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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The prevalence of a specific skin disease is very important&#58; it enables us to prioritize resources&#44; favors the design of epidemiological and clinical studies&#44; and makes it possible to calculate the impact of the disease and its treatment on costs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The results of a study performed 15 years ago showed the prevalence of psoriasis in Spain to be 1&#46;4&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In the last 10 years&#44; the advent of biologics has revolutionized the treatment of psoriasis by improving the outlook for safety and efficacy with respect to previous treatments&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The widespread use and acceptance of these new therapeutic options&#44; which have developed in line with knowledge of the pathogenesis of the disease&#44; are reflected in the exponential growth in information on psoriasis in both the scientific literature and the general press&#46; Consequently&#44; the number of visits for psoriasis has increased&#44; the disease is more easily recognized in primary care&#44; and access to specialists has improved&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We performed a study of the prevalence of psoriasis in the Spanish population&#46; We also investigated variations according to sex&#44; age group&#44; and geographic distribution &#40;autonomous communities&#41; by comparing our findings with those of the first study on psoriasis in Spain&#44; which was performed 15 years ago&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> immediately after the advent of biologics&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material and Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">The study was performed following the design of population studies and health surveys&#44; that is&#44; by interview&#46; We performed a population-based cross-sectional study using the individual as the primary source of information&#46; The sample was strictly random and representative of the Spanish population&#46; The study was performed between May 21 and September 23&#44; 2013 with the help of the market research company Demom&#233;trica Investigaci&#243;n de Mercados y Opini&#243;n P&#250;blica&#44; Madrid&#44; Spain&#46; Demom&#233;trica collected the data according to the requirements for processing and custody of data in Spain&#39;s Organic Law on the protection of personal data&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The target population comprised households in Spain&#46; No age limit was imposed&#44; and information was collected by computer-assisted telephone interview&#46; Data were entered into a computerized database&#44; and the results were expressed as absolute values and percentages&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">By assuming a prevalence of psoriasis of approximately 2&#37;&#44; we calculated the initial sample size to be 4750 households&#44; which were randomly selected from each stratum of the autonomous community and habitat&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Stratified random sampling was used&#46; The main criterion for stratification was the geographic area &#40;autonomous community&#44; 17 strata&#41; and the size of the town of residence &#40;5 strata&#58; &#60;<span class="elsevierStyleHsp" style=""></span>10 000 inhabitants&#44; 10 000 to 50 000 inhabitants&#44; 50 000 to 100 000 inhabitants&#44; 100 000 to 500 000 inhabitants&#44; and<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>500 000 inhabitants&#41;&#46; Sample allocation was proportional to the size of the population in each stratum formed by the cross between autonomous community and size of the town&#46; The unit of analysis was the household&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The head of the household&#44; his&#47;her partner&#44; or another valid person was contacted to record the age&#44; sex&#44; educational level&#44; and employment status of each member of the household&#46; Cases of psoriasis were then identified by an affirmative response to the following question&#58; &#8220;Could you tell me whether any member of your household has been diagnosed with a disease called psoriasis by a doctor&#63;&#8221; Each person identified as a valid case of psoriasis answered a specific predetermined questionnaire to ascertain the following&#58; type of specialist who diagnosed the disease &#40;dermatologist&#44; general practitioner&#44; or other&#41;&#44; characteristics of the disease &#40;type of psoriasis&#44; age at onset&#44; location of the lesions&#44; degree of activity&#44; severity&#44; treatment received&#44; and response to treatment&#41;&#44; and impact of the disease on quality of life using the Dermatology Life Quality Index&#46; This phase of the interview only applied to the person diagnosed with psoriasis&#46; Responses were not permitted from other members of the household&#46; If the person diagnosed with psoriasis was a minor&#44; the father&#44; mother&#44; or guardian was interviewed&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">If the response to the first question was negative&#44; the interviewee received a description of the signs of the disease as &#8220;reddish patches or excessive flaking of the skin mainly on the elbows&#44; knees&#44; or scalp&#8221; and was asked whether any member of the household had had any of these signs during the previous 12 months&#46; If the answer was &#8220;yes&#44;&#8221; the person was asked whether he&#47;she had visited the doctor&#44; and&#44; if the answer was &#8220;yes&#8221; again&#44; the patient was asked what diagnosis was made&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">The final valid sample comprised 4754 households with a mean size of 2&#46;7 persons per household and a total of 12 711 persons &#40;57&#46;5&#37; were male and 42&#46;5&#37; were female&#41;&#46; The distribution by age group is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46; The sample is representative of the Spanish population&#44; with no differences in terms of age or sex&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Psoriasis was diagnosed by a physician in 307 cases &#40;70&#37; by a dermatologist&#44; 28&#37; by a family physician&#44; and 2&#37; by another specialist or a doctor whose specialty the patient could not