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infection who had experienced frequent episodes of generalized wheals on a frequent basis over the past 15 years&#46; In the previous year&#44; the wheals had appeared daily&#46; She had been on maintenance treatment with H<span class="elsevierStyleInf">1</span> antihistamines &#40;ebastine 20<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h&#41; for the past 10 years&#46; In the past year&#44; despite antihistamine therapy&#44; she had required various cycles of oral prednisone to control her symptoms and had visited the emergency department on 2 occasions in the month before being referred to our department&#46; There were no evident triggers&#46; In the initial study&#44; the patient had a viral load of 20<span class="elsevierStyleHsp" style=""></span>200<span class="elsevierStyleHsp" style=""></span>IU&#47;mL and IgE levels of 370<span class="elsevierStyleHsp" style=""></span>kU&#47;L&#46; The other parameters in the workup were within normal ranges&#46; With a diagnosis of CSU&#44; the patient was started on bilastine 40<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span> combined with a 4-week cycle of prednisone&#46; Response was poor and the symptoms returned on initiation of prednisone tapering&#46; In view of the patient&#39;s failure to respond to the first- and second-line treatments and her clinical progress&#44; we decided to step up the intensity of treatment&#46; Following discussion with the hepatology unit&#44; it was agreed that there were no current indications to treat the HBV infection but that it was necessary to avoid immunosuppressants such as ciclosporin&#46; We therefore started treatment with omalizumab 300<span class="elsevierStyleHsp" style=""></span>mg every 4 weeks&#46; The dose of bilastine was gradually reduced&#46; Over the next 6 months&#44; the patient experienced no new episodes of urticaria&#44; even after complete withdrawal of the bilastine&#46; The Urticaria Activity Score 7 &#40;UAS7&#41; decreased from an initial score of 37 &#40;on a scale of 0-42&#41; to a score that consistently ranged between 0 and 5 after the second dose of omalizumab&#46; No adverse effects were observed&#46; There was no evident worsening of the HBV infection and we actually observed a reduction in viral load to 627<span class="elsevierStyleHsp" style=""></span>IU&#47;mL at the end of the 6-month treatment cycle&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the changes in UAS7 score and viral loads over the treatment period&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Based on our review of the literature&#44; we believe that this is the first report of the effective and safe use of omalizumab in a patient with CSU and active HBV infection&#46; Brodska and Schmid-Grendelmeier<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> described the case of a patient with cold urticaria and chronic HBV infection treated with omalizumab&#46; The treatment was effective and well tolerated&#44; but no information was provided on the clinical features of the infection or on subsequent progress&#46; Antonicelli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> described the case of a patient with HCV infection who achieved asthma control after 19 months of treatment with omalizumab&#46; There was no worsening of liver function and the patient subsequently underwent HVC eradication treatment with interferon and ribavarin&#46; Finally&#44; Leiva-Salinas et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> published a case in which omalizumab proved to be both effective and safe in a patient with CSU and HVC infection&#46; No worsening of liver disease was observed&#44; but the authors did not provide information on viral loads&#46; Omalizumab was effective in our patient and did not worsen the underlying HBV infection&#46; It was&#44; in fact&#44; even associated with a reduction in viral load&#46; We cannot provide a clear explanation for this reduction&#44; but other authors have described improved interferon-&#945; immune response to rhinovirus in patients on interferon-&#945; therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Omalizumab may be an effective and safe treatment alternative for refractory CSU in patients with HVB infection&#46; There is&#44; however&#44; no evidence as yet on possible adverse effects or worsening of viral infection in our patient or in similar cases&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">P&#46; Chicharro and P&#46; Rodr&#237;guez-Jim&#233;nez declare that they have no conflicts of interest&#46; D&#46; 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Case and Research Letter
Efficacy and Safety of Omalizumab in a Patient With Chronic Spontaneous Urticaria and Active Hepatitis B Virus Infection
Eficacia y seguridad de omalizumab en un paciente con urticaria crónica espontánea e infección activa por el virus de la hepatitis B
P. Chicharro
Corresponding author
somniem@gmail.com

Corresponding author.
