was read the article
array:24 [ "pii" => "S1578219017300483" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.02.019" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1590" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2017;108:365-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 617 "formatos" => array:3 [ "EPUB" => 51 "HTML" => 414 "PDF" => 152 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731017300467" "issn" => "00017310" "doi" => "10.1016/j.ad.2016.12.008" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1590" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2017;108:365-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 229 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 200 "PDF" => 26 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Foro de Residentes</span>" "titulo" => "FR-¿Son los nuevos agentes antivirales de acción directa un tratamiento eficaz para las manifestaciones cutáneas de la hepatitis <span class="elsevierStyleSmallCaps">C</span>?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "365" "paginaFinal" => "366" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "RF -Are the New Direct-Acting Antiviral Agents Effective for Treating the Cutaneous Manifestations of Hepatitis C?" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Morgado-Carrasco, X. Fustà-Novell, S. Podlipnik, P. Giavedoni" "autores" => array:4 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Morgado-Carrasco" ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Fustà-Novell" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Podlipnik" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Giavedoni" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219017300483" "doi" => "10.1016/j.adengl.2017.02.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300483?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017300467?idApp=UINPBA000044" "url" => "/00017310/0000010800000004/v2_201705020105/S0001731017300467/v2_201705020105/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219017300537" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.03.003" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1447" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2017;108:367" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 931 "formatos" => array:3 [ "EPUB" => 61 "HTML" => 761 "PDF" => 109 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>" "titulo" => "What Lies Beneath: Acropachy Hiding Subungual Osteochondroma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "367" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lo que la acropaquia esconde: osteocondroma subungueal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 732 "Ancho" => 1667 "Tamanyo" => 291028 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Galán-Gutierrez, F. Ramos Pleguezuelos, R. Ruiz-Villaverde" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Galán-Gutierrez" ] 1 => array:2 [ "nombre" => "F. Ramos" "apellidos" => "Pleguezuelos" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Ruiz-Villaverde" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016301739" "doi" => "10.1016/j.ad.2016.03.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301739?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300537?idApp=UINPBA000044" "url" => "/15782190/0000010800000004/v1_201704280927/S1578219017300537/v1_201704280927/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219017300495" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.02.020" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1452" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:363-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 634 "formatos" => array:3 [ "EPUB" => 52 "HTML" => 478 "PDF" => 104 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>" "titulo" => "Nodular Peristomal Lesions" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "363" "paginaFinal" => "364" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lesiones nodulares periestomales" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1227 "Ancho" => 1650 "Tamanyo" => 802660 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin-eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>10.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Latour-Álvarez, E. García-Peris, M.M. Pestana-Eliche, M. García-Bustínduy" "autores" => array:4 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Latour-Álvarez" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "García-Peris" ] 2 => array:2 [ "nombre" => "M.M." "apellidos" => "Pestana-Eliche" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "García-Bustínduy" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016301788" "doi" => "10.1016/j.ad.2016.02.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301788?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300495?idApp=UINPBA000044" "url" => "/15782190/0000010800000004/v1_201704280927/S1578219017300495/v1_201704280927/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Residents Forum</span>" "titulo" => "RF- Are the New Direct-Acting Antiviral Agents Effective for Treating the Cutaneous Manifestations of Hepatitis C?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "365" "paginaFinal" => "366" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "D. Morgado-Carrasco, X. Fustà-Novell, S. Podlipnik, P. Giavedoni" "autores" => array:4 [ 0 => array:4 [ "nombre" => "D." "apellidos" => "Morgado-Carrasco" "email" => array:1 [ 0 => "danielmorgado@yahoo.com.ar" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Fustà-Novell" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Podlipnik" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Giavedoni" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Dermatology Department, Hospital Clínic, Barcelona, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "FR-¿Son los nuevos agentes antivirales de acción directa un tratamiento eficaz para las manifestaciones cutáneas de la hepatitis <span class="elsevierStyleSmallCaps">C</span>?