remember&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Of these 307 persons with psoriasis&#44; 294 subsequently replied to the specific questionnaire on the characteristics of the disease and perceived quality of life&#46; The calculation of prevalence was performed using only these 294 persons&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Based on these data and the calculations performed during the design of the study&#44; prevalence was estimated at 2&#46;3&#37; &#40;95&#37; confidence interval &#91;CI&#93;&#44; 2&#46;0-2&#46;6&#41;&#46; An additional 2&#46;5&#37; of interviewees answered &#8220;yes&#8221; to the question on the signs of the disease &#40;patches or excessive flaking of the skin on the elbows&#44; knees&#44; or scalp&#41;&#44; even when they denied having received a medical diagnosis of psoriasis&#46; However&#44; 2&#37; had seen a doctor and been diagnosed with a skin disease other than psoriasis&#46; The remaining 0&#46;5&#37; reported that they had never seen a doctor and&#44; therefore&#44; did not have a diagnosis&#59; they were not included in the calculation of prevalence&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The estimated prevalence was greater for males &#40;2&#46;7&#37; &#91;95&#37; CI&#44; 2&#46;2&#37;-3&#46;2&#37;&#93;&#41; than for females &#40;1&#46;9&#37; &#91;95&#37; CI&#44; 1&#46;5&#37;-2&#46;3&#37;&#93;&#41;&#44; with differences in the limit of statistical significance&#46; <a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a> presents the differences in prevalence between the age groups by decade&#46; Values increase until 60-69 years&#44; when they start to decrease&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a> shows the prevalence by autonomous community&#46; Values ranged from 1&#46;7&#37; in Castile-Le&#243;n and Galicia to 4&#46;1&#37; in Cantabria&#46; If we group the autonomous communities into 3 regions according to climate &#40;Mediterranean and south&#44; temperate climate &#91;Canary Islands&#44; Andalusia&#44; Extremadura&#44; Murcia&#44; Valencia&#44; Catalonia&#44; and Balearic Islands&#93;&#59; center&#44; dry and cold climate &#91;Arag&#243;n&#44; Castile-Le&#243;n&#44; Castile-La Mancha&#44; Navarre&#44; and La Rioja&#93;&#59; and north&#44; wet and cold climate &#91;Asturias&#44; Cantabria&#44; Galicia&#44; Basque Country&#93;&#41;&#44; the estimated prevalence was 2&#46;2&#37;&#44; 2&#46;5&#37;&#44; and 2&#46;2&#37;&#44; respectively&#44; with no statistically significant differences between the regions&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">The world prevalence of psoriasis stands at about 2&#37;&#59; however&#44; figures vary widely between countries and geographical areas&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In addition to the influence of genetic&#44; racial&#44; climatic&#44; and environmental differences&#44; the variation in findings is clearly affected by the different study methodologies applied &#40;questionnaires&#44; clinical examination&#44; combination of questionnaire and clinical examination&#44; registry data&#41;&#44; the type of prevalence studied &#40;point prevalence&#44; period prevalence&#44; cumulative prevalence&#41;&#44; the characteristics of the study sample &#40;eg&#44; children only&#44; adults only&#44; and any age group&#41;&#44; and the case definition &#40;self-reported&#44; physician-diagnosed&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The present study is based on a representative sample of the Spanish population with no age restrictions&#46; The study was performed following the design of population studies and health surveys&#44; that is&#44; by interview&#46; In studies of this type&#44; the quality of the data depends essentially on the observer&#44; the content&#44; and the source used&#46; The estimated prevalence obtained&#44; 2&#46;3&#37;&#44; indicates that around 1 080 000 persons in Spain have been diagnosed with psoriasis&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The methodology applied is subject to a series of limitations&#46; First&#44; it is important to take into account reporting bias&#8212;some patients do not know they have the disease&#44; others do know but deny having it&#8212;which is common in skin diseases&#59; this limitation is inherent to the method used and cannot be quantified&#46; Second&#44; the study is also subject to classification bias&#44; since the disease is not reported spontaneously by the patient&#44; but only when he&#47;she is asked whether they have physician-diagnosed psoriasis&#46; Nevertheless&#44; the reliability and validity of the results are guaranteed by the sample size and reinforced by the fact that the informant was always the head of the household or the homemaker&#46; In addition&#44; almost all those cases reported as &#8220;physician-diagnosed psoriasis&#8221; &#40;293 of 307 &#91;95&#46;4&#37;&#93;&#41; were subsequently interviewed using a specific questionnaire on the clinical and epidemiologic characteristics of the disease and their perceived quality of life&#46; Thus&#44; the final prevalence value includes only those persons with physician-diagnosed psoriasis who had responded to the disease-specific questionnaire&#46; In other words&#44; the first contact served as a screening stage and was later contrasted with the person diagnosed with psoriasis&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The results of population-based studies in Europe similar to the present study and including persons of all ages show that cumulative prevalence varies between 0&#46;7&#37; in Scotland<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and 2&#46;9&#37; in Italy&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> with most countries having a prevalence greater than 1&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> These figures are consistent with those found in the present study&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In contrast&#44; a noteworthy difference was found between the data reported here and those recorded in Spain using a similar methodology 15 years ago&#44; when the estimated prevalence was 1&#46;4&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Such a large difference in only 15 years cannot be accounted for by the increasing trend in the incidence of psoriasis reported elsewhere<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> or in its prevalence&#44; as reported in the United States of America<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and