array:24 [
  "pii" => "S1578219016302141"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2016.08.011"
  "estado" => "S300"
  "fechaPublicacion" => "2016-11-01"
  "aid" => "1441"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2016;107:783-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1214
    "formatos" => array:3 [
      "EPUB" => 42
      "HTML" => 912
      "PDF" => 260
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731016301661"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2016.04.023"
      "estado" => "S300"
      "fechaPublicacion" => "2016-11-01"
      "aid" => "1441"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2016;107:783-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 251
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 201
          "PDF" => 48
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Lesiones orales y coriorretinitis placoide posterior como forma de presentaci&#243;n de s&#237;filis secundaria en un paciente inmunocompetente"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "783"
            "paginaFinal" => "784"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Secondary Syphilis Presenting as Oral Lesions and Posterior Placoid Chorioretinitis in an Immunocompetent Patient"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1125
                "Ancho" => 1500
                "Tamanyo" => 230768
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lesiones en forma de erosiones en el paladar duro y el pilar tonsilar derecho&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Plana-Pla, L&#46; Pelegr&#237;n-Col&#225;s, I&#46; Bielsa-Marsol, C&#46; Ferrandiz-Foraster"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Plana-Pla"
              ]
              1 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Pelegr&#237;n-Col&#225;s"
              ]
              2 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Bielsa-Marsol"
              ]
              3 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Ferrandiz-Foraster"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219016302141"
          "doi" => "10.1016/j.adengl.2016.08.011"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302141?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301661?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000009/v1_201611020109/S0001731016301661/v1_201611020109/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S157821901630213X"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.08.010"
    "estado" => "S300"
    "fechaPublicacion" => "2016-11-01"
    "aid" => "1440"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:785-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 795
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 512
        "PDF" => 232
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Pemphigus Herpetiformis With Autoantibodies to Desmoglein 1 and 3"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "785"
          "paginaFinal" => "786"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "P&#233;nfigo herpetiforme con anticuerpos anti-desmogle&#237;na 1 y 3"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 614
              "Ancho" => 1700
              "Tamanyo" => 274293
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histology images&#58; A&#44; Detail of neutrophilic spongiosis&#46; Hematoxylin and eosin&#44; original magnification &#215;40&#46; B&#44; Intercellular deposits of immunoglobulin G &#40;direct immunofluorescence&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;I&#46; Galva&#241;-P&#233;rez del Pulgar, J&#46; Tercedor-S&#225;nchez, D&#46; Jim&#233;nez-Gallo, M&#46; Linares-Barrios"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;I&#46;"
              "apellidos" => "Galva&#241;-P&#233;rez del Pulgar"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Tercedor-S&#225;nchez"
            ]
            2 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Jim&#233;nez-Gallo"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Linares-Barrios"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101630165X"
        "doi" => "10.1016/j.ad.2016.04.022"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101630165X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901630213X?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000009/v1_201611010039/S157821901630213X/v1_201611010039/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219016302189"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.08.015"
    "estado" => "S300"
    "fechaPublicacion" => "2016-11-01"
    "aid" => "1442"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:781-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 965
      "formatos" => array:3 [
        "EPUB" => 53
        "HTML" => 690
        "PDF" => 222
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Reactivation of Skin Lesions After Patch Testing to Investigate Drug Rash With Eosinophilia and Systemic Symptoms &#40;DRESS&#41; Syndrome"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "781"
          "paginaFinal" => "783"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Reactivaci&#243;n de las lesiones cut&#225;neas por pruebas epicut&#225;neas en el estudio de un s&#237;ndrome de DRESS"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1125
              "Ancho" => 750
              "Tamanyo" => 165961
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lesions of lesser intensity similar to those of the previous rash&#46; Reactivation after patch tests&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#46; C&#243;rdoba, B&#46; Navarro-Vidal, C&#46; Mart&#237;nez-Mor&#225;n, J&#46; Borbujo"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "C&#243;rdoba"
            ]
            1 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Navarro-Vidal"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Mart&#237;nez-Mor&#225;n"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Borbujo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731016301673"