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The hepatitis C virus (HCV) is one of the most common causes of chronic liver disease worldwide. The virus increases the risk of liver cirrhosis and hepatocellular carcinoma. HCV is associated with numerous extrahepatic manifestations, such as type 2 diabetes mellitus, chronic kidney disease, cardiovascular disease, non-Hodgkin lymphomas, and various skin diseases (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Patients infected with HCV may have symptomatic mixed cryoglobulinemia (cryoglobulinemic vasculitis), which has an estimated prevalence of 4.9%, as well as porphyria cutanea tarda and lichen planus, with a relative risk 2 and 8 times that of the general population, respectively.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Other skin disorders possibly associated with HCV are psoriasis, alopecia, pruritus, polyarteritis nodosa, sarcoidosis, and necrolytic migratory erythema. Urticaria, Behçet disease, erythema nodosum, and erythema multiforme have also been reported, although the association is less clear.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The recent introduction of the latest generation of direct acting antivirals (DAAs)—including sofosbuvir, ledipasvir, daclatasvir, asunaprevir, and others—has revolutionized the treatment of chronic HCV infection due to the very high effectiveness, excellent safety profile, and tolerability of these drugs.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Current clinical guidelines (September 2016) suggest initiating treatment in all patients with chronic HCV infection except those with limited life expectancy.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Recently there have been reports of improvement in skin diseases associated with HCV after successful treatment with DAAs. A prospective study in Spain of 64 patients with mixed cryoglobulinemia secondary to HCV infection, 35 of whom had manifestations of cryoglobulinemic vasculitis—including purpura (65%, 23 of 35 patients), joint or muscle pain (51%), and neurologic or renal involvement (70%)—found that complete clinical response was achieved in 71% of symptomatic patients after therapy with various combinations of DAAs. In the patients who had purpura, cutaneous involvement remitted after sustained virological response (SVR) in nearly all cases (21 of 23 patients).<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Nagao et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> presented a series of 7 patients with HCV and oral lichen planus—4 with erosive lichen planus (3 of whom were previously treated with topical corticosteroids)—who received daclatasvir-asunaprevir combination therapy with SVR; complete resolution of oral disease was achieved in 4 patients and partial improvement was achieved in 3. Finally, Tong et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> described 3 individuals diagnosed with porphyria cutanea tarda and HCV infection who were successfully treated with ledipasvir-sofosbuvir combination therapy. Remission of cutaneous symptoms was achieved in 2 patients, and a marked decrease in the number of erosive lesions was achieved in the third patient between 1 and 3 months after completion of antiviral therapy.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion, DAAs are highly effective and safe for the treatment of HCV infection. Some reports suggest that DAAs could also achieve improvement in some skin diseases associated with HCV and that these drugs could perhaps be a therapeutic option for patients with aggressive skin disorders or who do not respond to conventional treatments. Given that the use of these drugs is expected to increase, we will be able to see whether these effects occur in a larger number of patients and if the effects persist over time.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec830195" "palabras" => array:6 [ 0 => "Hepatitis C virus" 1 => "Direct-acting antiviral" 2 => "Antiviral therapy" 3 => "Skin manifestations" 4 => "Mixed cryoglobulinemia" 5 => "Lichen planus" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Morgado-Carrasco D, Fustà-Novell X, Podlipnik S, Giavedoni P. FR-¿Son los nuevos agentes antivirales de acción directa un tratamiento eficaz para las manifestaciones cutáneas de la hepatitis <span class="elsevierStyleSmallCaps">C</span>?. Actas Dermosifiliogr. 2017;108:365–366.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Source: Younossi et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Well-established association</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Porphyria cutanea tarda \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lichen planus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Symptomatic cryoglobulinemia (cryoglobulinemic vasculitis) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Possible association</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Psoriasis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Alopecia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Polyarteritis nodosa \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sarcoidosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Necrolytic migratory erythema \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Uncertain association</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Urticaria \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Erythema multiforme \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Erythema nodosum \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Behçet disease \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1406716.