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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Postirradiation morphea is a rare complication that may develop in areas treated for cancer with radiation therapy&#44; usually in breast cancer patients&#46; We present the case of a patient with carcinoma of the breast treated with surgery and radiation therapy who developed postirradiation morphea 1 year later&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 56-year-old woman who had been diagnosed with infiltrating ductal carcinoma of the left breast and treated with lumpectomy&#46; Sentinel node biopsy results were negative&#46; The patient had received adjuvant treatment consisting of chemotherapy&#44; letrozole endocrine therapy&#44; and external beam radiation therapy applied to the mammary gland using 6- and 18-MeV photons at a dose of 50<span class="elsevierStyleHsp" style=""></span>Gy followed by boost irradiation of the tumor bed at a dose of 66<span class="elsevierStyleHsp" style=""></span>Gy&#46; Treatment was well tolerated&#46; One year after completion of radiation therapy&#44; there was a sudden onset of painful induration of the left breast&#44; which also decreased in size&#46; Physical examination revealed asymmetry of the two breasts and a well-demarcated woody plaque with an erythematous border in the irradiated area &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Biopsy showed slight atrophy of the epidermis&#44; hyperpigmentation of the basal layer&#44; thickening of dermal collagen&#44; loss of adnexal structures&#44; and a discrete perivascular and interstitial lymphoplasmacytic inflammatory infiltrate that was both deep and superficial&#44; with few interstitial eosinophils in the deep dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Immune status was normal and serological testing for <span class="elsevierStyleItalic">Borrelia</span> was negative&#46; Magnetic resonance imaging and mammography showed no abnormalities of the mammary gland&#46; After treatment with oral prednisone at a dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d tapered over 2 months and topical treatment with clobetasol&#44; the patient&#39;s pain disappeared&#44; induration and erythema decreased&#44; and occasional vesicles developed&#46; One year later the patient remained stable without tumor recurrence&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Radiation dermatitis&#44; both acute and chronic&#44; is a frequent reaction to treatment&#44; whereas postirradiation morphea is a much rarer occurrence&#46; The first cases of postirradiation morphea were described in 1989 by Colver et al<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> in 9 patients&#46; Breast-conserving surgery with adjuvant radiation therapy has become the standard treatment in patients with early-stage breast cancer&#44; who have the highest rate of postirradiation morphea&#46; In one series of female patients with breast cancer the incidence rate was found to be 3 per 6000 patients&#44; which was clearly higher than the 2&#46;7 cases per 100&#160;000 persons per year for the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Our review of the literature found 68 cases of postirradiation morphea in patients aged 34 to 85 years&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;9</span></a> an older population than that with idiopathic morphea&#46; Most patients were white&#46; The majority were women with carcinoma of the breast treated with breast-conserving surgery&#44; though some had undergone mastectomy&#46; One patient also had carcinoma of the endometrium&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> and a small minority of patients had nonbreast cancer &#40;2 had cervical cancer&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;3</span></a> 1 had axillary adenocarcinoma of unknown origin&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and 1 had cancer of the endometrium<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#41;&#46; There were 4 men with personal histories of subcutaneous lymphoma&#44; carcinoma of the tongue&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> gastric cancer&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> and neck node metastatic cancer of unknown primary site&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Morphea typically develops within a year of radiation therapy&#44; but has been seen up to 32 years later &#40;range&#44; 1 month to 32 years&#41;&#46; Onset is sudden with an inflammatory stage that involves a rapidly growing&#44; generally painful erythematous or violaceous plaque in the irradiated area&#46; Progression leads to plaque induration and pigmentation&#46; Ultimately&#44; these changes cause breast retraction and size reduction&#44; although the mammary gland is not affected&#46; Vesicles and bullae may develop&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> as in our patient&#39;s case&#46; In over 25&#37; of cases&#44; induration extends beyond the irradiated area or even spreads to distant areas&#46; One case report describes linear lesions on the lower limbs&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> As with idiopathic morphea&#44; histology varies with disease progression&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The etiology of postirradiation morphea is unknown at present&#44; but age&#44; total radiation dose&#44; dose per fraction&#44; number of fractions&#44; and grade of acute radiodermatitis do not appear to matter&#46; However&#44; risk appears to be higher for patients with connective tissue disorders&#44; chiefly lupus erythematosus and scleroderma&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> The reason for the predominant location on the breast is also unknown&#44; but may have to do with the abundance of fatty tissue and the radiation dose received on overlying skin&#46; Thanks to modern linear accelerators and techniques that achieve dose conformity by modulating the intensity of the radiation beam&#44; skin damage from radiation therapy is minimal&#46; In the breast&#44; however&#44; the skin and fat are included in the irradiated volume because they are close to the irradiation