Case and Research Letters
Cutaneous Solitary Fibrous Tumor: A Spindle Cell Neoplasm With Distinctive Immunohistochemical Features
Tumor fibroso solitario cutáneo: una neoplasia fusocelular con una inmunohistoquímica particular
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"apellidos" => "Eguino Gorrochategui" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0001731017303411" "doi" => "10.1016/j.ad.2017.02.031" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017303411?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018300404?idApp=UINPBA000044" "url" => "/15782190/0000010900000002/v1_201803020443/S1578219018300404/v1_201803020443/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Cutaneous Solitary Fibrous Tumor: A Spindle Cell Neoplasm With Distinctive Immunohistochemical Features" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "183" "paginaFinal" => "185" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Santos-Juanes, B. García-García, Y. Hidalgo, B. Vivanco" "autores" => array:4 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Santos-Juanes" "email" => array:1 [ 0 => "jorgesantosjuanes@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "García-García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Y." "apellidos" => "Hidalgo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "B." "apellidos" => "Vivanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Central de Asturias, Oviedo, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Dermatopatología, Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tumor fibroso solitario cutáneo: una neoplasia fusocelular con una inmunohistoquímica particular" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1250 "Ancho" => 1631 "Tamanyo" => 544530 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Polypoid, nonencapsulated lesion with a well-circumscribed dermal proliferation (hematoxylin-eosin, original magnification ×20). B and C, Note the abundant extracellular collagenous matrix in some areas of the tumor (hematoxylin-eosin, original magnification ×100 [A] and ×200 [B]). D, Detail of cells with monomorphic elongated, oval nuclei (hematoxylin-eosin, original magnification ×400).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Solitary fibrous tumor (SFT) is a mesenchymal tumor that typically arises in the pleural cavity. Extrapleural locations, such as the skin, are rare.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Cutaneous SFT, alongside dermatofibrosarcoma protuberans (DFSP), spindle cell lipoma, dendritic fibromyxolipoma, and superficial acral fibromyxoma, forms part of the family of spindle cell tumors that express CD34.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 44-year-old woman presented with a slow-growing lesion in the right inguinal region that had been present for 2 years. Physical examination revealed a firm pedunculated tumor with a wide base measuring 1.2<span class="elsevierStyleHsp" style=""></span>cm in diameter. The tumor was excised.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathologic examination showed a polypoid, nonencapsulated lesion with a well-circumscribed dermal proliferation of variable cellular density composed of monomorphic, elongated, oval cells lacking atypia and with scant cytoplasm and no signs of necrosis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a><span class="elsevierStyleHsp" style=""></span>A-D). One mitotic figure was identified in 10 high-power fields. Immunohistochemical staining showed positive results for CD34, BCL-2, CD 99, and STAT-6 (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a> A and B) and negative results for epithelial membrane antigen (EMA), smooth muscle actin (SMA), and S-100 protein. The Ki67 index was 1%.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Cutaneous SFT mainly affects adults, is more common in men (male to female ratio of 4:1), and shows a predilection for the head and neck.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> The most characteristic histopathologic pattern in SFT is a “patternless spindle cell pattern”, with haphazardly arranged spindle cells that do not form a clear storiform, fascicular and/or herringbone, or wavy pattern. The cells are embedded in a collagenous matrix or in amorphous hyaline material, and a hemangiopericytoma-like vascular pattern is often seen in areas of the tumor. Diagnosis is challenging given the variable histopathologic findings. The main entity that should be considered in the differential diagnosis is DFSP. Apart from CD34, SFT expresses vimentin, bcl-2, and CD99 (with positive staining seen in between 40% and 100% of tumors in the case of bcl-2 and CD99). Staining is negative for EMA, SMA, desmin, and protein S-100. CD34 and CD99 positivity may also be observed in DFSP.