Cutaneous Metastases of Internal Tumors | Actas Dermo-Sifiliográficas

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A. Metástasis zosteriforme de un adenocarcinoma ductal de mama. Pápulas infiltradas, agrupadas en racimo y confluentes, algunas ulceradas con distribución metamérica. B. Metástasis umbilical (nódulo de la hermana María José). Múltiples pápulas y nódulos, confluentes, con ulceración en la región umbilical y periumbilical. C. Metástasis alopécica. Placa alopécica en una mujer, correspondiente a una metástasis de adenocarcinoma ductal mamario. D. Metástasis subungueal. Nódulo inflamatorio doloroso, con deformidad en la región de la falange distal, en el segundo dedo de la mano izquierda, correspondiente a una metástasis de carcinoma epidermoide pulmonar." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.C. Fernández-Antón Martínez, V. Parra-Blanco, J.A. Avilés Izquierdo, R.M. Suárez Fernández" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.C." "apellidos" => "Fernández-Antón Martínez" ] 1 => array:2 [ "nombre" => "V." 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Fernández-Antón Martínez, V. Parra-Blanco, J.A. Avilés Izquierdo, R.M. Suárez Fernández" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M.C." "apellidos" => "Fernández-Antón Martínez" "email" => array:1 [ 0 => "carmenfernandezanton@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "¿" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "V." "apellidos" => "Parra-Blanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.A." "apellidos" => "Avilés Izquierdo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "R.M." "apellidos" => "Suárez Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metástasis cutáneas de origen visceral" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 877 "Ancho" => 2500 "Tamanyo" => 254790 ] ] "descripcion" => array:1 [ "en" => "Skin metastases can manifest as primary or secondary skin lesions. A, Metastasis from a gastric adenocarcinoma. Papule of 7mm diameter on the abdomen. B, Metastasis from an adenocarcinoma of the ovary presenting as a plaque. C, Metastasis from a urothelial carcinoma of the bladder presenting as a nodule. D, Metastasis from an adenocarcinoma of the breast. The lesion started as a macule over the mastectomy scar. E, Ulcerated infiltrated plaque corresponding to a metastasis from an adenocarcinoma of the lung." ] ] ] "textoCompleto" => "IntroductionThe presence of metastases is one of the characteristics of malignant tumors that is a threat to the life of the patient and incontrovertibly signals the existence of a systemic disease.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> Considerable advances have been made in recent years in our understanding of how tumor cells circulating in the blood and in the lymphatic system are able to interact with and pass through the endothelium to reach distant sites, and of the properties that determine whether the cells of these disseminated tumors are able to survive and whether they will remain in a latent state or will be able to form macrometastases.<a class="elsevierStyleCrossRef" href="#bib0010">2</a> New discoveries concerning early metastatic seeding, parallel progression, self-seeding of circulating tumor cells from the primary tumor, and the induction of premetastatic niches in organs at a distance from the primary tumor are now at the forefront of research.<a class="elsevierStyleCrossRef" href="#bib0015">3</a>Skin metastases (SMs) are the result of infiltration of the skin by proliferations of cells from distant malignant tumors.<a class="elsevierStyleCrossRefs" href="#bib0020">4,5</a> The early detection of metastases within the body often requires sophisticated additional tests; however, SMs are usually easily observed on careful, targeted physical examination. Up to a third of SMs are diagnosed before or simultaneously with the primary tumor, and the role of the dermatologist in establishing an adequate clinical suspicion<a class="elsevierStyleCrossRefs" href="#bib0030">6,7</a> is essential.<a class="elsevierStyleCrossRef" href="#bib0040">8</a> The early clinical recognition of SMs is crucial, as it can lead to the diagnosis of a previously unidentified primary malignant tumor, provide evidence of the dissemination of a previously known tumor, or be an early sign of recurrence of a malignant tumor apparently in remission. The diagnosis of SMs can therefore alter the staging of a malignant disease, with the consequent therapeutic and prognostic implications<a class="elsevierStyleCrossRef" href="#bib0045">9</a>; their presence will often lead to drastic changes in the management plan, particularly when the metastases indicate the persistence of a tumor thought to be in remission.<a class="elsevierStyleCrossRef" href="#bib0050">10</a> Furthermore, SMs are easy to biopsy, which facilitates tests of sensitivity of the primary tumor to specific treatments, such as inhibitors of epidermal growth factor or of c-kit/CD117.<a class="elsevierStyleCrossRef" href="#bib0055">11</a>Some tumors appear to have a predilection to metastasize to certain areas. Recognition of these patterns can help to target the search for an unknown underlying tumor.<a class="elsevierStyleCrossRef" href="#bib0060">12</a>The recent presentation in various countries of a number of retrospective studies of SMs reflects current international interest in this subject.<a class="elsevierStyleCrossRef" href="#bib0065">13</a>Etiology and PathogenesisMetastases arise when neoplastic cells break away from a primary tumor and disseminate to other sites.<a class="elsevierStyleCrossRefs" href="#bib0070">14,15</a> Several mechanisms involving various pathways are implicated in the development of metastases.<a class="elsevierStyleCrossRefs" href="#bib0080">16,17</a> Hematogenous and lymphatic spread are the most common, although separation of these 2 pathways can be difficult as they are interconnected. Lymphatic spread is the most common initial route of propagation of the majority of malignant tumors and its role in the determination of metastatic patterns is a subject of current research.<a class="elsevierStyleCrossRef" href="#bib0090">18</a> Regional spread usually occurs through the body cavities, in particular the peritoneal cavity. Tumor-cell transplant due to the mechanical transport of fragments of tumor on surgical instruments during surgery or other invasive procedures can happen but is rare.<a class="elsevierStyleCrossRefs" href="#bib0095">19,20</a>Traditionally it has been postulated that a series of steps must occur for a metastasis to develop. First, the primary tumor must be large enough to release a sufficient number of neoplastic cells into the circulatory or lymphatic systems. The majority of free neoplastic cells are destroyed by the immune system, whereas groups of 6 or 7 cells appear to have a greater likelihood of forming a metastasis.<a class="elsevierStyleCrossRef" href="#bib0105">21</a> These cells, in turn, must have certain properties, such as cellular suspension and an adequate mitotic index, in order to survive.<a class="elsevierStyleCrossRef" href="#bib0110">22</a> Development of a clone with metastatic potential is initially favored by the activation of specific oncogenes<a class="elsevierStyleCrossRefs" href="#bib0115">23,24</a> and the loss of tumor suppressor genes.<a class="elsevierStyleCrossRefs" href="#bib0125">25,26</a> For neoplastic cells in the circulatory system to become established, they must pass through the vessel walls. After the cells adhere to the vessel wall, a thrombus forms around them due to a lesion of the endothelial cells. This thrombus serves to protect the neoplastic cells. The metastasis becomes established and initially obtains its nutrients by means of diffusion phenomena<a class="elsevierStyleCrossRef" href="#bib0135">27</a>; later it will form its own vessels (angiogenesis).<a class="elsevierStyleCrossRefs" href="#bib0140">28,29</a> In this classical model of cancer development, the metastases correspond to the final stage of the metastatic cascade. However, recent studies suggest a different model, which predicts that the expression of proteins that regulate epithelial-mesenchymal transition promote oncogenesis concomitantly with metastatic spread. In this alternative model, cell spread from the primary tumor can occur at any time during development of the cancer<a class="elsevierStyleCrossRef" href="#bib0150">30</a> (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>EpidemiologyThe true incidence of SMs is unknown. However, the incidence appears to be higher in some recent studies compared with historical series, although this may due to higher rates of biopsy and diagnosis rather than a true increase in the incidence.<a class="elsevierStyleCrossRef" href="#bib0155">31</a> SMs are a rare finding in clinical practice, and their prevalence varies between 0.7% and 9% of patients with internal tumors, depending on the series.<a class="elsevierStyleCrossRef" href="#bib0160">32</a>In theory, any malignant tumor can spread to the skin. However, in practice, a direct relationship has been found between the frequency of different malignant tumors and the appearance of SMs, with the most common malignant tumors in each sex being those that most frequently give rise to SMs. Thus, breast cancer in women, lung cancer in men, and adenocarcinomas of the digestive tract in both sexes are the most common origins of SMs.<a class="elsevierStyleCrossRef" href="#bib0165">33</a>A meta-analysis published in 2003 reviewed 1080 cases of SM in 20 380 cancer patients, and reported an estimated SM rate of 5.3%.<a class="elsevierStyleCrossRef" href="#bib0170">34</a> In a classic study from 1972, Brownstein and Helwig<a class="elsevierStyleCrossRef" href="#bib0060">12</a> examined the distribution of SMs in 724 male and female patients. In men, the most common malignant tumors that metastasized to the skin were carcinoma of the lung (24%), colorectal carcinoma (19%), melanoma (13%), and oral squamous cell carcinoma (12%), whereas, in women, the most common tumors were breast cancer (69%), colorectal carcinoma (9%), melanoma (5%), and carcinoma of the ovary (4%). The area most commonly affected was the anterior chest wall; the lower limbs were the least common sites. In men, around 75% of SMs were observed on the head and neck, whereas, in women, 75% of cases were found on the anterior chest wall and on the abdomen. In general, the back was an uncommon site for SMs.<a class="elsevierStyleCrossRef" href="#bib0175">35</a>In women the most common site of SMs is the thorax, followed by the abdomen, the back, the upper limbs, the scalp, and the neck; in men, the thorax is also the area most commonly affected, followed, in descending order of frequency, by the abdomen, the back, the scalp, the neck, the face, the upper and lower limbs, and the pelvis. The frequency of SMs by age and sex is summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. SMs are very rare in children. The most common primary tumors that produce SMs in this age group are rhabdomyosarcoma and neuroblastoma.<a class="elsevierStyleCrossRef" href="#bib0180">36</a><elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Clinical PresentationIn the majority of cases, SMs develop after diagnosis of the primary tumor. However, in a notable proportion of patients (up to a third of cases), the metastases are discovered prior to<a class="elsevierStyleCrossRef" href="#bib0185">37</a> or simultaneously with<a class="elsevierStyleCrossRef" href="#bib0190">38</a> the primary tumor.SMs tend to appear in a body region close to the primary tumor. Presentation is typically in the form of rapidly growing, mobile, round or oval nodules of firm or elastic consistency<a class="elsevierStyleCrossRef" href="#bib0195">39</a>; they may be ulcerated.<a class="elsevierStyleCrossRef" href="#bib0200">40</a> However, they can present as any primary or secondary skin lesion<a class="elsevierStyleCrossRef" href="#bib0205">41</a> (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The nodules are usually skin-colored, although metastatic nodules from renal cell or thyroid carcinoma often have a characteristic reddish or violaceous discoloration<a class="elsevierStyleCrossRefs" href="#bib0210">42,43</a> (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Some recent studies report that skin metastases present most often as a single nodular lesion, whereas older studies more commonly reported multiple nodules.<a class="elsevierStyleCrossRef" href="#bib0220">44</a> This may be because more SMs are now diagnosed earlier.<elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia>Although most SMs are asymptomatic, patients may describe pain, particularly with lesions in certain areas, such as subungual metastases.<a class="elsevierStyleCrossRef" href="#bib0225">45</a>Gastrointestinal cancers (specifically, colorectal and gastric carcinomas) often give rise to metastases on the abdomen and pelvis. These carcinomas can spread along the urachus to produce umbilical nodules known as Sister Mary Joseph's nodules.