Case and Research Letters
Dermoscopic Features of Pagetoid Dyskeratosis of the Palm
Dermatoscopia de la disqueratosis pagetoide palmar
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Loidi, J. Mitxelena, A. Córdoba, I. Yanguas" "autores" => array:4 [ 0 => array:4 [ "nombre" => "L." "apellidos" => "Loidi" "email" => array:1 [ 0 => "leyre.loidi.pascual@navarra.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Mitxelena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Córdoba" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Yanguas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicios de Dermatología, Complejo Hospitalario de Navarra, Pamplona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Complejo Hospitalario de Navarra, Pamplona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatoscopia de la disqueratosis pagetoide palmar" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 569 "Ancho" => 500 "Tamanyo" => 43248 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy of the lesion showing a parallel pattern of the cutaneous ridges.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pagetoid dyskeratosis is a frequent incidental finding in various skin lesions.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 27-year-old woman who consulted for an asymptomatic hyperpigmented lesion that had arisen on the left palm 18 months earlier. Examination revealed a dark brown, hyperpigmented macule measuring 40<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>mm, with well-defined borders and a linear appearance (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Dermoscopy showed a parallel pattern of the cutaneous ridges (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Incisional biopsy of the lesion revealed dyskeratotic cells in a pagetoid pattern (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Based on these findings we made a diagnosis of pagetoid dyskeratosis of the palm. Cryotherapy led to complete resolution of the lesion. After 2 years the patient remains practically asymptomatic. A very faint yellow macule persists at the same site, with no significant alterations on dermoscopy.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Pagetoid dyskeratosis can present clinically as a hyperpigmented macule. A literature search revealed only 3 cases in which this condition affected the palm.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a> To date, the dermoscopic pattern of a lesion located on the hand has only been described in 1 case.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> That patient presented a dark brown macule over the distal phalanx of the fifth finger; the dermoscopic features included a parallel pattern of the cutaneous ridges and a fibrillary pattern that led to the need to exclude palmoplantar melanoma.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of this condition are unknown, although it appears to be related to recurrent friction over the area. The prognosis is good.</p><p id="par0025" class="elsevierStylePara elsevierViewall">On histopathology, dyskeratotic cells are observed together with larger-than-usual, round keratinocytes with pale cytoplasm and a pyknotic nucleus surrounded by a pale halo, in a pagetoid distribution.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The dermoscopy findings in this patient should be noted, as this pattern was suggestive of malignant melanoma, though it was also compatible with a diagnosis of subcorneal hematoma. Pagetoid dyskeratosis must be included in the differential diagnosis of pigmented palmar lesions that show a parallel cutaneous ridge pattern on dermoscopy.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Loidi L, Mitxelena J, Córdoba A, Yanguas I. Dermatoscopia de la disqueratosis pagetoide palmar. Actas Dermosifiliogr. 2014;105:804–805.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 599 "Ancho" => 950 "Tamanyo" => 96433 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hyperpigmented macule with a linear pattern and well-defined borders, located on the palm.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 569 "Ancho" => 500 "Tamanyo" => 43248 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy of the lesion showing a parallel pattern of the cutaneous ridges.