array:25 [
  "pii" => "S1578219015000141"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.01.001"
  "estado" => "S300"
  "fechaPublicacion" => "2015-04-01"
  "aid" => "1057"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "ssu"
  "cita" => "Actas Dermosifiliogr. 2015;106:158-67"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3206
    "formatos" => array:3 [
      "EPUB" => 57
      "HTML" => 1764
      "PDF" => 1385
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731014004165"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.07.006"
      "estado" => "S300"
      "fechaPublicacion" => "2015-04-01"
      "aid" => "1057"
      "copyright" => "Elsevier España, S.L.U. and AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "ssu"
      "cita" => "Actas Dermosifiliogr. 2015;106:158-67"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3942
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 1352
          "PDF" => 2587
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
        "titulo" => "Histopatolog&#237;a de las alopecias&#46; Parte I&#58; alopecias no cicatriciales"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "158"
            "paginaFinal" => "167"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Histologic Features of Alopecias&#8211;Part I&#58; Nonscarring Alopecias"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 1154
                "Ancho" => 1500
                "Tamanyo" => 503936
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata&#46; A&#46; En cortes longitudinales se observa un infiltrado inflamatorio rodeando los bulbos de los fol&#237;culos pilosos terminales &#40;HE x10&#41;&#46; B&#46; Detalle de la anterior donde se observa que el infiltrado inflamatorio est&#225; compuesto mayoritariamente por linfocitos &#40;HE x200&#41;&#46; C&#46; Cortes transversales del mismo caso mostrando un infiltrado inflamatorio alrededor del segmento inferior de varios de los fol&#237;culos pilosos &#40;HE x10&#41;&#46; D&#46; Detalle de la anterior que muestra un intenso infiltrado linfocitario &#40;HE x200&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46; Bern&#225;rdez, A&#46;M&#46; Molina-Ruiz, L&#46; Requena"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Bern&#225;rdez"
              ]
              1 => array:2 [
                "nombre" => "A&#46;M&#46;"
                "apellidos" => "Molina-Ruiz"
              ]
              2 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Requena"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015000141"
          "doi" => "10.1016/j.adengl.2015.01.001"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000141?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004165?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000003/v3_202209240525/S0001731014004165/v3_202209240525/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S1578219015000153"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.01.002"
    "estado" => "S300"
    "fechaPublicacion" => "2015-04-01"
    "aid" => "1042"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "ssu"
    "cita" => "Actas Dermosifiliogr. 2015;106:168-79"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1829
      "formatos" => array:3 [
        "EPUB" => 46
        "HTML" => 700
        "PDF" => 1083
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Future Prospects in Dermatologic Applications of Lasers&#44; Nanotechnology&#44; and Other New Technologies"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "168"
          "paginaFinal" => "179"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Perspectivas de futuro en l&#225;seres&#44; nuevas tecnolog&#237;as y nanotecnolog&#237;a en dermatolog&#237;a"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1590
              "Ancho" => 2502
              "Tamanyo" => 142979
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Possible modifications to the surface of nanoparticles&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Boixeda, F&#46; Feltes, J&#46;L&#46; Santiago, J&#46; Paoli"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Boixeda"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Feltes"
            ]
            2 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "Santiago"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Paoli"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731014003895"
        "doi" => "10.1016/j.ad.2014.07.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014003895?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000153?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000153/v3_202209240641/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S1578219015000505"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2014.10.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-04-01"
    "aid" => "1062"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2015;106:155-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1684
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 801
        "PDF" => 832
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>"
      "titulo" => "Treatment goals for psoriasis&#58; Should PASI 90 become the standard of care&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "155"
          "paginaFinal" => "157"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Objetivos terap&#233;uticos en la psoriasis&#58; &#191;deber&#237;a ser la respuesta PASI90 la norma asistencial&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "T&#46; Torres, L&#46; Puig"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Torres"
            ]
            1 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Puig"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0001731014004219"
        "doi" => "10.1016/j.ad.2014.10.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004219?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000505?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000505/v3_202209240641/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Reviews</span>"
    "titulo" => "Histologic Features of Alopecias&#8211;Part I&#58; Nonscarring Alopecias"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "158"
        "paginaFinal" => "167"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; Bern&#225;rdez, A&#46;M&#46; Molina-Ruiz, L&#46; Requena"
        "autores" => array:3 [
          0 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Bern&#225;rdez"
          ]
          1 => array:4 [
            "nombre" => "A&#46;M&#46;"
            "apellidos" => "Molina-Ruiz"
            "email" => array:1 [
              0 => "lrequena@fjd.es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:2 [
            "nombre" => "L&#46;"
            "apellidos" => "Requena"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Fundaci&#243;n Jim&#233;nez D&#237;az&#44; Universidad Aut&#243;noma de Madrid&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Histopatolog&#237;a de las alopecias&#46; Parte I&#58; alopecias no cicatriciales"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1876
            "Ancho" => 2501
            "Tamanyo" => 961949
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Chemotherapy-induced telogen effluvium&#46; A&#44; Longitudinal sections showing several hair follicles in telogen&#44; surrounded by thick perifollicular connective sheaths &#40;hematoxylin -eosin &#91;HE&#93; x 10&#41;&#46; B&#44; Detail of the previous image showing a thick&#44; corrugated vitreous membrane around the telogen club hair &#40;HE x 200&#41;&#46; C&#44; Same case studied with transversal sections&#44; with several hair units &#40;HE x 20&#41;&#46; D&#44; Detail of the previous image showing a corrugated outer root sheath surrounded by a thick vitreous membrane &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">In our daily clinical practice&#44; dermatologists often encounter patients consulting for alopecia&#46; In many cases&#44; these processes can be correctly and rapidly diagnosed from the presentation and course of hair loss&#46; However&#44; sometimes&#44; biopsy is necessary to enable a definitive diagnosis to be established&#46; The first part of this article reviews in detail the main forms of nonscarring alopecia from a histopathological standpoint&#46; Our review will follow the traditional classification of alopecia into scarring alopecias and nonscarring alopecias&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">1</span></a> Scarring alopecias are those in which the hair follicle is replaced by fibrous scar tissue while in nonscarring alopecias&#44; the hair follicles resume their normal activity once the inflammatory process affecting them has been resolved&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Hair Cycle</span><p id="par0010" class="elsevierStylePara elsevierViewall">To describe the histopathology of alopecias&#44; we must have a good understanding of the hair cycle and the morphological changes that the hair follicles undergo in each of the phases of the cycle&#46; Alopecias will generally more frequently involve a given phase of the hair cycle&#44; with anagen&#44; that is&#44; the active growth phase &#40;with DNA synthesis and melanogenesis&#41;&#44; being the most vulnerable&#46;<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">3&#8211;9</span></a> When a hair follicle in anagen undergoes a reversible aggression&#44; the growth phase is shortened to give rise to early catagen and telogen&#46; This conversion from a metabolically highly active phase to an almost inert one helps prevent irreversible damage to the hair follicle&#44; thereby allowing the growth of new hair shafts once the aggression ceases&#46;<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">10&#8211;12</span></a> Of the 100 000 hair follicles in the normal human scalp&#44; approximately 85&#37; are in anagen&#44; with a mean duration in this phase of 2 to 7 years&#46; In late anagen&#44; the inferior segment of the hair follicles lies in the deep dermis or the hypodermis and typically has a pincer-like appearance&#44;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">3</span></a> with the papilla surrounded by germ cells that keratinize as they ascend&#46; After anagen&#44; the hair follicle enters into catagen&#44; the shortest phase of the cycle&#44; with a duration of approximately 2 to 3 weeks&#46; Catagen is characterized by retraction of the inferior segment of the hair follicle&#44; which is positioned nearer the surface&#44; leading to corrugation of the outer root sheath giving it an undulating appearance&#44; with disperse apoptotic cells&#44; especially in the lower part&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">13</span></a> In a normal scalp&#44; only 1&#37; to 2&#37; of these hair follicles are in catagen and it is common not to see any in this phase in a biopsy&#46; However&#44; the number of follicles in catagen can increase significantly in certain alopecias such as tricothylamany&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">1</span></a> Telogen is the last phase of the hair cycle&#44; lasting for a mean of 3 months&#46; In this phase&#44; DNA synthesis has completely stopped and melanogenesis has been interrupted&#46; At the end of telogen&#44; the hair shaft detaches&#44; and a new hair cycle begins&#46; Follicles in telogen have a retracted and bulky lower segment &#40;telogen club hair&#41; in the middle and upper dermis&#44; and appear composed mainly of the permanent part of the hair follicle &#40;infundibulum and isthmus&#41;&#46; They therefore have the form of a club and are surrounded by sheaths of retracted perifollicular connective tissue&#46; In addition&#44; an angiofibrotic streamer is often present in this phase&#44; running from the isthmus to the subcutaneous cellular tissue&#44; clearly revealing the site where the lower segment of the follicle is located&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">2</span></a> The stem cells of the hair follicle are found where the outer root sheath widens at site of insertion of the arrector pili muscle&#46; This structure is known as the bulge&#46; Recently&#44; relatively specific immunohistochemical markers such as PHLDA1 have been identified for these follicular stem cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0475"><span class="elsevierStyleSup">14&#44;15</span></a> In each hair cycle&#44; activation of these cells will give rise to the reappearance of the transient portion of the hair follicle and thus to a new hair cycle&#46; Permanent damage to these stem cells is the common feature of the pathophysiology of all scarring alopecias&#46;<a class="elsevierStyleCrossRefs" href="#bib0485"><span class="elsevierStyleSup">16&#44;17</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Nonscarring Alopecias</span><p id="par0015" class="elsevierStylePara elsevierViewall">In the physical exploration of nonscarring alopecias&#44; follicular orifices can sometimes still be seen&#46; This is key to diagnosis to differentiate from scarring alopecias&#44; where the follicular orifices appear obliterated&#46; This observation correlates histopathologically with the presence of follicular units with capacity for synthesizing hair shafts&#44; and is the reason why areas of alopecia become repopulated after removing the trigger for hair loss&#46; In the study of nonscarring alopecias&#44; it is very useful to assess the follicular density and dynamics of the hair cycle &#40;phase of the cycle in which the hair follicles observed histopathologically are found&#41;&#46; For this&#44; it is preferable that the biopsies are transversal sections&#44; as this makes it possible to observe many hair follicles in different phases at the same time&#46; In addition&#44; for the biopsy to be useful&#44; the sample must be taken from an active region of the lesion&#46; In alopecias with a patchy morphology&#44; it is preferable to take the sample from the edge of the lesion&#44; whereas with diffuse alopecias the sample should be taken from a region with a positive hair pull test&#46; Whenever possible&#44; it is also useful to obtain a biopsy from the occipital region&#44; as this will lower the chance of encountering hair follicles with androgenic effects&#44; which if present may mean that the sample is not representative&#46; Finally&#44; when we assess a sample from a patient with nonscarring alopecia&#44; we should remember that the disease is a dynamic process&#44; and so histopathologic findings may vary according to the point in the process at the time of biopsy&#46;<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">18</span></a> The key histopathological findings of use in the diagnosis of nonscarring alopecias are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Androgenic Alopecia</span><p id="par0020" class="elsevierStylePara elsevierViewall">Androgenic alopecia&#44; or common baldness&#44; is considered as a normal and physiological progression of hair follicles in the scalp rather than a disease as such&#46; The underlying cause of androgenic alopecia is an increased sensitivity of the hair follicles to androgens&#46; This is determined genetically and varies according to the region of the scalp&#44; with the follicles in the occipital zone being the least affected&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">19</span></a> It has been shown that both women and men with androgenic alopecia show higher levels of activity of the enzyme 5&#945;-reductase in the follicles of the frontal region of the scalp&#44; when compared with the activity of follicles of the occipital region of the same patient&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">20</span></a> This may explain the different sensitivity to androgens in certain areas of the scalp&#46; The pattern of androgenic alopecia is different in men and women&#46; Men tend to show a bitemporal receding hairline with subsequent involvement of the frontotemporal region and vertex whereas women start with diffuse hair loss&#44; which mainly affects the central area of the scalp&#46;<a class="elsevierStyleCrossRefs" href="#bib0510"><span class="elsevierStyleSup">21&#8211;23</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The key histopathological finding in androgenic alopecia is progressive miniaturization of terminal hair follicles&#44;<a class="elsevierStyleCrossRefs" href="#bib0525"><span class="elsevierStyleSup">24&#8211;29</span></a> leading some of them to convert into vellus follicles &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; However&#44; the total number of hair follicles remains stable&#44; with a reduction in their size and depth and a smaller diameter of the hair shaft&#46;<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">30&#44;31</span></a> The earliest change that can be observed in biopsies of androgenic alopecia is focal basophil degeneration of the vitreous membrane of the follicles in anagen&#46;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">32</span></a> In addition&#44; with the miniaturization&#44; there is an ascent of the inferior segment of the hair follicles towards the superficial dermis&#44; accompanied by an increase in the number of fibrous tracts&#46; Thus&#44; there is an increase in the number of follicles in telogen and a decrease in the normal anagen to telogen ratio from 7&#58;1 to 2&#58;1&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">33</span></a> Another characteristic of androgenic alopecia is the presence of apparently larger sebaceous glands compared to the size of the miniaturized hair follicles&#46; But this observation is really only an apparent sebaceous hyperplasia as the sebaceous glands are of normal size and morphology&#44;<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">34</span></a> but they appear larger compared to the miniaturized hair follicles&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The presence and significance of inflammatory infiltrate is a topic of debate in androgenic alopecia&#46; Traditionally&#44; the presence of an inflammatory infiltrate was a histopathological finding that pointed away from androgenic alopeica&#44;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">35</span></a> but several authors have reported inflammatory infiltrate in up to 75&#37; of patients with androgenic alopecia&#44; without any clinical signs of inflammation in the physical exploration&#46;<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">30&#44;31&#44;36&#8211;38</span></a> This infiltrate&#44; mainly composed of lymphocytes&#44; is usually found around the infundibulum&#44; but it has also been observed around the fibrous streamers&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">On staining for elastic fibers&#44; the biopsies from patients with androgenic alopecia show Arao-Perkins bodies&#44; which consist of small aggregates of elastic fibers in the fibrous streamers&#46;<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">39</span></a> They appear because of the agglomeration of elastic tissue surrounding the neck of the follicular papilla during catagen&#44; marking the initial site of the follicular papilla in the previous cycle&#46; In advanced androgenic alopecia&#44; multiple Arao-Perkins bodies can be observed in the fibrous streamers&#44; located increasingly nearer the surface&#46;<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">40</span></a> According to Pinkus&#44;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">8</span></a> these findings are diagnostic of androgenic alopecia&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Telogen Effluvium</span><p id="par0040" class="elsevierStylePara elsevierViewall">Telogen effluvium is a disorder of the hair cycle in which one or more etiologic agents of different characteristics give rise to an early finalization of anagen&#46; The underlying cause of this condition is an alteration of the biological clock of the follicular growth cycle&#44; with a premature transition of the follicles from anagen to telogen&#46;<a class="elsevierStyleCrossRefs" href="#bib0610"><span class="elsevierStyleSup">41&#8211;43</span></a> This early transition can be caused by a variety of situations&#44; including surgery&#44; infection&#44; general anesthetic&#44; surgical stress&#44; and several intercurrent systemic diseases&#46; These processes usually occur 2 to 3 months before the onset of effluvium &#40;the time equivalent to the duration of telogen&#41;&#46; Patients experience diffuse hair loss&#44; and if we examine the detached hairs under the microscope&#44; we see the typical club shape characteristic of telogen&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In all nonscarring alopecias&#44; it is important to know where in the process the patient is&#44; given that the histopathological characteristics vary according to disease progression&#46; This is particularly important in telogen effluvium&#44; where a trigger leads to a sudden transition of the follicles from anagen to telogen &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#44; but subsequently a new hair cycle begins&#46; The biopsy in a patient with telogen effluvium is therefore usually normal&#46; Thus&#44; if we suspect telogen effluvium and we perform a biopsy with normal findings&#44; we would be faced with a typical case of telogen effluvium&#44; as the patients do not usually attend the dermatologist until they notice hair loss&#44; which is usually when the disease is in an advanced phase&#46;<a class="elsevierStyleCrossRefs" href="#bib0625"><span class="elsevierStyleSup">44&#44;45</span></a> Only if we take a biopsy in an initial phase from a patient with telogen effluvium will we be able to detect a decrease in the ratio of anagen-to-telogen follicles&#44; with a percentage of follicles in telogen of greater than 25&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0635"><span class="elsevierStyleSup">46</span></a> In addition&#44; in biopsies of telogen effluvium&#44; we do not observe follicular abnormalities&#44;<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">47</span></a> inflammatory infiltrate&#44; or an increase in fibrous streamers&#44; while the number of follicles is normal&#46;<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">48</span></a> It is important to remember that some patients&#44; especially men&#44; can present with androgenic alopecia at the same time as telogen effluvium&#44; and so it is important that the biopsy