        "doi" => "10.1016/j.ad.2016.05.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301673?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302189?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000009/v1_201611010039/S1578219016302189/v1_201611010039/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Secondary Syphilis Presenting as Oral Lesions and Posterior Placoid Chorioretinitis in an Immunocompetent Patient"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "783"
        "paginaFinal" => "784"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Plana-Pla, L&#46; Pelegr&#237;n-Col&#225;s, I&#46; Bielsa-Marsol, C&#46; Ferrandiz-Foraster"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Plana-Pla"
            "email" => array:1 [
              0 => "adriplanapla&#64;yahoo&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Pelegr&#237;n-Col&#225;s"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "I&#46;"
            "apellidos" => "Bielsa-Marsol"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Ferrandiz-Foraster"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Hospital Universitari Germans Trias i Pujol&#44; Badalona&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Institut Cl&#237;nic d&#8217;Oftalmolog&#237;a&#44; Hospital Cl&#237;nic de Barcelona&#44; Barcelona&#44; Espa&#241;a"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Cl&#237;nica Bad&#237;a&#44; Matar&#243;&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Lesiones orales y coriorretinitis placoide posterior como forma de presentaci&#243;n de s&#237;filis secundaria en un paciente inmunocompetente"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 632
            "Ancho" => 1701
            "Tamanyo" => 122501
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A large&#44; circular&#44; yellowish placoid lesion on the pigmented epithelium of the retina&#44; at the macula&#46; B&#44; Image after treatment&#44; showing normalization of the retina&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Within the broad range of manifestations that syphilis can cause&#44; lesions on the oral mucosa and eye involvement are very rare&#44; particularly as isolated lesions&#46; We describe a patient with oral lesions and eye involvement&#44; with no associated skin lesions&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 59-year-old man&#44; with no past history of interest&#46; He was referred from another center to investigate a 1-year history of oral mucosal symptoms presenting as odynophagia&#44; a sensation of excess mucus secretion&#44; and painful erosive lesions in the oral cavity and pharynx&#46; The patient had also been seen in ophthalmology for a decrease in visual acuity over the previous 3 months&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed erosive lesions on the hard palate and on the right tonsillar pillar &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and difficulty swallowing&#46; On ophthalmologic examination&#44; a large&#44; circular&#44; yellowish placoid lesion was observed on the pigmented epithelium of the retina&#44; at the macula&#46; The lesion extended to the upper temporal vascular arches of the right eye &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2A</a>&#41;&#46; Visual acuity was 20&#47;50&#46; This was initially considered as a chorioretinitis of uncertain origin&#46; Biopsy of an oral lesion showed epidermal hyperplasia with a dense mixed inflammatory infiltrate with a predominance of plasma cells that extended into the deep dermis and was localized mainly around the blood vessels&#46; Lymphocyte exocytosis was also observed&#46; A provisional diagnosis of secondary syphilis was made&#44; and staining with antitreponemal antibody showed the presence of numerous spirochetes in the mucosa and in smaller numbers in the submucosa&#46; Syphilis serology in blood was positive &#40;rapid plasma reagin&#44; 1&#58;128&#59; treponema pallidum hemagglutination test&#44; &#43;&#41;&#46; On further questioning&#44; the patient denied previous skin lesions but did state that about 18 months earlier he had had an erosion on the glans that had been diagnosed as genital herpes at other center&#46; Based on these findings&#44; we made a diagnosis of posterior placoid chorioretinitis of probable syphilitic origin&#46; HIV serology was negative and lumbar puncture showed a slight increase in the protein content of the cerebrospinal fluid &#40;64<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; with normal cellularity and glucose levels and positive reagin antibodies titers &#40;Venereal Disease Research Laboratory&#41;&#46; A diagnosis was therefore made of secondary syphilis with central nervous system involvement &#40;neurosyphilis&#41; and the patient was treated with penicillin G sodium at a dose of 4 million IU intravenously every 4<span class="elsevierStyleHsp" style=""></span>hours for 14 days&#46; The clinical course was favorable&#44; with resolution of the oral lesions and a clear improvement in the ocular lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2B</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Syphilis can cause oral lesions in all of its stages&#44; but they are most common in the secondary stage &#40;30&#37; of patients&#41;&#46; However&#44; the absence of concomitant skin manifestations&#44; as in our case&#44; is very rare&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The oral lesions of secondary syphilis are clinically very heterogeneous and typically nonspecific&#59; they include macules&#44; papules&#44; plaques and ulcers&#44; which may be single or multiple&#44; and they are usually associated with nonspecific pharyngitis&#44; tonsillitis&#44; or laryngitis&#44; sometimes with palpable lymph nodes&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> These lesions most frequently occur together with the typical