<a class="elsevierStyleCrossRef" href="#bib0230">46</a> SMs from squamous cell carcinoma of the oral cavity usually arise in the same body region, and most frequently affect the face and neck. Renal cell carcinoma, among others, typically metastasizes to the scalp and, because it is a highly vascular tumour, the lesions may be confused with hemangiomas or pyogenic granulomas. SMs from hepatocellular carcinoma often develop on the fingers, palms, soles, or the back, while those from gastric carcinoma tend to develop on the head and neck.<a class="elsevierStyleCrossRef" href="#bib0235">47</a> Thus, the site of an SM can suggest a possible origin (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Specific Clinical Forms of SMsA very large number of specific clinical forms of SMs have been described. Erysipeloid or inflammatory carcinoma is often observed in patients with adenocarcinoma of the breast and is not uncommon in other types of cancer (pancreas, rectum, lung, ovary, and parotid).<a class="elsevierStyleCrossRefs" href="#bib0240">48,49</a> It presents as well-defined erythematous lesions that are hot and tender, similar to erysipelas.<a class="elsevierStyleCrossRef" href="#bib0250">50</a> Lymphatic obstruction by the neoplastic cells can give rise to localized lymphedema with peau d’orange. Lymphedema can cause the skin to become fibrous and yellowish, with a similar appearance to carcinoma en cuirasse<a class="elsevierStyleCrossRef" href="#bib0255">51</a> or scirrhous carcinoma. This clinical form presents as indurated erythematous plaques that infiltrate the chest wall. It is usually observed in metastases from breast cancer, although it can be a form of presentation of a primary breast tumor or of SMs of other origins.<a class="elsevierStyleCrossRef" href="#bib0260">52</a> The main differential diagnosis of this presentation is with infectious disorders. Erysipeloid carcinoma localized to the breast can be difficult to distinguish from mastitis. Persistent inflammation that does not respond to conventional therapy must therefore be carefully evaluated to exclude metastatic infiltration, particularly when there is no fever or leukocytosis.<a class="elsevierStyleCrossRef" href="#bib0265">53</a>Telangiectatic carcinoma, described by Weber<a class="elsevierStyleCrossRef" href="#bib0270">54</a> in 1933 in a patient with metastatic breast cancer, is characterized by the appearance of nodules, papules, or purpuric plaques on the chest wall,<a class="elsevierStyleCrossRef" href="#bib0275">55</a> usually in the proximity of a surgical scar.<a class="elsevierStyleCrossRefs" href="#bib0280">56,57</a>Zosteriform or herpetiform metastases present as papules, vesicles, nodules, or blisters affecting individual dermatomes,<a class="elsevierStyleCrossRefs" href="#bib0290">58,59</a> mimicking herpes zoster<a class="elsevierStyleCrossRefs" href="#bib0300">60,61</a> (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). Although their etiology and pathogenesis are not fully understood, most hypotheses suggest there is spread of the tumor cells from the cutaneous lymph vessels to the sensory nerves, via which they reach the dorsal root ganglia.<a class="elsevierStyleCrossRefs" href="#bib0310">62,63</a><elsevierMultimedia ident="fig0020"></elsevierMultimedia>Clown nose is considered to be the result of an SM arising on the tip of the nose, typically from a carcinoma of the lung or breast.<a class="elsevierStyleCrossRef" href="#bib0320">64</a>Alopecia neoplastica is defined as hair loss secondary to invasion of the scalp by malignant cells. It can present as 1 or more plaques of scarring alopecia that are often indurated and have a bluish or violaceous color. These plaques must be differentiated from alopecia areata<a class="elsevierStyleCrossRef" href="#bib0325">65</a> (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). The neoplastic cells can destroy the hair follicles by producing fibroplasia induced by the release of inflammatory mediators that bring inflammatory cells into the area, and/or by substitution of the normal cells.<a class="elsevierStyleCrossRef" href="#bib0330">66</a> Breast cancer is the underlying primary malignant tumor in 84% of patients with alopecia neoplastica.<a class="elsevierStyleCrossRef" href="#bib0335">67</a>Paget's disease of the nipple and areola is a skin sign associated with an underlying adenocarcinoma of the breast in 100% of cases.<a class="elsevierStyleCrossRef" href="#bib0340">68</a> This skin condition is produced by epidermotropic SMs due to the spread of an intraductal tumor along the lactiferous ducts to reach the overlying skin.Subungual metastases merit special consideration. These metastatic lesions are usually painful and often need to be differentiated from infectious disorders, in particular acute paronychia, or from glomus tumors<a class="elsevierStyleCrossRef" href="#bib0345">69</a> (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). Presentation as painless dactylitis has been reported.<a class="elsevierStyleCrossRef" href="#bib0350">70</a>Sister Mary Joseph's nodule or umbilical metastasis is widely described in the literature. This form of metastasis presents as single or multiple, indurated umbilical or periumbilical nodules that can sometimes ulcerate or have a friable appearance (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). Although the site of the primary tumor is unknown in approximately 29% of cases,<a class="elsevierStyleCrossRef" href="#bib0355">71</a> the majority of umbilical metastases come from tumors that arise in the stomach, ovary, colon, rectum, or pancreas.<a class="elsevierStyleCrossRef" href="#bib0360">72</a> The proposed pathogenesis of metastases in the umbilical region includes both contiguous infiltration and spread via the blood or lymph.<a class="elsevierStyleCrossRef" href="#bib0365">73</a>Finally, clinically occult metastases are those with no detectable clinical findings but which are discovered as incidental findings on a histopathological examination performed for some other reason.<a class="elsevierStyleCrossRef" href="#bib0370">74</a>Differential DiagnosisThe differential diagnosis of SMs is very broad and includes many more disorders in addition to those mentioned above. First we must consider primary skin tumors,<a class="elsevierStyleCrossRef" href="#bib0375">75</a> both benign (dermatofibroma, pyogenic granuloma,<a class="elsevierStyleCrossRef" href="#bib0380">76</a> epidermal cyst,<a class="elsevierStyleCrossRef" href="#bib0385">77</a> adnexal tumors<a class="elsevierStyleCrossRef" href="#bib0390">78</a>) and malignant (basal or squamous cell carcinoma, melanoma, Merkel cell tumor, angiosarcoma<a class="elsevierStyleCrossRef" href="#bib0395">79</a>). Other skin diseases to be considered are eczema, erythema annulare centrifugum,<a class="elsevierStyleCrossRef" href="#bib0400">80</a> erythema multiforme [target-shaped SMs], and vasculitis.<a class="elsevierStyleCrossRef" href="#bib0405">81</a>DiagnosisA detailed medical history and complete physical examination are essential to establish the initial diagnostic suspicion.The histopathology of SMs may reveal the same characteristics as the tumor of origin, or there may be a more anaplastic appearance. Immunohistochemistry can help to determine the possible origin in the case of undifferentiated tumors. Incisional or excisional skin biopsy is essential to reach a diagnosis. Cytology study by fine-needle aspiration biopsy can be useful in certain circumstances.<a class="elsevierStyleCrossRefs" href="#bib0410">82,83</a> The pattern observed and the microscopic appearance of the tissue often suggest its origin.<a class="elsevierStyleCrossRef" href="#bib0420">84</a>In some cases, such as renal cell carcinoma, characteristic histological findings will identify the primary tumor, but the majority of SMs can only be classified in general terms as adenocarcinoma, squamous cell carcinoma, or undifferentiated carcinoma. It is also necessary to differentiate between metastatic skin lesions and primary skin tumors; as these 2 types of lesion frequently have very similar morphological patterns, immunohistochemical markers can be very useful for their differentiation. <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> summarizes the results of the literature review published by Sarya et al.<a class="elsevierStyleCrossRef" href="#bib0425">85</a> in 2007.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>Certain histological features differentiate metastases from primary tumors. Characteristics suggestive of SMs include the presence of neoplastic cells within the lymph and blood vessels, localization of the lesion in the deep reticular dermis and hypodermis, and the presence of neoplastic cells running along the bundles of collagen.<a class="elsevierStyleCrossRef" href="#bib0430">86</a> Metastatic tumors typically develop as round nodules located in the dermis or hypodermis, and are not usually in contact with the epidermis. This Grenz zone is much more common in metastatic lesions. Fibrosis and inflammation may be evident (<a class="elsevierStyleCrossRefs" href="#fig0025">Figs. 5 and 6</a>).<elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia>Immunohistochemical markers and, sometimes, ultrastructural studies are valuable tools for establishing the origin of SMs.<a class="elsevierStyleCrossRef" href="#bib0435">87</a><a class="elsevierStyleCrossRef" href="#fig0035">Fig. 7</a> shows the diagnostic algorithm that should be applied for undifferentiated SMs. The basic recommended battery of markers includes CD45 (for lymphoid tumors), pancytokeratin AE1/AE3 (for the majority of carcinomas), S100 (for melanoma) and CD34 (for vascular tumors and leukemia). The second recommended battery of markers includes lymphoid markers (CD3 and CD20), epithelial markers such as epithelial membrane antigen and carcinoembryonic antigen, chromogranin (neuroendocrine tumors), prostate specific antigen and acid phosphatase (carcinoma of the prostate), thyroid transcription factor (carcinoma of the lung), Wilms’ tumor protein (carcinoma of the ovary), CDX2<a class="elsevierStyleCrossRef" href="#bib0440">88</a> (intestinal carcinomas), and Hep Par1<a class="elsevierStyleCrossRef" href="#bib0445">89</a> (hepatocellular carcinoma).<a class="elsevierStyleCrossRef" href="#bib0450">90</a> The immunophenotypes of the main tumors that metastasize to the skin are summarized in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>.<elsevierMultimedia ident="fig0035"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia>Ultrastructural studies can be useful in the identification of certain undifferentiated tumors. Desmosomes may be observed in carcinomas, cytoplasmic vacuoles in adenocarcinomas, melanosomes in melanomas, and neurosecretory granules in neuroendocrine tumors. However, ultrastructural studies are long and costly techniques that are not available in the majority of centers and require highly specialized staff; immunohistochemical studies therefore tend to be more useful in clinical practice.Positron emission tomography (PET) gives a large number of false positives.<a class="elsevierStyleCrossRef" href="#bib0455">91</a> PET-computed tomography is more useful.<a class="elsevierStyleCrossRef" href="#bib0460">92</a> However, PET may understage tumors in some cases, and small metastases or cerebral lesions may be missed.<a class="elsevierStyleCrossRef" href="#bib0465">93</a>PrognosisThe presence of metastatic disease in the skin usually implies widespread systemic disease with a high mortality, although the prognosis varies considerably depending on the type of primary tumor.<a class="elsevierStyleCrossRefs" href="#bib0470">94,95</a> SMs in the absence of other distant metastases only occur in 6.4% to 7.8% of cases.<a class="elsevierStyleCrossRef" href="#bib0480">96</a> However, it would appear that recent advances in chemotherapy have considerably increased survival.<a class="elsevierStyleCrossRef" href="#bib0485">97</a>It is estimated that mean survival after the diagnosis of SMs is 50% at 6 months. A number of survival analyses of patients with SMs have been published, those of Benmously et al.<a class="elsevierStyleCrossRef" href="#bib0490">98</a> and Schoenlaub et al.<a class="elsevierStyleCrossRef" href="#bib0485">97</a> being particularly relevant All the analyses report a better survival in cases of breast cancer than in other types of cancer.<a class="elsevierStyleCrossRefs" href="#bib0495">99,100</a>The mean interval between the diagnosis of a primary tumor and the appearance of SMs varies between 2 and 3 years, but periods of up to 22 years have been reported. Recent studies indicate that this interval varies depending on the type of primary tumor.<a class="elsevierStyleCrossRefs" href="#bib0505">101,102</a> In 141 patients analyzed by Hu et al.,<a class="elsevierStyleCrossRef" href="#bib0515">103</a> the mean interval between the excision or treatment of the primary tumor and the appearance of SMs was longer in patients with breast cancer (47.2 months) than in those with other tumors, such as lung cancer (15.7 months), colorectal cancer (16.5 months), or stomach cancer (19.8 months). According to some studies, lung cancer is the tumor that most rapidly metastasizes to the skin.<a class="elsevierStyleCrossRefs" href="#bib0520">104,105</a>TreatmentThe therapeutic approach to SMs is based on appropriate management of the primary tumor, if it has been identified.