field and become the target organ in postmastectomy patients&#46; This may explain the higher rate of postirradiation morphea on the breast&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Many adverse skin reactions to radiation therapy have been described &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Some are included in the differential diagnosis for postirradiation morphea&#46; In the inflammatory phase&#44; differential diagnosis includes infection&#44; radiation recall dermatitis&#44; and above all tumor recurrence &#40;erysipelas-like cutaneous metastasis&#44; carcinoma en cuirasse&#44; or carcinomatous mastitis&#41;<span class="elsevierStyleItalic">&#46;</span></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">For follow-up of postirradiation morphea patients&#44; ultrasound imaging is recommended instead of mammograms&#46; While the natural history of this condition is poorly understood&#44; it may improve after months or years&#44; although asymmetry and pigmentation will persist&#46; No effective treatment has been described&#46; Treatment is as for idiopathic morphea&#44; but immunosuppressive agents are not recommended&#46; Treatments attempted include topical&#44; intralesional&#44; and systemic corticosteroids&#44; topical calcipotriol&#44; intravenous penicillin&#44; hydroxychloroquine&#44; phototherapy&#44; and methotrexate &#40;2&#46;5-15<span class="elsevierStyleHsp" style=""></span>mg&#47;wk&#41;&#46; In extreme cases with very severe pain&#44; palliative mastectomy may be necessary&#44; 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Case for Diagnosis
Morphea Following Radiation Therapy in a Patient With Breast Cancer
Morfea tras radioterapia en paciente con cáncer de mama
M. García-Arpaa,
Corresponding author
mgarciaa73@yahoo.es

Corresponding author.
, E. Lozano-Martínb, C. Ramos-Rodríguezc, M. Rodríguez-Vázquezd
a Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
b Servicio de Oncología Radioterápica, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
c Servicio de Anatomía Patológica, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
d Servicio de Dermatología, Hospital General Universitario de Albacete, Albacete, Spain
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Notable reduction in left breast size&#46; The plaque is highly indurated and well-demarcated&#46; The skin surface is shiny&#44; some areas are hyperpigmented while others are pearly&#44; and adnexal structures are absent&#46; Note the erythematous border surrounding the entire plaque&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Postirradiation morphea is a rare complication that may develop in areas treated for cancer with radiation therapy&#44; usually in breast cancer patients&#46; We present the case of a patient with carcinoma of the breast treated with surgery and radiation therapy who developed postirradiation morphea 1 year later&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 56-year-old woman who had been diagnosed with infiltrating ductal carcinoma of the left breast and treated with lumpectomy&#46; Sentinel node biopsy results were negative&#46; The patient had received adjuvant treatment consisting of chemotherapy&#44; letrozole endocrine therapy&#44; and external beam radiation therapy applied to the mammary gland using 6- and 18-MeV photons at a dose of 50<span class="elsevierStyleHsp" style=""></span>Gy followed by boost irradiation of the tumor bed at a dose of 66<span class="elsevierStyleHsp" style=""></span>Gy&#46; Treatment was well tolerated&#46; One year after completion of radiation therapy&#44; there was a sudden onset of painful induration of the left breast&#44; which also decreased in size&#46; Physical examination revealed asymmetry of the two breasts and a well-demarcated woody plaque with an erythematous border in the irradiated area &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Biopsy showed slight atrophy of the epidermis&#44; hyperpigmentation of the basal layer&#44; thickening of dermal collagen&#44; loss of adnexal structures&#44; and a discrete perivascular and interstitial lymphoplasmacytic inflammatory infiltrate that was both deep and superficial&#44; with few interstitial eosinophils in the deep dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Immune status was normal and serological testing for <span class="elsevierStyleItalic">Borrelia</span> was negative&#46; Magnetic resonance imaging and mammography showed no abnormalities of the mammary gland&#46; After treatment with oral prednisone at a dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d tapered over 2 months and topical treatment with clobetasol&#44; the patient&#39;s pain disappeared&#44; induration and erythema decreased&#44; and occasional vesicles developed&#46; One year later the patient remained stable without tumor recurrence&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Radiation dermatitis&#44; both acute and chronic&#44; is a frequent reaction to treatment&#44; whereas postirradiation morphea is a much rarer occurrence&#46; The first cases of postirradiation morphea were described in 1989 by Colver et al<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> in 9 patients&#46; Breast-conserving surgery with adjuvant radiation therapy has become the standard treatment in patients with early-stage breast cancer&#44; who have the highest rate of postirradiation morphea&#46; In one series of female patients with breast cancer the incidence rate was found to be 3 per 6000 patients&#44; which was clearly higher than the 2&#46;7 cases per 100&#160;000 persons per year for the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Our review of the literature found 68 cases of postirradiation morphea in patients aged 34 to 85 years&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;9</span></a> an older population than that with idiopathic morphea&#46; Most patients were white&#46; The majority were women with carcinoma of the breast treated with breast-conserving surgery&#44; though some had undergone mastectomy&#46; One patient also had carcinoma of the endometrium&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> and a small minority of patients had nonbreast