in some European countries&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Thus&#44; in Norway&#44; the prevalence doubled in an adult cohort followed for 30 years &#40;1979-2008&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The increased prevalence of psoriasis in a single country has also been pointed out in recent comparisons between previous studies&#44; although in these cases it can be attributed&#44; at least in part&#44; to the different methodologies used&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Our methodology was almost identical to that of the previous study&#59; the diagnostic criteria of the disease have not changed in recent decades&#44; and it would be very difficult to maintain that changes in lifestyle and environmental factors have contributed to an increase in prevalence in such a short time&#46; Although the increase may not be real&#44; it could reflect greater awareness of the disease among physicians and the general public&#46; In this sense&#44; perhaps the most important contributing factor is the development and widespread prescription of biologic agents and their efficacy in treating psoriasis&#46; The increasing use of health care services by the population may also have played a role&#44; albeit a smaller one&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The development of biologics has led to numerous scientific publications and general press articles&#44; as well as refresher courses for dermatologists&#44; family and community medicine physicians&#44; and pharmacists&#46; All of these professionals have considerably improved their knowledge of psoriasis&#44; its diagnosis&#44; and therapeutic options&#46; Consequently&#44; many cases of psoriasis that once went undiagnosed and remained abandoned owing to the lack of genuinely efficacious treatment are now visible&#46; Cases not reported by the patient because of the fear of incomprehension of their disease and the paucity of therapeutic options could also be taken into consideration&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Prevalence was higher in men than in women&#59; this was not the case in the study performed in 2001&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> where prevalence was similar in both sexes&#44; as in most of the population-based studies that do not apply age restrictions&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;14</span></a> However&#44; this difference between the sexes did not reach statistical significance&#44; although it came very close&#46; Few studies of this type have shown statistically significant differences in one sense or another&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;16</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Since life expectancy is only affected by severe forms of psoriasis&#44; prevalence increased continuously&#44; as expected&#44; from the age of 16 years&#44; with values greater than 2&#46;5&#37; after 30 years until 60-69 years&#44; when it began to decrease&#46; The bimodal distribution in age at onset<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> and the increase in late-onset psoriasis highlighted in the literature<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> could play a role in this increased prevalence in older age groups&#46; However&#44; a careful analysis of the prevalence and confidence intervals found for the different age groups in our study reveals a certain degree of stability between 40 and 69 years&#44; although an increasing tendency that is not statistically significant is observed&#46; These findings are closer to those of the previous study&#44; in which the maximum prevalence was found in patients aged 30 to 40 years&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">The prevalence between the different autonomous communities varied between 1&#46;7&#37; in Castile-Le&#243;n and Galicia and 4&#46;1&#37; in Cantabria&#46; However&#44; prevalence was greater than 3&#37; in only 3 autonomous communities&#44; which were those whose sample comprised fewer than 200 interviews &#40;Cantabria&#44; Navarre&#44; and La Rioja&#41;&#46; In these cases&#44; estimation of prevalence is subject to high sampling error&#59; therefore&#44; the results should be interpreted with extreme caution&#46; The nonhomogeneous distribution of prevalence between the different regions of a single country&#44; which is observed mainly in studies from the north of Europe&#44; has been attributed to genetic differences and climatic factors&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;18</span></a> Given that it is difficult to determine such differences between the various Spanish autonomous communities&#44; we grouped autonomous communities into 3 large regions according to their common climatic characteristics&#46; The highest prevalence &#40;2&#46;5&#37;&#41; was observed in the central region&#44; which has a dry and cold climate&#44; although the difference between this region and the other 2 regions&#44; which had a similar prevalence&#44; was not statistically significant&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">This increase of 0&#46;9 percentage points in the prevalence of psoriasis in Spain could have major cost repercussions for the National Health System&#44; considering that it occurred alongside the advent of biologic therapy&#46; It is also important to remember that 20&#37; to 30&#37; of patients with moderate-to-severe psoriasis will require systemic treatment and that many of them will be prescribed biologics during the course of their disease&#44; since the threshold doses after which the risk of organ-specific toxicity becomes considerable are reached in just a few years with traditional systemic treatment&#46; The cost of comorbid conditions associated with moderate-to-severe psoriasis must also be taken into account&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; 2 similar studies &#40;one performed in 1998&#44; immediately before the advent of biologics&#44; and the other 15 years later in 2013&#41; show markedly different values for overall prevalence in Spain&#46; Nevertheless&#44; the comparison of values between age groups and between geographic areas classified according to climate suggests that prevalence remains unchanged&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The increase in prevalence could probably be attributed to the greater visibility of existing cases of psoriasis through comprehensive coverage of the