cutaneous manifestations of the disease&#44; and usually resolve within 3 to 12 weeks&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> In the present case&#44; however&#44; the lesions were isolated and persisted for at least a year&#46; In a review of the literature&#44; we found isolated case reports of oral lesions without associated skin manifestations&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> but none had a clinical course of more than 5 months in patients who&#44; like ours&#44; were immunocompetent&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Isolated lesions of syphilis on the oral mucosa are a considerable diagnostic challenge&#44; and the histology of these lesions must therefore be carefully evaluated for any detail that will help to reach the diagnosis&#46; In addition&#44; the patient must be questioned closely about noncutaneous features of the disease&#44; which must be investigated in detail as in the more common forms of the disease&#46; Microscopy is often relatively nonspecific&#44; but a recent article suggested that the presence of perivascular or perineural infiltrates of plasma cells and lymphocyte exocytosis could be signs that support the diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> In our case&#44; the infiltrate of plasma cells was very dense and intense lymphocyte exocytosis was observed&#44; leading us to suspect the diagnosis&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The extracutaneous manifestations can be very varied&#46; Eye involvement is one of the less common manifestations but&#44; when it occurs&#44; it usually develops during the secondary phase of the disease and it can affect any segment of the globe&#46; Scleritis and uveitis are the most common forms of presentation&#44; but keratitis and conjunctivitis can also develop&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#44;7</span></a> Acute syphilitic posterior placoid chorioretinitis &#40;ASPPC&#41; is a recently described ocular manifestation and is extremely rare in immunocompetent patients such as the patient we describe&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">ASPPC was first described in 1988 and&#44; since that time&#44; only 60 cases have been published&#44; of which 40&#37; were diagnosed in HIV-positive patients&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> Clinically&#44; ASPPC is characterized by the appearance of yellowish placoid lesions situated at the macula and there is a marked loss of visual acuity&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> The search for extracutaneous manifestations&#44; and for eye involvement in particular&#44; is essential in these patients &#40;especially if associated with immune compromise&#41;&#44; as these alterations not only affect the prognosis of the disease but they are also of importance when choosing the treatment to be administered&#46; The presence of syphilitic eye lesions&#44; as in the present case&#44; is diagnostic of neurosyphilis&#44; making the patient a candidate for intravenous treatment&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Although the incidence of neurosyphilis is low in immunocompetent patients &#40;0&#46;2-2&#46;1 cases per 100<span class="elsevierStyleHsp" style=""></span>000 population<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#41; and that of syphilitic ocular involvement is even lower&#44; the increase in the number of cases of syphilis in recent years in developed countries requires us to be aware of the most atypical and least common presentations of this disease as&#44; when this is not diagnosed early&#44; the infection can spread and the harm to the patient can increase&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Plana-Pla A&#44; Pelegr&#237;n-Col&#225;s L&#44; Bielsa-Marsol I&#44; Ferrandiz-Foraster C&#46; Lesiones orales y coriorretinitis placoide posterior como forma de presentaci&#243;n de s&#237;filis secundaria en un paciente inmunocompetente&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;783&#8211;784&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 675
            "Ancho" => 900
            "Tamanyo" => 115922
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erosions on the hard palate and the right tonsillar pillar&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 632
            "Ancho" => 1701
            "Tamanyo" => 122501
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A large&#44; circular&#44; yellowish placoid lesion on the pigmented epithelium of the retina&#44; at the macula&#46; B&#44; Image after treatment&#44; showing normalization of the retina&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral manifestations of syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;C&#46; Leao"
                            1 => "L&#46;A&#46; Gueiros"
                            2 => "S&#46;R&#46; Porter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "/S1807-59322006000200012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinics"
                        "fecha" => "2006"
                        "volumen" => "61"
                        "paginaInicial" => "161"
                        "paginaFinal" => "166"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16680334"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral syphilis&#58; A retrospective analysis of 12 cases and a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Leuci"
                            1 => "S&#46; Martina"
                            2 => "D&#46; Adamo"
                            3 => "E&#46; Ruoppo"
                            4 => "A&#46; Santarelli"
                            5 => "R&#46; Sorrentino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/odi.12058"
                      "Revista" => array:7 [
                        "tituloSerie" => "Oral Dis"
                        "fecha" => "2013"
                        "volumen" => "19"
                        "paginaInicial" => "738"
