in only 21%<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> to 54%<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> of cases. Spontaneous remission has not been reported. The lesion is treated by surgical excision, with an estimated recurrence risk of 3%-4%.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Medical History" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Physical Examination" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Histopathology" ] 3 => array:2 [ "identificador" => "sec0025" "titulo" => "Diagnosis" ] 4 => array:2 [ "identificador" => "sec0030" "titulo" => "Clinical Course" ] 5 => array:2 [ "identificador" => "sec0035" "titulo" => "Comment" ] 6 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of Interest" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Morales-Cardona CA, Rodríguez-Zakzuk C, Téllez-Lozada A. Tumor de rápido crecimiento en el párpado. Actas Dermosifiliogr. 2018;109:265–266.</p>" ] ] "multimedia" => array:3 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1283 "Ancho" => 1167 "Tamanyo" => 264708 ] ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1230 "Ancho" => 1167 "Tamanyo" => 528291 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin-eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>40.</p>" ] ] 2 => array:6 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1579 "Ancho" => 1167 "Tamanyo" => 236885 ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ulcerated giant pilomatrixoma in a child" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. 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Watanabe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2003" "volumen" => "49" "paginaInicial" => "146" "paginaFinal" => "147" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A clinical review of 209 pilomatricomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.G. Julian" 1 => "P.W. 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| 2023 January | 55 | 34 | 89 |
| 2022 December | 82 | 40 | 122 |
| 2022 November | 30 | 25 | 55 |
| 2022 October | 25 | 20 | 45 |
| 2022 September | 21 | 42 | 63 |
| 2022 August | 26 | 37 | 63 |
| 2022 July | 22 | 40 | 62 |
| 2022 June | 28 | 15 | 43 |
| 2022 May | 48 | 36 | 84 |
| 2022 April | 57 | 39 | 96 |
| 2022 March | 54 | 56 | 110 |
| 2022 February | 40 | 39 | 79 |
| 2022 January | 40 | 34 | 74 |
| 2021 December | 32 | 42 | 74 |
| 2021 November | 47 | 66 | 113 |
| 2021 October | 58 | 64 | 122 |
| 2021 September | 30 | 44 | 74 |
| 2021 August | 47 | 51 | 98 |
| 2021 July | 31 | 42 | 73 |
| 2021 June | 31 | 39 | 70 |
| 2021 May | 41 | 58 | 99 |
| 2021 April | 71 | 88 | 159 |
| 2021 March | 61 | 47 | 108 |
| 2021 February | 82 | 39 | 121 |
| 2021 January | 45 | 40 | 85 |
| 2020 December | 46 | 55 | 101 |
| 2020 November | 32 | 49 | 81 |
| 2020 October | 28 | 17 | 45 |
| 2020 September | 32 | 22 | 54 |
| 2020 August | 32 | 28 | 60 |
| 2020 July | 31 | 26 | 57 |
| 2020 June | 28 | 28 | 56 |
| 2020 May | 19 | 13 | 32 |
| 2020 April | 25 | 15 | 40 |
| 2020 March | 16 | 9 | 25 |
| 2020 February | 6 | 0 | 6 |
| 2020 January | 2 | 0 | 2 |
| 2019 December | 8 | 0 | 8 |
| 2019 November | 3 | 0 | 3 |
| 2019 September | 10 | 0 | 10 |
| 2019 August | 4 | 0 | 4 |
| 2019 July | 4 | 0 | 4 |
| 2019 June | 4 | 0 | 4 |
| 2019 May | 6 | 0 | 6 |
| 2019 April | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 February | 2 | 0 | 2 |
| 2018 December | 2 | 0 | 2 |
| 2018 November | 3 | 0 | 3 |
| 2018 October | 1 | 0 | 1 |
| 2018 September | 2 | 0 | 2 |
| 2018 May | 1 | 0 | 1 |
| 2018 April | 2 | 0 | 2 |
Show all