<a class="elsevierStyleCrossRef" href="#bib0530">106</a> As the presence of SMs implies the coexistence of other metastatic lesions in most cases, chemotherapy directed against the tumor of origin is usually the only option that might achieve complete remission.<a class="elsevierStyleCrossRef" href="#bib0535">107</a> Surgery and radiation therapy are often used to treat SMs due to the ease of access to the majority of these lesions; however, no clear increase in survival has been demonstrated, and the aim of such treatments is often only palliative.<a class="elsevierStyleCrossRef" href="#bib0540">108</a> It has been suggested that surgery might improve survival in cases of SM from lung cancer<a class="elsevierStyleCrossRef" href="#bib0545">109</a> or gastric cancer.<a class="elsevierStyleCrossRefs" href="#bib0550">110,111</a> Radiation therapy has achieved complete responses and lasting palliation in some cases of metastases from renal cell carcinoma.<a class="elsevierStyleCrossRef" href="#bib0560">112</a> In 1 study, pulsed brachytherapy achieved local control in 41 (89%) of 46 cases of SMs from breast cancer.<a class="elsevierStyleCrossRef" href="#bib0565">113</a> The topical application of 6% miltefosine solution to SMs from carcinoma of the breast achieved good control of the SM in comparison with placebo in a randomized study.<a class="elsevierStyleCrossRef" href="#bib0570">114</a> In another study, 10 patients with SM from breast or colon cancer were treated with intratumoral injections of recombinant single-chain antibodies targeted to ErbB2/HER2, with complete remission in 4 cases.<a class="elsevierStyleCrossRef" href="#bib0575">115</a>The results after intralesional immunotherapy with interferon alfa or interleukin 2<a class="elsevierStyleCrossRef" href="#bib0580">116</a> have been variable.<a class="elsevierStyleCrossRefs" href="#bib0585">117,118</a> Reports of metastatic melanoma treated with imiquimod have also been published.<a class="elsevierStyleCrossRef" href="#bib0595">119</a>Other locally ablative procedures, such as electrochemotherapy,<a class="elsevierStyleCrossRef" href="#bib0600">120</a> electrocoagulation, electroporation, and electrovaporization,<a class="elsevierStyleCrossRef" href="#bib0605">121</a> have also been used successfully. In particular, electrochemotherapy with bleomycin is an option in multiple skin and subcutaneous metastases. One study of electrochemotherapy with bleomycin included 174 tumor nodules in 52 patients with breast cancer<a class="elsevierStyleCrossRef" href="#bib0610">122</a>; complete responses were observed in 80% and partial remission in 20% after repeated application. Electrochemotherapy with cisplatin has also been evaluated in the treatment of SMs from breast cancer, but was less successful.<a class="elsevierStyleCrossRef" href="#bib0615">123</a>No specific chemotherapy has been shown to be the most effective for the systemic treatment of SMs. Observations of SMs that have regressed after systemic chemotherapy are limited to case reports, such as a patient with SMs from cancer of the pancreas treated with gemcitabine,<a class="elsevierStyleCrossRef" href="#bib0620">124</a> and a patient with urothelial carcinoma of the bladder treated with cyclophosphamide, methotrexate, and 5-fluorouracil.<a class="elsevierStyleCrossRef" href="#bib0625">125</a> Case reports of SMs from carcinomas of unknown origin treated with cisplatin, gemcitabine, vinorelbine, and paclitaxel have also been published.<a class="elsevierStyleCrossRefs" href="#bib0630">126,127</a> Determination of the expression of certain molecules such as EGF, Her-2/neu kinase, and c-kit tyrosine kinase is very important as it will provide possible targets for systemic therapy. In addition, drugs targeted against stromal function and angiogenesis could prove useful.<a class="elsevierStyleCrossRef" href="#bib0640">128</a>The palliative treatment of SMs includes adequate management of the pain, pruritus, possible bacterial superinfection, and, in some cases, of the unpleasant smell that these lesions can produce.<a class="elsevierStyleCrossRefs" href="#bib0645">129–132</a>ConclusionsThe majority of tumor recurrences are diagnosed on the basis of a detailed medical history and complete physical examination, combined with the relevant imaging studies. As SMs are usually asymptomatic, active screening is essential.SMs can play a crucial role in alerting the physician to a possible tumor recurrence or may even be the first sign of previously unknown tumor. The site and distribution of the skin lesions can suggest the organ of origin.Histological and immunohistochemical study of SMs is required in order to identify the primary tumor.Early detection of SMs is essential in order to start appropriate treatment. Although strong scientific evidence of a survival benefit is lacking, case reports and certain preliminary publications would suggest that early diagnosis improves life expectancy.Conflicts of InterestThe authors declare that they have no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:17 [ 0 => array:2 [ "identificador" => "xres295324" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec279245" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres295325" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec279246" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Etiology and Pathogenesis" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Epidemiology" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Clinical Presentation" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Specific Clinical Forms of SMs" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Differential Diagnosis" ] 10 => array:2 [ "identificador" => "sec0035" "titulo" => "Diagnosis" ] 11 => array:2 [ "identificador" => "sec0040" "titulo" => "Prognosis" ] 12 => array:2 [ "identificador" => "sec0045" "titulo" => "Treatment" ] 13 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusions" ] 14 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflicts of Interest" ] 15 => array:2 [ "identificador" => "xack69009" "titulo" => "Acknowledgments" ] 16 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-12-06" "fechaAceptado" => "2012-06-02" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec279245" "palabras" => array:6 [ 0 => "Cutaneous metastases" 1 => "Metastatic cascade" 2 => "Nodule" 3 => "Dissemination" 4 => "Metastatic pattern" 5 => "Immunohistochemistry" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec279246" "palabras" => array:6 [ 0 => "Metástasis cutáneas" 1 => "Cascada metastásica" 2 => "Nódulo" 3 => "Diseminación" 4 => "Patrones metastásicos" 5 => "Inmunohistoquímica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Cutaneous metastases are relatively rare in clinical practice and their diagnosis requires a high index of suspicion because clinical findings can be subtle. These metastases reveal the presence of disseminated malignant disease and can lead to the diagnosis of unsuspected internal tumors or the spread or recurrence of an already diagnosed tumor. Early recognition of cutaneous metastases can facilitate prompt and accurate diagnosis resulting in early treatment; however, they are generally indicative of a poor prognosis. Some tumors have a predilection to metastasize to specific areas. Recognition of these patterns provides essential information that can guide the search for the underlying tumor." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Las metástasis cutáneas son relativamente raras en la práctica clínica. Su diagnóstico requiere un alto índice de sospecha, pues los hallazgos clínicos pueden ser sutiles. Las metástasis cutáneas ponen de manifiesto la presencia de un tumor maligno diseminado y pueden permitir el diagnóstico de neoplasias internas no conocida o indicar la diseminación o recurrencia de otras ya diagnosticadas. Su reconocimiento temprano puede llevar a un diagnóstico preciso y rápido, con el consiguiente tratamiento oportuno, aunque en la mayoría de los casos son indicativas de un pronóstico infausto. Algunos tumores tienen predilección por metastatizar en áreas específicas. El reconocimiento de esos patrones es esencial para dirigir la búsqueda del tumor subyacente." ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Fernández-Antón Martínez MC, Parra-Blanco V, Avilés Izquierdo JA, Suárez Fernández RM. Metástasis cutáneas de origen visceral. Actas Dermosifiliogr. 2013;104:841–853." ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "This review is part of the introduction to the doctoral thesis entitled Metástasis cutáneas: estudio descriptivo clínico-histopatológico de las metástasis cutáneas de neoplasias viscerales." ] ] "multimedia" => array:11 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2253 "Ancho" => 3253 "Tamanyo" => 413057 ] ] "descripcion" => array:1 [ "en" => "Pathogenesis of skin metastases. Diagram that compares the classical model of metastasis production with the most recent hypotheses. Source: Sánchez-García I.<a class="elsevierStyleCrossRef" href="#bib0150">30</a>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 877 "Ancho" => 2500 "Tamanyo" => 254790 ] ] "descripcion" => array:1 [ "en" => "Skin metastases can manifest as primary or secondary skin lesions. A, Metastasis from a gastric adenocarcinoma. Papule of 7mm diameter on the abdomen. B, Metastasis from an adenocarcinoma of the ovary presenting as a plaque. C, Metastasis from a urothelial carcinoma of the bladder presenting as a nodule. D, Metastasis from an adenocarcinoma of the breast. The lesion started as a macule over the mastectomy scar. E, Ulcerated infiltrated plaque corresponding to a metastasis from an adenocarcinoma of the lung." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1187 "Ancho" => 1000 "Tamanyo" => 324168 ] ] "descripcion" => array:1 [ "en" => "Metastases from a follicular thyroid carcinoma. Violaceous nodules on the scalp with superficial telangiectasias." ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 975 "Ancho" => 1300 "Tamanyo" => 267144 ] ] "descripcion" => array:1 [ "en" => "Unusual skin metastases. A, Zosteriform metastases from a ductal adenocarcinoma of the breast. Clusters of infiltrated papules, some confluent and some ulcerated, in a metameric distribution. B, Umbilical metastasis (Sister Mary Joseph's nodule); multiple, confluent, ulcerated papules and nodules in the umbilical and periumbilical regions. C, Alopecia neoplastica. Plaque of alopecia over a metastasis from a ductal adenocarcinoma of the breast in a woman. D. Subungual metastasis. Metastasis from a squamous cell carcinoma of the lung presenting as a painful inflammatory nodule that deformed the distal phalanx of the second finger of the left hand." ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 781 "Ancho" => 1500 "Tamanyo" => 375619 ] ] "descripcion" => array:1 [ "en" => "Histological images of skin metastases. A, Dermal metastasis from a poorly differentiated carcinoma of unknown origin. Infiltration of the dermis by cords and nests of epithelioid cells (hematoxylin-eosin, original magnification x10). B, Dermal metastasis from a moderately differentiated adenocarcinoma of the pancreas. Glandular lumens lined by a layer of epithelial cells can be seen between the dermal collagen bundles (hematoxylin-eosin, original magnification x10)." ] ] 5 => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 1014 "Ancho" => 1500 "Tamanyo" => 464332 ] ] "descripcion" => array:1 [ "en" => "A, Dermal metastasis from a carcinoma of the ovary. Dilated dermal blood vessels occupied by atypical epithelial cells (hematoxylin-eosin, original magnification x20). B, Extensive dermal and vascular infiltration (lymphangitis carcinomatosa) by a poorly differentiated carcinoma." ] ] 6 => array:7 [ "identificador" => "fig0035" "etiqueta" => "Figure 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 2503 "Ancho" => 3253 "Tamanyo" => 434786 ] ] "descripcion" => array:1 [ "en" => "Diagnostic algorithm for undifferentiated skin metastases using immunohistochemical markers." ] ] 7 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Women \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">< 40 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MelanomaColon cancerLung cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Breast cancerCarcinoma of the colonOvarian cancer \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">> 40 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lung cancerColon cancerSquamous cell carcinoma of the oral cavityMelanoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Carcinoma of the breastCarcinoma of the colonLung cancerCarcinoma of the ovaryMelanoma \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab430527.