                        "paginaFinal" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23294141"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109797000302"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Isolated oral erosions&#58; An unusual manifestation of secondary syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Carlesimo"
                            1 => "E&#46; Palese"
                            2 => "E&#46; Mari"
                            3 => "G&#46; Feliziani"
                            4 => "M&#46; la Pietra"
                            5 => "G&#46; de Marco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2008"
                        "volumen" => "14"
                        "paginaInicial" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19061622"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Secondary syphilis simulating oral hairy leukoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Aquilina"
                            1 => "R&#46; Viraben"
                            2 => "P&#46; Denis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2003"
                        "volumen" => "49"
                        "paginaInicial" => "749"
                        "paginaFinal" => "751"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14512934"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic approaches in unsuspected oral lesions of syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;S&#46; Siqueira"
                            1 => "J&#46;L&#46; Saturno"
                            2 => "S&#46;C&#46; de Sousa"
                            3 => "F&#46;R&#46; da Silveira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijom.2014.09.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Oral Maxillofac Surg"
                        "fecha" => "2014"
                        "volumen" => "43"
                        "paginaInicial" => "1436"
                        "paginaFinal" => "1440"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25305698"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant syphilis with ocular involvement and organism-depleted lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Pleimes"
                            1 => "W&#46; Hartschuh"
                            2 => "H&#46; Kutzner"
                            3 => "A&#46;H&#46; Enk"
                            4 => "M&#46; Hartmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/594127"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "83"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19035775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Update on ocular syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;A&#46; Gaudio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Opin Ophtalmol"
                        "fecha" => "2006"
                        "volumen" => "17"
                        "paginaInicial" => "562"
                        "paginaFinal" => "566"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syphilitic acute posterior placoid chorioretinitis in nonimmune-compromised patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Joseph"
                            1 => "S&#46; Rogers"
                            2 => "A&#46; Browning"
                            3 => "N&#46; Hall"
                            4 => "C&#46; Barber"
                            5 => "A&#46; Lotery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eye &#40;Lond&#41;"
                        "fecha" => "2007"
                        "volumen" => "21"
                        "paginaInicial" => "1114"
                        "paginaFinal" => "1119"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute syphilitic posterior placoid chorioretinitis&#58; Report of a case series and comprehensive review of the literature"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "International Syphilis Study Group"
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;M&#46; Eandi"
                            1 => "P&#46; Neri"
                            2 => "R&#46;A&#46; Adelman"
                            3 => "L&#46;A&#46; Yannuzzi"
                            4 => "E&#46;T&#46; Cunningham Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/IAE.0b013e31825f3851"
                      "Revista" => array:6 [
                        "tituloSerie" => "Retina"
                        "fecha" => "2012"
                        "volumen" => "32"
                        "paginaInicial" => "1915"
                        "paginaFinal" => "1941"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22863970"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current clinical spectrum of neurosyphilis in immunocompetent patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;A&#46; Conde-Send&#237;n"
                            1 => "R&#46; Amela-Peris"
                            2 => "Y&#46; Aladro-Benito"
                            3 => "A&#46;A&#46; Maroto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000079391"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Neurol"
                        "fecha" => "2004"
                        "volumen" => "52"
                        "paginaInicial" => "29"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15237250"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000009/v1_201611010039/S1578219016302141/v1_201611010039/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000009/v1_201611010039/S1578219016302141/v1_201611010039/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302141?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case and Research Letters
Secondary Syphilis Presenting as Oral Lesions and Posterior Placoid Chorioretinitis in an Immunocompetent Patient
Lesiones orales y coriorretinitis placoide posterior como forma de presentación de sífilis secundaria en un paciente inmunocompetente
A. Plana-Plaa,
Corresponding author
adriplanapla@yahoo.es

Corresponding author.