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Skin Disorders Associated With Hepatitis C Virus Infection.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extrahepatic manifestations of hepatitis C: A meta-analysis of prevalence, quality of life, and economic burden" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Z. Younossi" 1 => "H. Park" 2 => "L. Henry" 3 => "A. Adeyemi" 4 => "M. Stepanova" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.gastro.2016.02.039" "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "2016" "volumen" => "150" "paginaInicial" => "1599" "paginaFinal" => "1608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26924097" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "pii: S1542-3565(16)30878-3" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Virologic, clinical, and immune response outcomes of patients with hepatitis C virus-associated cryoglobulinemia treated with direct-acting antivirals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Bonacci" 1 => "S. Lens" 2 => "M.C. Londoño" 3 => "Z. Mariño" 4 => "M.C. Cid" 5 => "M. Ramos-Casals" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Clin Gastroenterol Hepatol" "fecha" => "2016" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "AASLD-IDSA. Recommendations for testing, managing, and treating hepatitis C. <a href="http://www.hcvguidelines.org/">http://www.hcvguidelines.org</a>. Accessed October 23, 2016." ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of hepatitis C virus-associated oral lichen planus by interferon-free therapy with direct-acting antivirals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y. Nagao" 1 => "K. Kimura" 2 => "Y. Kawahigashi" 3 => "M. Sata" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ctg.2016.37" "Revista" => array:5 [ "tituloSerie" => "Clin Transl Gastroenterol" "fecha" => "2016" "volumen" => "7" "paginaInicial" => "e179" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27388424" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resolution of porphyria cutanea tarda in patients with hepatitis C following ledipasvir-sofosbuvir combination therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y. Tong" 1 => "Y.K. Song" 2 => "S. Tyring" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2016.3036" "Revista" => array:6 [ "tituloSerie" => "JAMA Dermatol" "fecha" => "2016" "volumen" => "152" "paginaInicial" => "1393" "paginaFinal" => "1395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27732687" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010800000004/v1_201704280927/S1578219017300483/v1_201704280927/en/main.assets" "Apartado" => array:4 [ "identificador" => "34945" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Resident's Forum" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010800000004/v1_201704280927/S1578219017300483/v1_201704280927/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300483?idApp=UINPBA000044" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 10 | 9 | 19 |
2024 October | 77 | 33 | 110 |
2024 September | 77 | 27 | 104 |
2024 August | 108 | 50 | 158 |
2024 July | 84 | 23 | 107 |
2024 June | 71 | 34 | 105 |
2024 May | 51 | 31 | 82 |
2024 April | 67 | 26 | 93 |
2024 March | 67 | 37 | 104 |
2024 February | 65 | 29 | 94 |
2024 January | 60 | 33 | 93 |
2023 December | 59 | 14 | 73 |
2023 November | 80 | 29 | 109 |
2023 October | 57 | 20 | 77 |
2023 September | 48 | 35 | 83 |
2023 August | 44 | 17 | 61 |
2023 July | 43 | 31 | 74 |
2023 June | 41 | 22 | 63 |
2023 May | 34 | 25 | 59 |
2023 April | 36 | 21 | 57 |
2023 March | 34 | 17 | 51 |
2023 February | 35 | 22 | 57 |
2023 January | 43 | 31 | 74 |
2022 December | 44 | 38 | 82 |
2022 November | 29 | 35 | 64 |
2022 October | 32 | 16 | 48 |
2022 September | 27 | 33 | 60 |
2022 August | 22 | 30 | 52 |
2022 July | 21 | 36 | 57 |
2022 June | 39 | 17 | 56 |
2022 May | 22 | 35 | 57 |
2022 April | 32 | 32 | 64 |
2022 March | 46 | 47 | 93 |
2022 February | 28 | 34 | 62 |
2022 January | 37 | 29 | 66 |
2021 December | 23 | 42 | 65 |
2021 November | 26 | 39 | 65 |
2021 October | 38 | 53 | 91 |
2021 September | 22 | 35 | 57 |
2021 August | 27 | 40 | 67 |
2021 July | 19 | 28 | 47 |
2021 June | 23 | 23 | 46 |
2021 May | 40 | 33 | 73 |
2021 April | 49 | 47 | 96 |
2021 March | 52 | 21 | 73 |
2021 February | 40 | 29 | 69 |
2021 January | 22 | 10 | 32 |
2020 December | 26 | 16 | 42 |
2020 November | 31 | 22 | 53 |
2020 October | 27 | 15 | 42 |
2020 September | 35 | 14 | 49 |
2020 August | 31 | 13 | 44 |
2020 July | 25 | 11 | 36 |
2020 June | 32 | 31 | 63 |
2020 May | 13 | 15 | 28 |
2020 April | 29 | 17 | 46 |
2020 March | 16 | 15 | 31 |
2020 February | 3 | 0 | 3 |
2020 January | 8 | 0 | 8 |
2019 December | 4 | 0 | 4 |
2019 November | 4 | 0 | 4 |
2019 October | 6 | 0 | 6 |
2019 September | 5 | 0 | 5 |
2019 August | 6 | 0 | 6 |
2019 July | 8 | 0 | 8 |
2019 June | 4 | 0 | 4 |
2019 May | 6 | 2 | 8 |
2019 April | 2 | 3 | 5 |
2019 February | 7 | 0 | 7 |
2018 December | 5 | 0 | 5 |
2018 November | 4 | 0 | 4 |
2018 October | 5 | 1 | 6 |
2018 September | 6 | 0 | 6 |
2018 February | 23 | 4 | 27 |
2018 January | 29 | 6 | 35 |
2017 December | 30 | 6 | 36 |
2017 November | 23 | 12 | 35 |
2017 October | 37 | 6 | 43 |
2017 September | 23 | 19 | 42 |
2017 August | 26 | 29 | 55 |
2017 July | 28 | 9 | 37 |
2017 June | 41 | 11 | 52 |
2017 May | 59 | 26 | 85 |
2017 April | 13 | 13 | 26 |
2017 March | 1 | 5 | 6 |