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Tumor marker analysis revealed only a slight increase of &#945;-fetoprotein levels&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A thoracoabdominopelvic computed tomography scan revealed a lytic lesion in the posterior third of the T12 vertebral body&#44; with slight invasion of the medullary canal&#44; minimal thickening of the antral wall &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A&#41;&#44; and swelling of the periaortic lymph nodes and gastrohepatic ligament lymph nodes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>B&#41;&#46; An upper endoscopy revealed a malignant-looking ulcerated lesion with irregular borders in the area of the gastric incisura&#44; extending towards the gastric body&#46; Biopsy of the lesion was compatible with poorly differentiated gastric adenocarcinoma&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">After treatment with palliative chemotherapy&#44; the patient&#39;s basal state worsened and the neoplastic disease progressed with the appearance of multiple pulmonary nodules&#46; One year after diagnosis the patient died following a respiratory infection&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">More than 50 types of cutaneous paraneoplastic manifestations have been described&#44; including malignant acanthosis nigricans &#40;MAN&#41;&#44; florid cutaneous and mucosal papillomatosis&#44; and acquired pachydermatoglyphia&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">MAN is characterized by the presence of brownish&#44; symmetric&#44; nonpruritic plaques in the skin folds and on the back of the neck that can infiltrate and present as hyperkeratotic plaques&#46; In contrast to the benign form of acanthosis nigricans&#44; the paraneoplastic form is characterized by abrupt onset&#44; rapid progression&#44; and involvement of a large skin surface area&#46; There is a strong correlation between MAN and intra-abdominal tumors&#44; particularly tumors of gastric origin&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Florid cutaneous and mucosal papillomatosis is characterized by the rapid appearance of verrucous papules on the trunk and extremities&#46; The oral or genital mucosa may also be affected&#46; This condition is most strongly correlated with tumors of gastric origin&#44; in particular adenocarcinoma&#46; While these lesions are clinically indistinguishable from viral warts&#44; histologic analysis reveals marked hyperkeratosis with irregular acanthosis and papillomatosis&#44; and no evidence of human papillomavirus infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Tripe palms is characterized by the enhancement of the epidermal ridges of the palms&#44; which become slightly thickened and acquire a velvety texture&#44; resembling the intestinal villi&#46; In 90&#37; to 95&#37; of cases this condition is associated with the presence of a solid tumor&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Tripe palms has been associated with many types of cancer&#44; the most common of which are those of the gastrointestinal tract &#40;30&#37;&#41; and lungs &#40;20&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The presence of all 3 of these paraneoplastic dermatoses &#40;MAN&#44; florid cutaneous and mucosal papillomatosis&#44; and tripe palms&#41; in the same patient has been previously described in the literature&#44; suggesting potentially common etiological and pathogenic mechanisms&#46; In fact&#44; both tripe palms and florid cutaneous and mucosal papillomatosis are considered by some authors as clinical variants of MAN&#46; Several studies suggest that epidermal growth factor alpha is secreted by the tumor and transported in the blood to the skin surface&#44; where it stimulates the development of keratinocytes by activating tyrosine kinase receptors&#44; which promote widespread mitotic and antiapoptotic cellular activity&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#8211;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Of particular interest in the present case is the association of several distinct paraneoplastic cutaneous manifestations in the same patient&#46; Recognition and identification of these conditions can enable early diagnosis and treatment of associated neoplasms&#44; in some cases resulting in a better long-term prognosis for the patient&#46;</p></span>"
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Case and Research Letters
Malignant Acanthosis Nigricans, Florid Cutaneous and Mucosal Papillomatosis and Tripe Palms in a man with gastric adenocarcinoma
Acantosis nigricans maligna, papilomatosis cutáneo-mucosa florida y paquidermatoglifia adquirida en paciente con adenocarcinoma gástrico
A. Vilas-Sueiro
Corresponding author
, Ó. Suárez-Amor, B. Monteagudo, C. de las Heras