, L. Pelegrín-Colásb,c, I. Bielsa-Marsola, C. Ferrandiz-Forastera
a Departamento de Dermatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
b Institut Clínic d’Oftalmología, Hospital Clínic de Barcelona, Barcelona, España
c Clínica Badía, Mataró, Barcelona, Spain
Read
10058
Times
was read the article
2188
Total PDF
7870
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219016302141"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2016.08.011"
  "estado" => "S300"
  "fechaPublicacion" => "2016-11-01"
  "aid" => "1441"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2016;107:783-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1214
    "formatos" => array:3 [
      "EPUB" => 42
      "HTML" => 912
      "PDF" => 260
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731016301661"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2016.04.023"
      "estado" => "S300"
      "fechaPublicacion" => "2016-11-01"
      "aid" => "1441"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2016;107:783-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 251
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 201
          "PDF" => 48
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Lesiones orales y coriorretinitis placoide posterior como forma de presentaci&#243;n de s&#237;filis secundaria en un paciente inmunocompetente"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "783"
            "paginaFinal" => "784"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Secondary Syphilis Presenting as Oral Lesions and Posterior Placoid Chorioretinitis in an Immunocompetent Patient"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1125
                "Ancho" => 1500
                "Tamanyo" => 230768
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lesiones en forma de erosiones en el paladar duro y el pilar tonsilar derecho&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Plana-Pla, L&#46; Pelegr&#237;n-Col&#225;s, I&#46; Bielsa-Marsol, C&#46; Ferrandiz-Foraster"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Plana-Pla"
              ]
              1 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Pelegr&#237;n-Col&#225;s"
              ]
              2 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Bielsa-Marsol"
              ]
              3 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Ferrandiz-Foraster"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219016302141"
          "doi" => "10.1016/j.adengl.2016.08.011"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302141?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301661?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000009/v1_201611020109/S0001731016301661/v1_201611020109/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S157821901630213X"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.08.010"
    "estado" => "S300"
    "fechaPublicacion" => "2016-11-01"
    "aid" => "1440"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:785-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 795
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 512
        "PDF" => 232
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Pemphigus Herpetiformis With Autoantibodies to Desmoglein 1 and 3"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "785"
          "paginaFinal" => "786"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "P&#233;nfigo herpetiforme con anticuerpos anti-desmogle&#237;na 1 y 3"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 614
              "Ancho" => 1700
              "Tamanyo" => 274293
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histology images&#58; A&#44; Detail of neutrophilic spongiosis&#46; Hematoxylin and eosin&#44; original magnification &#215;40&#46; B&#44; Intercellular deposits of immunoglobulin G &#40;direct immunofluorescence&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;I&#46; Galva&#241;-P&#233;rez del Pulgar, J&#46; Tercedor-S&#225;nchez, D&#46; Jim&#233;nez-Gallo, M&#46; Linares-Barrios"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;I&#46;"
              "apellidos" => "Galva&#241;-P&#233;rez del Pulgar"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Tercedor-S&#225;nchez"
            ]
            2 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Jim&#233;nez-Gallo"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Linares-Barrios"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101630165X"
        "doi" => "10.1016/j.ad.2016.04.022"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101630165X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901630213X?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000009/v1_201611010039/S157821901630213X/v1_201611010039/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219016302189"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.08.015"
    "estado" => "S300"
    "fechaPublicacion" => "2016-11-01"
    "aid" => "1442"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:781-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 965
      "formatos" => array:3 [
        "EPUB" => 53
        "HTML" => 690
        "PDF" => 222
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Reactivation of Skin Lesions After Patch Testing to Investigate Drug Rash With Eosinophilia and Systemic Symptoms &#40;DRESS&#41; Syndrome"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "781"
          "paginaFinal" => "783"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Reactivaci&#243;n de las lesiones cut&#225;neas por pruebas epicut&#225;neas en el estudio de un s&#237;ndrome de DRESS"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1125
              "Ancho" => 750
              "Tamanyo" => 165961
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lesions of lesser intensity similar to those of the previous rash&#46; Reactivation after patch tests&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#46; C&#243;rdoba, B&#46; Navarro-Vidal, C&#46; Mart&#237;nez-Mor&#225;n, J&#46; Borbujo"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "C&#243;rdoba"
            ]
            1 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Navarro-Vidal"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Mart&#237;nez-Mor&#225;n"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Borbujo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731016301673"