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Frequency of Skin Metastases According to Age and Sex (in Decreasing Frequency)." ] ] 8 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Site of the Skin Metastases \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Most Common Primary Tumors \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Scalp \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Breast, lung, and kidney \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neck \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Oral squamous cell carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Face \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Oral squamous cell carcinoma, renal cell, and lung \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chest \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Breast and lung \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Abdomen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Colon, lung, stomach, breast, and ovary \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Umbilicus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stomach, pancreas, colon, kidney, ovary, and breast \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pelvis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Colon \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lower abdomen, groin, or thigh \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ovary and uterus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Limbs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Breast, lung, kidney, and bowel \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Back \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lung \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab430528.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Most Common Primary Tumors Giving Rise to Skin Metastases According to the Site of the Metastases." ] ] 9 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "Source: Sarya et al.<a class="elsevierStyleCrossRef" href="#bib0425">85</a> Abbreviations: BCC, basal cell carcinoma; SCC, squamous cell carcinoma." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Antibodies \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">General Characteristics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Metastatic Carcinomas \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Adnexal Tumors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Usefulness \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">p63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Homolog of p53, expressed in the basal cells of the skin and mucosas and in the myoepithelial cells of the breast, salivary glands, and prostatePositive in SCC at various sites, urothelial carcinoma, BCC, adnexal tumors, 30% of lung cancers, and some pancreatic, biliary, gastric, ovarian, breast, hepatic, renal, colon, and thymus cancers \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative in the published literatureNegative in 25/32, positive in 2/2 from urothelial tumors, 2/8 from lung tumors, 1/2 from gastric tumors, and 2/6 from carcinomas of the breast \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Positive in all cases published in the literaturePositive in 24/25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Most useful markerHowever, it should not be used alone \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">B72.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tumor-associated glycoprotein. Expressed in many adenocarcinomas. Useful to differentiate lung cancer from mesothelioma and in adnexal tumors of apocrine origin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Positive 26/31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative in 18/25, focally positive in 6/25, and diffusely positive in 1 mucinous carcinoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Positivity useful in metastatic carcinomas that are positive for p63 and CK5/6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Calretinin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Calcium-binding protein expressed in mesothelial, epithelial, and stromal cells. Used to differentiate adenocarcinoma from mesothelioma and in sex-cord stromal tumors of the testis and ovary \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative in 23/32, positive in 9 (pancreas, lung, breast sporadically) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Positive in 16/25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negativity useful in metastatic carcinomas that are positive for p63 and CK5/6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK5/6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intermediate-sized cytokeratin expressed in the skin, squamous mucosa, myoepithelial cells of breast, salivary glands, and prostatePositive in SCC, BCC, thymoma, salivary gland tumors, biphasic mesothelioma, and some urothelial, pancreatic, endometrial, breast, and ovarian tumors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative in the published literatureNegative in 14/32, positive in 18/32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Positive in the published literaturePositive in 25/25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consistent expression in skin tumors. Useful in the panel of markers \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab430530.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Summary of the Immunohistochemical Markers Useful for the Differentiation Between Skin Metastases and Primary Skin Tumors, and Synopsis of the Data Obtained in the Series by Sarya et al." ] ] 10 => array:7 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Primary Tumor \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Immunohistochemical Markers<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Breast \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK7 (+), CAM 5.2 (+), vimentin (−), TTF-1 (−), Ber-EP4 (+), WT-1 (−), DPC4 (−) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Adenocarcinoma of the lung \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK7 (+), CAM 5.2 (+), CEA (+), Ber-EP4 (+), WT-1 (−), DPC4 (−) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Colon and rectum \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK20 (+), CAM 5.2 (+), CK17 (−), CK19 (+), CEA (+), TTF-1 (−), Ber-EP4 (+), S100 (−), WT-1 (−), DPC4 (−) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stomach \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CAM 5.2 (+), vimentin (−), TTF-1 (−), ER (−), Ber-EP4 (+), WT-1 (−), DPC4 (−) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Prostate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK7 (−), CK20 (−), CAM 5.2 (+), CD5/6 (−), CK17 (−), CEA (−), vimentin (−), TTF-1 (−), ER (−), Ber-EP4 (+), S100 (−), WT-1 (−), DPC4 (−) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pancreas \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK7 (+), CAM 5.2 (+), vimentin (−), TTF-1 ((), ER (−), Ber-EP4 (+), S100 (−), WT-1 (−), DPC 4 (+) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Kidney \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK7 (−), CK20 (−), CAM 5.2 (+), CEA (−), TTF-1 (−), Ca-125 (−), ER (−), CD10 (+), WT-1 (−), DPC4 (−) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neuroendocrine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK20 (−), CK5/6 (−), Ca-125 (−), ER (−), Ber-EP4 (−), WT-1 (−), DPC4 (−) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Squamous cell carcinoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK7 (−), CK20 (−), CK5/6 (+), CK17 (+), TTF-1 (−), CA19.9 (−), Ca-125 (−), ER (−), Ber-EP4 (−), CD10 (−), S100 (−), WT-1 (−), DPC4 (−) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab430529.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "(+) indicates “always positive” and (−) “negative, with rare exceptions”. Abbreviations: Ber-EP4, human epithelial antigen; CA, carcinoid antigen; CEA, carcinoembryonic antigen; CK, cytokeratin; ER, estrogen receptors; TTF, thyroid transcription factor; WT-1: Wilms’ tumor protein." ] ] ] "descripcion" => array:1 [ "en" => "Immunophenotypes of the Metastases of the Principal Carcinomas." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:132 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Clinical Dermatology" "paginaInicial" => "1" "paginaFinal" => "7" "serieFecha" => "1997" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Do all roads lead to Rome? Routes to metastasis development?" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.26027" "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2011" "volumen" => "128" "paginaInicial" => "2511" "paginaFinal" => "2526" "link" => array:1 [ …1] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor cells caught in the act of invading: their strategy for enhanced cell motility" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tcb.2005.01.003" "Revista" => array:6 [ "tituloSerie" => "Trends Cell Biol" "fecha" => "2005" "volumen" => "15" "paginaInicial" => "138" "paginaFinal" => "145" "link" => array:1 [ …1] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The lymph node as a bridgehead in the metastatic dissemination of tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Recent Results Cancer Res" "fecha" => "2000" "volumen" => "157" "paginaInicial" => "55" "paginaFinal" => "81" "link" => array:1 [ …1] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dissemination and growth of cancer cells in metastatic sites" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrc865" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Cancer" "fecha" => "2002" "volumen" => "2" "paginaInicial" => "563" "paginaFinal" => "572" "link" => array:1 [ …1] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous manifestations of internal malignancies" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "290" "paginaFinal" => "297" "link" => array:1 [ …1] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastatic disease" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Acad Dermalol" "fecha" => "1995" "volumen" => "33" "paginaInicial" => "161" "paginaFinal" => "182" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El proceso metastático (ii): diseminación tumoral directa, linfática y hemática" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "1999" "volumen" => "90" "paginaInicial" => "277" "paginaFinal" => "290" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases in internal malignancy" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Egypt Dermatol Online J" "fecha" => "2007" "volumen" => "3" "paginaInicial" => "1" "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástasis cutánea inflamatoria como primer signo de recidiva de carcinoma escamoso de pulmón" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "157" "paginaFinal" => "159" "link" => array:1 [ …1] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin involvement as the presenting sign of internal carcinoma: a retrospective study of 7,316 cancer patients" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1990" "volumen" => "22" "paginaInicial" => "19" "paginaFinal" => "26" "link" => array:1 [ …1] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patterns of cutaneous metastasis" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1972" "volumen" => "105" "paginaInicial" => "862" "paginaFinal" => "868" "link" => array:1 [ …1] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases of internal malignancies" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0378-6323.60548" "Revista" => array:7 [ "tituloSerie" => "Indian J Dermatol Venereol Leprol" "fecha" => "2010" "volumen" => "76" "paginaInicial" => "125" "paginaFinal" => "131" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic tumors of the skin" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1972" "volumen" => "29" "paginaInicial" => "1298" "paginaFinal" => "1307" "link" => array:1 [ …1] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastasis mechanisms" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1796" "volumen" => "2009" "paginaInicial" => "293" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases from internal carcinoma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1966" "volumen" => "19" "paginaInicial" => "162" "paginaFinal" => "168" "link" => array:1 [ …1] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin metastases in cancer patients" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cutis" "fecha" => "1987" "volumen" => "39" "paginaInicial" => "119" "paginaFinal" => "121" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complex networks orchestrate epithelial-mesenchymal transitions" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrm1835" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Mol Cell Biol" "fecha" => "2006" "volumen" => "7" "paginaInicial" => "131" "paginaFinal" => "142" "link" => array:1 [ …1] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatic and skin metastases after laparoscopic radical prostatectomy for prostate cancer" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Gastrointestin Liver" "fecha" => "2007" "volumen" => "16" "paginaInicial" => "333" "paginaFinal" => "335" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastasis of pleural mesothelioma: two cases" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Dermatol Venereol" "fecha" => "2003" "volumen" => "130" "paginaInicial" => "455" "paginaFinal" => "459" "link" => array:1 [ …1] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/0008-5472.CAN-09-4442" "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "2010" "volumen" => "70" "paginaInicial" => "6071" "paginaFinal" => "6082" "link" => array:1 [ …1] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pathogenesis of cancer metastasis" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1979" "volumen" => "283" "paginaInicial" => "139" "paginaFinal" => "146" "link" => array:1 [ …1] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Ras branch of small GTPases: Ras family members don’t fall far from the tree" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Curr Opin Cell Biol" "fecha" => "2000" "volumen" => "12" "paginaInicial" => "157" "paginaFinal" => "165" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell Signal" "fecha" => "1994" "volumen" => "6" "paginaInicial" => "581" "paginaFinal" => "589" "link" => array:1 [ …1] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ras oncogenes in human cancer: A review" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1989" "volumen" => "49" "paginaInicial" => "4682" "paginaFinal" => "4689" "link" => array:1 [ …1] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhibitors of the ras oncogene as therapeutic targets" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hematol Oncol Clin North Am" "fecha" => "2002" "volumen" => "16" "paginaInicial" => "1065" "paginaFinal" => "1088" "link" => array:1 [ …1] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular mechanisms of tumor metastasis and angiogenesis" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Langenbecks Arch Surg" "fecha" => "1999" "volumen" => "384" "paginaInicial" => "133" "link" => array:1 [ …1] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "General mechanisms of metastasis" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer" "fecha" => "1997" "volumen" => "80" "paginaInicial" => "1529" "link" => array:1 [ …1] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Axis of evil: molecular mechanisms of cancer metastasis" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.onc.1206757" "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "2003" "volumen" => "22" "paginaInicial" => "6524" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The crossroads of oncogenesis and metastasis" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "2009" "volumen" => "15" "paginaInicial" => "297" "paginaFinal" => "299" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastases in carcinoma; analysis of 1000 autopsied cases" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1950" "volumen" => "3" "paginaInicial" => "74" "paginaFinal" => "85" "link" => array:1 [ …1] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases. Clinical pathological review" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Med Chil" "fecha" => "1996" "volumen" => "124" "paginaInicial" => "1519" "link" => array:1 [ …1] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases in patients with metastatic carcinoma: A retrospective study of 4020 patients" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1993" "volumen" => "29" "paginaInicial" => "228" "paginaFinal" => "236" "link" => array:1 [ …1] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases: a metaanalysis of data" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.SMJ.0000053676.73249.E5" "Revista" => array:6 [ "tituloSerie" => "South Med J" "fecha" => "2003" "volumen" => "96" "paginaInicial" => "164" "paginaFinal" => "167" "link" => array:1 [ …1] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic Patterns of Cancers: Results From a Large Autopsy Study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Pathol Lab Med" "fecha" => "2008" "volumen" => "6" "paginaInicial" => "931 L 939" "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-hematopoietic cutaneous metastases in children and adolescents: thirty years experience at St. Jude Children's Research Hospital" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "2000" "volumen" => "27" "paginaInicial" => "485" "paginaFinal" => "492" "link" => array:1 [ …1] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástasis cutánea por carcinoma pancreático como primera manifestación clínica" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2010" "volumen" => "101" "paginaInicial" => "93" "paginaFinal" => "95" "link" => array:1 [ …1] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástasis cutáneas generalizadas como forma de presentación de un adenocarcinoma gástrico" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2007" "volumen" => "98" "paginaInicial" => "213" "paginaFinal" => "218" "link" => array:1 [ …1] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A study of 70 cases of cutaneous metastases from internal carcinoma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic cancer of the skin" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ …4] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous manifestations of malignant disease" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ …7] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastasis of a radiation associated thyroid medullary carcinoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF03349501" "Revista" => array:5 [ …5] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastasis from follicular carcinoma of the thyroid gland" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/thy.1993.3.235" "Revista" => array:5 [ …5] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous infiltration by cancer" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2007.01.034" "Revista" => array:6 [ …6] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic tumors to the nail unit: subungueal metastases" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nódulo umbilical" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous lesions of metastatic visceral malignancy mimicking pyogenic granuloma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma erysipelatoides from squamous cell carcinoma of unknown origin" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1368-5031.2005.00588.x" "Revista" => array:6 [ …6] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástasis cutánea inflamatoria como primer signo de recidiva de carcinoma escamoso de pulmón" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases from carcinoma breast: the common and the rare" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0378-6323.55395" "Revista" => array:6 [ …6] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Narrative review: diseases that masquerade as infection cellulitis" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ …7] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases–carcinoma en cuirasse" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory metastatic carcinoma. Carcinoma erysipelatoides" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bilateral thoracic zosteroid spreading marginate telangiectasia – probably a variety of carcinoma erysipelatoides – associated with unilateral mammary carcinoma, and better termed carcinoma telangiectaticum" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Telangiectatic metastatic breast carcinoma preceded by en cuirasse metastatic breast carcinoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2004.06140.x" "Revista" => array:6 [ …6] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recognizing malignant skin changes following breast cancer" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ …7] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bilateral thoracic zosteroid spreading marginate telangiectasia–probably a variant of carcinoma telangiectatum" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Zosteriform cutaneous metastases: a literature meta-analysis and a clinical report of three melanoma cases" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2009.01241.x" "Revista" => array:6 [ …6] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástasis cutáneas de adenocarcinoma de recto con distribución herpetiforme" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ …7] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Zosteriform metastasis: case presentation and review of the literature" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous malignancies mimicking herpes zoster" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Zosteriform inflammatory metastatic carcinoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Zosteriform cutaneous metastases from breast adenocarcinoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2005.01205.x" "Revista" => array:6 [ …6] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nariz de payaso como manifestación inicial de un carcinoma epidermoide de pulmón" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2008.02.003" "Revista" => array:7 [ …7] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0325" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast cancer metastasized to the scalp mimicking alopecia areata: alopecia neoplastica" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4741.2006.00372.x" "Revista" => array:6 [ …6] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0330" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Review of scalp alopecia due to a clinically unapparent or minimally apparent neoplasm (SACUMAN)" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-0160" "Revista" => array:6 [ …6] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0335" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastasis of breast carcinoma presenting as alopecia neoplastica" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/SMJ.0b013e31819b0c26" "Revista" => array:6 [ …6] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0340" "etiqueta" => "68" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pigmented mammary Paget disease and pigmented epidermotropic metastases from breast carcinoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0345" "etiqueta" => "69" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic tumors to the nail unit: subungual metastases" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0350" "etiqueta" => "70" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dactilitis crónica indolora como hallazgo inicial de un adenocarcinoma pulmonar diseminado" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0355" "etiqueta" => "71" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumors of the umbilicus" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ …7] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0360" "etiqueta" => "72" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermal and subcutaneous tumors" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ …5] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0365" "etiqueta" => "73" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sister Mary Joseph's nodule: a clinical and histologic study" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0370" "etiqueta" => "74" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinically occult cutaneous cutaneous metastases" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2006.05.011" "Revista" => array:6 [ …6] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0375" "etiqueta" => "75" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic breast carcinoma mimicking granular cell tumor" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib0380" "etiqueta" => "76" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastasis from hepatocellular carcinoma resembling pyogenic granuloma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib0385" "etiqueta" => "77" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastasis of carcinoma of the prostate to the scalp: simulation of large sebaceous cyst" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib0390" "etiqueta" => "78" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A benign-looking subcutaneous metastasis from squamous cell cervical carcinoma: a case report and review of the literature" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib0395" "etiqueta" => "79" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adrenal carcinoma presenting as a lesion resembling cutaneous angiosarcoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib0400" "etiqueta" => "80" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory carcinoma masquerading as erythema annulare centrifugum" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib0405" "etiqueta" => "81" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic carcinoma of the breast: an unusual presentation mimicking cutaneous vasculitis" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib0410" "etiqueta" => "82" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The significance of cutaneous metastasis from visceral tumors diagnosed by fine-needle aspiration biopsy" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib0415" "etiqueta" => "83" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of fine-needle aspiration cytology in evaluation of cutaneous metastases" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/dc.21119" "Revista" => array:6 [ …6] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib0420" "etiqueta" => "84" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases: where do they come from and what can they mimic?" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib0425" "etiqueta" => "85" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinicopathologic correlation of cutaneous metastases Experience from a cancer center" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.143.5.613" "Revista" => array:6 [ …6] ] ] ] ] ] 85 => array:3 [ "identificador" => "bib0430" "etiqueta" => "86" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin clues to primary and metastatic malignancy" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 86 => array:3 [ "identificador" => "bib0435" "etiqueta" => "87" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.0303-6987.2004.00207.x" "Revista" => array:6 [ …6] ] ] ] ] ] 87 => array:3 [ "identificador" => "bib0440" "etiqueta" => "88" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 88 => array:3 [ "identificador" => "bib0445" "etiqueta" => "89" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastasis of hepatocellular carcinoma diagnosed with hepatocyte paraffin (Hep Par 1) antibody immunohistochemistry" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ …4] ] ] ] ] ] 89 => array:3 [ "identificador" => "bib0450" "etiqueta" => "90" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin metastasis: a pathologist's perspective" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0560.2009.01469.x" "Revista" => array:6 [ …6] ] ] ] ] ] 90 => array:3 [ "identificador" => "bib0455" "etiqueta" => "91" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography in disseminated carcinoma of unknown primary site" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.22410" "Revista" => array:6 [ …6] ] ] ] ] ] 91 => array:3 [ "identificador" => "bib0460" "etiqueta" => "92" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastases in the absence of a primary tumor: advances in the diagnosis and treatment of CUP syndrome" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3238/arztebl.2008.0733" "Revista" => array:6 [ …6] ] ] ] ] ] 92 => array:3 [ "identificador" => "bib0465" "etiqueta" => "93" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "F-18 FDG uptake in cutaneous metastases from breast cancer" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/RLU.0b013e318177934e" "Revista" => array:6 [ …6] ] ] ] ] ] 93 => array:3 [ "identificador" => "bib0470" "etiqueta" => "94" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Twenty-three years of disease-free survival following cutaneous metastasis from a primary bladder transitional cell carcinoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1442-2042.2004.00939.x" "Revista" => array:5 [ …5] ] ] ] ] ] 94 => array:3 [ "identificador" => "bib0475" "etiqueta" => "95" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Supervivencia de trece años en una paciente con metástasis cutáneas aisladas de adenocarcinoma gástrico. ¿Ante qué enfermedad nos encontramos?" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ …7] ] ] ] ] ] 95 => array:3 [ "identificador" => "bib0480" "etiqueta" => "96" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human immunodeficiency virus-associated lung carcinoma presenting as cutaneous metastases" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3816/CLC.2009.n.083" "Revista" => array:6 [ …6] ] ] ] ] ] 96 => array:3 [ "identificador" => "bib0485" "etiqueta" => "97" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival after cutaneous metastasis: a study of 200 cases" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 97 => array:3 [ "identificador" => "bib0490" "etiqueta" => "98" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases from internal cancers" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 98 => array:3 [ "identificador" => "bib0495" "etiqueta" => "99" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distant cutaneous metastasis after laparoscopic cholecystectomy in a case of unsuspected gallbladder cancer" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 99 => array:3 [ "identificador" => "bib0500" "etiqueta" => "100" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin manifestations of internal malignancy" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 100 => array:3 [ "identificador" => "bib0505" "etiqueta" => "101" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal cell carcinoma with cutaneous metastases" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1440-0960.2005.00169.x" "Revista" => array:6 [ …6] ] ] ] ] ] 101 => array:3 [ "identificador" => "bib0510" "etiqueta" => "102" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases in renal cell carcinoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "30440" "Revista" => array:6 [ …6] ] ] ] ] ] 102 => array:3 [ "identificador" => "bib0515" "etiqueta" => "103" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rates of cutaneous metastases from different internal malignancies: experience from a Taiwanese medical center" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2008.10.007" "Revista" => array:6 [ …6] ] ] ] ] ] 103 => array:3 [ "identificador" => "bib0520" "etiqueta" => "104" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástasis cutáneas en el cáncer de pulmón: revisión de la literatura a propósito de dos casos" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 104 => array:3 [ "identificador" => "bib0525" "etiqueta" => "105" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin metastases from lung cancer" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 105 => array:3 [ "identificador" => "bib0530" "etiqueta" => "106" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of Metastatic Cancer" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ …5] ] ] ] ] ] 106 => array:3 [ "identificador" => "bib0535" "etiqueta" => "107" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of cutaneous and brain metastasis of gastric carcinoma, treated effectively by chemotherapy with CDDP, MMC, etoposide and 5′-DFUR" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ …4] ] ] ] ] ] 107 => array:3 [ "identificador" => "bib0540" "etiqueta" => "108" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases from different internal malignancies: a clinical and prognostic appraisal" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2008.02590.x" "Revista" => array:7 [ …7] ] ] ] ] ] 108 => array:3 [ "identificador" => "bib0545" "etiqueta" => "109" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prolonged survival after extracranial metastasectomy from synchronous resectable lung cancer" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 109 => array:3 [ "identificador" => "bib0550" "etiqueta" => "110" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resection of skin metastases from gastric carcinoma with long-term follow-up: an unusual clinical presentation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000082266" "Revista" => array:7 [ …7] ] ] ] ] ] 110 => array:3 [ "identificador" => "bib0555" "etiqueta" => "111" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin metastases in lung cancer: analysis of a 10-year experience" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 111 => array:3 [ "identificador" => "bib0560" "etiqueta" => "112" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complete response in a cutaneous facial metastatic nodule from renal cell carcinoma after hypofractionated radiotherapy" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 112 => array:3 [ "identificador" => "bib0565" "etiqueta" => "113" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term results of pulsed irradiation of skin metastases from breast cancer. Effectiveness and sequelae" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 113 => array:3 [ "identificador" => "bib0570" "etiqueta" => "114" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.2001.19.21.4150" "Revista" => array:6 [ …6] ] ] ] ] ] 114 => array:3 [ "identificador" => "bib0575" "etiqueta" => "115" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regression of cutaneous tumor lesions in patients intratumorally injected with a recombinant single-chain antibody-toxin targeted to ErbB2/HER2" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 115 => array:3 [ "identificador" => "bib0580" "etiqueta" => "116" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experiencia en el tratamiento de satelitosis y metástasis cutáneas en tránsito de melanoma con interleucina 2 intralesional" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 116 => array:3 [ "identificador" => "bib0585" "etiqueta" => "117" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic gastric adenocarcinoma presenting as an enlarging plaque on the scalp" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 117 => array:3 [ "identificador" => "bib0590" "etiqueta" => "118" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin metastases from vulvar cancer: a fatal event" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 118 => array:3 [ "identificador" => "bib0595" "etiqueta" => "119" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imiquimod para el tratamiento de las metástasis cutáneas de melanoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 119 => array:3 [ "identificador" => "bib0600" "etiqueta" => "120" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of metastatic skin lesions with electrochemotherapy" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 120 => array:3 [ "identificador" => "bib0605" "etiqueta" => "121" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 121 => array:3 [ "identificador" => "bib0610" "etiqueta" => "122" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bleomycin-based electrochemotherapy: clinical outcome from a single institution's experience with 52 patients" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1245/s10434-008-0204-8" "Revista" => array:6 [ …6] ] ] ] ] ] 122 => array:3 [ "identificador" => "bib0615" "etiqueta" => "123" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Electrochemotherapy with cisplatin of cutaneous tumor lesions in breast cancer" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 123 => array:3 [ "identificador" => "bib0620" "etiqueta" => "124" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solitary cutaneous metastasis on the buttock: a disclosing sign of pancreatic adenocarcinoma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 124 => array:3 [ "identificador" => "bib0625" "etiqueta" => "125" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Responsiveness of skin metastases to CMF in a patient with urothelial carcinoma of the bladder: a case report" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 125 => array:3 [ "identificador" => "bib0630" "etiqueta" => "126" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bjc.6603942" "Revista" => array:6 [ …6] ] ] ] ] ] 126 => array:3 [ "identificador" => "bib0635" "etiqueta" => "127" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cisplatin and gemcitabine with either vinorelbine or paclitaxel in the treatment of carcinomas of unknown primary site: results of an Italian multicenter, randomized, phase ii study" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.22379" "Revista" => array:6 [ …6] ] ] ] ] ] 127 => array:3 [ "identificador" => "bib0640" "etiqueta" => "128" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stroma-targeted palliative tumor therapy with biomodulators" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1610-0387.2006.05908.x" "Revista" => array:6 [ …6] ] ] ] ] ] 128 => array:3 [ "identificador" => "bib0645" "etiqueta" => "129" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The management of cutaneous metastases" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00120-006-1278-1" "Revista" => array:6 [ …6] ] ] ] ] ] 129 => array:3 [ "identificador" => "bib0650" "etiqueta" => "130" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic pruritus: targets, mechanisms and future therapies" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1358/dnp.2008.21.10.1314057" "Revista" => array:6 [ …6] ] ] ] ] ] 130 => array:3 [ "identificador" => "bib0655" "etiqueta" => "131" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant fungating wounds: managing pain, bleeding and psychosocial issues" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.12968/jowc.2009.18.10.44603" "Revista" => array:6 [ …6] ] ] ] ] ] 131 => array:3 [ "identificador" => "bib0660" "etiqueta" => "132" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An overview of caring for those with palliative wounds" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.12968/bjcn.2008.13.1.27977" "Revista" => array:7 [ …7] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack69009" "titulo" => "Acknowledgments" "texto" => "We would like to thank Dr Concepción Román Curto, author of the doctoral thesis “Tumores cutaneous metastásicos. Estudio clinic, histológico y ultraestructural” for her help and Dr Jesús Millán Núñez-Cortés, Professor of Medicine, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, in Madrid, Spain, for his inestimable collaboration." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010400000010/v1_201311281142/S1578219013002369/v1_201311281142/en/main.assets" "Apartado" => array:4 [ "identificador" => "6177" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Reviews" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000010/v1_201311281142/S1578219013002369/v1_201311281142/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002369?idApp=UINPBA000044"]

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Review

Cutaneous Metastases of Internal Tumors

Metástasis cutáneas de origen visceral

M.C. Fernández-Antón Martíneza,

Corresponding author

carmenfernandezanton@hotmail.com

Corresponding author.

