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Epidermis hiperqueratósica con paraqueratosis, focos de degeneración vacuolar de la basal e infiltrado perivascular y en banda con escasos eosinófilos (hematoxilina-eosina, ×20). B. Mayor aumento (×40) evidenciando queratinocitos necróticos en epidermis.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Rodríguez-Lomba, I. Molina-López, R. Suárez-Fernández, O. Baniandrés-Rodríguez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Rodríguez-Lomba" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Molina-López" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Suárez-Fernández" ] 3 => array:2 [ "nombre" => "O." "apellidos" => "Baniandrés-Rodríguez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219017301439" "doi" => "10.1016/j.adengl.2017.05.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017301439?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016304446?idApp=UINPBA000044" "url" => "/00017310/0000010800000006/v3_201707250313/S0001731016304446/v3_201707250313/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219017301427" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.05.001" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "1574" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:597-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 593 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 438 "PDF" => 122 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Oral Oxybutynin for Local and Multifocal Hyperhidrosis: A Multicenter Study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "597" "paginaFinal" => "599" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio multicéntrico sobre el uso de oxibutinina oral en hiperhidrosis local y multifocal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2031 "Ancho" => 2663 "Tamanyo" => 124725 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Numbers of patients with given Hyperhidrosis Disease Severity Scale (HDSS) scores before (left) and after (right) treatment.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "T. Toledo-Pastrana, J. Márquez-Enríquez, J.F. Millán-Cayetano" "autores" => array:3 [ 0 => array:2 [ "nombre" => "T." "apellidos" => "Toledo-Pastrana" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Márquez-Enríquez" ] 2 => array:2 [ "nombre" => "J.F." "apellidos" => "Millán-Cayetano" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016304434" "doi" => "10.1016/j.ad.2016.11.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016304434?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017301427?idApp=UINPBA000044" "url" => "/15782190/0000010800000006/v1_201706300050/S1578219017301427/v1_201706300050/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S157821901730207X" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.11.020" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "1579" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:593-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 385 "formatos" => array:3 [ "EPUB" => 28 "HTML" => 260 "PDF" => 97 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Refractory solar urticaria successfully treated with omalizumab with normalization of phototest" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "593" "paginaFinal" => "594" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Urticaria solar refractaria tratada satisfactoriamente con omalizumab y normalización del fototest" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 996 "Ancho" => 990 "Tamanyo" => 67385 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Phototest before omalizumab (Waldman® UV 181 UVA) was positive for UVA, minimal urticarial dose 7<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span>. 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Rodríguez-Lomba, I. Molina-López, R. Suárez-Fernández, O. Baniandrés-Rodríguez" "autores" => array:4 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Rodríguez-Lomba" "email" => array:1 [ 0 => "enriquerlomba@outlook.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Molina-López" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Suárez-Fernández" ] 3 => array:2 [ "nombre" => "O." "apellidos" => "Baniandrés-Rodríguez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de eritema tenar periarticular y onicolisis: una manifestación de toxicidad cutánea por taxanos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1266 "Ancho" => 950 "Tamanyo" => 369100 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histology of the lesion on the dorsum of the hand of patient<span class="elsevierStyleHsp" style=""></span>2. A, Hyperkeratotic epidermis with parakeratosis, foci of vacuolar degeneration of the basal layer, and a band-like perivascular infiltrate with occasional eosinophils. Hematoxylin and eosin, original magnification ×10. B, At higher power, evidence of necrotic keratinocytes in the epidermis. Hematoxylin and eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×40.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In recent years, the widespread use of taxane-based chemotherapy regimens for the management of malignant tumors of various origins has evidenced the high frequency of cutaneous toxicity induced by this pharmacological group.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> In 2003, among its possible manifestations, Childress and Lokich<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> defined periarticular thenar erythema and onycholysis (PATEO) syndrome as a rare subtype of hand-foot syndrome associated with nail changes in patients treated with paclitaxel and docetaxel. In contrast to typical palmar-plantar erythrodysesthesia, or classic hand-foot syndrome, skin involvement in this syndrome is characterized by an absence of involvement of the palms and soles and by the presence of alterations predominantly affecting the dorsum of the hands (particularly around the base of the thumb and fifth finger), the area of the Achilles tendon, and the perimaleolar skin.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present 3 patients on chemotherapy with taxanes who developed clinical manifestations similar to those described in this syndrome.