        "doi" => "10.1016/j.ad.2016.05.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301673?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302189?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000009/v1_201611010039/S1578219016302189/v1_201611010039/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Secondary Syphilis Presenting as Oral Lesions and Posterior Placoid Chorioretinitis in an Immunocompetent Patient"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "783"
        "paginaFinal" => "784"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Plana-Pla, L&#46; Pelegr&#237;n-Col&#225;s, I&#46; Bielsa-Marsol, C&#46; Ferrandiz-Foraster"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Plana-Pla"
            "email" => array:1 [
              0 => "adriplanapla&#64;yahoo&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Pelegr&#237;n-Col&#225;s"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "I&#46;"
            "apellidos" => "Bielsa-Marsol"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Ferrandiz-Foraster"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Hospital Universitari Germans Trias i Pujol&#44; Badalona&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Institut Cl&#237;nic d&#8217;Oftalmolog&#237;a&#44; Hospital Cl&#237;nic de Barcelona&#44; Barcelona&#44; Espa&#241;a"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Cl&#237;nica Bad&#237;a&#44; Matar&#243;&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Lesiones orales y coriorretinitis placoide posterior como forma de presentaci&#243;n de s&#237;filis secundaria en un paciente inmunocompetente"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 632
            "Ancho" => 1701
            "Tamanyo" => 122501
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A large&#44; circular&#44; yellowish placoid lesion on the pigmented epithelium of the retina&#44; at the macula&#46; B&#44; Image after treatment&#44; showing normalization of the retina&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Within the broad range of manifestations that syphilis can cause&#44; lesions on the oral mucosa and eye involvement are very rare&#44; particularly as isolated lesions&#46; We describe a patient with oral lesions and eye involvement&#44; with no associated skin lesions&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 59-year-old man&#44; with no past history of interest&#46; He was referred from another center to investigate a 1-year history of oral mucosal symptoms presenting as odynophagia&#44; a sensation of excess mucus secretion&#44; and painful erosive lesions in the oral cavity and pharynx&#46; The patient had also been seen in ophthalmology for a decrease in visual acuity over the previous 3 months&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed erosive lesions on the hard palate and on the right tonsillar pillar &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and difficulty swallowing&#46; On ophthalmologic examination&#44; a large&#44; circular&#44; yellowish placoid lesion was observed on the pigmented epithelium of the retina&#44; at the macula&#46; The lesion extended to the upper temporal vascular arches of the right eye &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2A</a>&#41;&#46; Visual acuity was 20&#47;50&#46; This was initially considered as a chorioretinitis of uncertain origin&#46; Biopsy of an oral lesion showed epidermal hyperplasia with a dense mixed inflammatory infiltrate with a predominance of plasma cells that extended into the deep dermis and was localized mainly around the blood vessels&#46; Lymphocyte exocytosis was also observed&#46; A provisional diagnosis of secondary syphilis was made&#44; and staining with antitreponemal antibody showed the presence of numerous spirochetes in the mucosa and in smaller numbers in the submucosa&#46; Syphilis serology in blood was positive &#40;rapid plasma reagin&#44; 1&#58;128&#59; treponema pallidum hemagglutination test&#44; &#43;&#41;&#46; On further questioning&#44; the patient denied previous skin lesions but did state that about 18 months earlier he had had an erosion on the glans that had been diagnosed as genital herpes at other center&#46; Based on these findings&#44; we made a diagnosis of posterior placoid chorioretinitis of probable syphilitic origin&#46; HIV serology was negative and lumbar puncture showed a slight increase in the protein content of the cerebrospinal fluid &#40;64<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; with normal cellularity and glucose levels and positive reagin antibodies titers &#40;Venereal Disease Research Laboratory&#41;&#46; A diagnosis was therefore made of secondary syphilis with central nervous system involvement &#40;neurosyphilis&#41; and the patient was treated with penicillin G sodium at a dose of 4 million IU intravenously every 4<span class="elsevierStyleHsp" style=""></span>hours for 14 days&#46; The clinical course was favorable&#44; with resolution of the oral lesions and a clear improvement in the ocular lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2B</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Syphilis can cause oral lesions in all of its stages&#44; but they are most common in the secondary stage &#40;30&#37; of patients&#41;&#46; However&#44; the absence of concomitant skin manifestations&#44; as in our case&#44; is very rare&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The oral lesions of secondary syphilis are clinically very heterogeneous and typically nonspecific&#59; they include macules&#44; papules&#44; plaques and ulcers&#44; which may be single or multiple&#44; and they are usually associated with nonspecific pharyngitis&#44; tonsillitis&#44; or laryngitis&#44; sometimes with palpable lymph nodes&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> These lesions most frequently occur together with the typical cutaneous manifestations of the disease&#44; and usually resolve within 3 to 12 weeks&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> In the present case&#44; however&#44; the lesions were isolated and persisted for at least a year&#46; In a review of the literature&#44; we found isolated case reports of oral lesions without associated skin manifestations&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> but none had a clinical course of more than 5 months in patients who&#44; like ours&#44; were immunocompetent&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Isolated lesions of syphilis on the