is performed in the occipital region of the scalp&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Chronic telogen effluvium is described as diffuse hair loss lasting more than 6 months&#46; It differs from acute telogen effluvium in that it is more common among women &#40;especially during menopause&#41; and its etiology is not so clear&#46; Onset is usually sudden and progression fluctuates but is self-limiting&#59; in addition it often presents as a bitemporal regression of the hairline&#46;<a class="elsevierStyleCrossRefs" href="#bib0650"><span class="elsevierStyleSup">49&#44;50</span></a> It has been suggested that the process is due to a decreased duration of the anagen phase&#44; thereby impeding the growth of long hairs&#46;<a class="elsevierStyleCrossRefs" href="#bib0630"><span class="elsevierStyleSup">45&#44;51</span></a> Biopsy reveals a scalp that hardly differs&#44; if at all&#44; from a normal scalp&#44; with a slight increase in the percentage of follicles in telogen if the biopsy is performed during the most active phases&#46; According to Whitting&#44;<a class="elsevierStyleCrossRef" href="#bib0665"><span class="elsevierStyleSup">52</span></a> hair loss in the absence of histopathological changes is characteristic of this condition&#46; To differentiate from female-pattern androgenic alopecia&#44; whose clinical characteristics are very similar&#44; it is useful to determine the telogen to anagen ratio in the biopsy&#46; In the case of female-pattern androgenic alopecia&#44; this ratio is usually increased but does not exceed 4&#58;1&#44; whereas if the ratio is greater than 8&#58;1&#44; this is indicative of chronic telogen effluvium&#46;<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">53</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Alopecia Areata</span><p id="par0055" class="elsevierStylePara elsevierViewall">Alopecia areata is a relatively common cause of alopecia&#46; The most likely pathogenesis is a genetically determined autoimmune disorder mediated by T lymphocytes against aberrant HLA-RR expressed by keratinocytes of the hair follicles&#46;<a class="elsevierStyleCrossRefs" href="#bib0675"><span class="elsevierStyleSup">54&#44;55</span></a> It tends to affect children and young adults more frequently but can present at any age&#46; It is manifest clinically as one or several oval or round patches of alopecia&#44; without loss of follicular orifices&#46; The process can affect any hair-bearing region of the body&#46; In alopecia areata&#44; characteristically&#44; hairs in the form of exclamation marks can be seen&#44; particularly at the margins of the lesion&#46; These correspond to small broken hairs&#44; with a conical attenuated bulb and thicker distal end&#46;<a class="elsevierStyleCrossRefs" href="#bib0685"><span class="elsevierStyleSup">56&#44;57</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">From the histopathological point of view&#44; alopecia areata is characterized by the presence of an inflammatory infiltrate of small lymphocytes that surround the bulb of the follicles in anagen &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#44; thereby inducing early conversion to catagen and telogen&#46; The infiltrate adopts a peri- and intrabulbar distribution&#44; creating a honeycomb effect&#44; and is composed mainly of CD4&#43; T lymphocytes and Langerhans cells&#46; Histiocytes&#44; plasma cells&#44; mast cells&#44; and eosinophils can also be observed&#46;<a class="elsevierStyleCrossRefs" href="#bib0695"><span class="elsevierStyleSup">58&#8211;63</span></a> T lymphocytes induce apoptosis of matrix cells of the bulb&#44; starting with the peripheral ones&#44; which are the ones responsible for the formation of the inner root sheath and the cortex of the hair shaft&#46;<a class="elsevierStyleCrossRef" href="#bib0715"><span class="elsevierStyleSup">62</span></a> This gives rise to a narrowing of the hair shaft&#44; which is responsible for the appearance of exclamation mark hairs&#46; This also induces an early transition from catagen to telogen&#44; in turn leading to a reversal of the anagen to telogen ratio&#44; typical in alopecia areata&#46; Therefore&#44; in biopsies of this process&#44; there is an increased number of follicles in catagen and telogen&#44; all with an accompanying fibrous streamer&#46; This abundance of hair follicles all in the same phase of the cycle is a key to the diagnosis of alopecia areata&#46;<a class="elsevierStyleCrossRef" href="#bib0725"><span class="elsevierStyleSup">64</span></a> However&#44; the characteristic inflammatory infiltrate that is normally observed in alopecia areata may be absent at times&#44; particularly in cases of long-standing disease&#46; In such cases&#44; it may be useful to search for other histopathological characteristics suggestive of alopecia areata&#44; such as the presence of eosinophils&#44; lymphocytes&#44; and melanin in the fibrous streamers&#46; Other characteristics&#44; less specific to alopecia areata but nevertheless of assistance in diagnosis include an increased number of follicles in catagen and telogen&#44; incontinentia pigmenti &#40;both peribulbar and in the fibrous streamer&#41;&#44; and tricholamalacia&#46; In alopecia areata&#44; but also in other forms of alopecia&#44; a proliferation of ducts similar to syringoma can be observed&#44; although these lack the sclerotic stroma characteristic of this tumor&#46; This is therefore thought to correspond to a reactive ductal hyperplasia&#46;<a class="elsevierStyleCrossRef" href="#bib0730"><span class="elsevierStyleSup">65</span></a> Moreover&#44; in longstanding alopecia areata&#44; there is a miniaturization of the hair follicles with an almost complete absence of terminal follicles&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Unlike scarring alopecias&#44; the inflammatory infiltrate in alopecia areata does not involve stem cells&#44; so the hair follicle maintains its capacity to regenerate after an aggression&#46; If the inflammation has resolved when the follicle enters a new growth cycle&#44; the affected region will progressively repopulate&#46; If&#44; on the other hand&#44; the follicle in anagen is still affected by the inflammatory infiltrate&#44; the hair cycle will be interrupted once again in early anagen phase&#44; leading to premature catagen and telogen<a class="elsevierStyleCrossRef" href="#bib0735"><span class="elsevierStyleSup">66</span></a> and persistence of the disease&#46; Although alopecia areata is a nonscarring condition&#44; in chronic forms of alopecia areata resistant to treatment&#44; biopsies show a lack of hair follicles and these appear to be replaced by nodules of fibroplasia and collagen tissue arranged in concentric rings&#46; Such findings are indicative of alopecia areata in which repopulation will not occur&#46;<a class="elsevierStyleCrossRef" href="#bib0740"><span class="elsevierStyleSup">67</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Syphilitic Alopecia</span><p id="par0070" class="elsevierStylePara elsevierViewall">Syphilitic alopecia is a secondary manifestation of infection and is the result of inflammation caused by local aggression of <span class="elsevierStyleItalic">Treponema pallidum</span> on the hair follicles&#46; Syphilitic alopecia rarely presents in isolation&#44; but when it does so&#44; whether in its patchy clinical presentation &#40;moth-eaten alopecia&#41; or its diffuse form&#44; the clinician may be faced with diagnostic uncertainty as a high degree of clinical suspicion is required and in most cases it will be necessary to request syphilis testing to establish diagnosis&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">From the histopathological point of view&#44; it is important to try to detect the spirochetes in the inflammatory infiltrate through histochemical study&#44; as this is the most sensitive technique at present &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0745"><span class="elsevierStyleSup">68</span></a> Syphilitic alopecia presents as a lymphohistiocytic inflammatory infiltrate with a striking plasma cell component&#44; which surrounds the fibrous streamers and the bulb&#46; Moreover&#44; in biopsies of syphilitic alopecia&#44; we see an increase in the number of follicles in telogen and catagen&#46; This latter observation is important in the differential diagnosis with alopecia areata as both show clinical and histopathological similarities&#46; Different authors have searched for other histopathological findings that would help in the differential diagnosis of syphilitic alopecia and alopecia areata&#46; One of the proposals has been the presence of eosinophils&#46; Some studies&#44; such as the one by Jordaan and Louw&#44;<a class="elsevierStyleCrossRef" href="#bib0750"><span class="elsevierStyleSup">69</span></a> describe the presence of eosinophils in syphilitic alopecia&#44; whereas other authors&#44; such as Lee and Hsu<a class="elsevierStyleCrossRef" href="#bib0755"><span class="elsevierStyleSup">70</span></a> report their absence and consider this criterion useful for differential diagnosis with alopecia areata&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Trichotillomania</span><p id="par0080" class="elsevierStylePara elsevierViewall">Trichotillomania is a self-inflicted pathological process&#44; either consciously or unconsciously&#44; in which patients experience the compulsion to twist or pull their hair and so achieve pleasure or relief&#46;<a class="elsevierStyleCrossRef" href="#bib0760"><span class="elsevierStyleSup">71</span></a> Such patients usually show an aberrant clinical pattern of alopecia&#44; which generally involves the scalp but which can also affect any hair-bearing region of the body&#46;<a class="elsevierStyleCrossRef" href="#bib0765"><span class="elsevierStyleSup">72</span></a> The areas of alopecia appear patchy and with irregular borders&#46; Characteristically&#44; hair of different lengths can be seen&#44; and in extreme cases&#44; broken or frayed ends may be present due to pulling and breakage of the hairs over time&#46; Unlike alopecia areata&#44; the patches do not usually show complete hair loss&#44; as the hair cycle progresses normally despite the constant aggressions&#46;<a class="elsevierStyleCrossRef" href="#bib0765"><span class="elsevierStyleSup">72</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">The consequences of hair follicle lesion due to repeated trauma are reflected histopathologically&#46; Often&#44; in the same biopsy&#44; it is possible to observe alternating damaged and intact follicles&#44; even very close to one another&#44;<a class="elsevierStyleCrossRefs" href="#bib0770"><span class="elsevierStyleSup">73&#8211;75</span></a> and this finding correlates with the clinical observation of incomplete hair loss in the patches of alopecia&#46; There is also a lack of perifollicular inflammatory infiltrate&#44;<a class="elsevierStyleCrossRef" href="#bib0785"><span class="elsevierStyleSup">76</span></a> although at times perivascular inflammation is observed in the superficial dermis&#46; As evidence of trauma&#44; the individual damaged follicles show tricholamalacia&#44; incontinentia pigmenti&#44; and intra- and perifollicular hemorrhage&#46;<a class="elsevierStyleCrossRef" href="#bib0785"><span class="elsevierStyleSup">76</span></a> Trichomalacia is the most characteristic histopathological finding of this disease&#44; and refers to distortion of the hair shaft &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Figure 5</a>&#41;&#44; although it may not always be present&#46;<a class="elsevierStyleCrossRefs" href="#bib0780"><span class="elsevierStyleSup">75&#8211;77</span></a> The damage to bulbar melanocytes gives rise to incontinentia pigmenti&#44; which is observed in the form of irregular pigmented masses in the permanent part of the follicle&#44; both in the infundibulum and in the isthmus&#44; occupying the now corrugated outer root sheath&#46;<a class="elsevierStyleCrossRef" href="#bib0780"><span class="elsevierStyleSup">75</span></a> In fair- and red-haired individuals&#44; it is uncommon to find these accumulations of pigment&#46;<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">18</span></a> Follicular hemorrhages appear in the early phases of the process and are not a constant finding&#44; but when they are observed&#44; they constitute a finding that almost confirms diagnosis of trichotillomania&#46;<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">44</span></a> It is sometimes possible to observe a granulomatous reaction around the follicles of the hairs that have been pulled out&#44; probably in response to broken hair shafts in direct contact with the dermis and without the protection afforded by the follicular root sheaths&#46;<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">3&#44;10</span></a> The presence of empty follicular channels<a class="elsevierStyleCrossRef" href="#bib0785"><span class="elsevierStyleSup">76</span></a> is also a common finding in this process&#44; but unfortunately it does not help diagnosis as this is a frequent finding in many of the scalp biopsies due to the microtome actions&#46; If it is possible to obtain a biopsy with the hair shafts conserved&#44; the characteristic <span class="elsevierStyleItalic">hamburger sign</span> can be seen&#44; resulting from longitudinal breakage of the hair shaft with accumulation of protein material and erythrocytes in the resulting intermediate space&#46;<a class="elsevierStyleCrossRef" href="#bib0795"><span class="elsevierStyleSup">78</span></a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Transversal sections show an increase in the number of follicles in catagen in the earliest stages&#46;<a class="elsevierStyleCrossRefs" href="#bib0585"><span class="elsevierStyleSup">36&#44;75&#8211;77</span></a> As with alopecia areata&#44; lesion of follicles in anagen hastens the transition to catagen and telogen&#46; According to Whitting&#44;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">12</span></a> trichotillomania is the alopecia in which most follicles are in catagen&#44; although the total number of follicles or the ratio of terminal to vellus follicles does not vary&#46; The main histopathological criterion for establishing differential diagnosis with alopecia areata is the absence of peribulbar inflammatory infiltrate in trichotillomania&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Traction Alopecia</span><p id="par0095" class="elsevierStylePara elsevierViewall">Traction alopecia is included along with trichotillomania in the group of mechanically induced alopecias&#46; The chronic form can be seen fairly often in clinical practice&#46; In general&#44; it is caused by inappropriate hair styling&#44; such as pulled-back hair or the use of elastic bands for the hair&#46;<a class="elsevierStyleCrossRef" href="#bib0800"><span class="elsevierStyleSup">79</span></a> In this form&#44; hair loss occurs in the regions where there is greatest traction&#44; leading in time to a recession of the hairline or a widening of the separation between hair parting and progressive centrifugal hair loss&#46;<a class="elsevierStyleCrossRef" href="#bib0805"><span class="elsevierStyleSup">80</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Traction alopecia is very well characterized from a clinical point of view&#44; but its histopathological characteristics are not so well known&#46; By and large&#44; the histological findings of traction alopecia are very similar to those observed in trichotillomania&#44; although over time it can give rise to a scarring alopecia&#44; which is known as follicular degeneration syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0810"><span class="elsevierStyleSup">81</span></a> In the early phases&#44; when the alopecia is still reversible&#44; changes similar to those described for trichotillomania can be observed&#44; such as the presence of trichomalacia and incontinentia pigmenti&#44; although less severe and with fewer involved hair follicles&#46;<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">48</span></a> In advanced phases&#44; when the alopecia is irreversible&#44; regions of fibrosis can be observed in places where the terminal hair follicles were previously found&#46;<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">48</span></a> A characteristic finding of traction alopecia is a decrease in the number of terminal hair follicles&#44; with a normal number of vellus follicles&#46; Characteristically&#44; inflammatory infiltrate is not observed at any time during the course of traction alopecia&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">1</span></a></p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflicts of Interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:9 [
        0 => array:3 [
          "identificador" => "xres1774107"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1558304"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1774106"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1558303"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Hair Cycle"
        ]
        6 => array:3 [
          "identificador" => "sec0015"
          "titulo" => "Nonscarring Alopecias"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Androgenic Alopecia"
            ]
            1 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Telogen Effluvium"
            ]
            2 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Alopecia Areata"
            ]
            3 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Syphilitic Alopecia"
            ]
            4 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Trichotillomania"
            ]
            5 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Traction Alopecia"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conflicts of Interest"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-04-29"
    "fechaAceptado" => "2014-07-13"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1558304"
          "palabras" => array:10 [
            0 => "Dermatopathology"
            1 => "Alopecia"
            2 => "Review"
            3 => "Nonscarring alopecia"
            4 => "Androgenetic alopecia"
            5 => "Telogen effluvium"
            6 => "Alopecia areata"
            7 => "Syphilitic alopecia"
            8 => "Trichotillomania"
            9 => "Traction alopecia"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1558303"
          "palabras" => array:10 [
            0 => "Dermatopatolog&#237;a"
            1 => "Alopecia"
            2 => "Revisi&#243;n"
            3 => "Alopecias no cicatriciales"
            4 => "Alopecia androgen&#233;tica"
            5 => "Efluvio tel&#243;geno"
            6 => "Alopecia areata"
            7 => "Alopecia sifil&#237;tica"
            8 => "Tricotiloman&#237;a"
            9 => "Alopecia por tracci&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The diagnosis of disorders of the hair and scalp can generally be made on clinical grounds&#44; but clinical signs are not always diagnostic and in some cases more invasive techniques&#44; such as a biopsy&#44; may be necessary&#46; This 2-part article is a detailed review of the histologic features of the main types of alopecia based on the traditional classification of these disorders into 2 major groups&#58; scarring and nonscarring alopecias&#46; Scarring alopecias are disorders in which the hair follicle is replaced by fibrous scar tissue&#44; a process that leads to permanent hair loss&#46; In nonscarring alopecias&#44; the follicles are preserved and hair growth can resume when the cause of the problem is eliminated&#46; In the first part of this review&#44; we describe the histologic features of the main forms of nonscarring alopecia&#46; Since a close clinical-pathological correlation is essential for making a correct histologic diagnosis of alopecia&#44; we also include a brief description of the clinical features of the principal forms of this disorder&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El diagn&#243;stico de las enfermedades del cabello y del cuero cabelludo se basa&#44; en la mayor&#237;a de las ocasiones&#44; en el reconocimiento de signos cl&#237;nicos&#59; sin embargo&#44; dichos signos no siempre son caracter&#237;sticos y&#44; en ocasiones&#44; tenemos que recurrir a t&#233;cnicas m&#225;s invasivas como la realizaci&#243;n de una biopsia&#46; En este art&#237;culo se revisa de forma detallada las principales formas de alopecia desde un punto de vista histopatol&#243;gico&#44; y para ello se utiliza la clasificaci&#243;n tradicional de las alopecias que las divide en 2 grandes grupos&#58; las alopecias cicatriciales y las no cicatriciales&#46; Las alopecias cicatriciales son aquellas en las cuales el fol&#237;culo piloso es sustituido por tejido fibroso cicatricial&#44; causando una p&#233;rdida permanente del cabello&#46; En las alopecias no cicatriciales el fol&#237;culo permanece intacto y puede retomar su actividad cuando cesa el est&#237;mulo desencadenante&#46; La primera parte de este art&#237;culo revisa las principales formas de alopecia no cicatricial desde un punto de vista histopatol&#243;gico&#46; Dado que una buena correlaci&#243;n cl&#237;nico-patol&#243;gica es fundamental para realizar el correcto diagn&#243;stico histopatol&#243;gico de las alopecias&#44; en este art&#237;culo se incluye tambi&#233;n una breve descripci&#243;n de las caracter&#237;sticas cl&#237;nicas de las principales formas de alopecia&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Bern&#225;rdez C&#44; Molina-Ruiz AM&#44; Requena L&#46; Histopatolog&#237;a de las alopecias&#46; Parte I&#58; alopecias no cicatriciales&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;158&#8211;167&#46;</p>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1876
            "Ancho" => 2501
            "Tamanyo" => 1054938
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Androgenic alopecia&#46; A&#44; The longitudinal sections show a miniaturization of the terminal follicles&#44; which convert to vellus follicles &#40;hematoxylin-eosin &#91;HE&#93; x 20&#41;&#46; B&#44; Miniaturized hair follicles and apparently hypertrophic sebaceous glands &#40;HE x 200&#41;&#46; C&#44; Same case studied with transversal sections&#44; with several hair units of smaller size than normal in the scalp &#40;HE x 20&#41;&#46; D&#44; Detail of the previous image in which sebaceous glands can be seen with a proportionally greater volume compared to the size of the hair follicles &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1876