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The 3 patients were women aged 35, 56, and 68 years, with infiltrating ductal adenocarcinoma of the breast on adjuvant treatment with docetaxel and cyclophosphamide (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). They sought dermatologic evaluation for the appearance of painful erythematous-violaceous plaques with fine superficial desquamation on the dorsum of both hands (Fig. 1A). The lesions interfered with their activities of daily living. The lesions had arisen 3 to 12 days after the administration of chemotherapy, and showed a clearly progressive deterioration with each cycle, despite the use of topical corticosteroids. Associated nail involvement in the 3 cases varied from fine parallel Beau lines and subungual splinter hemorrhages to frank distal onycholysis of the nail plate (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> B). Physical examination revealed no lesions on the rest of the skin, and the patients presented an otherwise good general state of health. Histology of a 4-mm punch biopsy from the dorsum of the hand of patient number 2 revealed a hyperkeratotic epidermis with parakeratosis, necrotic keratinocytes, focal vacuolar degeneration of the basal layer, and a band-like perivascular lymphocytic inflammatory infiltrate with occasional eosinophils (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>,<span class="elsevierStyleHsp" style=""></span>A and<span class="elsevierStyleHsp" style=""></span>B). These findings were consistent with a clinical suspicion of taxane-induced toxicity. Dose adjustment of the chemotherapy, together with the application of topical corticosteroid therapy under occlusion controlled the lesions and significantly improved symptoms in all 3 patients. Only 1 patient required a single course of a tapered regimen of oral corticosteroids for a severe deterioration of the lesions on the dorsum of the hands that interfered with her activities of daily living.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">PATEO syndrome is a manifestation of taxane-induced cutaneous toxicity predominantly affecting acral areas and with associated nail alterations. The frequency of this complication has been reported as 10% and 5%, respectively, in patients treated with paclitaxel and docetaxel, and its intensity appears to increase with the cumulative dose and with weekly regimens.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a> Skin involvement is characterized by the presence of painful erythematous-violaceous plaques on the dorsum of the hands, on the feet, and in the area of the Achilles tendon; these lesions can subsequently develop vesicles and flaking. Severity is very variable, from asymptomatic forms to ones that have a marked impact on the basic activities of daily living. Some classifications, such as those of the World Health Organization and the National Cancer Institute, have established criteria of severity to evaluate acral skin involvement.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Nail changes in these patients are due to the cytotoxic effect of taxanes and their presence is characteristic of this condition, in contrast to other hand-foot syndromes secondary to anthracyclines or multikinase inhibitors.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> The cytotoxicity of these agents is due to their inhibition of microtubule function in cell division, and is most intense in those epithelia with high rates of cell proliferation, such as the nail matrix. The most common changes described after the administration of these drugs are Beau lines, onychomadesis, onycholysis, subungual splinter hemorrhages, subungual hematomas, leukonychia, paronychia, and nail hyperpigmentation.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,5</span></a> Although the clinical manifestations are not usually severe, some manifestations, such as subungual hematomas, abscesses, and distal onycholysis can cause significant morbidity in oncologic patients and must be taken into consideration.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Histology of the skin lesions reveals changes similar to those observed in typical palmar-plantar erythrodysesthesia induced by other chemotherapeutic agents. It is characterized by the presence of a hyperkeratotic and acanthotic epidermis, with necrotic keratinocytes, focal vacuolar degeneration of the basal layer, blood-vessel dilatation, and a lichenoid inflammatory infiltrate with few lymphocytes, neutrophils, or eosinophils.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3,7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In clinical practice, the impact of PATEO syndrome on the quality of life of oncology patients is a frequent cause of dose reduction of the chemotherapy regimen, as occurred in our patient number 2. In the most severe and disabling cases, discontinuation of treatment may even be indicated.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Preventive measures are an essential strategy to reduce the morbidity associated with these treatments in debilitated patients. Local hypothermia using socks or gloves during infusions of the drug can be effective, though this cannot be extended to other chemotherapy regimens with oral administration.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9,10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Given the high frequency of dermatologic consultations related to the side effects of chemotherapy in oncology patients, we consider it important to be aware of this atypical form of acral erythema and of its management as, in disabling cases, it can require dose reduction or a temporary interruption of the chemotherapy treatment. It is notable that all 3 of our patients were on combined treatment with cyclophosphamide and docetaxel for adenocarcinoma of the breast, and the possibility that the combination may have increased the cutaneous morbidity compared with the administration of docetaxel in monotherapy cannot therefore be excluded.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Please cite this article as: Rodríguez-Lomba E, Molina-López I, Suárez-Fernández R, Baniandrés-Rodríguez O. Síndrome de eritema tenar periarticular y onicolisis: una manifestación de toxicidad cutánea por taxanos. Actas Dermosifiliogr. 2017;108:595–597.