oral mucosa are a considerable diagnostic challenge&#44; and the histology of these lesions must therefore be carefully evaluated for any detail that will help to reach the diagnosis&#46; In addition&#44; the patient must be questioned closely about noncutaneous features of the disease&#44; which must be investigated in detail as in the more common forms of the disease&#46; Microscopy is often relatively nonspecific&#44; but a recent article suggested that the presence of perivascular or perineural infiltrates of plasma cells and lymphocyte exocytosis could be signs that support the diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> In our case&#44; the infiltrate of plasma cells was very dense and intense lymphocyte exocytosis was observed&#44; leading us to suspect the diagnosis&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The extracutaneous manifestations can be very varied&#46; Eye involvement is one of the less common manifestations but&#44; when it occurs&#44; it usually develops during the secondary phase of the disease and it can affect any segment of the globe&#46; Scleritis and uveitis are the most common forms of presentation&#44; but keratitis and conjunctivitis can also develop&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#44;7</span></a> Acute syphilitic posterior placoid chorioretinitis &#40;ASPPC&#41; is a recently described ocular manifestation and is extremely rare in immunocompetent patients such as the patient we describe&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">ASPPC was first described in 1988 and&#44; since that time&#44; only 60 cases have been published&#44; of which 40&#37; were diagnosed in HIV-positive patients&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> Clinically&#44; ASPPC is characterized by the appearance of yellowish placoid lesions situated at the macula and there is a marked loss of visual acuity&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> The search for extracutaneous manifestations&#44; and for eye involvement in particular&#44; is essential in these patients &#40;especially if associated with immune compromise&#41;&#44; as these alterations not only affect the prognosis of the disease but they are also of importance when choosing the treatment to be administered&#46; The presence of syphilitic eye lesions&#44; as in the present case&#44; is diagnostic of neurosyphilis&#44; making the patient a candidate for intravenous treatment&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Although the incidence of neurosyphilis is low in immunocompetent patients &#40;0&#46;2-2&#46;1 cases per 100<span class="elsevierStyleHsp" style=""></span>000 population<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a>&#41; and that of syphilitic ocular involvement is even lower&#44; the increase in the number of cases of syphilis in recent years in developed countries requires us to be aware of the most atypical and least common presentations of this disease as&#44; when this is not diagnosed early&#44; the infection can spread and the harm to the patient can increase&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Plana-Pla A&#44; Pelegr&#237;n-Col&#225;s L&#44; Bielsa-Marsol I&#44; Ferrandiz-Foraster C&#46; Lesiones orales y coriorretinitis placoide posterior como forma de presentaci&#243;n de s&#237;filis secundaria en un paciente inmunocompetente&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;783&#8211;784&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 675
            "Ancho" => 900
            "Tamanyo" => 115922
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erosions on the hard palate and the right tonsillar pillar&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 632
            "Ancho" => 1701
            "Tamanyo" => 122501
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A large&#44; circular&#44; yellowish placoid lesion on the pigmented epithelium of the retina&#44; at the macula&#46; B&#44; Image after treatment&#44; showing normalization of the retina&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral manifestations of syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;C&#46; Leao"
                            1 => "L&#46;A&#46; Gueiros"
                            2 => "S&#46;R&#46; Porter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "/S1807-59322006000200012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinics"
                        "fecha" => "2006"
                        "volumen" => "61"
                        "paginaInicial" => "161"
                        "paginaFinal" => "166"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16680334"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral syphilis&#58; A retrospective analysis of 12 cases and a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Leuci"
                            1 => "S&#46; Martina"
                            2 => "D&#46; Adamo"
                            3 => "E&#46; Ruoppo"
                            4 => "A&#46; Santarelli"
                            5 => "R&#46; Sorrentino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/odi.12058"
                      "Revista" => array:7 [
                        "tituloSerie" => "Oral Dis"
                        "fecha" => "2013"
                        "volumen" => "19"
                        "paginaInicial" => "738"
                        "paginaFinal" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23294141"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109797000302"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Isolated oral erosions&#58; An unusual manifestation of secondary syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Carlesimo"
                            1 => "E&#46; Palese"
                            2 => "E&#46; Mari"
                            3 => "G&#46; Feliziani"
                            4 => "M&#46; la Pietra"
                            5 => "G&#46; de Marco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2008"
                        "volumen" => "14"
                        "paginaInicial" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19061622"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Secondary syphilis simulating oral hairy leukoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Aquilina"
                            1 => "R&#46; Viraben"
                            2 => "P&#46; Denis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2003"