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1311 "Ancho" => 950 "Tamanyo" => 475410 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histopathology: dyskeratotic cells in a pagetoid distribution. A, Hematoxylin and eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>200. B, Hematoxylin and eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>400.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pagetoid dyskeratosis: A frequent pitfall in dermatopathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Kanitakis" 1 => "V. 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Delacrétraz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatologica" "fecha" => "1974" "volumen" => "148" "paginaInicial" => "135" "paginaFinal" => "142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4836955" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pagetoid dyskeratosis of the hand" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.C. Wang" 1 => "M.M. Medenica" 2 => "C.R. Shea" 3 => "S. Busbey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0190" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2004" "volumen" => "50" "paginaInicial" => "483" "paginaFinal" => "484" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14988702" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack94289" "titulo" => "Acknowledgments" "texto" => "<p id="par0035" class="elsevierStylePara elsevierViewall">We would like to thank Dr. Luis Requena for his help in reaching the diagnosis of the lesion in this patient.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010500000008/v1_201409260034/S1578219014002145/v1_201409260034/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010500000008/v1_201409260034/S1578219014002145/v1_201409260034/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014002145?idApp=UINPBA000044" ]
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| 2022 April | 108 | 43 | 151 |
| 2022 March | 57 | 41 | 98 |
| 2022 February | 63 | 22 | 85 |
| 2022 January | 55 | 33 | 88 |
| 2021 December | 57 | 27 | 84 |
| 2021 November | 58 | 55 | 113 |
| 2021 October | 49 | 47 | 96 |
| 2021 September | 62 | 30 | 92 |
| 2021 August | 65 | 43 | 108 |
| 2021 July | 38 | 28 | 66 |
| 2021 June | 70 | 24 | 94 |
| 2021 May | 64 | 34 | 98 |
| 2021 April | 92 | 43 | 135 |
| 2021 March | 82 | 11 | 93 |
| 2021 February | 81 | 30 | 111 |
| 2021 January | 55 | 15 | 70 |
| 2020 December | 26 | 13 | 39 |
| 2020 November | 30 | 9 | 39 |
| 2020 October | 37 | 8 | 45 |
| 2020 September | 51 | 7 | 58 |
| 2020 August | 11 | 10 | 21 |
| 2020 July | 35 | 17 | 52 |
| 2020 June | 46 | 20 | 66 |
| 2020 May | 26 | 7 | 33 |
| 2020 April | 33 | 16 | 49 |
| 2020 March | 33 | 16 | 49 |
| 2020 February | 1 | 3 | 4 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 10 | 0 | 10 |
| 2019 November | 4 | 0 | 4 |
| 2019 October | 0 | 1 | 1 |
| 2019 September | 5 | 1 | 6 |
| 2019 August | 4 | 0 | 4 |
| 2019 July | 8 | 1 | 9 |
| 2019 June | 4 | 6 | 10 |
| 2019 May | 6 | 19 | 25 |
| 2019 April | 4 | 2 | 6 |
| 2019 March | 4 | 6 | 10 |
| 2019 February | 10 | 0 | 10 |
| 2019 January | 3 | 0 | 3 |
| 2018 December | 2 | 0 | 2 |
| 2018 November | 4 | 0 | 4 |
| 2018 October | 7 | 2 | 9 |
| 2018 September | 1 | 0 | 1 |
| 2018 March | 1 | 0 | 1 |
| 2018 February | 26 | 4 | 30 |
| 2018 January | 43 | 9 | 52 |
| 2017 December | 43 | 5 | 48 |
| 2017 November | 36 | 2 | 38 |
| 2017 October | 39 | 4 | 43 |
| 2017 September | 30 | 2 | 32 |
| 2017 August | 34 | 6 | 40 |
| 2017 July | 31 | 7 | 38 |
| 2017 June | 44 | 12 | 56 |
| 2017 May | 31 | 9 | 40 |
| 2017 April | 32 | 11 | 43 |
| 2017 March | 26 | 7 | 33 |
| 2017 February | 60 | 4 | 64 |
| 2017 January | 138 | 6 | 144 |
| 2016 December | 29 | 15 | 44 |
| 2016 November | 38 | 13 | 51 |
| 2016 October | 31 | 9 | 40 |
| 2016 September | 1 | 5 | 6 |
| 2016 August | 0 | 6 | 6 |
| 2016 July | 3 | 1 | 4 |
| 2016 June | 10 | 2 | 12 |
| 2016 May | 15 | 10 | 25 |
| 2016 April | 6 | 4 | 10 |
| 2016 March | 3 | 9 | 12 |
| 2016 February | 9 | 1 | 10 |
| 2016 January | 4 | 11 | 15 |
| 2015 December | 8 | 3 | 11 |
| 2015 November | 13 | 0 | 13 |
| 2015 October | 10 | 1 | 11 |
| 2015 September | 2 | 2 | 4 |
| 2015 August | 10 | 2 | 12 |
| 2015 July | 37 | 3 | 40 |
| 2015 June | 28 | 3 | 31 |
| 2015 May | 44 | 7 | 51 |
| 2015 April | 17 | 4 | 21 |
| 2015 March | 7 | 7 | 14 |
| 2015 February | 7 | 4 | 11 |
| 2015 January | 14 | 1 | 15 |
| 2014 December | 6 | 2 | 8 |
| 2014 November | 6 | 2 | 8 |
| 2014 October | 12 | 0 | 12 |
Show all