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1219 "Ancho" => 900 "Tamanyo" => 177042 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Periarticular thenar erythema and onycholysis syndrome: Docetaxel-induced skin and nail changes. A, Patient<span class="elsevierStyleHsp" style=""></span>1. Erythematous-violaceous plaques on the dorsum of the hands and over the proximal phalanx. B, Nail changes in patient 3: parallel Beau lines and onycholysis of the distal third of the nail plate.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1266 "Ancho" => 950 "Tamanyo" => 369100 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histology of the lesion on the dorsum of the hand of patient<span class="elsevierStyleHsp" style=""></span>2. A, Hyperkeratotic epidermis with parakeratosis, foci of vacuolar degeneration of the basal layer, and a band-like perivascular infiltrate with occasional eosinophils. Hematoxylin and eosin, original magnification ×10. B, At higher power, evidence of necrotic keratinocytes in the epidermis. Hematoxylin and eosin, original magnification<span class="elsevierStyleHsp" style=""></span>×40.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: G-CSF, granulocyte colony stimulating factor; NCI, National Cancer Institute.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age, y \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tumor \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Adjuvant Chemotherapy \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Latency<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cumulative Dose<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">NCI Grade<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Infiltrating ductal adenocarcinoma of the right breast, T2N1M0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Docetaxel<span class="elsevierStyleHsp" style=""></span>+ cyclophosphamide \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Third cycle \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Topical corticosteroid<br>Oral pyridoxine \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Infiltrating ductal adenocarcinoma of the left breast, T2N0M0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Docetaxel<span class="elsevierStyleHsp" style=""></span>+ cyclophosphamide<span class="elsevierStyleHsp" style=""></span>+ G-CSF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Second cycle \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Topical corticosteroid<br>Tapering regimen of prednisone \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Infiltrating ductal adenocarcinoma of the left breast, T2N0M0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Docetaxel<span class="elsevierStyleHsp" style=""></span>+ cyclophosphamide<span class="elsevierStyleHsp" style=""></span>+ G-CSF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Second cycle \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Topical corticosteroid \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1450901.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Time to onset of symptoms after the most recent administration of chemotherapy.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Chemotherapy cycle being administered when symptoms first arose.</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">National Cancer Institute classification of the severity of acral erythema.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,7</span></a></p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Epidemiologic, Clinical, and Therapeutic Details of 3 Cases of Periarticular Thenar Erythema and Onycholysis Syndrome.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "203.e1-203e12" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous reactions to chemotherapeutic drugs and targeted therapies for cancer: Part I. 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Year/Month | Html | Total | |
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2024 November | 8 | 13 | 21 |
2024 October | 113 | 70 | 183 |
2024 September | 110 | 64 | 174 |
2024 August | 128 | 84 | 212 |
2024 July | 209 | 105 | 314 |
2024 June | 104 | 47 | 151 |
2024 May | 93 | 44 | 137 |
2024 April | 88 | 25 | 113 |
2024 March | 106 | 35 | 141 |
2024 February | 78 | 39 | 117 |
2024 January | 92 | 38 | 130 |
2023 December | 72 | 23 | 95 |
2023 November | 90 | 32 | 122 |
2023 October | 88 | 32 | 120 |
2023 September | 96 | 37 | 133 |
2023 August | 74 | 28 | 102 |
2023 July | 91 | 59 | 150 |
2023 June | 95 | 39 | 134 |
2023 May | 97 | 68 | 165 |
2023 April | 101 | 31 | 132 |
2023 March | 89 | 47 | 136 |
2023 February | 78 | 36 | 114 |
2023 January | 66 | 48 | 114 |
2022 December | 90 | 41 | 131 |
2022 November | 51 | 35 | 86 |
2022 October | 65 | 30 | 95 |
2022 September | 30 | 37 | 67 |
2022 August | 27 | 55 | 82 |
2022 July | 22 | 49 | 71 |
2022 June | 33 | 22 | 55 |
2022 May | 121 | 56 | 177 |
2022 April | 141 | 43 | 184 |
2022 March | 130 | 49 | 179 |
2022 February | 111 | 34 | 145 |
2022 January | 120 | 54 | 174 |
2021 December | 96 | 39 | 135 |
2021 November | 83 | 51 | 134 |
2021 October | 79 | 64 | 143 |
2021 September | 92 | 49 | 141 |
2021 August | 136 | 37 | 173 |
2021 July | 95 | 36 | 131 |
2021 June | 65 | 44 | 109 |
2021 May | 90 | 56 | 146 |
2021 April | 216 | 95 | 311 |
2021 March | 126 | 50 | 176 |
2021 February | 104 | 47 | 151 |
2021 January | 73 | 33 | 106 |
2020 December | 67 | 26 | 93 |
2020 November | 54 | 25 | 79 |
2020 October | 97 | 21 | 118 |
2020 September | 81 | 27 | 108 |
2020 August | 54 | 28 | 82 |
2020 July | 59 | 18 | 77 |
2020 June | 83 | 43 | 126 |
2020 May | 26 | 14 | 40 |
2020 April | 24 | 14 | 38 |
2020 March | 20 | 11 | 31 |
2020 February | 6 | 0 | 6 |
2020 January | 4 | 0 | 4 |
2019 December | 4 | 0 | 4 |
2019 November | 4 | 0 | 4 |
2019 September | 4 | 0 | 4 |
2019 August | 4 | 0 | 4 |
2019 July | 4 | 0 | 4 |
2019 June | 4 | 0 | 4 |
2019 May | 4 | 0 | 4 |
2019 April | 3 | 0 | 3 |
2019 February | 2 | 0 | 2 |
2019 January | 4 | 0 | 4 |
2018 December | 3 | 0 | 3 |
2018 October | 1 | 0 | 1 |
2018 September | 8 | 0 | 8 |
2018 February | 51 | 4 | 55 |
2018 January | 69 | 6 | 75 |
2017 December | 67 | 8 | 75 |
2017 November | 53 | 4 | 57 |
2017 October | 54 | 7 | 61 |
2017 September | 40 | 10 | 50 |
2017 August | 65 | 19 | 84 |
2017 July | 75 | 22 | 97 |
2017 June | 26 | 16 | 42 |