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based on both pathology results&#44; a diagnosis of pulmonary and cutaneous sarcoidosis associated with pulmonary tuberculosis was made&#46; Prednisone&#44; 30<span class="elsevierStyleHsp" style=""></span>mg&#44; was added to the antituberculous treatment and was subsequently tapered to reach a maintenance dose of 5<span class="elsevierStyleHsp" style=""></span>mg&#59; there was a good clinical and radiologic response&#46; The skin lesions resolved&#44; leaving residual scars in the areas of previous central atrophy&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Sarcoidosis and tuberculosis are both granulomatous diseases that rarely occur concomitantly&#46; In contrast to tuberculosis&#44; sarcoidosis is noncaseating&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The most commonly affected organ in sarcoidosis is the lung&#44; followed by skin involvement&#44; which occurs in approximately 24&#37; of cases&#46; Many clinical variants have been described&#44; including papular&#44; plaque&#44; psoriasiform&#44; annular&#44; atrophic&#44; and mixed forms&#46; Long-standing sarcoidosis and lupus pernio lesions typically heal leaving a scar&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a> Histologically&#44; the granulomas are formed mainly of epithelioid cells&#44; sometimes with scattered lymphocytes peripherally&#59; Langhans-type multinucleated giant cells may be present&#59; they are more common in longer-standing lesions&#44; though they have also been described in large numbers in early lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The etiology of sarcoidosis remains unknown&#44; though <span class="elsevierStyleItalic">M tuberculosis</span> has been implicated&#46; Using PCR&#44; Li et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">3</span></a> identified DNA from <span class="elsevierStyleItalic">M tuberculosis</span> and from <span class="elsevierStyleItalic">Mycobacterium avium</span> in up to 50&#37; of lung biopsies from patients diagnosed with sarcoidosis&#46; Another study that looked at the etiology and pathogenesis of sarcoidosis was performed by Ding et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">4</span></a> Thos authors identified genetic material related to mycobacterial heat shock proteins in 21&#37; of skin biopsies from patients diagnosed with sarcoidosis and concluded that this infection could be a direct etiologic factor&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In clinical practice&#44; there are few reports of patients who have presented the 2 diseases concomitantly or in whom the diagnosis of sarcoidosis was made after that of tuberculosis&#59; these cases are listed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5&#8211;12</span></a> In our review&#44; we have excluded patients who were on corticosteroid treatment for sarcoidosis and who subsequently developed tuberculosis&#44; as the most common cause of the infection in such patients is immunosuppression&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">In patients in whom we suspect the concomitant presence of the 2 diseases&#44; it is essential to determine whether the lesions corresponds to one or other granulomatous disease&#44; as skin lesions mimicking sarcoidosis have been reported in patients with tuberculosis&#44; such as the case published by Chokoeva et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">13</span></a> in which the diagnosis of sarcoid-like lesions was only achieved with the aid of the QuantiFERON-TB test and a positive Ziehl Neelsen stain&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Biomarkers that can differentiate between these 2 diseases have been sought&#46; Serum markers related with sarcoidosis&#44; including soluble interleukin-2 receptor &#40;IL-2R&#41;&#44; ACE&#44; and Krebs von den Lungen-6 &#40;KL-6&#41;&#44; are not sufficiently sensitive or specific to separate these diagnoses&#46; It has recently been observed that the combination of leptin and intercellular adhesion molecule-1 has a sensitivity of 86&#46;5&#37; and a specificity of 73&#46;1&#37; as a marker of sarcoidosis&#44; and this combination could therefore be employed to differentiate the 2 conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; the diagnoses of sarcoidosis and tuberculosis are not mutually exclusive&#46; It is likely that tuberculosis has been a triggering agent of sarcoidosis&#44; although further studies will be necessary to determine its etiologic role&#46; Finally&#44; to prevent the complications of sarcoidosis&#44; corticosteroid treatment should not be delayed&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; de la Fuente-Meira S&#44; Gracia-Caza&#241;a T&#44; Pastushenko I&#44; Ara M&#46; Sarcoidosis y tuberculosis&#58; un desaf&#237;o diagn&#243;stico&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;605&#8211;607&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous papules with an atrophic central zone&#44; situated in the frontal region&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age&#47;Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tuberculosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sarcoidosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis of Sarcoidosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Wong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lymphatic and<br>pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 15 months after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mise et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cutaneous and pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Concomitant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gupta et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Renal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cutaneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 4 years after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ahmad et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cutaneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 3 years after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ganguly et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28 y<br>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cutaneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 9 months after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mandal et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Miliary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Concomitant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Oluboyo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS<br>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Concomitant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Papaetis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Concomitant diagnosis&#44; although the authors state that undiagnosed sarcoidosis had been present for 8 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">De la Fuente et al&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 y<br>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cutaneous and pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 3 months after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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Case and Research Letters
Sarcoidosis and Tuberculosis: A Diagnostic Challenge
Sarcoidosis y tuberculosis: un desafío diagnóstico
S. de la Fuente-Meiraa,
Corresponding author
delafuente.sonia@gmail.com

Corresponding author.