disease in the specialized and general press as a result of widespread use of biologics and appreciation of their therapeutic potential&#46; The increase could also be attributed to better knowledge of the disease among nonspecialist physicians and increased awareness among patients&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Protection of persons and animals</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Confidentiality of data</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors declare that they have followed their hospital&#39;s protocol on the publication of data concerning patients and that all patients included in the study have received sufficient information and have given their written informed consent to participate in the study&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Right to privacy and informed consent</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicts of Interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The prevalence of psoriasis in Spain was estimated to be 1&#46;4&#37; before the advent of biologic agents&#46; Fifteen years later&#44; new therapeutic options based on biologic agents have led to greater awareness of the disease and better understanding&#59; case detection and diagnosis may have improved as a result&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To investigate the current prevalence of psoriasis in Spain and compare the results with those of an earlier study that used the same methodology&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Population-based cross-sectional survey&#46; Information was collected through computer-assisted telephone interviews with a randomly selected representative sample of the Spanish population &#40;12&#44;711 individuals from 4&#44;754 households&#41;&#46; Interviews were conducted by trained personnel using a questionnaire&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The prevalence was 2&#46;3&#37; and there were no statistically significant differences between the sexes&#46; Prevalence increased with age &#40;range with highest prevalence&#44; 60-69 years&#41;&#46; Central Spain&#8212;a region with a cold&#44; dry climate&#8212;had the highest prevalence&#44; but differences between regions were not significant&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Psoriasis is substantially more prevalent in Spain than was previously estimated&#46; The increase in prevalence may reflect greater awareness and better diagnosis of the disease rather than a true increase in number of cases&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de la psoriasis en Espa&#241;a en la era prebiol&#243;gica se estim&#243; en el 1&#44;4&#37;&#46; Quince a&#241;os despu&#233;s la amplia difusi&#243;n y mejor conocimiento de la enfermedad&#44; generada por las nuevas perspectivas terap&#233;uticas aportadas por los agentes biol&#243;gicos&#44; pueden haber mejorado el diagn&#243;stico e identificaci&#243;n de la enfermedad&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Investigar la prevalencia de la psoriasis en Espa&#241;a en el momento actual y comparar los resultados con los obtenidos en un estudio previo realizado con la misma metodolog&#237;a&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Material y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal de base poblacional&#44; utilizando como fuente primaria de informaci&#243;n el individuo&#44; a trav&#233;s de una muestra estrictamente aleatoria y representativa de la poblaci&#243;n espa&#241;ola &#40;12&#46;711 sujetos de 4&#46;754 hogares&#41; con recogida de informaci&#243;n a trav&#233;s de una entrevista telef&#243;nica asistida por ordenador realizada por personal entrenado y utilizando un cuestionario predeterminado&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La prevalencia estimada fue del 2&#44;3&#37;&#44; sin diferencias estad&#237;sticamente significativas entre sexos&#46; La prevalencia en los distintos grupos de edad sigui&#243; una curva ascendente hasta los 60-69 a&#241;os&#46; La prevalencia m&#225;s alta correspondi&#243; a la zona central del pa&#237;s de clima fr&#237;o y seco&#44; aunque sin diferencias significativas con otras regiones&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La cifra de prevalencia de la psoriasis en Espa&#241;a es sensiblemente superior a la estimada en estudios previos&#46; Este incremento podr&#237;a reflejar un mejor conocimiento y diagn&#243;stico de la enfermedad m&#225;s que un aumento real de la prevalencia&#46;</p>"
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Original Article
Prevalence of Psoriasis in Spain in the Age of Biologics
Prevalencia de la psoriasis en España en la era de los agentes biológicos
C. Ferrándiz
Corresponding author
, J.M. Carrascosa, M. Toro
Servicio de Dermatología, Hospital Universitario Germans Trias i Pujol, Universitat Autónoma de Barcelona, Badalona, Barcelona, Spain
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            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Plasma levels of miR-33a and miR-126 in each sample were calculated using the 2-<span class="elsevierStyleSup">&#916;&#916;</span>CT method<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> &#40;see Materials and Methods&#41;&#46; Results are presented as the median and interquartile range in logarithmic scale &#40;base 10&#41;&#46; Anti-logarithmic values are indicated in the vertical axes&#46; The Wilcoxon signed rank test was used to compare the median of the patient group &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#41; with that of the control group &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#41;&#46; Plasma levels of miR-33 expression were lower in controls than in psoriasis patients &#40;a&#41;&#46; Plasma miR-33 levels were quantified in 7 of the 11 controls studied &#40;see Results&#41;&#46; Analyses were performed using Graph-Pad Prism software &#40;version 5&#46;01&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The prevalence of a specific skin disease is very important&#58; it enables us to prioritize resources&#44; favors the design of epidemiological and clinical studies&#44; and makes it possible to calculate the impact of the disease and its treatment on costs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The results of a study performed 15 years ago showed the prevalence of psoriasis in Spain to be 1&#46;4&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In the last 10 years&#44; the advent