            "Ancho" => 2501
            "Tamanyo" => 961949
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Chemotherapy-induced telogen effluvium&#46; A&#44; Longitudinal sections showing several hair follicles in telogen&#44; surrounded by thick perifollicular connective sheaths &#40;hematoxylin -eosin &#91;HE&#93; x 10&#41;&#46; B&#44; Detail of the previous image showing a thick&#44; corrugated vitreous membrane around the telogen club hair &#40;HE x 200&#41;&#46; C&#44; Same case studied with transversal sections&#44; with several hair units &#40;HE x 20&#41;&#46; D&#44; Detail of the previous image showing a corrugated outer root sheath surrounded by a thick vitreous membrane &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1924
            "Ancho" => 2501
            "Tamanyo" => 1066434
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata&#46; A&#44; Longitudinal sections showing an inflammatory infiltrate surrounding the bulbs of the terminal hair follicles &#40;hematoxylin-eosin &#91;HE&#93; x 10&#41;&#46; B&#44; Detail of the previous image showing that the inflammatory infiltrate is made up mainly of lymphocytes &#40;HE x 200&#41;&#46; C&#44; Transversal sections of the same case showing an inflammatory infiltrate around the inferior segment of several of the hair follicles &#40;HE x 10&#41;&#46; D&#44; Detail of the previous image showing an intense lymphocyte infiltrate &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1972
            "Ancho" => 2501
            "Tamanyo" => 912466
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Syphilitic alopecia&#46; A&#44; A lichenoid infiltrate at the dermal-epidermal junction along with a dense perifollicular infiltrate &#40;hematoxylin-eosin &#91;HE&#93; x 10&#41;&#46; B&#46; At higher magnification&#44; we see that the infiltrate is made up mainly of lymphocytes and plasma cells &#40;HE x 400&#41;&#46; C&#46; Immunohistochemistry of the same case for <span class="elsevierStyleItalic">Treponema pallidum</span> &#40;HE x 10&#41;<span class="elsevierStyleItalic">&#46;</span> D&#46; Numerous treponemas between the epithelium of the outer root sheath of the follicle &#40;HE x 400&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 1921
            "Ancho" => 2501
            "Tamanyo" => 917507
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Trichotillomania&#46; A&#44; Longitudinal sections showing normal hair follicles in alternation with abnormal ones &#40;hematoxylin-eosin &#91;HE&#93; x 10&#41;&#46; B&#44; Trichomalacia showing pigmented and corrugated shafts in the follicular channel &#40;HE x 200&#41;&#46; C&#44; Same case studied with transversal sections &#40;HE x20&#41;&#46; D&#44; Detail of the previous image in which a broken hair shaft is observed with abundant pigment &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Type of Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Key Histopathological Features&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Androgenic Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Miniaturization of hair follicles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sebaceous pseudohyperplasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Telogen Effluvium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Predominance of hair follicles in telogen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absence of significant histopathological changes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alopecia Areata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peri- and intrabulbar lymphocytic infiltrate &#40;honeycomb pattern&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Several follicles from the biopsy in the same phase of the cycle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inversion of the anagen to telogen ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Syphilitic Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Abundant plasma cells in the inflammatory infiltrate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of <span class="elsevierStyleItalic">Treponema pallidum</span> with immunohistochemical staining&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trichotillomania&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absence of peribulbar inflammatory infiltrate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trichomalacia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Incontinentia pigmenti&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intra and perifollicular hemorrhage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Traction Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Similar to trichotillomania&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reduction of terminal hair follicles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Key Histopathological Features of Nonscarring Alopecias&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:81 [
            0 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histopathologic evaluation of alopecias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Sellheyer"
                            1 => "W&#46;F&#46; Bergfel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00000372-200606000-00051"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2006"
                        "volumen" => "28"
                        "paginaInicial" => "236"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16778532"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Weedon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "D&#46;Weedon"
                        "titulo" => "Diseases of cutaneous appendages&#46; Weedon&#39;s skin pathology"
                        "paginaInicial" => "417"
                        "paginaFinal" => "431"
                        "serieFecha" => "2010"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia&#58; Histologic changes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;F&#46; Bergfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Dermatol"
                        "fecha" => "1989"
                        "volumen" => "4"
                        "paginaInicial" => "301"
                        "paginaFinal" => "322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2701796"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;F&#46; Bergfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "S&#46;L&#46;Moschella, H&#46;J&#46;Hurley"
                        "titulo" => "Dermatology"
                        "paginaInicial" => "1541"
                        "paginaFinal" => "1560"
                        "edicion" => "3rd ed&#46;"
                        "serieFecha" => "1992"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia&#58; A pathologist&#39;s view"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Ioannides"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4362.1982.tb03137.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1982"
                        "volumen" => "21"
                        "paginaInicial" => "316"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6749712"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair loss&#58; An overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Mulinari-Brenner"
                            1 => "W&#46;F&#46; Bergfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Nurs"
                        "fecha" => "2001"
                        "volumen" => "13"
                        "paginaInicial" => "277"
                        "paginaFinal" => "278"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The biology of hair follicles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Paus"
                            1 => "G&#46; Cotsarelis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199908123410706"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1999"
                        "volumen" => "341"
                        "paginaInicial" => "491"
                        "paginaFinal" => "497"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10441606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia&#46; Clinicopathologic correlations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Pinkus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4362.1980.tb00318.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1980"
                        "volumen" => "19"
                        "paginaInicial" => "245"
                        "paginaFinal" => "253"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7390687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair and systemic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46;C&#46; Sperling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0733-8635(05)70310-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "2001"
                        "volumen" => "19"
                        "paginaInicial" => "711"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11705356"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosing common alopecias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Stengel"
                            1 => "A&#46;B&#46; Ackerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am Fam Physician"
                        "fecha" => "1978"
                        "volumen" => "18"
                        "paginaInicial" => "76"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/717231"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0923753419312967"
                          "estado" => "S300"
                          "issn" => "09237534"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair and nail physiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Stenn"
                            1 => "P&#46; Fleckman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "M&#46;K&#46;Hordinsky, M&#46;E&#46;Sawaya, R&#46;K&#46;Scher"
                        "titulo" => "Atlas of hair and nails"
                        "paginaInicial" => "3"
                        "paginaFinal" => "8"
                        "serieFecha" => "2000"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disorders of cutaneous appendages"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;A&#46; Whiting"
                            1 => "S&#46;F&#46; Templeton"
                            2 => "A&#46;R&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "R&#46;L&#46;Barnhill"
                        "titulo" => "Textbook of dermatopathology"
                        "paginaInicial" => "201"
                        "paginaFinal" => "231"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The recognition of early stages of catagen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Weedon"
                            1 => "G&#46; Strutton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00000372-198412000-00006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1984"
                        "volumen" => "6"
                        "paginaInicial" => "553"
                        "paginaFinal" => "555"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6524637"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization and isolation of stem cell enriched human hair follicle bulge cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Ohyama"
                            1 => "A&#46; Terunuma"
                            2 => "C&#46;L&#46; Tock"
                            3 => "M&#46;F&#46; Radonovich"
                            4 => "C&#46;A&#46; Pise-Masison"
                            5 => "S&#46;B&#46; Hopping"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI26043"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2006"
                        "volumen" => "116"
                        "paginaInicial" => "249"
                        "paginaFinal" => "260"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16395407"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follicular stem cell marker PHLDA1 &#40;TDAG51&#41; is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Sellheyer"
                            1 => "P&#46; Nelson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.2011.01693.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2011"
                        "volumen" => "38"
                        "paginaInicial" => "542"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21352265"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0923753419374393"
                          "estado" => "S300"
                          "issn" => "09237534"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Label-retaining cells reside in the bulge area of pilosebaceous unit&#58; Implications for follicular stem cells&#44; hair cycle&#44; and skin carcinogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Cotsarelis"
                            1 => "T&#46;T&#46; Sun"
                            2 => "R&#46;M&#46; Lavker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0092-8674(90)90696-c"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1990"
                        "volumen" => "61"
                        "paginaInicial" => "1329"
                        "paginaFinal" => "1337"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2364430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair follicular stem cells&#46; The bulge activation hypothesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;T&#46; Sun"
                            1 => "G&#46; Cotsarelis"
                            2 => "R&#46;M&#46; Lavker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1991"
                        "volumen" => "96"
                        "paginaInicial" => "779"
                        "paginaFinal" => "789"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The histopathology of noncicatricial alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Eudy"
                            1 => "A&#46;R&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.sder.2006.01.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Cutan Med Surg"
                        "fecha" => "2006"
                        "volumen" => "25"
                        "paginaInicial" => "35"
                        "paginaFinal" => "40"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16616301"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanism of action of androgen in dermal papilla cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Itami"
                            1 => "S&#46; Kurata"
                            2 => "T&#46; Sonoda"
                            3 => "S&#46; Takayasu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1749-6632.1991.tb24403.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann N Y Acad Sci"
                        "fecha" => "1991"
                        "volumen" => "642"
                        "paginaInicial" => "385"
                        "paginaFinal" => "395"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1809094"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Different levels of 5&#945;-reductase type <span class="elsevierStyleSmallCaps">i</span> and <span class="elsevierStyleSmallCaps">ii</span>&#44; aromatase and androgen receptor in hair follicles of women and men with androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;E&#46; Sawaya"
                            1 => "V&#46;H&#46; Price"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1523-1747.ep12335779"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1997"
                        "volumen" => "109"
                        "paginaInicial" => "296"
                        "paginaFinal" => "300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9284093"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Approach to the adult female patient with diffuse nonscarring alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;B&#46; Chartier"
                            1 => "D&#46;M&#46; Hoss"
                            2 => "J&#46;M&#46; Grant-Kels"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mjd.2002.128771"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "47"
                        "paginaInicial" => "809"
                        "paginaFinal" => "818"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12451364"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Androgenic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;F&#46; Bergfeld"
                            1 => "G&#46;P&#46; Redmond"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "1987"
                        "volumen" => "5"
                        "paginaInicial" => "491"
                        "paginaFinal" => "500"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3301107"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0959804920302276"
                          "estado" => "S300"
                          "issn" => "09598049"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Tosti"
                            1 => "B&#46;M&#46; Piraccini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-4362.1999.00007.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1999"
                        "volumen" => "38"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10515522"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Male pattern alopecia&#46; A histopathologic and histochemical study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Lattanand"
                            1 => "W&#46;C&#46; Johnson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1975.tb00209.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1975"
                        "volumen" => "2"
                        "paginaInicial" => "58"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/777055"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Whiting"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0190-9622(93)70106-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1993"
                        "volumen" => "28"
                        "paginaInicial" => "755"
                        "paginaFinal" => "763"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8496421"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scalp biopsy as a diagnostic and prognostic tool in androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Whiting"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther"
                        "fecha" => "1998"
                        "volumen" => "8"
                        "paginaInicial" => "24"
                        "paginaFinal" => "33"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Whiting"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2001"
                        "volumen" => "45"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "81"
                        "paginaFinal" => "86"
                        "itemHostRev" => array:3 [
                          "pii" => "S0168827818302150"
                          "estado" => "S300"
                          "issn" => "01688278"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections on serial scalp biopsies&#58; Results of finasteride 1<span class="elsevierStyleHsp" style=""></span>mg treatment of men and postmenopausal women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;A&#46; Whiting"
                            1 => "J&#46; Waldstreicher"
                            2 => "M&#46; Sanchez"
                            3 => "K&#46;D&#46; Kaufman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol Symp Proc"
                        "fecha" => "1999"
                        "volumen" => "4"
                        "paginaInicial" => "282"
                        "paginaFinal" => "284"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia&#58; Histologic diagnosis by transverse sections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;F&#46; Templeton"
                            1 => "D&#46;J&#46; Santa Cruz"
                            2 => "A&#46;R&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Diagn Pathol"
                        "fecha" => "1996"
                        "volumen" => "13"
                        "paginaInicial" => "2"
                        "paginaFinal" => "18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8834512"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology of male pattern alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Abell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1984"
                        "volumen" => "120"
                        "paginaInicial" => "1607"
                        "paginaFinal" => "1608"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histologic response to topically applied minoxidil in male-pattern alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Abell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0738-081x(88)90086-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "1988"
                        "volumen" => "6"
                        "paginaInicial" => "191"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3214821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diseases of the hair and scalp"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Rook"
                            1 => "R&#46; Dawber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1982"
                        "editorial" => "Blackwell Scientific Publications"
                        "editorialLocalizacion" => "Oxford"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The comparative histopathology of male-pattern baldness and senescent baldness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;M&#46; Kligman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0738-081x(88)90074-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "1988"
                        "volumen" => "6"
                        "paginaInicial" => "108"
                        "paginaFinal" => "118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3214816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clue 1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;B&#46; Ackerman"
                            1 => "Y&#46; Guo"
                            2 => "P&#46; Vitale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:6 [
                        "titulo" => "Clues to diagnosis in dermatopathology ii"
                        "fecha" => "1992"
                        "paginaInicial" => "1"
                        "paginaFinal" => "4"