                        "volumen" => "49"
                        "paginaInicial" => "749"
                        "paginaFinal" => "751"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14512934"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic approaches in unsuspected oral lesions of syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;S&#46; Siqueira"
                            1 => "J&#46;L&#46; Saturno"
                            2 => "S&#46;C&#46; de Sousa"
                            3 => "F&#46;R&#46; da Silveira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijom.2014.09.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Oral Maxillofac Surg"
                        "fecha" => "2014"
                        "volumen" => "43"
                        "paginaInicial" => "1436"
                        "paginaFinal" => "1440"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25305698"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant syphilis with ocular involvement and organism-depleted lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Pleimes"
                            1 => "W&#46; Hartschuh"
                            2 => "H&#46; Kutzner"
                            3 => "A&#46;H&#46; Enk"
                            4 => "M&#46; Hartmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/594127"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "83"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19035775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Update on ocular syphilis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;A&#46; Gaudio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Opin Ophtalmol"
                        "fecha" => "2006"
                        "volumen" => "17"
                        "paginaInicial" => "562"
                        "paginaFinal" => "566"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syphilitic acute posterior placoid chorioretinitis in nonimmune-compromised patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Joseph"
                            1 => "S&#46; Rogers"
                            2 => "A&#46; Browning"
                            3 => "N&#46; Hall"
                            4 => "C&#46; Barber"
                            5 => "A&#46; Lotery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eye &#40;Lond&#41;"
                        "fecha" => "2007"
                        "volumen" => "21"
                        "paginaInicial" => "1114"
                        "paginaFinal" => "1119"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute syphilitic posterior placoid chorioretinitis&#58; Report of a case series and comprehensive review of the literature"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "International Syphilis Study Group"
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;M&#46; Eandi"
                            1 => "P&#46; Neri"
                            2 => "R&#46;A&#46; Adelman"
                            3 => "L&#46;A&#46; Yannuzzi"
                            4 => "E&#46;T&#46; Cunningham Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/IAE.0b013e31825f3851"
                      "Revista" => array:6 [
                        "tituloSerie" => "Retina"
                        "fecha" => "2012"
                        "volumen" => "32"
                        "paginaInicial" => "1915"
                        "paginaFinal" => "1941"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22863970"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current clinical spectrum of neurosyphilis in immunocompetent patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;A&#46; Conde-Send&#237;n"
                            1 => "R&#46; Amela-Peris"
                            2 => "Y&#46; Aladro-Benito"
                            3 => "A&#46;A&#46; Maroto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000079391"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Neurol"
                        "fecha" => "2004"
                        "volumen" => "52"
                        "paginaInicial" => "29"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15237250"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000009/v1_201611010039/S1578219016302141/v1_201611010039/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000009/v1_201611010039/S1578219016302141/v1_201611010039/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302141?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 17 21 38
2024 October 92 85 177
2024 September 132 58 190
2024 August 141 86 227
2024 July 94 76 170
2024 June 126 60 186
2024 May 122 60 182
2024 April 129 54 183
2024 March 191 35 226
2024 February 236 36 272
2024 January 211 36 247
2023 December 272 12 284
2023 November 249 25 274
2023 October 262 24 286
2023 September 253 26 279
2023 August 240 15 255
2023 July 146 41 187
2023 June 178 26 204
2023 May 328 26 354
2023 April 223 21 244
2023 March 179 20 199
2023 February 153 28 181
2023 January 162 29 191
2022 December 176 40 216
2022 November 151 29 180
2022 October 81 28 109
2022 September 26 29 55
2022 August 22 26 48
2022 July 74 27 101
2022 June 138 18 156
2022 May 146 39 185
2022 April 178 36 214
2022 March 145 39 184
2022 February 193 34 227
2022 January 242 46 288
2021 December 136 39 175
2021 November 132 48 180
2021 October 134 63 197
2021 September 112 43 155
2021 August 110 28 138
2021 July 66 32 98
2021 June 50 19 69
2021 May 42 44 86
2021 April 87 72 159
2021 March 65 31 96
2021 February 39 27 66
2021 January 28 17 45
2020 December 32 16 48
2020 November 29 38 67
2020 October 28 18 46
2020 September 24 13 37
2020 August 22 17 39
2020 July 22 11 33
2020 June 24 28 52
2020 May 15 9 24
2020 April 23 12 35
2020 March 28 12 40
2020 February 2 0 2
2019 December 4 0 4
2019 September 4 0 4
2019 August 2 0 2
2019 June 3 0 3
2019 April 1 3 4
2019 March 3 0 3
2019 February 1 0 1
2019 January 3 0 3
2018 December 3 0 3
2018 November 7 0 7
2018 October 11 0 11
2018 September 2 0 2
2018 February 61 3 64
2018 January 93 18 111
2017 December 98 15 113
2017 November 67 11 78
2017 October 73 11 84
2017 September 52 14 66
2017 August 50 7 57
2017 July 57 10 67
2017 June 48 22 70
2017 May 41 12 53
2017 April 38 16 54
2017 March 30 21 51
2017 February 25 11 36
2017 January 28 15 43
2016 December 35 25 60
2016 November 64 37 101
2016 October 8 9 17
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?