of biologics has revolutionized the treatment of psoriasis by improving the outlook for safety and efficacy with respect to previous treatments&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The widespread use and acceptance of these new therapeutic options&#44; which have developed in line with knowledge of the pathogenesis of the disease&#44; are reflected in the exponential growth in information on psoriasis in both the scientific literature and the general press&#46; Consequently&#44; the number of visits for psoriasis has increased&#44; the disease is more easily recognized in primary care&#44; and access to specialists has improved&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We performed a study of the prevalence of psoriasis in the Spanish population&#46; We also investigated variations according to sex&#44; age group&#44; and geographic distribution &#40;autonomous communities&#41; by comparing our findings with those of the first study on psoriasis in Spain&#44; which was performed 15 years ago&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> immediately after the advent of biologics&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material and Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">The study was performed following the design of population studies and health surveys&#44; that is&#44; by interview&#46; We performed a population-based cross-sectional study using the individual as the primary source of information&#46; The sample was strictly random and representative of the Spanish population&#46; The study was performed between May 21 and September 23&#44; 2013 with the help of the market research company Demom&#233;trica Investigaci&#243;n de Mercados y Opini&#243;n P&#250;blica&#44; Madrid&#44; Spain&#46; Demom&#233;trica collected the data according to the requirements for processing and custody of data in Spain&#39;s Organic Law on the protection of personal data&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The target population comprised households in Spain&#46; No age limit was imposed&#44; and information was collected by computer-assisted telephone interview&#46; Data were entered into a computerized database&#44; and the results were expressed as absolute values and percentages&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">By assuming a prevalence of psoriasis of approximately 2&#37;&#44; we calculated the initial sample size to be 4750 households&#44; which were randomly selected from each stratum of the autonomous community and habitat&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Stratified random sampling was used&#46; The main criterion for stratification was the geographic area &#40;autonomous community&#44; 17 strata&#41; and the size of the town of residence &#40;5 strata&#58; &#60;<span class="elsevierStyleHsp" style=""></span>10 000 inhabitants&#44; 10 000 to 50 000 inhabitants&#44; 50 000 to 100 000 inhabitants&#44; 100 000 to 500 000 inhabitants&#44; and<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>500 000 inhabitants&#41;&#46; Sample allocation was proportional to the size of the population in each stratum formed by the cross between autonomous community and size of the town&#46; The unit of analysis was the household&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The head of the household&#44; his&#47;her partner&#44; or another valid person was contacted to record the age&#44; sex&#44; educational level&#44; and employment status of each member of the household&#46; Cases of psoriasis were then identified by an affirmative response to the following question&#58; &#8220;Could you tell me whether any member of your household has been diagnosed with a disease called psoriasis by a doctor&#63;&#8221; Each person identified as a valid case of psoriasis answered a specific predetermined questionnaire to ascertain the following&#58; type of specialist who diagnosed the disease &#40;dermatologist&#44; general practitioner&#44; or other&#41;&#44; characteristics of the disease &#40;type of psoriasis&#44; age at onset&#44; location of the lesions&#44; degree of activity&#44; severity&#44; treatment received&#44; and response to treatment&#41;&#44; and impact of the disease on quality of life using the Dermatology Life Quality Index&#46; This phase of the interview only applied to the person diagnosed with psoriasis&#46; Responses were not permitted from other members of the household&#46; If the person diagnosed with psoriasis was a minor&#44; the father&#44; mother&#44; or guardian was interviewed&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">If the response to the first question was negative&#44; the interviewee received a description of the signs of the disease as &#8220;reddish patches or excessive flaking of the skin mainly on the elbows&#44; knees&#44; or scalp&#8221; and was asked whether any member of the household had had any of these signs during the previous 12 months&#46; If the answer was &#8220;yes&#44;&#8221; the person was asked whether he&#47;she had visited the doctor&#44; and&#44; if the answer was &#8220;yes&#8221; again&#44; the patient was asked what diagnosis was made&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">The final valid sample comprised 4754 households with a mean size of 2&#46;7 persons per household and a total of 12 711 persons &#40;57&#46;5&#37; were male and 42&#46;5&#37; were female&#41;&#46; The distribution by age group is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46; The sample is representative of the Spanish population&#44; with no differences in terms of age or sex&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Psoriasis was diagnosed by a physician in 307 cases &#40;70&#37; by a dermatologist&#44; 28&#37; by a family physician&#44; and 2&#37; by another specialist or a doctor whose specialty the patient could not remember&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Of these 307 persons with psoriasis&#44; 294 subsequently replied to the specific questionnaire on the characteristics of the disease and perceived quality of life&#46; The calculation of prevalence was performed using only these 294 persons&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Based on these data and the calculations performed during the design of the study&#44; prevalence was estimated at 2&#46;3&#37; &#40;95&#37; confidence interval &#91;CI&#93;&#44; 2&#46;0-2&#46;6&#41;&#46; An additional 2&#46;5&#37; of interviewees answered &#8220;yes&#8221; to the