                        "editorial" => "ASCP Press"
                        "editorialLocalizacion" => "Chicago&#44; IL&#44; USA"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair neogenesis in man&#58; A histoquantitative study based on 1&#44;000 scalp biopsies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Schreck-Purola"
                            1 => "B&#46; Lindroos"
                            2 => "R&#46;E&#46;A&#46; Nystr&#246;m"
                            3 => "K&#46; Stel&#228;l&#228;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "C&#46;E&#46;Orfanos, W&#46;Montagna, G&#46;St&#252;ttgen"
                        "titulo" => "Hair research&#46; Status and future aspects"
                        "paginaInicial" => "344"
                        "paginaFinal" => "352"
                        "serieFecha" => "1981"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The value of horizontal sections of scalp biopsies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Whiting"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cutan Aging Cosmet Dermatol"
                        "fecha" => "1990"
                        "volumen" => "1"
                        "paginaInicial" => "165"
                        "paginaFinal" => "173"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous immunopathology of androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;W&#46; Young"
                            1 => "E&#46;T&#46; Conte"
                            2 => "M&#46;L&#46; Leavitt"
                            3 => "M&#46;A&#46; Nafz"
                            4 => "A&#46;L&#46; Schroeter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Osteopath Assoc"
                        "fecha" => "1991"
                        "volumen" => "91"
                        "paginaInicial" => "765"
                        "paginaFinal" => "771"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1744007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of inflammatory infiltrates in male pattern alopecia&#58; Implications for pathogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Jaworsky"
                            1 => "A&#46;M&#46; Kligman"
                            2 => "G&#46;F&#46; Murphy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.1992.tb00121.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1992"
                        "volumen" => "127"
                        "paginaInicial" => "239"
                        "paginaFinal" => "246"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1390168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential patterns of elastic fibers in scarring and non-scarring alopecias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Pinkus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1978.tb00946.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1978"
                        "volumen" => "5"
                        "paginaInicial" => "93"
                        "paginaFinal" => "104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/79579"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1470204520305556"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The interrelation of elastic tissue and human hair follicles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Arao"
                            1 => "E&#46;M&#46; Perkins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "W&#46;Montagna, R&#46;L&#46;Dobson"
                        "titulo" => "Hair growth"
                        "paginaInicial" => "433"
                        "paginaFinal" => "441"
                        "serieFecha" => "1969"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Telogen effluvium&#46; A clinically useful concept&#44; with traction alopecia as an example"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;D&#46; Steck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cutis"
                        "fecha" => "1978"
                        "volumen" => "21"
                        "paginaInicial" => "543"
                        "paginaFinal" => "548"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/639573"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diffuse hair loss"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Sinclair"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-4362.1999.00003.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1999"
                        "volumen" => "38"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "8"
                        "paginaFinal" => "18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10369535"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Telogen effluvium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Harrison"
                            1 => "R&#46; Sinclair"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-2230.2002.01080.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2002"
                        "volumen" => "27"
                        "paginaInicial" => "389"
                        "paginaFinal" => "395"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12190639"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The transversely sectioned scalp biopsy specimen&#58; the technique and an algorithm for its use in the diagnosis of alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;R&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Dermatol"
                        "fecha" => "1994"
                        "volumen" => "9"
                        "paginaInicial" => "127"
                        "paginaFinal" => "157"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8060734"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Telogen effluvium&#46; New concepts and review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.129.3.356"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1993"
                        "volumen" => "129"
                        "paginaInicial" => "356"
                        "paginaFinal" => "363"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transverse anatomy of telogen effluvium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Ass Milit Dermatol"
                        "fecha" => "1990"
                        "volumen" => "16"
                        "paginaInicial" => "3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of clinical and histologic correlations in alopecia areata and telogen effluvium&#58; Adversities in alopecia pattern mimicry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cutis"
                        "fecha" => "2013"
                        "volumen" => "91"
                        "paginaInicial" => "141"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histopathology of non-scarring alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1995.tb01391.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1995"
                        "volumen" => "22"
                        "paginaInicial" => "97"
                        "paginaFinal" => "114"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and histological challenge in the differential diagnosis of diffuse alopecia&#58; Female androgenetic alopecia&#44; telogen effluvium and alopecia areata-part <span class="elsevierStyleSmallCaps">ii</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0365-05962012000600010"
                      "Revista" => array:6 [
                        "tituloSerie" => "An Bras Dermatol"
                        "fecha" => "2012"
                        "volumen" => "87"
                        "paginaInicial" => "884"
                        "paginaFinal" => "890"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic telogen effluvium&#58; Increased scalp hair shedding in middle-aged women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1996"
                        "volumen" => "35"
                        "paginaInicial" => "899"
                        "paginaFinal" => "906"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic telogen effluvium is due to a reduction in the variance of anagen duration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-0960.2010.00654.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Australas J Dermatol"
                        "fecha" => "2010"
                        "volumen" => "51"
                        "paginaInicial" => "163"
                        "paginaFinal" => "167"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Update on chronic telogen effluvium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "1999"
                        "volumen" => "8"
                        "paginaInicial" => "305"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic telogen effluvium&#58; A study of 5 patients over 7 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2004.05.040"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "12"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0675"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2000"
                        "volumen" => "42"
                        "paginaInicial" => "549"
                        "paginaFinal" => "566"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0680"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.det.2012.08.010"
                      "Revista" => array:7 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "2013"
                        "volumen" => "31"
                        "paginaInicial" => "93"
                        "paginaFinal" => "108"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673609604840"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0685"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "E&#46;A&#46;Olsen"
                        "titulo" => "Disorders of hair growth&#58; Diagnosis and treatment"
                        "paginaInicial" => "195"
                        "paginaFinal" => "222"
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0690"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased ratio of helper to suppressor T cells in alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.1984.tb07463.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1984"
                        "volumen" => "110"
                        "paginaInicial" => "171"
                        "paginaFinal" => "175"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S147020452030557X"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0695"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistochemical and electron microscopic characterization of the cellular infiltrate in alopecia &#40;areata&#44; totalis&#44; and universalis&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1523-1747.ep12261627"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1984"
                        "volumen" => "83"
                        "paginaInicial" => "7"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0700"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "T cell subpopulations in alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0190-9622(84)70152-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1984"
                        "volumen" => "11"
                        "paginaInicial" => "216"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S014067361831078X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0705"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical immunotherapy changes the composition of the peribulbar infiltrate in alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF00412926"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol Res"
                        "fecha" => "1986"
                        "volumen" => "278"
                        "paginaInicial" => "214"
                        "paginaFinal" => "218"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0710"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata&#58; Alterations in the hair growth cycle and correlation with the follicular pathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.1986.tb02825.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1986"
                        "volumen" => "114"
                        "paginaInicial" => "337"
                        "paginaFinal" => "347"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0715"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lesional alopecia areata T lymphocytes downregulate epithelial cell proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s004030050209"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Dermatol Res"
                        "fecha" => "1997"
                        "volumen" => "289"
                        "paginaInicial" => "384"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0168827812007520"
                          "estado" => "S300"
                          "issn" => "01688278"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0720"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histologic features of alopecia areata other than peribulbar lymphocytic infiltrates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2011.02.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2011"
                        "volumen" => "65"
                        "paginaInicial" => "615"
                        "paginaFinal" => "620"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0725"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clue 83"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "B&#46;Ackerman, Y&#46;Guo, P&#46;Vitale"
                        "titulo" => "Clues to diagnosis in dermatopathology <span class="elsevierStyleSmallCaps">ii</span>"
                        "paginaInicial" => "329"
                        "paginaFinal" => "332"
                        "serieFecha" => "1992"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0730"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syringoma-like sweat duct proliferation in scalp alopecias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1990.tb00112.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1990"
                        "volumen" => "17"
                        "paginaInicial" => "355"
                        "paginaFinal" => "357"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0167814019330208"
                          "estado" => "S300"
                          "issn" => "01678140"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0735"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cellular activity in the dermis surrounding the hair bulb in alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1975.tb00172.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1975"
                        "volumen" => "2"
                        "paginaInicial" => "240"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0740"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:6 [
                        "titulo" => "Histologic diagnosis of inflammatory skin diseases"
                        "fecha" => "1978"
                        "paginaInicial" => "696"
                        "paginaFinal" => "701"
                        "editorial" => "Lea and Febiger"
                        "editorialLocalizacion" => "Philadelphia"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0745"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia syphilitica with detection of treponema pallidum in the hair follicle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2007"
                        "volumen" => "1"
                        "numero" => "34 Suppl"
                        "paginaInicial" => "37"
                        "paginaFinal" => "40"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0750"
              "etiqueta" => "69"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The moth-eaten alopecia of secondary syphilis&#46; A histopathological study of 12 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00000372-199504000-00008"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1995"
                        "volumen" => "17"
                        "paginaInicial" => "158"
                        "paginaFinal" => "162"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1470204517300864"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0755"
              "etiqueta" => "70"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia syphilitica&#44; a simulator of alopecia areata&#58; Histopathology and differential diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1991.tb00133.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1991"
                        "volumen" => "18"
                        "paginaInicial" => "87"
                        "paginaFinal" => "92"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1470204515000042"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0760"
              "etiqueta" => "71"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.12788/j.sder.0007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Trichotillomania&#46; Semin Cutan Med Surg"
                        "fecha" => "2013"
                        "volumen" => "32"
                        "paginaInicial" => "88"
                        "paginaFinal" => "94"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib0765"
              "etiqueta" => "72"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichotillomania"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mjd.2002.122749"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "46"
                        "paginaInicial" => "807"
                        "paginaFinal" => "821"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib0770"
              "etiqueta" => "73"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histopathology of alopecia&#58; A clinicopathological approach to diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2559.2009.03439.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Histopathology"
                        "fecha" => "2010"
                        "volumen" => "56"
                        "paginaInicial" => "24"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib0775"
              "etiqueta" => "74"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichotillomania&#46; A clinicopathologic study of 24 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.105.4.535"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1972"
                        "volumen" => "105"
                        "paginaInicial" => "535"
                        "paginaFinal" => "540"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib0780"
              "etiqueta" => "75"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichotillomania&#58; A histopathologic study in sixty-six patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0190-9622(90)70186-l"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1990"
                        "volumen" => "23"
                        "paginaInicial" => "56"
                        "paginaFinal" => "62"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib0785"
              "etiqueta" => "76"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Traumatic alopecia in trichotillomania&#58; A pathogenic interpretation of histologic lesions in the pilosebaceous unit"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1977.tb00890.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1977"
                        "volumen" => "4"
                        "paginaInicial" => "51"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib0790"
              "etiqueta" => "77"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The combined utilization of clinical and histological findings in the diagnosis of trichotillomania"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1034/j.1600-0560.2002.290403.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2002"
                        "volumen" => "29"
                        "paginaInicial" => "207"
                        "paginaFinal" => "214"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib0795"
              "etiqueta" => "78"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Splitting hairs&#58; The &#8216;hamburger sign&#8217; in trichotillomania"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.2006.00526.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2006"
                        "volumen" => "33"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "63"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib0800"
              "etiqueta" => "79"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious&#44; physical&#44; and inflammatory causes of hair and scalp abnormalities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "E&#46;A&#46;Olsen"
                        "titulo" => "Disorders of hair growth&#58; Diagnosis and treatment"
                        "paginaInicial" => "71"
                        "paginaFinal" => "90"
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            79 => array:3 [
              "identificador" => "bib0805"
              "etiqueta" => "80"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disorders of hair growth in African Americans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "E&#46;A&#46;Olsen"
                        "titulo" => "Disorders of hair growth&#58; Diagnosis and treatment"
                        "paginaInicial" => "389"
                        "paginaFinal" => "407"
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            80 => array:3 [
              "identificador" => "bib0810"
              "etiqueta" => "81"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hot comb alopecia&#47;follicular degeneration syndrome in African-American women is traction alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatopathol Pract Concept"
                        "fecha" => "2000"
                        "volumen" => "6"
                        "paginaInicial" => "320"
                        "paginaFinal" => "336"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000141/v3_202209240641/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6177"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Reviews"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000003/v3_202209240641/S1578219015000141/v3_202209240641/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000141?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Reviews
Histologic Features of Alopecias–Part I: Nonscarring Alopecias
Histopatología de las alopecias. Parte I: alopecias no cicatriciales
C. Bernárdez, A.M. Molina-Ruiz
Corresponding author
lrequena@fjd.es

Corresponding author.