, P. Rodríguez-Jiménez, D. de Argila
Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, España
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    "titulo" => "Efficacy and Safety of Omalizumab in a Patient With Chronic Spontaneous Urticaria and Active Hepatitis B Virus Infection"
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        "titulo" => "Eficacia y seguridad de omalizumab en un paciente con urticaria cr&#243;nica espont&#225;nea e infecci&#243;n activa por el virus de la hepatitis B"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Changes in Urticaria Activity Score 7 &#40;UAS7&#41; scores and hepatitis B viral loads measured by polymerase chain reaction &#40;PCR HBV&#41; during treatment with omazlizumab&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic spontaneous urticaria &#40;CSU&#41; has a significant impact on patient quality of life&#46; It is defined as the persistence of wheals&#44; with or without angioedema&#44; for a period of longer than 6 weeks in the absence of an evident trigger&#46; Nonsedating H<span class="elsevierStyleInf">1</span> antihistamines are considered the first-line treatment for CSU&#44; but some patients respond poorly&#44; even at doses 4 times the usual dose&#46; Third-line treatments include ciclosporin and omalizumab&#44; a humanized recombinant monoclonal antibody that selectively binds to free immunoglobulin &#40;Ig&#41; E and was recently approved for the treatment of CSU&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 56-year-old woman with a history of untreated active chronic hepatitis B virus &#40;HBV&#41; infection who had experienced frequent episodes of generalized wheals on a frequent basis over the past 15 years&#46; In the previous year&#44; the wheals had appeared daily&#46; She had been on maintenance treatment with H<span class="elsevierStyleInf">1</span> antihistamines &#40;ebastine 20<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h&#41; for the past 10 years&#46; In the past year&#44; despite antihistamine therapy&#44; she had required various cycles of oral prednisone to control her symptoms and had visited the emergency department on 2 occasions in the month before being referred to our department&#46; There were no evident triggers&#46; In the initial study&#44; the patient had a viral load of 20<span class="elsevierStyleHsp" style=""></span>200<span class="elsevierStyleHsp" style=""></span>IU&#47;mL and IgE levels of 370<span class="elsevierStyleHsp" style=""></span>kU&#47;L&#46; The other parameters in the workup were within normal ranges&#46; With a diagnosis of CSU&#44; the patient was started on bilastine 40<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span> combined with a 4-week cycle of prednisone&#46; Response was poor and the symptoms returned on initiation of prednisone tapering&#46; In view of the patient&#39;s failure to respond to the first- and second-line treatments and her clinical progress&#44; we decided to step up the intensity of treatment&#46; Following discussion with the hepatology unit&#44; it was agreed that there were no current indications to treat the HBV infection but that it was necessary to avoid immunosuppressants such as ciclosporin&#46; We therefore started treatment with omalizumab 300<span class="elsevierStyleHsp" style=""></span>mg every 4 weeks&#46; The dose of bilastine was gradually reduced&#46; Over the next 6 months&#44; the patient experienced no new episodes of urticaria&#44; even after complete withdrawal of the bilastine&#46; The Urticaria Activity Score 7 &#40;UAS7&#41; decreased from an initial score of 37 &#40;on a scale of 0-42&#41; to a score that consistently ranged between 0 and 5 after the second dose of omalizumab&#46; No adverse effects were observed&#46; There was no evident worsening of the HBV infection and we actually observed a reduction in viral load to 627<span class="elsevierStyleHsp" style=""></span>IU&#47;mL at the end of the 6-month treatment cycle&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the changes in UAS7 score and viral loads over the treatment period&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Based on our review of the literature&#44; we believe that this is the first report of the effective and safe use of omalizumab in a patient with CSU and active HBV infection&#46; Brodska and Schmid-Grendelmeier<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> described the case of a patient with cold urticaria and chronic HBV infection treated with omalizumab&#46; The treatment was effective and well tolerated&#44; but no information was provided on the clinical features of the infection or on subsequent progress&#46; Antonicelli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> described the case of a patient with HCV infection who achieved asthma control after 19 months of treatment with omalizumab&#46; There was no worsening of liver function and the patient subsequently underwent HVC eradication treatment with interferon and ribavarin&#46; Finally&#44; Leiva-Salinas et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> published a case in which omalizumab proved to be both effective and safe in a patient with CSU and HVC infection&#46; No worsening of liver disease was observed&#44; but the authors did not provide information on viral loads&#46; Omalizumab was effective in our patient and did not worsen the underlying HBV infection&#46; It was&#44; in fact&#44; even associated with a reduction in viral load&#46; We cannot provide a clear explanation for this reduction&#44; but other authors have described improved interferon-&#945; immune response to rhinovirus in patients on interferon-&#945; therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Omalizumab may be an effective and safe treatment alternative for refractory CSU in patients with HVB infection&#46; There is&#44; however&#44; no evidence as yet on possible adverse effects or worsening of viral infection in our patient or in similar cases&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">P&#46; Chicharro and P&#46; Rodr&#237;guez-Jim&#233;nez declare that they have no conflicts of interest&#46; D&#46; de Argila has worked as a clinical advisor and participated in clinical trials sponsored by Novartis&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Chicharro P&#44; Rodr&#237;guez-Jim&#233;nez P&#44; de Argila D&#46; Eficacia y seguridad de omalizumab en un paciente con urticaria cr&#243;nica espont&#225;nea e infecci&#243;n activa por el virus de la hepatitis B&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;383&#8211;384&#46;</p>"
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Article information
ISSN: 15782190
Original language: English
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?