, T. Gracia-Cazañab, I. Pastushenkoc, M. Arad
a Servicio de Dermatología, Hospital Ernest Lluch, Zaragoza, Spain
b Servicio de Dermatología, Hospital de Barbastro, Huesca, Spain
c Interdisciplinary Research Institute (IRIBHM), Université Libre de Bruxelles (ULB). Bruselas, Bélgica
d Servicio de Dermatología, Hospital Clínico Lozano Blesa, Zaragoza, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sarcoidosis is a multiorgan disease of unknown etiology&#44; characterized by the presence of noncaseating granulomas&#46; Factors implicated in its etiology include certain microorganisms&#44; such as <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#44; and a genetic predisposition&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Our patient was a 31-year-old man from Morocco who had been living in Spain for 11 years&#46; He was seen in dermatology outpatients for evaluation of asymptomatic lesions that had been present on his forehead for 8 months and that he found unsightly&#46; His medical history revealed that he had been on treatment with isoniazid&#44; rifampicin&#44; pyrazinamide&#44; and ethambutol for 2 months for low-grade fever and dyspnea&#44; diagnosed as pulmonary tuberculosis&#46; He brought a discharge report from another hospital in the same Autonomous Community in Spain&#44; with details of following additional tests&#58; x-ray study showing a gangliopulmonary pattern&#44; a positive QuantiFERON-TB test&#44; and sputum culture positive for <span class="elsevierStyleItalic">M tuberculosis</span>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed an erythematous annular maculopapular rash with central atrophy in the frontal region&#44; in areas in which there were no previous scars &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Histology of a biopsy from 1 of the lesions in the frontal region revealed a granulomatous inflammatory infiltrate formed mainly of a number of Langhans-type giant cells and epithelioid cells &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Given the patient&#39;s history of tuberculosis&#44; Ziehl-Neelsen stain and polymerase chain reaction &#40;PCR&#41; for mycobacteria were performed on the skin biopsy sample&#44; with a negative result&#44; compatible with cutaneous sarcoidosis&#46; In view of the dermatologic findings and persistence of the patient&#39;s dyspnea&#44; transbronchial biopsy was performed&#46; This showed numerous granulomas with no necrosis&#44; but with fibrosis and a discreet peripheral ring of lymphocytes&#59; Ziehl-Neelsen stain was negative&#46; Blood tests revealed an increase in angiotensin-converting enzyme &#40;ACE&#41; levels to 134<span class="elsevierStyleHsp" style=""></span>U&#47;L &#40;normal range&#44; 8-55<span class="elsevierStyleHsp" style=""></span>U&#47;L&#41; and elevation of uric acid levels to 9&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;normal range&#44; 3&#46;5-7&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#59; the other laboratory parameters were normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Finally&#44; based on both pathology results&#44; a diagnosis of pulmonary and cutaneous sarcoidosis associated with pulmonary tuberculosis was made&#46; Prednisone&#44; 30<span class="elsevierStyleHsp" style=""></span>mg&#44; was added to the antituberculous treatment and was subsequently tapered to reach a maintenance dose of 5<span class="elsevierStyleHsp" style=""></span>mg&#59; there was a good clinical and radiologic response&#46; The skin lesions resolved&#44; leaving residual scars in the areas of previous central atrophy&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Sarcoidosis and tuberculosis are both granulomatous diseases that rarely occur concomitantly&#46; In contrast to tuberculosis&#44; sarcoidosis is noncaseating&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The most commonly affected organ in sarcoidosis is the lung&#44; followed by skin involvement&#44; which occurs in approximately 24&#37; of cases&#46; Many clinical variants have been described&#44; including papular&#44; plaque&#44; psoriasiform&#44; annular&#44; atrophic&#44; and mixed forms&#46; Long-standing sarcoidosis and lupus pernio lesions typically heal leaving a scar&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a> Histologically&#44; the granulomas are formed mainly of epithelioid cells&#44; sometimes with scattered lymphocytes peripherally&#59; Langhans-type multinucleated giant cells may be present&#59; they are more common in longer-standing lesions&#44; though they have also been described in large numbers in early lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The etiology of sarcoidosis remains unknown&#44; though <span class="elsevierStyleItalic">M tuberculosis</span> has been implicated&#46; Using PCR&#44; Li et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">3</span></a> identified DNA from <span class="elsevierStyleItalic">M tuberculosis</span> and from <span class="elsevierStyleItalic">Mycobacterium avium</span> in up to 50&#37; of lung biopsies from patients diagnosed with sarcoidosis&#46; Another study that looked at the etiology and pathogenesis of sarcoidosis was performed by Ding et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">4</span></a> Thos authors identified genetic material related to mycobacterial heat shock proteins in 21&#37; of skin biopsies from patients diagnosed with sarcoidosis and concluded that this infection could be a direct etiologic factor&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In clinical practice&#44; there are few reports of patients who have presented the 2 diseases concomitantly or in whom the diagnosis of sarcoidosis was made after that