, L. Requena
Servicio de Dermatología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain
Read
23711
Times
was read the article
5857
Total PDF
17854
Total HTML
Share statistics
 array:25 [
  "pii" => "S1578219015000141"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.01.001"
  "estado" => "S300"
  "fechaPublicacion" => "2015-04-01"
  "aid" => "1057"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "ssu"
  "cita" => "Actas Dermosifiliogr. 2015;106:158-67"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3206
    "formatos" => array:3 [
      "EPUB" => 57
      "HTML" => 1764
      "PDF" => 1385
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731014004165"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.07.006"
      "estado" => "S300"
      "fechaPublicacion" => "2015-04-01"
      "aid" => "1057"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "ssu"
      "cita" => "Actas Dermosifiliogr. 2015;106:158-67"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3942
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 1352
          "PDF" => 2587
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
        "titulo" => "Histopatolog&#237;a de las alopecias&#46; Parte I&#58; alopecias no cicatriciales"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "158"
            "paginaFinal" => "167"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Histologic Features of Alopecias&#8211;Part I&#58; Nonscarring Alopecias"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 1154
                "Ancho" => 1500
                "Tamanyo" => 503936
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata&#46; A&#46; En cortes longitudinales se observa un infiltrado inflamatorio rodeando los bulbos de los fol&#237;culos pilosos terminales &#40;HE x10&#41;&#46; B&#46; Detalle de la anterior donde se observa que el infiltrado inflamatorio est&#225; compuesto mayoritariamente por linfocitos &#40;HE x200&#41;&#46; C&#46; Cortes transversales del mismo caso mostrando un infiltrado inflamatorio alrededor del segmento inferior de varios de los fol&#237;culos pilosos &#40;HE x10&#41;&#46; D&#46; Detalle de la anterior que muestra un intenso infiltrado linfocitario &#40;HE x200&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46; Bern&#225;rdez, A&#46;M&#46; Molina-Ruiz, L&#46; Requena"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Bern&#225;rdez"
              ]
              1 => array:2 [
                "nombre" => "A&#46;M&#46;"
                "apellidos" => "Molina-Ruiz"
              ]
              2 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Requena"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015000141"
          "doi" => "10.1016/j.adengl.2015.01.001"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000141?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004165?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000003/v3_202209240525/S0001731014004165/v3_202209240525/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S1578219015000153"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.01.002"
    "estado" => "S300"
    "fechaPublicacion" => "2015-04-01"
    "aid" => "1042"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "ssu"
    "cita" => "Actas Dermosifiliogr. 2015;106:168-79"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1829
      "formatos" => array:3 [
        "EPUB" => 46
        "HTML" => 700
        "PDF" => 1083
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Future Prospects in Dermatologic Applications of Lasers&#44; Nanotechnology&#44; and Other New Technologies"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "168"
          "paginaFinal" => "179"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Perspectivas de futuro en l&#225;seres&#44; nuevas tecnolog&#237;as y nanotecnolog&#237;a en dermatolog&#237;a"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figure 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1590
              "Ancho" => 2502
              "Tamanyo" => 142979
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Possible modifications to the surface of nanoparticles&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Boixeda, F&#46; Feltes, J&#46;L&#46; Santiago, J&#46; Paoli"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Boixeda"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Feltes"
            ]
            2 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "Santiago"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Paoli"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731014003895"
        "doi" => "10.1016/j.ad.2014.07.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014003895?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000153?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000153/v3_202209240641/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S1578219015000505"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2014.10.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-04-01"
    "aid" => "1062"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2015;106:155-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1684
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 801
        "PDF" => 832
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>"
      "titulo" => "Treatment goals for psoriasis&#58; Should PASI 90 become the standard of care&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "155"
          "paginaFinal" => "157"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Objetivos terap&#233;uticos en la psoriasis&#58; &#191;deber&#237;a ser la respuesta PASI90 la norma asistencial&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "T&#46; Torres, L&#46; Puig"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Torres"
            ]
            1 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Puig"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0001731014004219"
        "doi" => "10.1016/j.ad.2014.10.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004219?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000505?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000505/v3_202209240641/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Reviews</span>"
    "titulo" => "Histologic Features of Alopecias&#8211;Part I&#58; Nonscarring Alopecias"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "158"
        "paginaFinal" => "167"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; Bern&#225;rdez, A&#46;M&#46; Molina-Ruiz, L&#46; Requena"
        "autores" => array:3 [
          0 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Bern&#225;rdez"
          ]
          1 => array:4 [
            "nombre" => "A&#46;M&#46;"
            "apellidos" => "Molina-Ruiz"
            "email" => array:1 [
              0 => "lrequena@fjd.es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:2 [
            "nombre" => "L&#46;"
            "apellidos" => "Requena"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Fundaci&#243;n Jim&#233;nez D&#237;az&#44; Universidad Aut&#243;noma de Madrid&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Histopatolog&#237;a de las alopecias&#46; Parte I&#58; alopecias no cicatriciales"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1876
            "Ancho" => 2501
            "Tamanyo" => 961949
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Chemotherapy-induced telogen effluvium&#46; A&#44; Longitudinal sections showing several hair follicles in telogen&#44; surrounded by thick perifollicular connective sheaths &#40;hematoxylin -eosin &#91;HE&#93; x 10&#41;&#46; B&#44; Detail of the previous image showing a thick&#44; corrugated vitreous membrane around the telogen club hair &#40;HE x 200&#41;&#46; C&#44; Same case studied with transversal sections&#44; with several hair units &#40;HE x 20&#41;&#46; D&#44; Detail of the previous image showing a corrugated outer root sheath surrounded by a thick vitreous membrane &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">In our daily clinical practice&#44; dermatologists often encounter patients consulting for alopecia&#46; In many cases&#44; these processes can be correctly and rapidly diagnosed from the presentation and course of hair loss&#46; However&#44; sometimes&#44; biopsy is necessary to enable a definitive diagnosis to be established&#46; The first part of this article reviews in detail the main forms of nonscarring alopecia from a histopathological standpoint&#46; Our review will follow the traditional classification of alopecia into scarring alopecias and nonscarring alopecias&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">1</span></a> Scarring alopecias are those in which the hair follicle is replaced by fibrous scar tissue while in nonscarring alopecias&#44; the hair follicles resume their normal activity once the inflammatory process affecting them has been resolved&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Hair Cycle</span><p id="par0010" class="elsevierStylePara elsevierViewall">To describe the histopathology of alopecias&#44; we must have a good understanding of the hair cycle and the morphological changes that the hair follicles undergo in each of the phases of the cycle&#46; Alopecias will generally more frequently involve a given phase of the hair cycle&#44; with anagen&#44; that is&#44; the active growth phase &#40;with DNA synthesis and melanogenesis&#41;&#44; being the most vulnerable&#46;<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">3&#8211;9</span></a> When a hair follicle in anagen undergoes a reversible aggression&#44; the growth phase is shortened to give rise to early catagen and telogen&#46; This conversion from a metabolically highly active phase to an almost inert one helps prevent irreversible damage to the hair follicle&#44; thereby allowing the growth of new hair shafts once the aggression ceases&#46;<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">10&#8211;12</span></a> Of the 100 000 hair follicles in the normal human scalp&#44; approximately 85&#37; are in anagen&#44; with a mean duration in this phase of 2 to 7 years&#46; In late anagen&#44; the inferior segment of the hair follicles lies in the deep dermis or the hypodermis and typically has a pincer-like appearance&#44;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">3</span></a> with the papilla surrounded by germ cells that keratinize as they ascend&#46; After anagen&#44; the hair follicle enters into catagen&#44; the shortest phase of the cycle&#44; with a duration of approximately 2 to 3 weeks&#46; Catagen is characterized by retraction of the inferior segment of the hair follicle&#44; which is positioned nearer the surface&#44; leading to corrugation of the outer root sheath giving it an undulating appearance&#44; with disperse apoptotic cells&#44; especially in the lower part&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">13</span></a> In a normal scalp&#44; only 1&#37; to 2&#37; of these hair follicles are in catagen and it is common not to see any in this phase in a biopsy&#46; However&#44; the number of follicles in catagen can increase significantly in certain alopecias such as tricothylamany&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">1</span></a> Telogen is the last phase of the hair cycle&#44; lasting for a mean of 3 months&#46; In this phase&#44; DNA synthesis has completely stopped and melanogenesis has been interrupted&#46; At the end of telogen&#44; the hair shaft detaches&#44; and a new hair cycle begins&#46; Follicles in telogen have a retracted and bulky lower segment &#40;telogen club hair&#41; in the middle and upper dermis&#44; and appear composed mainly of the permanent part of the hair follicle &#40;infundibulum and isthmus&#41;&#46; They therefore have the form of a club and are surrounded by sheaths of retracted perifollicular connective tissue&#46; In addition&#44; an angiofibrotic streamer is often present in this phase&#44; running from the isthmus to the subcutaneous cellular tissue&#44; clearly revealing the site where the lower segment of the follicle is located&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">2</span></a> The stem cells of the hair follicle are found where the outer root sheath widens at site of insertion of the arrector pili muscle&#46; This structure is known as the bulge&#46; Recently&#44; relatively specific immunohistochemical markers such as PHLDA1 have been identified for these follicular stem cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0475"><span class="elsevierStyleSup">14&#44;15</span></a> In each hair cycle&#44; activation of these cells will give rise to the reappearance of the transient portion of the hair follicle and thus to a new hair cycle&#46; Permanent damage to these stem cells is the common feature of the pathophysiology of all scarring alopecias&#46;<a class="elsevierStyleCrossRefs" href="#bib0485"><span class="elsevierStyleSup">16&#44;17</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Nonscarring Alopecias</span><p id="par0015" class="elsevierStylePara elsevierViewall">In the physical exploration of nonscarring alopecias&#44; follicular orifices can sometimes still be seen&#46; This is key to diagnosis to differentiate from scarring alopecias&#44; where the follicular orifices appear obliterated&#46; This observation correlates histopathologically with the presence of follicular units with capacity for synthesizing hair shafts&#44; and is the reason why areas of alopecia become repopulated after removing the trigger for hair loss&#46; In the study of nonscarring alopecias&#44; it is very useful to assess the follicular density and dynamics of the hair cycle &#40;phase of the cycle in which the hair follicles observed histopathologically are found&#41;&#46; For this&#44; it is preferable that the biopsies are transversal sections&#44; as this makes it possible to observe many hair follicles in different phases at the same time&#46; In addition&#44; for the biopsy to be useful&#44; the sample must be taken from an active region of the lesion&#46; In alopecias with a patchy morphology&#44; it is preferable to take the sample from the edge of the lesion&#44; whereas with diffuse alopecias the sample should be taken from a region with a positive hair pull test&#46; Whenever possible&#44; it is also useful to obtain a biopsy from the occipital region&#44; as this will lower the chance of encountering hair follicles with androgenic effects&#44; which if present may mean that the sample is not representative&#46; Finally&#44; when we assess a sample from a patient with nonscarring alopecia&#44; we should remember that the disease is a dynamic process&#44; and so histopathologic findings may vary according to the point in the process at the time of biopsy&#46;<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">18</span></a> The key histopathological findings of use in the diagnosis of nonscarring alopecias are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Androgenic Alopecia</span><p id="par0020" class="elsevierStylePara elsevierViewall">Androgenic alopecia&#44; or common baldness&#44; is considered as a normal and physiological progression of hair follicles in the scalp rather than a disease as such&#46; The underlying cause of androgenic alopecia is an increased sensitivity of the hair follicles to androgens&#46; This is determined genetically and varies according to the region of the scalp&#44; with the follicles in the occipital zone being the least affected&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">19</span></a> It has been shown that both women and men with androgenic alopecia show higher levels of activity of the enzyme 5&#945;-reductase in the follicles of the frontal region of the scalp&#44; when compared with the activity of follicles of the occipital region of the same patient&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">20</span></a> This may explain the different sensitivity to androgens in certain areas of the scalp&#46; The pattern of androgenic alopecia is different in men and women&#46; Men tend to show a bitemporal receding hairline with subsequent involvement of the frontotemporal region and vertex whereas women start with diffuse hair loss&#44; which mainly affects the central area of the scalp&#46;<a class="elsevierStyleCrossRefs" href="#bib0510"><span class="elsevierStyleSup">21&#8211;23</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The key histopathological finding in androgenic alopecia is progressive miniaturization of terminal hair follicles&#44;<a class="elsevierStyleCrossRefs" href="#bib0525"><span class="elsevierStyleSup">24&#8211;29</span></a> leading some of them to convert into vellus follicles &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; However&#44; the total number of hair follicles remains stable&#44; with a reduction in their size and depth and a smaller diameter of the hair shaft&#46;<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">30&#44;31</span></a> The earliest change that can be observed in biopsies of androgenic alopecia is focal basophil degeneration of the vitreous membrane of the follicles in anagen&#46;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">32</span></a> In addition&#44; with the miniaturization&#44; there is an ascent of the inferior segment of the hair follicles towards the superficial dermis&#44; accompanied by an increase in the number of fibrous tracts&#46; Thus&#44; there is an increase in the number of follicles in telogen and a decrease in the normal anagen to telogen ratio from 7&#58;1 to 2&#58;1&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">33</span></a> Another characteristic of androgenic alopecia is the presence of apparently larger sebaceous glands compared to the size of the miniaturized hair follicles&#46; But this observation is really only an apparent sebaceous hyperplasia as the sebaceous glands are of normal size and morphology&#44;<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">34</span></a> but they appear larger compared to the miniaturized hair follicles&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The presence and significance of inflammatory infiltrate is a topic of debate in androgenic alopecia&#46; Traditionally&#44; the presence of an inflammatory infiltrate was a histopathological finding that pointed away from androgenic alopeica&#44;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">35</span></a> but several authors have reported inflammatory infiltrate in up to 75&#37; of patients with androgenic alopecia&#44; without any clinical signs of inflammation in the physical exploration&#46;<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">30&#44;31&#44;36&#8211;38</span></a> This infiltrate&#44; mainly composed of lymphocytes&#44; is usually found around the infundibulum&#44; but it has also been observed around the fibrous streamers&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">On staining for elastic fibers&#44; the biopsies from patients with androgenic alopecia show Arao-Perkins bodies&#44; which consist of small aggregates of elastic fibers in the fibrous streamers&#46;<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">39</span></a> They appear because of the agglomeration of elastic tissue surrounding the neck of the follicular papilla during catagen&#44; marking the initial site of the follicular papilla in the previous cycle&#46; In advanced androgenic alopecia&#44; multiple Arao-Perkins bodies can be observed in the fibrous streamers&#44; located increasingly nearer the surface&#46;<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">40</span></a> According to Pinkus&#44;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">8</span></a> these findings are diagnostic of androgenic alopecia&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Telogen Effluvium</span><p id="par0040" class="elsevierStylePara elsevierViewall">Telogen effluvium is a disorder of the hair cycle in which one or more etiologic agents of different characteristics give rise to an early finalization of anagen&#46; The underlying cause of this condition is an alteration of the biological clock of the follicular growth cycle&#44; with a premature transition of the follicles from anagen to telogen&#46;<a class="elsevierStyleCrossRefs" href="#bib0610"><span class="elsevierStyleSup">41&#8211;43</span></a> This early transition can be caused by a variety of situations&#44; including surgery&#44; infection&#44; general anesthetic&#44; surgical stress&#44; and several intercurrent systemic diseases&#46; These processes usually occur 2 to 3 months before the onset of effluvium &#40;the time equivalent to the duration of telogen&#41;&#46; Patients experience diffuse hair loss&#44; and if we examine the detached hairs under the microscope&#44; we see the typical club shape characteristic of telogen&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In all nonscarring alopecias&#44; it is important to know where in the process the patient is&#44; given that the histopathological characteristics vary according to disease progression&#46; This is particularly important in telogen effluvium&#44; where a trigger leads to a sudden transition of the follicles from anagen to telogen &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#44; but subsequently a new hair cycle begins&#46; The biopsy in a patient with telogen effluvium is therefore usually normal&#46; Thus&#44; if we suspect telogen effluvium and we perform a biopsy with normal findings&#44; we would be faced with a typical case of telogen effluvium&#44; as the patients do not usually attend the dermatologist until they notice hair loss&#44; which is usually when the disease is in an advanced phase&#46;<a class="elsevierStyleCrossRefs" href="#bib0625"><span class="elsevierStyleSup">44&#44;45</span></a> Only if we take a biopsy in an initial phase from a patient with telogen effluvium will we be able to detect a decrease in the ratio of anagen-to-telogen follicles&#44; with a percentage of follicles in telogen of greater than 25&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0635"><span class="elsevierStyleSup">46</span></a> In addition&#44; in biopsies of telogen effluvium&#44; we do not observe follicular abnormalities&#44;<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">47</span></a> inflammatory infiltrate&#44; or an increase in fibrous streamers&#44; while the number of follicles is normal&#46;<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">48</span></a> It is important to remember that some patients&#44; especially men&#44; can present with androgenic alopecia at the same time as telogen effluvium&#44; and so it is important that the biopsy is performed in the occipital region of the scalp&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Chronic telogen effluvium is described as diffuse hair loss lasting more than 6 months&#46; It differs from acute telogen effluvium in that it is more common among women &#40;especially during menopause&#41; and its etiology is not so clear&#46; Onset is usually sudden and progression fluctuates but is self-limiting&#59; in addition it often presents as a