cancer &#40;2 had cervical cancer&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;3</span></a> 1 had axillary adenocarcinoma of unknown origin&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and 1 had cancer of the endometrium<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&#41;&#46; There were 4 men with personal histories of subcutaneous lymphoma&#44; carcinoma of the tongue&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> gastric cancer&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> and neck node metastatic cancer of unknown primary site&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Morphea typically develops within a year of radiation therapy&#44; but has been seen up to 32 years later &#40;range&#44; 1 month to 32 years&#41;&#46; Onset is sudden with an inflammatory stage that involves a rapidly growing&#44; generally painful erythematous or violaceous plaque in the irradiated area&#46; Progression leads to plaque induration and pigmentation&#46; Ultimately&#44; these changes cause breast retraction and size reduction&#44; although the mammary gland is not affected&#46; Vesicles and bullae may develop&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> as in our patient&#39;s case&#46; In over 25&#37; of cases&#44; induration extends beyond the irradiated area or even spreads to distant areas&#46; One case report describes linear lesions on the lower limbs&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> As with idiopathic morphea&#44; histology varies with disease progression&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The etiology of postirradiation morphea is unknown at present&#44; but age&#44; total radiation dose&#44; dose per fraction&#44; number of fractions&#44; and grade of acute radiodermatitis do not appear to matter&#46; However&#44; risk appears to be higher for patients with connective tissue disorders&#44; chiefly lupus erythematosus and scleroderma&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> The reason for the predominant location on the breast is also unknown&#44; but may have to do with the abundance of fatty tissue and the radiation dose received on overlying skin&#46; Thanks to modern linear accelerators and techniques that achieve dose conformity by modulating the intensity of the radiation beam&#44; skin damage from radiation therapy is minimal&#46; In the breast&#44; however&#44; the skin and fat are included in the irradiated volume because they are close to the irradiation field and become the target organ in postmastectomy patients&#46; This may explain the higher rate of postirradiation morphea on the breast&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Many adverse skin reactions to radiation therapy have been described &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Some are included in the differential diagnosis for postirradiation morphea&#46; In the inflammatory phase&#44; differential diagnosis includes infection&#44; radiation recall dermatitis&#44; and above all tumor recurrence &#40;erysipelas-like cutaneous metastasis&#44; carcinoma en cuirasse&#44; or carcinomatous mastitis&#41;<span class="elsevierStyleItalic">&#46;</span></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">For follow-up of postirradiation morphea patients&#44; ultrasound imaging is recommended instead of mammograms&#46; While the natural history of this condition is poorly understood&#44; it may improve after months or years&#44; although asymmetry and pigmentation will persist&#46; No effective treatment has been described&#46; Treatment is as for idiopathic morphea&#44; but immunosuppressive agents are not recommended&#46; Treatments attempted include topical&#44; intralesional&#44; and systemic corticosteroids&#44; topical calcipotriol&#44; intravenous penicillin&#44; hydroxychloroquine&#44; phototherapy&#44; and methotrexate &#40;2&#46;5-15<span class="elsevierStyleHsp" style=""></span>mg&#47;wk&#41;&#46; In extreme cases with very severe pain&#44; palliative mastectomy may be necessary&#44; but reconstructive surgery is contraindicated&#46;</p></span>"
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                  \t\t\t\t"><span class="elsevierStyleItalic">Autoimmune bullous disorders &#40;pemphigus vulgaris&#44; pemphigus foliaceus&#44; bullous pemphigoid&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Autoimmune diseases of connective tissue &#40;lupus erythematosus&#44; dermatomyositis&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Stevens-Johnson syndrome&#44; toxic epidermal necrolysis&#44; erythema multiforme</span>&nbsp;\t\t\t\t\t\t\n
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                      "titulo" => "Post-irradiation morphoea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;B&#46; Colver"
                            1 => "A&#46; Rodger"
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                      "titulo" => "Localized scleroderma in breast cancer patients treated with supervoltage external beam radiation&#58; Radiation port scleroderma"
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                            0 => "D&#46;A&#46; Davis"
                            1 => "P&#46;R&#46; Cohen"
                            2 => "M&#46;D&#46; McNeese"
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                        "tituloSerie" => "J Rheumatol"
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                      "titulo" => "Unrecognized radiation-induced localized scleroderma&#58; a cause of postoperative wound-healing disorder"
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                      "doi" => "10.1259/0007-1285-63-754-804"
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                  "contribucion" => array:1 [
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                      "titulo" => "Irradiation-induced morphea&#58; X-rays as triggers of autoimmunity"
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Article information
ISSN: 15782190
Original language: English
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Idiomas
Actas Dermo-Sifiliográficas
es en

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