, V. Parra-Blancob, J.A. Avilés Izquierdoa, R.M. Suárez Fernándeza

a Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain

b Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, Spain

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The presence of metastases is one of the characteristics of malignant tumors that is a threat to the life of the patient and incontrovertibly signals the existence of a systemic disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Considerable advances have been made in recent years in our understanding of how tumor cells circulating in the blood and in the lymphatic system are able to interact with and pass through the endothelium to reach distant sites&#44; and of the properties that determine whether the cells of these disseminated tumors are able to survive and whether they will remain in a latent state or will be able to form macrometastases&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> New discoveries concerning early metastatic seeding&#44; parallel progression&#44; self-seeding of circulating tumor cells from the primary tumor&#44; and the induction of premetastatic niches in organs at a distance from the primary tumor are now at the forefront of research&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Skin metastases &#40;SMs&#41; are the result of infiltration of the skin by proliferations of cells from distant malignant tumors&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> The early detection of metastases within the body often requires sophisticated additional tests&#59; however&#44; SMs are usually easily observed on careful&#44; targeted physical examination&#46; Up to a third of SMs are diagnosed before or simultaneously with the primary tumor&#44; and the role of the dermatologist in establishing an adequate clinical suspicion<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> is essential&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The early clinical recognition of SMs is crucial&#44; as it can lead to the diagnosis of a previously unidentified primary malignant tumor&#44; provide evidence of the dissemination of a previously known tumor&#44; or be an early sign of recurrence of a malignant tumor apparently in remission&#46; The diagnosis of SMs can therefore alter the staging of a malignant disease&#44; with the consequent therapeutic and prognostic implications<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#59; their presence will often lead to drastic changes in the management plan&#44; particularly when the metastases indicate the persistence of a tumor thought to be in remission&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Furthermore&#44; SMs are easy to biopsy&#44; which facilitates tests of sensitivity of the primary tumor to specific treatments&#44; such as inhibitors of epidermal growth factor or of c-kit&#47;CD117&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Some tumors appear to have a predilection to metastasize to certain areas&#46; Recognition of these patterns can help to target the search for an unknown underlying tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The recent presentation in various countries of a number of retrospective studies of SMs reflects current international interest in this subject&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Etiology and Pathogenesis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Metastases arise when neoplastic cells break away from a primary tumor and disseminate to other sites&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a> Several mechanisms involving various pathways are implicated in the development of metastases&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a> Hematogenous and lymphatic spread are the most common&#44; although separation of these 2 pathways can be difficult as they are interconnected&#46; Lymphatic spread is the most common initial route of propagation of the majority of malignant tumors and its role in the determination of metastatic patterns is a subject of current research&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Regional spread usually occurs through the body cavities&#44; in particular the peritoneal cavity&#46; Tumor-cell transplant due to the mechanical transport of fragments of tumor on surgical instruments during surgery or other invasive procedures can happen but is rare&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Traditionally it has been postulated that a series of steps must occur for a metastasis to develop&#46; First&#44; the primary tumor must be large enough to release a sufficient number of neoplastic cells into the circulatory or lymphatic systems&#46; The majority of free neoplastic cells are destroyed by the immune system&#44; whereas groups of 6 or 7 cells appear to have a greater likelihood of forming a metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> These cells&#44; in turn&#44; must have certain properties&#44; such as cellular suspension and an adequate mitotic index&#44; in order to survive&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Development of a clone with metastatic potential is initially favored by the activation of specific oncogenes<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;24</span></a> and the loss of tumor suppressor genes&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#44;26</span></a> For neoplastic cells in the circulatory system to become established&#44; they must pass through the vessel walls&#46; After the cells adhere to the vessel wall&#44; a thrombus forms around them due to a lesion of the endothelial cells&#46; This thrombus serves to protect the neoplastic cells&#46; The metastasis becomes established and initially obtains its nutrients by means of diffusion phenomena<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a>&#59; later it will form its own vessels &#40;angiogenesis&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;29</span></a> In this classical model of cancer development&#44; the metastases correspond to the final stage of the metastatic cascade&#46; However&#44; recent studies suggest a different model&#44; which predicts that the expression of proteins that regulate epithelial-mesenchymal transition promote oncogenesis concomitantly with metastatic spread&#46; In this alternative model&#44; cell spread from the primary tumor can occur at any time during development of the cancer<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Epidemiology</span><p id="par0035" class="elsevierStylePara elsevierViewall">The true incidence of SMs is unknown&#46; However&#44; the incidence appears to be higher in some recent studies compared with historical series&#44; although this may due to higher rates of biopsy and diagnosis rather than a true increase in the incidence&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> SMs are a rare finding in clinical practice&#44; and their prevalence varies between 0&#46;7&#37; and 9&#37; of patients with internal tumors&#44; depending on the series&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In theory&#44; any malignant tumor can spread to the skin&#46; However&#44; in practice&#44; a direct relationship has been found between the frequency of different malignant tumors and the appearance of SMs&#44; with the most common malignant tumors in each sex being those that most frequently give rise to SMs&#46; Thus&#44; breast cancer in women&#44; lung cancer in men&#44; and adenocarcinomas of the digestive tract in both sexes are the most common origins of SMs&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A meta-analysis published in 2003 reviewed 1080 cases of SM in 20&#160;380 cancer patients&#44; and reported an estimated SM rate of 5&#46;3&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> In a classic study from 1972&#44; Brownstein and Helwig<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> examined the distribution of SMs in 724 male and female patients&#46; In men&#44; the most common malignant tumors that metastasized to the skin were carcinoma of the lung &#40;24&#37;&#41;&#44; colorectal carcinoma &#40;19&#37;&#41;&#44; melanoma &#40;13&#37;&#41;&#44; and oral squamous cell carcinoma &#40;12&#37;&#41;&#44; whereas&#44; in women&#44; the most common tumors were breast cancer &#40;69&#37;&#41;&#44; colorectal carcinoma &#40;9&#37;&#41;&#44; melanoma &#40;5&#37;&#41;&#44; and carcinoma of the ovary &#40;4&#37;&#41;&#46; The area most commonly affected was the anterior chest wall&#59; the lower limbs were the least common sites&#46; In men&#44; around 75&#37; of SMs were observed on the head and neck&#44; whereas&#44; in women&#44; 75&#37; of cases were found on the anterior chest wall and on the abdomen&#46; In general&#44; the back was an uncommon site for SMs&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In women the most common site of SMs is the thorax&#44; followed by the abdomen&#44; the back&#44; the upper limbs&#44; the scalp&#44; and the neck&#59; in men&#44; the thorax is also the area most commonly affected&#44; followed&#44; in descending order of frequency&#44; by the abdomen&#44; the back&#44; the scalp&#44; the neck&#44; the face&#44; the upper and lower limbs&#44; and the pelvis&#46; The frequency of SMs by age and sex is summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; SMs are very rare in children&#46; The most common primary tumors that produce SMs in this age group are rhabdomyosarcoma and neuroblastoma&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Clinical Presentation</span><p id="par0055" class="elsevierStylePara elsevierViewall">In the majority of cases&#44; SMs develop after diagnosis of the primary tumor&#46; However&#44; in a notable proportion of patients &#40;up to a third of cases&#41;&#44; the metastases are discovered prior to<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> or simultaneously with<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> the primary tumor&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">SMs tend to appear in a body region close to the primary tumor&#46; Presentation is typically in the form of rapidly growing&#44; mobile&#44; round or oval nodules of firm or elastic consistency<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a>&#59; they may be ulcerated&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> However&#44; they can present as any primary or secondary skin lesion<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The nodules are usually skin-colored&#44; although metastatic nodules from renal cell or thyroid carcinoma often have a characteristic reddish or violaceous discoloration<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">42&#44;43</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Some recent studies report that skin metastases present most often as a single nodular lesion&#44; whereas older studies more commonly reported multiple nodules&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> This may be because more SMs are now diagnosed earlier&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Although most SMs are asymptomatic&#44; patients may describe pain&#44; particularly with lesions in certain areas&#44; such as subungual metastases&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Gastrointestinal cancers &#40;specifically&#44; colorectal and gastric carcinomas&#41; often give rise to metastases on the abdomen and pelvis&#46; These carcinomas can spread along the urachus to produce umbilical nodules known as Sister Mary Joseph&#39;s nodules&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> SMs from squamous cell carcinoma of the oral cavity usually arise in the same body region&#44; and most frequently affect the face and neck&#46; Renal cell carcinoma&#44; among others&#44; typically metastasizes to the scalp and&#44; because it is a highly vascular tumour&#44; the lesions may be confused with hemangiomas or pyogenic granulomas&#46; SMs from hepatocellular carcinoma often develop on the fingers&#44; palms&#44; soles&#44; or the back&#44; while those from gastric carcinoma tend to develop on the head and neck&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> Thus&#44; the site of an SM can suggest a possible origin &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Specific Clinical Forms of SMs</span><p id="par0075" class="elsevierStylePara elsevierViewall">A very large number of specific clinical forms of SMs have been described&#46; Erysipeloid or inflammatory carcinoma is often observed in patients with adenocarcinoma of the breast and is not uncommon in other types of cancer &#40;pancreas&#44; rectum&#44; lung&#44; ovary&#44; and parotid&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48&#44;49</span></a> It presents as well-defined erythematous lesions that are hot and tender&#44; similar to erysipelas&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> Lymphatic obstruction by the neoplastic cells can give rise to localized lymphedema with peau d&#8217;orange&#46; Lymphedema can cause the skin to become fibrous and yellowish&#44; with a similar appearance to carcinoma en cuirasse<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> or scirrhous carcinoma&#46; This clinical form presents as indurated erythematous plaques that infiltrate the chest wall&#46; It is usually observed in metastases from breast cancer&#44; although it can be a form of presentation of a primary breast tumor or of SMs of other origins&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> The main differential diagnosis of this presentation is with infectious disorders&#46; Erysipeloid carcinoma localized to the breast can be difficult to distinguish from mastitis&#46; Persistent inflammation that does not respond to conventional therapy must therefore be carefully evaluated to exclude metastatic infiltration&#44; particularly when there is no fever or leukocytosis&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Telangiectatic carcinoma&#44; described by Weber<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a> in 1933 in a patient with metastatic breast cancer&#44; is characterized by the appearance of nodules&#44; papules&#44; or purpuric plaques on the chest wall&#44;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> usually in the proximity of a surgical scar&#46;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">56&#44;57</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Zosteriform or herpetiform metastases present as papules&#44; vesicles&#44; nodules&#44; or blisters affecting individual dermatomes&#44;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">58&#44;59</span></a> mimicking herpes zoster<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">60&#44;61</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; Although their etiology and pathogenesis are not fully understood&#44; most hypotheses suggest there is spread of the tumor cells from the cutaneous lymph vessels to the sensory nerves&#44; via which they reach the dorsal root ganglia&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">62&#44;63</span></a></p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Clown nose is considered to be the result of an SM arising on the tip of the nose&#44; typically from a carcinoma of the lung or breast&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Alopecia neoplastica is defined as hair loss secondary to invasion of the scalp by malignant cells&#46; It can present as 1 or more