bitemporal regression of the hairline&#46;<a class="elsevierStyleCrossRefs" href="#bib0650"><span class="elsevierStyleSup">49&#44;50</span></a> It has been suggested that the process is due to a decreased duration of the anagen phase&#44; thereby impeding the growth of long hairs&#46;<a class="elsevierStyleCrossRefs" href="#bib0630"><span class="elsevierStyleSup">45&#44;51</span></a> Biopsy reveals a scalp that hardly differs&#44; if at all&#44; from a normal scalp&#44; with a slight increase in the percentage of follicles in telogen if the biopsy is performed during the most active phases&#46; According to Whitting&#44;<a class="elsevierStyleCrossRef" href="#bib0665"><span class="elsevierStyleSup">52</span></a> hair loss in the absence of histopathological changes is characteristic of this condition&#46; To differentiate from female-pattern androgenic alopecia&#44; whose clinical characteristics are very similar&#44; it is useful to determine the telogen to anagen ratio in the biopsy&#46; In the case of female-pattern androgenic alopecia&#44; this ratio is usually increased but does not exceed 4&#58;1&#44; whereas if the ratio is greater than 8&#58;1&#44; this is indicative of chronic telogen effluvium&#46;<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">53</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Alopecia Areata</span><p id="par0055" class="elsevierStylePara elsevierViewall">Alopecia areata is a relatively common cause of alopecia&#46; The most likely pathogenesis is a genetically determined autoimmune disorder mediated by T lymphocytes against aberrant HLA-RR expressed by keratinocytes of the hair follicles&#46;<a class="elsevierStyleCrossRefs" href="#bib0675"><span class="elsevierStyleSup">54&#44;55</span></a> It tends to affect children and young adults more frequently but can present at any age&#46; It is manifest clinically as one or several oval or round patches of alopecia&#44; without loss of follicular orifices&#46; The process can affect any hair-bearing region of the body&#46; In alopecia areata&#44; characteristically&#44; hairs in the form of exclamation marks can be seen&#44; particularly at the margins of the lesion&#46; These correspond to small broken hairs&#44; with a conical attenuated bulb and thicker distal end&#46;<a class="elsevierStyleCrossRefs" href="#bib0685"><span class="elsevierStyleSup">56&#44;57</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">From the histopathological point of view&#44; alopecia areata is characterized by the presence of an inflammatory infiltrate of small lymphocytes that surround the bulb of the follicles in anagen &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a>&#41;&#44; thereby inducing early conversion to catagen and telogen&#46; The infiltrate adopts a peri- and intrabulbar distribution&#44; creating a honeycomb effect&#44; and is composed mainly of CD4&#43; T lymphocytes and Langerhans cells&#46; Histiocytes&#44; plasma cells&#44; mast cells&#44; and eosinophils can also be observed&#46;<a class="elsevierStyleCrossRefs" href="#bib0695"><span class="elsevierStyleSup">58&#8211;63</span></a> T lymphocytes induce apoptosis of matrix cells of the bulb&#44; starting with the peripheral ones&#44; which are the ones responsible for the formation of the inner root sheath and the cortex of the hair shaft&#46;<a class="elsevierStyleCrossRef" href="#bib0715"><span class="elsevierStyleSup">62</span></a> This gives rise to a narrowing of the hair shaft&#44; which is responsible for the appearance of exclamation mark hairs&#46; This also induces an early transition from catagen to telogen&#44; in turn leading to a reversal of the anagen to telogen ratio&#44; typical in alopecia areata&#46; Therefore&#44; in biopsies of this process&#44; there is an increased number of follicles in catagen and telogen&#44; all with an accompanying fibrous streamer&#46; This abundance of hair follicles all in the same phase of the cycle is a key to the diagnosis of alopecia areata&#46;<a class="elsevierStyleCrossRef" href="#bib0725"><span class="elsevierStyleSup">64</span></a> However&#44; the characteristic inflammatory infiltrate that is normally observed in alopecia areata may be absent at times&#44; particularly in cases of long-standing disease&#46; In such cases&#44; it may be useful to search for other histopathological characteristics suggestive of alopecia areata&#44; such as the presence of eosinophils&#44; lymphocytes&#44; and melanin in the fibrous streamers&#46; Other characteristics&#44; less specific to alopecia areata but nevertheless of assistance in diagnosis include an increased number of follicles in catagen and telogen&#44; incontinentia pigmenti &#40;both peribulbar and in the fibrous streamer&#41;&#44; and tricholamalacia&#46; In alopecia areata&#44; but also in other forms of alopecia&#44; a proliferation of ducts similar to syringoma can be observed&#44; although these lack the sclerotic stroma characteristic of this tumor&#46; This is therefore thought to correspond to a reactive ductal hyperplasia&#46;<a class="elsevierStyleCrossRef" href="#bib0730"><span class="elsevierStyleSup">65</span></a> Moreover&#44; in longstanding alopecia areata&#44; there is a miniaturization of the hair follicles with an almost complete absence of terminal follicles&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Unlike scarring alopecias&#44; the inflammatory infiltrate in alopecia areata does not involve stem cells&#44; so the hair follicle maintains its capacity to regenerate after an aggression&#46; If the inflammation has resolved when the follicle enters a new growth cycle&#44; the affected region will progressively repopulate&#46; If&#44; on the other hand&#44; the follicle in anagen is still affected by the inflammatory infiltrate&#44; the hair cycle will be interrupted once again in early anagen phase&#44; leading to premature catagen and telogen<a class="elsevierStyleCrossRef" href="#bib0735"><span class="elsevierStyleSup">66</span></a> and persistence of the disease&#46; Although alopecia areata is a nonscarring condition&#44; in chronic forms of alopecia areata resistant to treatment&#44; biopsies show a lack of hair follicles and these appear to be replaced by nodules of fibroplasia and collagen tissue arranged in concentric rings&#46; Such findings are indicative of alopecia areata in which repopulation will not occur&#46;<a class="elsevierStyleCrossRef" href="#bib0740"><span class="elsevierStyleSup">67</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Syphilitic Alopecia</span><p id="par0070" class="elsevierStylePara elsevierViewall">Syphilitic alopecia is a secondary manifestation of infection and is the result of inflammation caused by local aggression of <span class="elsevierStyleItalic">Treponema pallidum</span> on the hair follicles&#46; Syphilitic alopecia rarely presents in isolation&#44; but when it does so&#44; whether in its patchy clinical presentation &#40;moth-eaten alopecia&#41; or its diffuse form&#44; the clinician may be faced with diagnostic uncertainty as a high degree of clinical suspicion is required and in most cases it will be necessary to request syphilis testing to establish diagnosis&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">From the histopathological point of view&#44; it is important to try to detect the spirochetes in the inflammatory infiltrate through histochemical study&#44; as this is the most sensitive technique at present &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0745"><span class="elsevierStyleSup">68</span></a> Syphilitic alopecia presents as a lymphohistiocytic inflammatory infiltrate with a striking plasma cell component&#44; which surrounds the fibrous streamers and the bulb&#46; Moreover&#44; in biopsies of syphilitic alopecia&#44; we see an increase in the number of follicles in telogen and catagen&#46; This latter observation is important in the differential diagnosis with alopecia areata as both show clinical and histopathological similarities&#46; Different authors have searched for other histopathological findings that would help in the differential diagnosis of syphilitic alopecia and alopecia areata&#46; One of the proposals has been the presence of eosinophils&#46; Some studies&#44; such as the one by Jordaan and Louw&#44;<a class="elsevierStyleCrossRef" href="#bib0750"><span class="elsevierStyleSup">69</span></a> describe the presence of eosinophils in syphilitic alopecia&#44; whereas other authors&#44; such as Lee and Hsu<a class="elsevierStyleCrossRef" href="#bib0755"><span class="elsevierStyleSup">70</span></a> report their absence and consider this criterion useful for differential diagnosis with alopecia areata&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Trichotillomania</span><p id="par0080" class="elsevierStylePara elsevierViewall">Trichotillomania is a self-inflicted pathological process&#44; either consciously or unconsciously&#44; in which patients experience the compulsion to twist or pull their hair and so achieve pleasure or relief&#46;<a class="elsevierStyleCrossRef" href="#bib0760"><span class="elsevierStyleSup">71</span></a> Such patients usually show an aberrant clinical pattern of alopecia&#44; which generally involves the scalp but which can also affect any hair-bearing region of the body&#46;<a class="elsevierStyleCrossRef" href="#bib0765"><span class="elsevierStyleSup">72</span></a> The areas of alopecia appear patchy and with irregular borders&#46; Characteristically&#44; hair of different lengths can be seen&#44; and in extreme cases&#44; broken or frayed ends may be present due to pulling and breakage of the hairs over time&#46; Unlike alopecia areata&#44; the patches do not usually show complete hair loss&#44; as the hair cycle progresses normally despite the constant aggressions&#46;<a class="elsevierStyleCrossRef" href="#bib0765"><span class="elsevierStyleSup">72</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">The consequences of hair follicle lesion due to repeated trauma are reflected histopathologically&#46; Often&#44; in the same biopsy&#44; it is possible to observe alternating damaged and intact follicles&#44; even very close to one another&#44;<a class="elsevierStyleCrossRefs" href="#bib0770"><span class="elsevierStyleSup">73&#8211;75</span></a> and this finding correlates with the clinical observation of incomplete hair loss in the patches of alopecia&#46; There is also a lack of perifollicular inflammatory infiltrate&#44;<a class="elsevierStyleCrossRef" href="#bib0785"><span class="elsevierStyleSup">76</span></a> although at times perivascular inflammation is observed in the superficial dermis&#46; As evidence of trauma&#44; the individual damaged follicles show tricholamalacia&#44; incontinentia pigmenti&#44; and intra- and perifollicular hemorrhage&#46;<a class="elsevierStyleCrossRef" href="#bib0785"><span class="elsevierStyleSup">76</span></a> Trichomalacia is the most characteristic histopathological finding of this disease&#44; and refers to distortion of the hair shaft &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Figure 5</a>&#41;&#44; although it may not always be present&#46;<a class="elsevierStyleCrossRefs" href="#bib0780"><span class="elsevierStyleSup">75&#8211;77</span></a> The damage to bulbar melanocytes gives rise to incontinentia pigmenti&#44; which is observed in the form of irregular pigmented masses in the permanent part of the follicle&#44; both in the infundibulum and in the isthmus&#44; occupying the now corrugated outer root sheath&#46;<a class="elsevierStyleCrossRef" href="#bib0780"><span class="elsevierStyleSup">75</span></a> In fair- and red-haired individuals&#44; it is uncommon to find these accumulations of pigment&#46;<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">18</span></a> Follicular hemorrhages appear in the early phases of the process and are not a constant finding&#44; but when they are observed&#44; they constitute a finding that almost confirms diagnosis of trichotillomania&#46;<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">44</span></a> It is sometimes possible to observe a granulomatous reaction around the follicles of the hairs that have been pulled out&#44; probably in response to broken hair shafts in direct contact with the dermis and without the protection afforded by the follicular root sheaths&#46;<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">3&#44;10</span></a> The presence of empty follicular channels<a class="elsevierStyleCrossRef" href="#bib0785"><span class="elsevierStyleSup">76</span></a> is also a common finding in this process&#44; but unfortunately it does not help diagnosis as this is a frequent finding in many of the scalp biopsies due to the microtome actions&#46; If it is possible to obtain a biopsy with the hair shafts conserved&#44; the characteristic <span class="elsevierStyleItalic">hamburger sign</span> can be seen&#44; resulting from longitudinal breakage of the hair shaft with accumulation of protein material and erythrocytes in the resulting intermediate space&#46;<a class="elsevierStyleCrossRef" href="#bib0795"><span class="elsevierStyleSup">78</span></a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Transversal sections show an increase in the number of follicles in catagen in the earliest stages&#46;<a class="elsevierStyleCrossRefs" href="#bib0585"><span class="elsevierStyleSup">36&#44;75&#8211;77</span></a> As with alopecia areata&#44; lesion of follicles in anagen hastens the transition to catagen and telogen&#46; According to Whitting&#44;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">12</span></a> trichotillomania is the alopecia in which most follicles are in catagen&#44; although the total number of follicles or the ratio of terminal to vellus follicles does not vary&#46; The main histopathological criterion for establishing differential diagnosis with alopecia areata is the absence of peribulbar inflammatory infiltrate in trichotillomania&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Traction Alopecia</span><p id="par0095" class="elsevierStylePara elsevierViewall">Traction alopecia is included along with trichotillomania in the group of mechanically induced alopecias&#46; The chronic form can be seen fairly often in clinical practice&#46; In general&#44; it is caused by inappropriate hair styling&#44; such as pulled-back hair or the use of elastic bands for the hair&#46;<a class="elsevierStyleCrossRef" href="#bib0800"><span class="elsevierStyleSup">79</span></a> In this form&#44; hair loss occurs in the regions where there is greatest traction&#44; leading in time to a recession of the hairline or a widening of the separation between hair parting and progressive centrifugal hair loss&#46;<a class="elsevierStyleCrossRef" href="#bib0805"><span class="elsevierStyleSup">80</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Traction alopecia is very well characterized from a clinical point of view&#44; but its histopathological characteristics are not so well known&#46; By and large&#44; the histological findings of traction alopecia are very similar to those observed in trichotillomania&#44; although over time it can give rise to a scarring alopecia&#44; which is known as follicular degeneration syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0810"><span class="elsevierStyleSup">81</span></a> In the early phases&#44; when the alopecia is still reversible&#44; changes similar to those described for trichotillomania can be observed&#44; such as the presence of trichomalacia and incontinentia pigmenti&#44; although less severe and with fewer involved hair follicles&#46;<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">48</span></a> In advanced phases&#44; when the alopecia is irreversible&#44; regions of fibrosis can be observed in places where the terminal hair follicles were previously found&#46;<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">48</span></a> A characteristic finding of traction alopecia is a decrease in the number of terminal hair follicles&#44; with a normal number of vellus follicles&#46; Characteristically&#44; inflammatory infiltrate is not observed at any time during the course of traction alopecia&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">1</span></a></p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflicts of Interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:9 [
        0 => array:3 [
          "identificador" => "xres1774107"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1558304"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1774106"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1558303"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Hair Cycle"
        ]
        6 => array:3 [
          "identificador" => "sec0015"
          "titulo" => "Nonscarring Alopecias"
          "secciones" => array:6 [
            0 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Androgenic Alopecia"
            ]
            1 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Telogen Effluvium"
            ]
            2 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Alopecia Areata"
            ]
            3 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Syphilitic Alopecia"
            ]
            4 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Trichotillomania"
            ]
            5 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Traction Alopecia"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conflicts of Interest"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-04-29"
    "fechaAceptado" => "2014-07-13"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1558304"
          "palabras" => array:10 [
            0 => "Dermatopathology"
            1 => "Alopecia"
            2 => "Review"
            3 => "Nonscarring alopecia"
            4 => "Androgenetic alopecia"
            5 => "Telogen effluvium"
            6 => "Alopecia areata"
            7 => "Syphilitic alopecia"
            8 => "Trichotillomania"
            9 => "Traction alopecia"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1558303"
          "palabras" => array:10 [
            0 => "Dermatopatolog&#237;a"
            1 => "Alopecia"
            2 => "Revisi&#243;n"
            3 => "Alopecias no cicatriciales"
            4 => "Alopecia androgen&#233;tica"
            5 => "Efluvio tel&#243;geno"
            6 => "Alopecia areata"
            7 => "Alopecia sifil&#237;tica"
            8 => "Tricotiloman&#237;a"
            9 => "Alopecia por tracci&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The diagnosis of disorders of the hair and scalp can generally be made on clinical grounds&#44; but clinical signs are not always diagnostic and in some cases more invasive techniques&#44; such as a biopsy&#44; may be necessary&#46; This 2-part article is a detailed review of the histologic features of the main types of alopecia based on the traditional classification of these disorders into 2 major groups&#58; scarring and nonscarring alopecias&#46; Scarring alopecias are disorders in which the hair follicle is replaced by fibrous scar tissue&#44; a process that leads to permanent hair loss&#46; In nonscarring alopecias&#44; the follicles are preserved and hair growth can resume when the cause of the problem is eliminated&#46; In the first part of this review&#44; we describe the histologic features of the main forms of nonscarring alopecia&#46; Since a close clinical-pathological correlation is essential for making a correct histologic diagnosis of alopecia&#44; we also include a brief description of the clinical features of the principal forms of this disorder&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El diagn&#243;stico de las enfermedades del cabello y del cuero cabelludo se basa&#44; en la mayor&#237;a de las ocasiones&#44; en el reconocimiento de signos cl&#237;nicos&#59; sin embargo&#44; dichos signos no siempre son caracter&#237;sticos y&#44; en ocasiones&#44; tenemos que recurrir a t&#233;cnicas m&#225;s invasivas como la realizaci&#243;n de una biopsia&#46; En este art&#237;culo se revisa de forma detallada las principales formas de alopecia desde un punto de vista histopatol&#243;gico&#44; y para ello se utiliza la clasificaci&#243;n tradicional de las alopecias que las divide en 2 grandes grupos&#58; las alopecias cicatriciales y las no cicatriciales&#46; Las alopecias cicatriciales son aquellas en las cuales el fol&#237;culo piloso es sustituido por tejido fibroso cicatricial&#44; causando una p&#233;rdida permanente del cabello&#46; En las alopecias no cicatriciales el fol&#237;culo permanece intacto y puede retomar su actividad cuando cesa el est&#237;mulo desencadenante&#46; La primera parte de este art&#237;culo revisa las principales formas de alopecia no cicatricial desde un punto de vista histopatol&#243;gico&#46; Dado que una buena correlaci&#243;n cl&#237;nico-patol&#243;gica es fundamental para realizar el correcto diagn&#243;stico histopatol&#243;gico de las alopecias&#44; en este art&#237;culo se incluye tambi&#233;n una breve descripci&#243;n de las caracter&#237;sticas cl&#237;nicas de las principales formas de alopecia&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Bern&#225;rdez C&#44; Molina-Ruiz AM&#44; Requena L&#46; Histopatolog&#237;a de las alopecias&#46; Parte I&#58; alopecias no cicatriciales&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;158&#8211;167&#46;</p>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1876
            "Ancho" => 2501
            "Tamanyo" => 1054938
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Androgenic alopecia&#46; A&#44; The longitudinal sections show a miniaturization of the terminal follicles&#44; which convert to vellus follicles &#40;hematoxylin-eosin &#91;HE&#93; x 20&#41;&#46; B&#44; Miniaturized hair follicles and apparently hypertrophic sebaceous glands &#40;HE x 200&#41;&#46; C&#44; Same case studied with transversal sections&#44; with several hair units of smaller size than normal in the scalp &#40;HE x 20&#41;&#46; D&#44; Detail of the previous image in which sebaceous glands can be seen with a proportionally greater volume compared to the size of the hair follicles &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1876
            "Ancho" => 2501
            "Tamanyo" => 961949
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Chemotherapy-induced telogen effluvium&#46; A&#44; Longitudinal sections showing several hair follicles in telogen&#44; surrounded by thick perifollicular connective sheaths &#40;hematoxylin -eosin &#91;HE&#93; x 10&#41;&#46; B&#44; Detail of the previous image showing a thick&#44; corrugated vitreous membrane around the telogen club hair &#40;HE x 200&#41;&#46; C&#44; Same case studied with transversal sections&#44; with several hair units &#40;HE x 20&#41;&#46; D&#44; Detail of the previous image showing a corrugated outer root sheath surrounded by a thick vitreous membrane &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1924
            "Ancho" => 2501
            "Tamanyo" => 1066434