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4,5</span></a> One recent study reported that <span class="elsevierStyleItalic">NAB2-STAT6</span> fusion genes were specific to SFT, indicating that the study of these genes could be of use in overlap cases.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Nuclear immunostaining with STAT6 has high sensitivity and specificity, with positivity rates ranging from 91% in meningeal SFTs to 100% in soft tissue SFTs.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2,6,7</span></a> Immunohistochemical markers are important diagnostic tools in cutaneous SFT, and as occurs with SFTs in other locations, STAT6 has a key role in establishing an accurate diagnosis. Distant metastasis has not been observed in cutaneous SFT, but there have been 3 reports of local recurrence.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1,8,9</span></a> Cutaneous SFT, thus, like its counterparts in other locations, is considered to be a borderline tumor and hence complete surgical excision is recommended.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Santos-Juanes J, García-García B, Hidalgo Y, Vivanco B. Tumor fibroso solitario cutáneo: una neoplasia fusocelular con una inmunohistoquímica particular. Actas Dermosifiliogr. 2018;109:183–185.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1250 "Ancho" => 1631 "Tamanyo" => 544530 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Polypoid, nonencapsulated lesion with a well-circumscribed dermal proliferation (hematoxylin-eosin, original magnification ×20). B and C, Note the abundant extracellular collagenous matrix in some areas of the tumor (hematoxylin-eosin, original magnification ×100 [A] and ×200 [B]). D, Detail of cells with monomorphic elongated, oval nuclei (hematoxylin-eosin, original magnification ×400).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1472 "Ancho" => 967 "Tamanyo" => 429437 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Diffuse immunohistochemical staining of tumor cells for CD34 (CD34, original magnification ×200). B, Nuclear staining of Stat 6 (Stat 6, original magnification ×200).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solitary fibrous tumor of the skin: A clinicopathologic study of 10 cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Erdag" 1 => "H.S. Qureshi" 2 => "J.W. Patterson" 3 => "M.R. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 14 | 8 | 22 |
| 2024 October | 118 | 41 | 159 |
| 2024 September | 146 | 25 | 171 |
| 2024 August | 184 | 54 | 238 |
| 2024 July | 122 | 27 | 149 |
| 2024 June | 140 | 26 | 166 |
| 2024 May | 116 | 34 | 150 |
| 2024 April | 105 | 20 | 125 |
| 2024 March | 128 | 32 | 160 |
| 2024 February | 107 | 33 | 140 |
| 2024 January | 82 | 34 | 116 |
| 2023 December | 105 | 26 | 131 |
| 2023 November | 129 | 28 | 157 |
| 2023 October | 112 | 32 | 144 |
| 2023 September | 102 | 31 | 133 |
| 2023 August | 82 | 14 | 96 |
| 2023 July | 100 | 30 | 130 |
| 2023 June | 102 | 22 | 124 |
| 2023 May | 101 | 24 | 125 |
| 2023 April | 100 | 18 | 118 |
| 2023 March | 100 | 27 | 127 |
| 2023 February | 88 | 27 | 115 |
| 2023 January | 70 | 38 | 108 |
| 2022 December | 75 | 49 | 124 |
| 2022 November | 45 | 30 | 75 |
| 2022 October | 43 | 28 | 71 |
| 2022 September | 44 | 46 | 90 |
| 2022 August | 42 | 38 | 80 |
| 2022 July | 41 | 33 | 74 |
| 2022 June | 41 | 29 | 70 |
| 2022 May | 100 | 58 | 158 |
| 2022 April | 108 | 48 | 156 |
| 2022 March | 108 | 72 | 180 |
| 2022 February | 99 | 42 | 141 |
| 2022 January | 110 | 52 | 162 |
| 2021 December | 67 | 63 | 130 |
| 2021 November | 83 | 54 | 137 |
| 2021 October | 62 | 60 | 122 |
| 2021 September | 76 | 51 | 127 |
| 2021 August | 83 | 41 | 124 |
| 2021 July | 69 | 36 | 105 |
| 2021 June | 68 | 45 | 113 |
| 2021 May | 90 | 44 | 134 |
| 2021 April | 137 | 85 | 222 |
| 2021 March | 100 | 42 | 142 |
| 2021 February | 62 | 55 | 117 |
| 2021 January | 66 | 45 | 111 |
| 2020 December | 76 | 39 | 115 |
| 2020 November | 51 | 47 | 98 |
| 2020 October | 50 | 21 | 71 |
| 2020 September | 71 | 25 | 96 |
| 2020 August | 47 | 38 | 85 |
| 2020 July | 34 | 26 | 60 |
| 2020 June | 44 | 43 | 87 |
| 2020 May | 19 | 9 | 28 |
| 2020 April | 26 | 15 | 41 |
| 2020 March | 51 | 19 | 70 |
| 2020 February | 6 | 0 | 6 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 8 | 0 | 8 |
| 2019 November | 4 | 0 | 4 |
| 2019 September | 9 | 0 | 9 |
| 2019 August | 4 | 0 | 4 |
| 2019 July | 4 | 0 | 4 |
| 2019 June | 4 | 0 | 4 |
| 2019 May | 8 | 0 | 8 |
| 2019 April | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 February | 2 | 0 | 2 |
| 2018 December | 3 | 0 | 3 |
| 2018 November | 2 | 0 | 2 |
| 2018 October | 1 | 2 | 3 |
| 2018 September | 2 | 0 | 2 |
| 2018 February | 5 | 23 | 28 |
| 2018 January | 3 | 10 | 13 |
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