question on the signs of the disease &#40;patches or excessive flaking of the skin on the elbows&#44; knees&#44; or scalp&#41;&#44; even when they denied having received a medical diagnosis of psoriasis&#46; However&#44; 2&#37; had seen a doctor and been diagnosed with a skin disease other than psoriasis&#46; The remaining 0&#46;5&#37; reported that they had never seen a doctor and&#44; therefore&#44; did not have a diagnosis&#59; they were not included in the calculation of prevalence&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The estimated prevalence was greater for males &#40;2&#46;7&#37; &#91;95&#37; CI&#44; 2&#46;2&#37;-3&#46;2&#37;&#93;&#41; than for females &#40;1&#46;9&#37; &#91;95&#37; CI&#44; 1&#46;5&#37;-2&#46;3&#37;&#93;&#41;&#44; with differences in the limit of statistical significance&#46; <a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a> presents the differences in prevalence between the age groups by decade&#46; Values increase until 60-69 years&#44; when they start to decrease&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0015">Figure 3</a> shows the prevalence by autonomous community&#46; Values ranged from 1&#46;7&#37; in Castile-Le&#243;n and Galicia to 4&#46;1&#37; in Cantabria&#46; If we group the autonomous communities into 3 regions according to climate &#40;Mediterranean and south&#44; temperate climate &#91;Canary Islands&#44; Andalusia&#44; Extremadura&#44; Murcia&#44; Valencia&#44; Catalonia&#44; and Balearic Islands&#93;&#59; center&#44; dry and cold climate &#91;Arag&#243;n&#44; Castile-Le&#243;n&#44; Castile-La Mancha&#44; Navarre&#44; and La Rioja&#93;&#59; and north&#44; wet and cold climate &#91;Asturias&#44; Cantabria&#44; Galicia&#44; Basque Country&#93;&#41;&#44; the estimated prevalence was 2&#46;2&#37;&#44; 2&#46;5&#37;&#44; and 2&#46;2&#37;&#44; respectively&#44; with no statistically significant differences between the regions&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">The world prevalence of psoriasis stands at about 2&#37;&#59; however&#44; figures vary widely between countries and geographical areas&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In addition to the influence of genetic&#44; racial&#44; climatic&#44; and environmental differences&#44; the variation in findings is clearly affected by the different study methodologies applied &#40;questionnaires&#44; clinical examination&#44; combination of questionnaire and clinical examination&#44; registry data&#41;&#44; the type of prevalence studied &#40;point prevalence&#44; period prevalence&#44; cumulative prevalence&#41;&#44; the characteristics of the study sample &#40;eg&#44; children only&#44; adults only&#44; and any age group&#41;&#44; and the case definition &#40;self-reported&#44; physician-diagnosed&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The present study is based on a representative sample of the Spanish population with no age restrictions&#46; The study was performed following the design of population studies and health surveys&#44; that is&#44; by interview&#46; In studies of this type&#44; the quality of the data depends essentially on the observer&#44; the content&#44; and the source used&#46; The estimated prevalence obtained&#44; 2&#46;3&#37;&#44; indicates that around 1 080 000 persons in Spain have been diagnosed with psoriasis&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The methodology applied is subject to a series of limitations&#46; First&#44; it is important to take into account reporting bias&#8212;some patients do not know they have the disease&#44; others do know but deny having it&#8212;which is common in skin diseases&#59; this limitation is inherent to the method used and cannot be quantified&#46; Second&#44; the study is also subject to classification bias&#44; since the disease is not reported spontaneously by the patient&#44; but only when he&#47;she is asked whether they have physician-diagnosed psoriasis&#46; Nevertheless&#44; the reliability and validity of the results are guaranteed by the sample size and reinforced by the fact that the informant was always the head of the household or the homemaker&#46; In addition&#44; almost all those cases reported as &#8220;physician-diagnosed psoriasis&#8221; &#40;293 of 307 &#91;95&#46;4&#37;&#93;&#41; were subsequently interviewed using a specific questionnaire on the clinical and epidemiologic characteristics of the disease and their perceived quality of life&#46; Thus&#44; the final prevalence value includes only those persons with physician-diagnosed psoriasis who had responded to the disease-specific questionnaire&#46; In other words&#44; the first contact served as a screening stage and was later contrasted with the person diagnosed with psoriasis&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The results of population-based studies in Europe similar to the present study and including persons of all ages show that cumulative prevalence varies between 0&#46;7&#37; in Scotland<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and 2&#46;9&#37; in Italy&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> with most countries having a prevalence greater than 1&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> These figures are consistent with those found in the present study&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In contrast&#44; a noteworthy difference was found between the data reported here and those recorded in Spain using a similar methodology 15 years ago&#44; when the estimated prevalence was 1&#46;4&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Such a large difference in only 15 years cannot be accounted for by the increasing trend in the incidence of psoriasis reported elsewhere<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> or in its prevalence&#44; as reported in the United States of America<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and in some European countries&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Thus&#44; in Norway&#44; the prevalence doubled in an adult cohort followed for 30 years &#40;1979-2008&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The increased prevalence of psoriasis in a single country has also been pointed out in recent comparisons between previous studies&#44; although in these cases it can be attributed&#44; at least in part&#44; to the different methodologies used&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Our methodology was almost identical to that of the