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata&#46; A&#44; Longitudinal sections showing an inflammatory infiltrate surrounding the bulbs of the terminal hair follicles &#40;hematoxylin-eosin &#91;HE&#93; x 10&#41;&#46; B&#44; Detail of the previous image showing that the inflammatory infiltrate is made up mainly of lymphocytes &#40;HE x 200&#41;&#46; C&#44; Transversal sections of the same case showing an inflammatory infiltrate around the inferior segment of several of the hair follicles &#40;HE x 10&#41;&#46; D&#44; Detail of the previous image showing an intense lymphocyte infiltrate &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1972
            "Ancho" => 2501
            "Tamanyo" => 912466
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Syphilitic alopecia&#46; A&#44; A lichenoid infiltrate at the dermal-epidermal junction along with a dense perifollicular infiltrate &#40;hematoxylin-eosin &#91;HE&#93; x 10&#41;&#46; B&#46; At higher magnification&#44; we see that the infiltrate is made up mainly of lymphocytes and plasma cells &#40;HE x 400&#41;&#46; C&#46; Immunohistochemistry of the same case for <span class="elsevierStyleItalic">Treponema pallidum</span> &#40;HE x 10&#41;<span class="elsevierStyleItalic">&#46;</span> D&#46; Numerous treponemas between the epithelium of the outer root sheath of the follicle &#40;HE x 400&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 1921
            "Ancho" => 2501
            "Tamanyo" => 917507
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Trichotillomania&#46; A&#44; Longitudinal sections showing normal hair follicles in alternation with abnormal ones &#40;hematoxylin-eosin &#91;HE&#93; x 10&#41;&#46; B&#44; Trichomalacia showing pigmented and corrugated shafts in the follicular channel &#40;HE x 200&#41;&#46; C&#44; Same case studied with transversal sections &#40;HE x20&#41;&#46; D&#44; Detail of the previous image in which a broken hair shaft is observed with abundant pigment &#40;HE x 200&#41;&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Type of Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Key Histopathological Features&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Androgenic Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Miniaturization of hair follicles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sebaceous pseudohyperplasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Telogen Effluvium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Predominance of hair follicles in telogen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absence of significant histopathological changes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alopecia Areata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peri- and intrabulbar lymphocytic infiltrate &#40;honeycomb pattern&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Several follicles from the biopsy in the same phase of the cycle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inversion of the anagen to telogen ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Syphilitic Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Abundant plasma cells in the inflammatory infiltrate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of <span class="elsevierStyleItalic">Treponema pallidum</span> with immunohistochemical staining&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trichotillomania&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absence of peribulbar inflammatory infiltrate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trichomalacia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Incontinentia pigmenti&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intra and perifollicular hemorrhage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Traction Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Similar to trichotillomania&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reduction of terminal hair follicles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Key Histopathological Features of Nonscarring Alopecias&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:81 [
            0 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histopathologic evaluation of alopecias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Sellheyer"
                            1 => "W&#46;F&#46; Bergfel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00000372-200606000-00051"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2006"
                        "volumen" => "28"
                        "paginaInicial" => "236"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16778532"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Weedon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "D&#46;Weedon"
                        "titulo" => "Diseases of cutaneous appendages&#46; Weedon&#39;s skin pathology"
                        "paginaInicial" => "417"
                        "paginaFinal" => "431"
                        "serieFecha" => "2010"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia&#58; Histologic changes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;F&#46; Bergfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Dermatol"
                        "fecha" => "1989"
                        "volumen" => "4"
                        "paginaInicial" => "301"
                        "paginaFinal" => "322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2701796"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;F&#46; Bergfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "S&#46;L&#46;Moschella, H&#46;J&#46;Hurley"
                        "titulo" => "Dermatology"
                        "paginaInicial" => "1541"
                        "paginaFinal" => "1560"
                        "edicion" => "3rd ed&#46;"
                        "serieFecha" => "1992"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia&#58; A pathologist&#39;s view"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Ioannides"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4362.1982.tb03137.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1982"
                        "volumen" => "21"
                        "paginaInicial" => "316"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6749712"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair loss&#58; An overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Mulinari-Brenner"
                            1 => "W&#46;F&#46; Bergfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Nurs"
                        "fecha" => "2001"
                        "volumen" => "13"
                        "paginaInicial" => "277"
                        "paginaFinal" => "278"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The biology of hair follicles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Paus"
                            1 => "G&#46; Cotsarelis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199908123410706"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1999"
                        "volumen" => "341"
                        "paginaInicial" => "491"
                        "paginaFinal" => "497"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10441606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia&#46; Clinicopathologic correlations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Pinkus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4362.1980.tb00318.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1980"
                        "volumen" => "19"
                        "paginaInicial" => "245"
                        "paginaFinal" => "253"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7390687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair and systemic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46;C&#46; Sperling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0733-8635(05)70310-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "2001"
                        "volumen" => "19"
                        "paginaInicial" => "711"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11705356"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosing common alopecias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Stengel"
                            1 => "A&#46;B&#46; Ackerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am Fam Physician"
                        "fecha" => "1978"
                        "volumen" => "18"
                        "paginaInicial" => "76"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/717231"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0923753419312967"
                          "estado" => "S300"
                          "issn" => "09237534"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair and nail physiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Stenn"
                            1 => "P&#46; Fleckman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "M&#46;K&#46;Hordinsky, M&#46;E&#46;Sawaya, R&#46;K&#46;Scher"
                        "titulo" => "Atlas of hair and nails"
                        "paginaInicial" => "3"
                        "paginaFinal" => "8"
                        "serieFecha" => "2000"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disorders of cutaneous appendages"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;A&#46; Whiting"
                            1 => "S&#46;F&#46; Templeton"
                            2 => "A&#46;R&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "R&#46;L&#46;Barnhill"
                        "titulo" => "Textbook of dermatopathology"
                        "paginaInicial" => "201"
                        "paginaFinal" => "231"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The recognition of early stages of catagen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Weedon"
                            1 => "G&#46; Strutton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00000372-198412000-00006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1984"
                        "volumen" => "6"
                        "paginaInicial" => "553"
                        "paginaFinal" => "555"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6524637"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization and isolation of stem cell enriched human hair follicle bulge cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Ohyama"
                            1 => "A&#46; Terunuma"
                            2 => "C&#46;L&#46; Tock"
                            3 => "M&#46;F&#46; Radonovich"
                            4 => "C&#46;A&#46; Pise-Masison"
                            5 => "S&#46;B&#46; Hopping"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI26043"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2006"
                        "volumen" => "116"
                        "paginaInicial" => "249"
                        "paginaFinal" => "260"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16395407"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follicular stem cell marker PHLDA1 &#40;TDAG51&#41; is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Sellheyer"
                            1 => "P&#46; Nelson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.2011.01693.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2011"
                        "volumen" => "38"
                        "paginaInicial" => "542"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21352265"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0923753419374393"
                          "estado" => "S300"
                          "issn" => "09237534"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Label-retaining cells reside in the bulge area of pilosebaceous unit&#58; Implications for follicular stem cells&#44; hair cycle&#44; and skin carcinogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Cotsarelis"
                            1 => "T&#46;T&#46; Sun"
                            2 => "R&#46;M&#46; Lavker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0092-8674(90)90696-c"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1990"
                        "volumen" => "61"
                        "paginaInicial" => "1329"
                        "paginaFinal" => "1337"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2364430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair follicular stem cells&#46; The bulge activation hypothesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;T&#46; Sun"
                            1 => "G&#46; Cotsarelis"
                            2 => "R&#46;M&#46; Lavker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1991"
                        "volumen" => "96"
                        "paginaInicial" => "779"
                        "paginaFinal" => "789"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The histopathology of noncicatricial alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Eudy"
                            1 => "A&#46;R&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.sder.2006.01.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Cutan Med Surg"
                        "fecha" => "2006"
                        "volumen" => "25"
                        "paginaInicial" => "35"
                        "paginaFinal" => "40"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16616301"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanism of action of androgen in dermal papilla cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Itami"
                            1 => "S&#46; Kurata"
                            2 => "T&#46; Sonoda"
                            3 => "S&#46; Takayasu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1749-6632.1991.tb24403.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann N Y Acad Sci"
                        "fecha" => "1991"
                        "volumen" => "642"
                        "paginaInicial" => "385"
                        "paginaFinal" => "395"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1809094"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Different levels of 5&#945;-reductase type <span class="elsevierStyleSmallCaps">i</span> and <span class="elsevierStyleSmallCaps">ii</span>&#44; aromatase and androgen receptor in hair follicles of women and men with androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;E&#46; Sawaya"
                            1 => "V&#46;H&#46; Price"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1523-1747.ep12335779"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1997"
                        "volumen" => "109"
                        "paginaInicial" => "296"
                        "paginaFinal" => "300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9284093"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Approach to the adult female patient with diffuse nonscarring alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;B&#46; Chartier"
                            1 => "D&#46;M&#46; Hoss"
                            2 => "J&#46;M&#46; Grant-Kels"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mjd.2002.128771"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "47"
                        "paginaInicial" => "809"
                        "paginaFinal" => "818"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12451364"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Androgenic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;F&#46; Bergfeld"
                            1 => "G&#46;P&#46; Redmond"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "1987"
                        "volumen" => "5"
                        "paginaInicial" => "491"
                        "paginaFinal" => "500"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3301107"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0959804920302276"
                          "estado" => "S300"
                          "issn" => "09598049"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Tosti"
                            1 => "B&#46;M&#46; Piraccini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-4362.1999.00007.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1999"
                        "volumen" => "38"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10515522"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Male pattern alopecia&#46; A histopathologic and histochemical study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Lattanand"
                            1 => "W&#46;C&#46; Johnson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1975.tb00209.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1975"
                        "volumen" => "2"
                        "paginaInicial" => "58"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/777055"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Whiting"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0190-9622(93)70106-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1993"
                        "volumen" => "28"
                        "paginaInicial" => "755"
                        "paginaFinal" => "763"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8496421"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scalp biopsy as a diagnostic and prognostic tool in androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Whiting"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther"
                        "fecha" => "1998"
                        "volumen" => "8"
                        "paginaInicial" => "24"
                        "paginaFinal" => "33"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Whiting"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2001"
                        "volumen" => "45"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "81"
                        "paginaFinal" => "86"
                        "itemHostRev" => array:3 [
                          "pii" => "S0168827818302150"
                          "estado" => "S300"
                          "issn" => "01688278"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections on serial scalp biopsies&#58; Results of finasteride 1<span class="elsevierStyleHsp" style=""></span>mg treatment of men and postmenopausal women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;A&#46; Whiting"
                            1 => "J&#46; Waldstreicher"
                            2 => "M&#46; Sanchez"
                            3 => "K&#46;D&#46; Kaufman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol Symp Proc"
                        "fecha" => "1999"
                        "volumen" => "4"
                        "paginaInicial" => "282"
                        "paginaFinal" => "284"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia&#58; Histologic diagnosis by transverse sections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;F&#46; Templeton"
                            1 => "D&#46;J&#46; Santa Cruz"
                            2 => "A&#46;R&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Diagn Pathol"
                        "fecha" => "1996"
                        "volumen" => "13"
                        "paginaInicial" => "2"
                        "paginaFinal" => "18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8834512"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology of male pattern alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Abell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1984"
                        "volumen" => "120"
                        "paginaInicial" => "1607"
                        "paginaFinal" => "1608"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histologic response to topically applied minoxidil in male-pattern alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Abell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0738-081x(88)90086-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "1988"
                        "volumen" => "6"
                        "paginaInicial" => "191"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3214821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diseases of the hair and scalp"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Rook"
                            1 => "R&#46; Dawber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1982"
                        "editorial" => "Blackwell Scientific Publications"
                        "editorialLocalizacion" => "Oxford"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The comparative histopathology of male-pattern baldness and senescent baldness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;M&#46; Kligman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0738-081x(88)90074-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "1988"
                        "volumen" => "6"
                        "paginaInicial" => "108"
                        "paginaFinal" => "118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3214816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clue 1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;B&#46; Ackerman"
                            1 => "Y&#46; Guo"
                            2 => "P&#46; Vitale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:6 [
                        "titulo" => "Clues to diagnosis in dermatopathology ii"
                        "fecha" => "1992"
                        "paginaInicial" => "1"
                        "paginaFinal" => "4"
                        "editorial" => "ASCP Press"
                        "editorialLocalizacion" => "Chicago&#44; IL&#44; USA"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair neogenesis in man&#58; A histoquantitative study based on 1&#44;000 scalp biopsies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Schreck-Purola"
                            1 => "B&#46; Lindroos"
                            2 => "R&#46;E&#46;A&#46; Nystr&#246;m"
                            3 => "K&#46; Stel&#228;l&#228;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "C&#46;E&#46;Orfanos, W&#46;Montagna, G&#46;St&#252;ttgen"
                        "titulo" => "Hair research&#46; Status and future aspects"
                        "paginaInicial" => "344"
                        "paginaFinal" => "352"
                        "serieFecha" => "1981"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The value of horizontal sections of scalp biopsies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Whiting"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cutan Aging Cosmet Dermatol"
                        "fecha" => "1990"
                        "volumen" => "1"
                        "paginaInicial" => "165"
                        "paginaFinal" => "173"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous immunopathology of androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;W&#46; Young"
                            1 => "E&#46;T&#46; Conte"
                            2 => "M&#46;L&#46; Leavitt"
                            3 => "M&#46;A&#46; Nafz"
                            4 => "A&#46;L&#46; Schroeter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Osteopath Assoc"