Servicio de Dermatología, Complejo Hospitalario Universitario de Ferrol, Área Sanitaria de Ferrol, SERGAS, Ferrol, A Coruña, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We describe the case of a 67-year-old man with a clinical history of smoking&#44; hypertension&#44; and hyperhomocysteinemia&#46; The patient was referred for verrucous lesions on the face that had appeared more than 1 month earlier&#46; A dermatological examination revealed several small&#44; hyperkeratotic lesions on the cheeks and around the mouth &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>A&#41;&#44; as well as brownish plaques in the axillary and inguinal folds &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>B&#41;&#46; Both hands showed marked accentuation of the dermatoglyphics &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>C&#41;&#46; The patient reported that these symptoms had appeared abruptly within a period of less than 2 months&#46; Based on clinical suspicion of a paraneoplastic dermatosis&#44; additional tests were requested to identify the primary tumor&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Analyses revealed a cholestatic pattern with elevated levels of alkaline phosphatase and &#947;-glutamyl transpeptidase&#46; Tumor marker analysis revealed only a slight increase of &#945;-fetoprotein levels&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A thoracoabdominopelvic computed tomography scan revealed a lytic lesion in the posterior third of the T12 vertebral body&#44; with slight invasion of the medullary canal&#44; minimal thickening of the antral wall &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A&#41;&#44; and swelling of the periaortic lymph nodes and gastrohepatic ligament lymph nodes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>B&#41;&#46; An upper endoscopy revealed a malignant-looking ulcerated lesion with irregular borders in the area of the gastric incisura&#44; extending towards the gastric body&#46; Biopsy of the lesion was compatible with poorly differentiated gastric adenocarcinoma&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">After treatment with palliative chemotherapy&#44; the patient&#39;s basal state worsened and the neoplastic disease progressed with the appearance of multiple pulmonary nodules&#46; One year after diagnosis the patient died following a respiratory infection&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">More than 50 types of cutaneous paraneoplastic manifestations have been described&#44; including malignant acanthosis nigricans &#40;MAN&#41;&#44; florid cutaneous and mucosal papillomatosis&#44; and acquired pachydermatoglyphia&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">MAN is characterized by the presence of brownish&#44; symmetric&#44; nonpruritic plaques in the skin folds and on the back of the neck that can infiltrate and present as hyperkeratotic plaques&#46; In contrast to the benign form of acanthosis nigricans&#44; the paraneoplastic form is characterized by abrupt onset&#44; rapid progression&#44; and involvement of a large skin surface area&#46; There is a strong correlation between MAN and intra-abdominal tumors&#44; particularly tumors of gastric origin&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Florid cutaneous and mucosal papillomatosis is characterized by the rapid appearance of verrucous papules on the trunk and extremities&#46; The oral or genital mucosa may also be affected&#46; This condition is most strongly correlated with tumors of gastric origin&#44; in particular adenocarcinoma&#46; While these lesions are clinically indistinguishable from viral warts&#44; histologic analysis reveals marked hyperkeratosis with irregular acanthosis and papillomatosis&#44; and no evidence of human papillomavirus infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Tripe palms is characterized by the enhancement of the epidermal ridges of the palms&#44; which become slightly thickened and acquire a velvety texture&#44; resembling the intestinal villi&#46; In 90&#37; to 95&#37; of cases this condition is associated with the presence of a solid tumor&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Tripe palms has been associated with many types of cancer&#44; the most common of which are those of the gastrointestinal tract &#40;30&#37;&#41; and lungs &#40;20&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The presence of all 3 of these paraneoplastic dermatoses &#40;MAN&#44; florid cutaneous and mucosal papillomatosis&#44; and tripe palms&#41; in the same patient has been previously described in the literature&#44; suggesting potentially common etiological and pathogenic mechanisms&#46; In fact&#44; both tripe palms and florid cutaneous and mucosal papillomatosis are considered by some authors as clinical variants of MAN&#46; Several studies suggest that epidermal growth factor alpha is secreted by the tumor and transported in the blood to the skin surface&#44; where it stimulates the development of keratinocytes by activating tyrosine kinase receptors&#44; which promote widespread mitotic and antiapoptotic cellular activity&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#8211;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Of particular interest in the present case is the association of several distinct paraneoplastic cutaneous manifestations in the same patient&#46; Recognition and identification of these conditions can enable early diagnosis and treatment of associated neoplasms&#44; in some cases resulting in a better long-term prognosis for the patient&#46;</p></span>"
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Article information
ISSN: 15782190
Original language: English
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