previous study&#59; the diagnostic criteria of the disease have not changed in recent decades&#44; and it would be very difficult to maintain that changes in lifestyle and environmental factors have contributed to an increase in prevalence in such a short time&#46; Although the increase may not be real&#44; it could reflect greater awareness of the disease among physicians and the general public&#46; In this sense&#44; perhaps the most important contributing factor is the development and widespread prescription of biologic agents and their efficacy in treating psoriasis&#46; The increasing use of health care services by the population may also have played a role&#44; albeit a smaller one&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The development of biologics has led to numerous scientific publications and general press articles&#44; as well as refresher courses for dermatologists&#44; family and community medicine physicians&#44; and pharmacists&#46; All of these professionals have considerably improved their knowledge of psoriasis&#44; its diagnosis&#44; and therapeutic options&#46; Consequently&#44; many cases of psoriasis that once went undiagnosed and remained abandoned owing to the lack of genuinely efficacious treatment are now visible&#46; Cases not reported by the patient because of the fear of incomprehension of their disease and the paucity of therapeutic options could also be taken into consideration&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Prevalence was higher in men than in women&#59; this was not the case in the study performed in 2001&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> where prevalence was similar in both sexes&#44; as in most of the population-based studies that do not apply age restrictions&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;14</span></a> However&#44; this difference between the sexes did not reach statistical significance&#44; although it came very close&#46; Few studies of this type have shown statistically significant differences in one sense or another&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;16</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Since life expectancy is only affected by severe forms of psoriasis&#44; prevalence increased continuously&#44; as expected&#44; from the age of 16 years&#44; with values greater than 2&#46;5&#37; after 30 years until 60-69 years&#44; when it began to decrease&#46; The bimodal distribution in age at onset<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> and the increase in late-onset psoriasis highlighted in the literature<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> could play a role in this increased prevalence in older age groups&#46; However&#44; a careful analysis of the prevalence and confidence intervals found for the different age groups in our study reveals a certain degree of stability between 40 and 69 years&#44; although an increasing tendency that is not statistically significant is observed&#46; These findings are closer to those of the previous study&#44; in which the maximum prevalence was found in patients aged 30 to 40 years&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">The prevalence between the different autonomous communities varied between 1&#46;7&#37; in Castile-Le&#243;n and Galicia and 4&#46;1&#37; in Cantabria&#46; However&#44; prevalence was greater than 3&#37; in only 3 autonomous communities&#44; which were those whose sample comprised fewer than 200 interviews &#40;Cantabria&#44; Navarre&#44; and La Rioja&#41;&#46; In these cases&#44; estimation of prevalence is subject to high sampling error&#59; therefore&#44; the results should be interpreted with extreme caution&#46; The nonhomogeneous distribution of prevalence between the different regions of a single country&#44; which is observed mainly in studies from the north of Europe&#44; has been attributed to genetic differences and climatic factors&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;18</span></a> Given that it is difficult to determine such differences between the various Spanish autonomous communities&#44; we grouped autonomous communities into 3 large regions according to their common climatic characteristics&#46; The highest prevalence &#40;2&#46;5&#37;&#41; was observed in the central region&#44; which has a dry and cold climate&#44; although the difference between this region and the other 2 regions&#44; which had a similar prevalence&#44; was not statistically significant&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">This increase of 0&#46;9 percentage points in the prevalence of psoriasis in Spain could have major cost repercussions for the National Health System&#44; considering that it occurred alongside the advent of biologic therapy&#46; It is also important to remember that 20&#37; to 30&#37; of patients with moderate-to-severe psoriasis will require systemic treatment and that many of them will be prescribed biologics during the course of their disease&#44; since the threshold doses after which the risk of organ-specific toxicity becomes considerable are reached in just a few years with traditional systemic treatment&#46; The cost of comorbid conditions associated with moderate-to-severe psoriasis must also be taken into account&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; 2 similar studies &#40;one performed in 1998&#44; immediately before the advent of biologics&#44; and the other 15 years later in 2013&#41; show markedly different values for overall prevalence in Spain&#46; Nevertheless&#44; the comparison of values between age groups and between geographic areas classified according to climate suggests that prevalence remains unchanged&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The increase in prevalence could probably be attributed to the greater visibility of existing cases of psoriasis through comprehensive coverage of the disease in the specialized and general press as a result of widespread use of biologics and appreciation of their therapeutic potential&#46; The increase could also be attributed to better knowledge of the disease among nonspecialist physicians and increased awareness among patients&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Protection of persons and animals</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Confidentiality of data</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors declare that they have followed their hospital&#39;s protocol on the publication of data