                        "fecha" => "1991"
                        "volumen" => "91"
                        "paginaInicial" => "765"
                        "paginaFinal" => "771"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1744007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of inflammatory infiltrates in male pattern alopecia&#58; Implications for pathogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Jaworsky"
                            1 => "A&#46;M&#46; Kligman"
                            2 => "G&#46;F&#46; Murphy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.1992.tb00121.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1992"
                        "volumen" => "127"
                        "paginaInicial" => "239"
                        "paginaFinal" => "246"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1390168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential patterns of elastic fibers in scarring and non-scarring alopecias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Pinkus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1978.tb00946.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1978"
                        "volumen" => "5"
                        "paginaInicial" => "93"
                        "paginaFinal" => "104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/79579"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1470204520305556"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The interrelation of elastic tissue and human hair follicles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Arao"
                            1 => "E&#46;M&#46; Perkins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "W&#46;Montagna, R&#46;L&#46;Dobson"
                        "titulo" => "Hair growth"
                        "paginaInicial" => "433"
                        "paginaFinal" => "441"
                        "serieFecha" => "1969"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Telogen effluvium&#46; A clinically useful concept&#44; with traction alopecia as an example"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;D&#46; Steck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cutis"
                        "fecha" => "1978"
                        "volumen" => "21"
                        "paginaInicial" => "543"
                        "paginaFinal" => "548"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/639573"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diffuse hair loss"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Sinclair"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-4362.1999.00003.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1999"
                        "volumen" => "38"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "8"
                        "paginaFinal" => "18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10369535"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Telogen effluvium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Harrison"
                            1 => "R&#46; Sinclair"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-2230.2002.01080.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2002"
                        "volumen" => "27"
                        "paginaInicial" => "389"
                        "paginaFinal" => "395"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12190639"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The transversely sectioned scalp biopsy specimen&#58; the technique and an algorithm for its use in the diagnosis of alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;R&#46; Solomon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Dermatol"
                        "fecha" => "1994"
                        "volumen" => "9"
                        "paginaInicial" => "127"
                        "paginaFinal" => "157"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8060734"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Telogen effluvium&#46; New concepts and review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.129.3.356"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1993"
                        "volumen" => "129"
                        "paginaInicial" => "356"
                        "paginaFinal" => "363"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transverse anatomy of telogen effluvium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Ass Milit Dermatol"
                        "fecha" => "1990"
                        "volumen" => "16"
                        "paginaInicial" => "3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of clinical and histologic correlations in alopecia areata and telogen effluvium&#58; Adversities in alopecia pattern mimicry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cutis"
                        "fecha" => "2013"
                        "volumen" => "91"
                        "paginaInicial" => "141"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histopathology of non-scarring alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1995.tb01391.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1995"
                        "volumen" => "22"
                        "paginaInicial" => "97"
                        "paginaFinal" => "114"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and histological challenge in the differential diagnosis of diffuse alopecia&#58; Female androgenetic alopecia&#44; telogen effluvium and alopecia areata-part <span class="elsevierStyleSmallCaps">ii</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0365-05962012000600010"
                      "Revista" => array:6 [
                        "tituloSerie" => "An Bras Dermatol"
                        "fecha" => "2012"
                        "volumen" => "87"
                        "paginaInicial" => "884"
                        "paginaFinal" => "890"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic telogen effluvium&#58; Increased scalp hair shedding in middle-aged women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1996"
                        "volumen" => "35"
                        "paginaInicial" => "899"
                        "paginaFinal" => "906"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic telogen effluvium is due to a reduction in the variance of anagen duration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-0960.2010.00654.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Australas J Dermatol"
                        "fecha" => "2010"
                        "volumen" => "51"
                        "paginaInicial" => "163"
                        "paginaFinal" => "167"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Update on chronic telogen effluvium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "1999"
                        "volumen" => "8"
                        "paginaInicial" => "305"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic telogen effluvium&#58; A study of 5 patients over 7 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2004.05.040"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "12"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0675"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2000"
                        "volumen" => "42"
                        "paginaInicial" => "549"
                        "paginaFinal" => "566"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0680"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.det.2012.08.010"
                      "Revista" => array:7 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "2013"
                        "volumen" => "31"
                        "paginaInicial" => "93"
                        "paginaFinal" => "108"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673609604840"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0685"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "E&#46;A&#46;Olsen"
                        "titulo" => "Disorders of hair growth&#58; Diagnosis and treatment"
                        "paginaInicial" => "195"
                        "paginaFinal" => "222"
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0690"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased ratio of helper to suppressor T cells in alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.1984.tb07463.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1984"
                        "volumen" => "110"
                        "paginaInicial" => "171"
                        "paginaFinal" => "175"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S147020452030557X"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0695"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistochemical and electron microscopic characterization of the cellular infiltrate in alopecia &#40;areata&#44; totalis&#44; and universalis&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1523-1747.ep12261627"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1984"
                        "volumen" => "83"
                        "paginaInicial" => "7"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0700"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "T cell subpopulations in alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0190-9622(84)70152-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1984"
                        "volumen" => "11"
                        "paginaInicial" => "216"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S014067361831078X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0705"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical immunotherapy changes the composition of the peribulbar infiltrate in alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF00412926"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol Res"
                        "fecha" => "1986"
                        "volumen" => "278"
                        "paginaInicial" => "214"
                        "paginaFinal" => "218"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0710"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata&#58; Alterations in the hair growth cycle and correlation with the follicular pathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.1986.tb02825.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1986"
                        "volumen" => "114"
                        "paginaInicial" => "337"
                        "paginaFinal" => "347"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0715"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lesional alopecia areata T lymphocytes downregulate epithelial cell proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s004030050209"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Dermatol Res"
                        "fecha" => "1997"
                        "volumen" => "289"
                        "paginaInicial" => "384"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0168827812007520"
                          "estado" => "S300"
                          "issn" => "01688278"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0720"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histologic features of alopecia areata other than peribulbar lymphocytic infiltrates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2011.02.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2011"
                        "volumen" => "65"
                        "paginaInicial" => "615"
                        "paginaFinal" => "620"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0725"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clue 83"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "B&#46;Ackerman, Y&#46;Guo, P&#46;Vitale"
                        "titulo" => "Clues to diagnosis in dermatopathology <span class="elsevierStyleSmallCaps">ii</span>"
                        "paginaInicial" => "329"
                        "paginaFinal" => "332"
                        "serieFecha" => "1992"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0730"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syringoma-like sweat duct proliferation in scalp alopecias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1990.tb00112.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1990"
                        "volumen" => "17"
                        "paginaInicial" => "355"
                        "paginaFinal" => "357"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0167814019330208"
                          "estado" => "S300"
                          "issn" => "01678140"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0735"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cellular activity in the dermis surrounding the hair bulb in alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1975.tb00172.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1975"
                        "volumen" => "2"
                        "paginaInicial" => "240"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0740"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:6 [
                        "titulo" => "Histologic diagnosis of inflammatory skin diseases"
                        "fecha" => "1978"
                        "paginaInicial" => "696"
                        "paginaFinal" => "701"
                        "editorial" => "Lea and Febiger"
                        "editorialLocalizacion" => "Philadelphia"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0745"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia syphilitica with detection of treponema pallidum in the hair follicle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2007"
                        "volumen" => "1"
                        "numero" => "34 Suppl"
                        "paginaInicial" => "37"
                        "paginaFinal" => "40"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0750"
              "etiqueta" => "69"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The moth-eaten alopecia of secondary syphilis&#46; A histopathological study of 12 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00000372-199504000-00008"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1995"
                        "volumen" => "17"
                        "paginaInicial" => "158"
                        "paginaFinal" => "162"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1470204517300864"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0755"
              "etiqueta" => "70"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia syphilitica&#44; a simulator of alopecia areata&#58; Histopathology and differential diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1991.tb00133.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1991"
                        "volumen" => "18"
                        "paginaInicial" => "87"
                        "paginaFinal" => "92"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1470204515000042"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0760"
              "etiqueta" => "71"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.12788/j.sder.0007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Trichotillomania&#46; Semin Cutan Med Surg"
                        "fecha" => "2013"
                        "volumen" => "32"
                        "paginaInicial" => "88"
                        "paginaFinal" => "94"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib0765"
              "etiqueta" => "72"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichotillomania"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mjd.2002.122749"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "46"
                        "paginaInicial" => "807"
                        "paginaFinal" => "821"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib0770"
              "etiqueta" => "73"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histopathology of alopecia&#58; A clinicopathological approach to diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2559.2009.03439.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Histopathology"
                        "fecha" => "2010"
                        "volumen" => "56"
                        "paginaInicial" => "24"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib0775"
              "etiqueta" => "74"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichotillomania&#46; A clinicopathologic study of 24 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.105.4.535"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1972"
                        "volumen" => "105"
                        "paginaInicial" => "535"
                        "paginaFinal" => "540"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib0780"
              "etiqueta" => "75"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichotillomania&#58; A histopathologic study in sixty-six patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0190-9622(90)70186-l"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1990"
                        "volumen" => "23"
                        "paginaInicial" => "56"
                        "paginaFinal" => "62"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib0785"
              "etiqueta" => "76"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Traumatic alopecia in trichotillomania&#58; A pathogenic interpretation of histologic lesions in the pilosebaceous unit"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.1977.tb00890.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1977"
                        "volumen" => "4"
                        "paginaInicial" => "51"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib0790"
              "etiqueta" => "77"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The combined utilization of clinical and histological findings in the diagnosis of trichotillomania"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1034/j.1600-0560.2002.290403.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2002"
                        "volumen" => "29"
                        "paginaInicial" => "207"
                        "paginaFinal" => "214"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib0795"
              "etiqueta" => "78"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Splitting hairs&#58; The &#8216;hamburger sign&#8217; in trichotillomania"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.2006.00526.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2006"
                        "volumen" => "33"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "63"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib0800"
              "etiqueta" => "79"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious&#44; physical&#44; and inflammatory causes of hair and scalp abnormalities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "E&#46;A&#46;Olsen"
                        "titulo" => "Disorders of hair growth&#58; Diagnosis and treatment"
                        "paginaInicial" => "71"
                        "paginaFinal" => "90"
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            79 => array:3 [
              "identificador" => "bib0805"
              "etiqueta" => "80"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disorders of hair growth in African Americans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "E&#46;A&#46;Olsen"
                        "titulo" => "Disorders of hair growth&#58; Diagnosis and treatment"
                        "paginaInicial" => "389"
                        "paginaFinal" => "407"
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            80 => array:3 [
              "identificador" => "bib0810"
              "etiqueta" => "81"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hot comb alopecia&#47;follicular degeneration syndrome in African-American women is traction alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatopathol Pract Concept"
                        "fecha" => "2000"
                        "volumen" => "6"
                        "paginaInicial" => "320"
                        "paginaFinal" => "336"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000141/v3_202209240641/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6177"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Reviews"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000003/v3_202209240641/S1578219015000141/v3_202209240641/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000141?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 34 9 43
2024 October 461 74 535
2024 September 565 79 644
2024 August 472 91 563
2024 July 460 75 535
2024 June 392 76 468
2024 May 451 97 548
2024 April 382 108 490
2024 March 416 75 491
2024 February 417 75 492
2024 January 458 92 550
2023 December 454 74 528
2023 November 534 99 633
2023 October 530 106 636
2023 September 418 109 527
2023 August 277 51 328
2023 July 334 97 431
2023 June 300 72 372
2023 May 322 94 416
2023 April 261 67 328
2023 March 277 95 372
2023 February 123 71 194
2023 January 166 69 235
2022 December 167 77 244
2022 November 100 49 149
2022 October 76 64 140
2022 September 71 67 138
2022 August 58 70 128
2022 July 69 72 141
2022 June 62 39 101
2022 May 303 130 433
2022 April 366 93 459
2022 March 300 155 455
2022 February 295 105 400
2022 January 337 145 482
2021 December 249 96 345
2021 November 404 113 517
2021 October 692 112 804
2021 September 261 91 352
2021 August 248 81 329
2021 July 220 82 302
2021 June 287 103 390
2021 May 353 50 403
2021 April 694 213 907
2021 March 348 77 425
2021 February 335 49 384
2021 January 199 46 245
2020 December 148 48 196
2020 November 163 57 220
2020 October 116 47 163
2020 September 102 31 133
2020 August 95 41 136
2020 July 97 48 145
2020 June 107 50 157
2020 May 114 53 167
2020 April 79 36 115
2020 March 66 26 92
2020 February 5 2 7
2020 January 4 5 9
2019 December 4 6 10
2019 November 4 9 13
2019 October 0 13 13
2019 September 0 9 9
2019 August 4 7 11
2019 July 4 22 26
2019 June 5 37 42
2019 May 6 107 113
2019 April 3 64 67
2019 March 5 23 28
2019 February 2 19 21
2019 January 7 11 18
2018 December 1 6 7
2018 November 3 0 3
2018 October 10 0 10
2018 September 5 25 30
2018 August 0 96 96
2018 July 0 31 31
2018 June 0 25 25
2018 May 0 24 24
2018 April 0 15 15
2018 March 10 10 20
2018 February 180 27 207
2018 January 356 20 376
2017 December 131 23 154
2017 November 125 32 157
2017 October 106 27 133
2017 September 81 35 116
2017 August 81 33 114
2017 July 51 39 90
2017 June 63 43 106
2017 May 51 43 94
2017 April 50 38 88
2017 March 40 60 100
2017 February 82 40 122
2017 January 56 28 84
2016 December 34 21 55
2016 November 50 42 92
2016 October 30 51 81
2016 September 0 20 20
2016 August 0 25 25
2016 July 9 13 22
2016 June 11 8 19
2016 May 9 6 15
2016 April 11 4 15
2016 March 8 6 14
2016 February 12 3 15
2016 January 3 3 6
2015 December 9 4 13
2015 November 10 9 19
2015 October 5 5 10
2015 September 0 18 18
2015 August 0 12 12
2015 July 14 8 22
2015 June 11 14 25
2015 May 4 23 27
2015 April 4 37 41
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?