of tuberculosis&#59; these cases are listed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5&#8211;12</span></a> In our review&#44; we have excluded patients who were on corticosteroid treatment for sarcoidosis and who subsequently developed tuberculosis&#44; as the most common cause of the infection in such patients is immunosuppression&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">In patients in whom we suspect the concomitant presence of the 2 diseases&#44; it is essential to determine whether the lesions corresponds to one or other granulomatous disease&#44; as skin lesions mimicking sarcoidosis have been reported in patients with tuberculosis&#44; such as the case published by Chokoeva et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">13</span></a> in which the diagnosis of sarcoid-like lesions was only achieved with the aid of the QuantiFERON-TB test and a positive Ziehl Neelsen stain&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Biomarkers that can differentiate between these 2 diseases have been sought&#46; Serum markers related with sarcoidosis&#44; including soluble interleukin-2 receptor &#40;IL-2R&#41;&#44; ACE&#44; and Krebs von den Lungen-6 &#40;KL-6&#41;&#44; are not sufficiently sensitive or specific to separate these diagnoses&#46; It has recently been observed that the combination of leptin and intercellular adhesion molecule-1 has a sensitivity of 86&#46;5&#37; and a specificity of 73&#46;1&#37; as a marker of sarcoidosis&#44; and this combination could therefore be employed to differentiate the 2 conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; the diagnoses of sarcoidosis and tuberculosis are not mutually exclusive&#46; It is likely that tuberculosis has been a triggering agent of sarcoidosis&#44; although further studies will be necessary to determine its etiologic role&#46; Finally&#44; to prevent the complications of sarcoidosis&#44; corticosteroid treatment should not be delayed&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Wong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lymphatic and<br>pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 15 months after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mise et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cutaneous and pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Concomitant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gupta et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Renal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 4 years after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cutaneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 3 years after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28 y<br>Male&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cutaneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 9 months after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mandal et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Miliary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Concomitant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Oluboyo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS<br>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Concomitant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Papaetis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67 y<br>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Concomitant diagnosis&#44; although the authors state that undiagnosed sarcoidosis had been present for 8 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">De la Fuente et al&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 y<br>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cutaneous and pulmonary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diagnosis of sarcoidosis 3 months after the diagnosis of tuberculosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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2024 March 164 47 211
2024 February 203 39 242
2024 January 175 35 210
2023 December 255 16 271
2023 November 218 38 256
2023 October 191 32 223
2023 September 160 30 190
2023 August 133 24 157
2023 July 127 38 165
2023 June 106 29 135
2023 May 134 35 169
2023 April 137 18 155
2023 March 85 17 102
2023 February 106 28 134
2023 January 69 24 93
2022 December 61 39 100
2022 November 46 28 74
2022 October 43 22 65
2022 September 38 47 85
2022 August 32 40 72
2022 July 25 41 66
2022 June 28 26 54
2022 May 76 57 133
2022 April 95 16 111
2022 March 140 54 194
2022 February 104 35 139
2022 January 105 52 157
2021 December 82 41 123
2021 November 74 46 120
2021 October 74 54 128
2021 September 81 50 131
2021 August 71 33 104
2021 July 63 32 95
2021 June 62 29 91
2021 May 58 44 102
2021 April 81 62 143
2021 March 65 24 89
2021 February 38 25 63
2021 January 20 17 37
2020 December 27 10 37
2020 November 28 22 50
2020 October 22 8 30
2020 September 25 15 40
2020 August 28 17 45
2020 July 17 20 37
2020 June 25 31 56
2020 May 19 13 32
2020 April 21 20 41
2020 March 17 14 31
2020 February 2 0 2
2019 December 2 0 2
2019 September 4 0 4
2019 June 2 0 2
2019 May 2 0 2
2019 April 0 3 3
2019 March 2 0 2
2019 February 1 0 1
2019 January 4 0 4
2018 October 5 0 5
2018 September 1 0 1
2018 February 16 1 17
2018 January 28 10 38
2017 December 32 21 53
2017 November 26 4 30
2017 October 30 8 38
2017 September 22 4 26
2017 August 20 9 29
2017 July 18 11 29
2017 June 29 4 33
2017 May 27 12 39
2017 April 14 10 24
2017 March 14 8 22
2017 February 13 5 18
2017 January 16 5 21
2016 December 23 24 47
2016 November 22 17 39
2016 October 25 23 48
2016 July 0 4 4
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Idiomas
Actas Dermo-Sifiliográficas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?