concerning patients and that all patients included in the study have received sufficient information and have given their written informed consent to participate in the study&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Right to privacy and informed consent</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicts of Interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The prevalence of psoriasis in Spain was estimated to be 1&#46;4&#37; before the advent of biologic agents&#46; Fifteen years later&#44; new therapeutic options based on biologic agents have led to greater awareness of the disease and better understanding&#59; case detection and diagnosis may have improved as a result&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To investigate the current prevalence of psoriasis in Spain and compare the results with those of an earlier study that used the same methodology&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Population-based cross-sectional survey&#46; Information was collected through computer-assisted telephone interviews with a randomly selected representative sample of the Spanish population &#40;12&#44;711 individuals from 4&#44;754 households&#41;&#46; Interviews were conducted by trained personnel using a questionnaire&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The prevalence was 2&#46;3&#37; and there were no statistically significant differences between the sexes&#46; Prevalence increased with age &#40;range with highest prevalence&#44; 60-69 years&#41;&#46; Central Spain&#8212;a region with a cold&#44; dry climate&#8212;had the highest prevalence&#44; but differences between regions were not significant&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Psoriasis is substantially more prevalent in Spain than was previously estimated&#46; The increase in prevalence may reflect greater awareness and better diagnosis of the disease rather than a true increase in number of cases&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de la psoriasis en Espa&#241;a en la era prebiol&#243;gica se estim&#243; en el 1&#44;4&#37;&#46; Quince a&#241;os despu&#233;s la amplia difusi&#243;n y mejor conocimiento de la enfermedad&#44; generada por las nuevas perspectivas terap&#233;uticas aportadas por los agentes biol&#243;gicos&#44; pueden haber mejorado el diagn&#243;stico e identificaci&#243;n de la enfermedad&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Investigar la prevalencia de la psoriasis en Espa&#241;a en el momento actual y comparar los resultados con los obtenidos en un estudio previo realizado con la misma metodolog&#237;a&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Material y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal de base poblacional&#44; utilizando como fuente primaria de informaci&#243;n el individuo&#44; a trav&#233;s de una muestra estrictamente aleatoria y representativa de la poblaci&#243;n espa&#241;ola &#40;12&#46;711 sujetos de 4&#46;754 hogares&#41; con recogida de informaci&#243;n a trav&#233;s de una entrevista telef&#243;nica asistida por ordenador realizada por personal entrenado y utilizando un cuestionario predeterminado&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La prevalencia estimada fue del 2&#44;3&#37;&#44; sin diferencias estad&#237;sticamente significativas entre sexos&#46; La prevalencia en los distintos grupos de edad sigui&#243; una curva ascendente hasta los 60-69 a&#241;os&#46; La prevalencia m&#225;s alta correspondi&#243; a la zona central del pa&#237;s de clima fr&#237;o y seco&#44; aunque sin diferencias significativas con otras regiones&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La cifra de prevalencia de la psoriasis en Espa&#241;a es sensiblemente superior a la estimada en estudios previos&#46; Este incremento podr&#237;a reflejar un mejor conocimiento y diagn&#243;stico de la enfermedad m&#225;s que un aumento real de la prevalencia&#46;</p>"
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Article information
ISSN: 15782190
Original language: English
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2023 November 120 39 159
2023 October 84 40 124
2023 September 93 43 136
2023 August 84 18 102
2023 July 94 49 143
2023 June 95 43 138
2023 May 102 42 144
2023 April 59 24 83
2023 March 93 38 131
2023 February 86 30 116
2023 January 49 36 85
2022 December 98 55 153
2022 November 60 34 94
2022 October 71 46 117
2022 September 45 44 89
2022 August 47 45 92
2022 July 37 46 83
2022 June 35 42 77
2022 May 85 81 166
2022 April 131 43 174
2022 March 149 69 218
2022 February 126 46 172
2022 January 142 47 189
2021 December 65 41 106
2021 November 97 56 153
2021 October 66 60 126
2021 September 65 44 109
2021 August 94 34 128
2021 July 83 39 122
2021 June 57 39 96
2021 May 53 36 89
2021 April 116 75 191
2021 March 126 29 155
2021 February 101 43 144
2021 January 60 33 93
2020 December 68 14 82
2020 November 47 25 72
2020 October 58 15 73
2020 September 53 21 74
2020 August 39 15 54
2020 July 36 22 58
2020 June 49 29 78
2020 May 56 26 82
2020 April 41 21 62
2020 March 39 22 61
2020 February 6 0 6
2019 December 2 3 5
2019 October 0 3 3
2019 September 4 0 4
2019 August 0 1 1
2019 June 2 5 7
2019 May 2 7 9
2019 April 0 4 4
2019 March 2 6 8
2019 February 1 0 1
2019 January 2 0 2
2018 December 1 0 1
2018 November 18 2 20
2018 October 4 0 4
2018 September 3 2 5
2018 June 0 7 7
2018 May 0 6 6
2018 April 0 1 1
2018 March 18 7 25
2018 February 87 10 97
2018 January 80 10 90
2017 December 56 12 68
2017 November 60 9 69
2017 October 45 14 59
2017 September 55 13 68
2017 August 50 11 61
2017 July 56 27 83
2017 June 84 19 103
2017 May 78 15 93
2017 April 60 15 75
2017 March 50 18 68
2017 February 36 13 49
2017 January 32 15 47
2016 December 47 18 65
2016 November 53 22 75
2016 October 49 16 65
2016 September 58 16 74
2016 August 54 10 64
2016 July 53 15 68
2016 June 5 15 20
2016 May 1 5 6
2016 April 5 8 13
2016 March 8 11 19
2016 February 5 6 11
2016 January 14 4 18
2015 December 4 4 8
2015 November 6 4 10
2015 October 2 4 6
2015 September 3 5 8
2015 August 5 1 6
2015 July 35 1 36
2015 June 34 6 40
2015 May 32 4 36
2015 April 28 12 40
2015 March 33 2 35
2015 February 24 3 27
2015 January 23 2 25
2014 December 32 11 43
2014 November 19 10 29
2014 October 24 3 27
2014 September 14 5 19
2014 August 15 16 31
2014 July 16 6 22
2014 June 13 8 21
2014 May 2 3 5
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Idiomas
Actas Dermo-Sifiliográficas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?