plaques of scarring alopecia that are often indurated and have a bluish or violaceous color&#46; These plaques must be differentiated from alopecia areata<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; The neoplastic cells can destroy the hair follicles by producing fibroplasia induced by the release of inflammatory mediators that bring inflammatory cells into the area&#44; and&#47;or by substitution of the normal cells&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a> Breast cancer is the underlying primary malignant tumor in 84&#37; of patients with alopecia neoplastica&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Paget&#39;s disease of the nipple and areola is a skin sign associated with an underlying adenocarcinoma of the breast in 100&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">68</span></a> This skin condition is produced by epidermotropic SMs due to the spread of an intraductal tumor along the lactiferous ducts to reach the overlying skin&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Subungual metastases merit special consideration&#46; These metastatic lesions are usually painful and often need to be differentiated from infectious disorders&#44; in particular acute paronychia&#44; or from glomus tumors<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">69</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; Presentation as painless dactylitis has been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Sister Mary Joseph&#39;s nodule or umbilical metastasis is widely described in the literature&#46; This form of metastasis presents as single or multiple&#44; indurated umbilical or periumbilical nodules that can sometimes ulcerate or have a friable appearance &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; Although the site of the primary tumor is unknown in approximately 29&#37; of cases&#44;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a> the majority of umbilical metastases come from tumors that arise in the stomach&#44; ovary&#44; colon&#44; rectum&#44; or pancreas&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a> The proposed pathogenesis of metastases in the umbilical region includes both contiguous infiltration and spread via the blood or lymph&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Finally&#44; clinically occult metastases are those with no detectable clinical findings but which are discovered as incidental findings on a histopathological examination performed for some other reason&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">74</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Differential Diagnosis</span><p id="par0120" class="elsevierStylePara elsevierViewall">The differential diagnosis of SMs is very broad and includes many more disorders in addition to those mentioned above&#46; First we must consider primary skin tumors&#44;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">75</span></a> both benign &#40;dermatofibroma&#44; pyogenic granuloma&#44;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">76</span></a> epidermal cyst&#44;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">77</span></a> adnexal tumors<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">78</span></a>&#41; and malignant &#40;basal or squamous cell carcinoma&#44; melanoma&#44; Merkel cell tumor&#44; angiosarcoma<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a>&#41;&#46; Other skin diseases to be considered are eczema&#44; erythema annulare centrifugum&#44;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">80</span></a> erythema multiforme &#91;target-shaped SMs&#93;&#44; and vasculitis&#46;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">81</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Diagnosis</span><p id="par0125" class="elsevierStylePara elsevierViewall">A detailed medical history and complete physical examination are essential to establish the initial diagnostic suspicion&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The histopathology of SMs may reveal the same characteristics as the tumor of origin&#44; or there may be a more anaplastic appearance&#46; Immunohistochemistry can help to determine the possible origin in the case of undifferentiated tumors&#46; Incisional or excisional skin biopsy is essential to reach a diagnosis&#46; Cytology study by fine-needle aspiration biopsy can be useful in certain circumstances&#46;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">82&#44;83</span></a> The pattern observed and the microscopic appearance of the tissue often suggest its origin&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">84</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">In some cases&#44; such as renal cell carcinoma&#44; characteristic histological findings will identify the primary tumor&#44; but the majority of SMs can only be classified in general terms as adenocarcinoma&#44; squamous cell carcinoma&#44; or undifferentiated carcinoma&#46; It is also necessary to differentiate between metastatic skin lesions and primary skin tumors&#59; as these 2 types of lesion frequently have very similar morphological patterns&#44; immunohistochemical markers can be very useful for their differentiation&#46; <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> summarizes the results of the literature review published by Sarya et al&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">85</span></a> in 2007&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">Certain histological features differentiate metastases from primary tumors&#46; Characteristics suggestive of SMs include the presence of neoplastic cells within the lymph and blood vessels&#44; localization of the lesion in the deep reticular dermis and hypodermis&#44; and the presence of neoplastic cells running along the bundles of collagen&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">86</span></a> Metastatic tumors typically develop as round nodules located in the dermis or hypodermis&#44; and are not usually in contact with the epidermis&#46; This Grenz zone is much more common in metastatic lesions&#46; Fibrosis and inflammation may be evident &#40;<a class="elsevierStyleCrossRefs" href="#fig0025">Figs&#46; 5 and 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0145" class="elsevierStylePara elsevierViewall">Immunohistochemical markers and&#44; sometimes&#44; ultrastructural studies are valuable tools for establishing the origin of SMs&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">87</span></a><a class="elsevierStyleCrossRef" href="#fig0035">Fig&#46; 7</a> shows the diagnostic algorithm that should be applied for undifferentiated SMs&#46; The basic recommended battery of markers includes CD45 &#40;for lymphoid tumors&#41;&#44; pancytokeratin AE1&#47;AE3 &#40;for the majority of carcinomas&#41;&#44; S100 &#40;for melanoma&#41; and CD34 &#40;for vascular tumors and leukemia&#41;&#46; The second recommended battery of markers includes lymphoid markers &#40;CD3 and CD20&#41;&#44; epithelial markers such as epithelial membrane antigen and carcinoembryonic antigen&#44; chromogranin &#40;neuroendocrine tumors&#41;&#44; prostate specific antigen and acid phosphatase &#40;carcinoma of the prostate&#41;&#44; thyroid transcription factor &#40;carcinoma of the lung&#41;&#44; Wilms&#8217; tumor protein &#40;carcinoma of the ovary&#41;&#44; CDX2<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">88</span></a> &#40;intestinal carcinomas&#41;&#44; and Hep Par1<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">89</span></a> &#40;hepatocellular carcinoma&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">90</span></a> The immunophenotypes of the main tumors that metastasize to the skin are summarized in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#46;</p><elsevierMultimedia ident="fig0035"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0150" class="elsevierStylePara elsevierViewall">Ultrastructural studies can be useful in the identification of certain undifferentiated tumors&#46; Desmosomes may be observed in carcinomas&#44; cytoplasmic vacuoles in adenocarcinomas&#44; melanosomes in melanomas&#44; and neurosecretory granules in neuroendocrine tumors&#46; However&#44; ultrastructural studies are long and costly techniques that are not available in the majority of centers and require highly specialized staff&#59; immunohistochemical studies therefore tend to be more useful in clinical practice&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Positron emission tomography &#40;PET&#41; gives a large number of false positives&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">91</span></a> PET-computed tomography is more useful&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">92</span></a> However&#44; PET may understage tumors in some cases&#44; and small metastases or cerebral lesions may be missed&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">93</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Prognosis</span><p id="par0160" class="elsevierStylePara elsevierViewall">The presence of metastatic disease in the skin usually implies widespread systemic disease with a high mortality&#44; although the prognosis varies considerably depending on the type of primary tumor&#46;<a class="elsevierStyleCrossRefs" href="#bib0470"><span class="elsevierStyleSup">94&#44;95</span></a> SMs in the absence of other distant metastases only occur in 6&#46;4&#37; to 7&#46;8&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">96</span></a> However&#44; it would appear that recent advances in chemotherapy have considerably increased survival&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">97</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">It is estimated that mean survival after the diagnosis of SMs is 50&#37; at 6 months&#46; A number of survival analyses of patients with SMs have been published&#44; those of Benmously et al&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">98</span></a> and Schoenlaub et al&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">97</span></a> being particularly relevant All the analyses report a better survival in cases of breast cancer than in other types of cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib0495"><span class="elsevierStyleSup">99&#44;100</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">The mean interval between the diagnosis of a primary tumor and the appearance of SMs varies between 2 and 3 years&#44; but periods of up to 22 years have been reported&#46; Recent studies indicate that this interval varies depending on the type of primary tumor&#46;<a class="elsevierStyleCrossRefs" href="#bib0505"><span class="elsevierStyleSup">101&#44;102</span></a> In 141 patients analyzed by Hu et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">103</span></a> the mean interval between the excision or treatment of the primary tumor and the appearance of SMs was longer in patients with breast cancer &#40;47&#46;2 months&#41; than in those with other tumors&#44; such as lung cancer &#40;15&#46;7 months&#41;&#44; colorectal cancer &#40;16&#46;5 months&#41;&#44; or stomach cancer &#40;19&#46;8 months&#41;&#46; According to some studies&#44; lung cancer is the tumor that most rapidly metastasizes to the skin&#46;<a class="elsevierStyleCrossRefs" href="#bib0520"><span class="elsevierStyleSup">104&#44;105</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Treatment</span><p id="par0175" class="elsevierStylePara elsevierViewall">The therapeutic approach to SMs is based on appropriate management of the primary tumor&#44; if it has been identified&#46;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">106</span></a> As the presence of SMs implies the coexistence of other metastatic lesions in most cases&#44; chemotherapy directed against the tumor of origin is usually the only option that might achieve complete remission&#46;<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">107</span></a> Surgery and radiation therapy are often used to treat SMs due to the ease of access to the majority of these lesions&#59; however&#44; no clear increase in survival has been demonstrated&#44; and the aim of such treatments is often only palliative&#46;<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">108</span></a> It has been suggested that surgery might improve survival in cases of SM from lung cancer<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">109</span></a> or gastric cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib0550"><span class="elsevierStyleSup">110&#44;111</span></a> Radiation therapy has achieved complete responses and lasting palliation in some cases of metastases from renal cell carcinoma&#46;<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">112</span></a> In 1 study&#44; pulsed brachytherapy achieved local control in 41 &#40;89&#37;&#41; of 46 cases of SMs from breast cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">113</span></a> The topical application of 6&#37; miltefosine solution to SMs from carcinoma of the breast achieved good control of the SM in comparison with placebo in a randomized study&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">114</span></a> In another study&#44; 10 patients with SM from breast or colon cancer were treated with intratumoral injections of recombinant single-chain antibodies targeted to ErbB2&#47;HER2&#44; with complete remission in 4 cases&#46;<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">115</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">The results after intralesional immunotherapy with interferon alfa or interleukin 2<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">116</span></a> have been variable&#46;<a class="elsevierStyleCrossRefs" href="#bib0585"><span class="elsevierStyleSup">117&#44;118</span></a> Reports of metastatic melanoma treated with imiquimod have also been published&#46;<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">119</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">Other locally ablative procedures&#44; such as electrochemotherapy&#44;<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">120</span></a> electrocoagulation&#44; electroporation&#44; and electrovaporization&#44;<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">121</span></a> have also been used successfully&#46; In particular&#44; electrochemotherapy with bleomycin is an option in multiple skin and subcutaneous metastases&#46; One study of electrochemotherapy with bleomycin included 174 tumor nodules in 52 patients with breast cancer<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">122</span></a>&#59; complete responses were observed in 80&#37; and partial remission in 20&#37; after repeated application&#46; Electrochemotherapy with cisplatin has also been evaluated in the treatment of SMs from breast cancer&#44; but was less successful&#46;<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">123</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">No specific chemotherapy has been shown to be the most effective for the systemic treatment of SMs&#46; Observations of SMs that have regressed after systemic chemotherapy are limited to case reports&#44; such as a patient with SMs from cancer of the pancreas treated with gemcitabine&#44;<a class="elsevierStyleCrossRef" href="#bib0620"><span class="elsevierStyleSup">124</span></a> and a patient with urothelial carcinoma of the bladder treated with cyclophosphamide&#44; methotrexate&#44; and 5-fluorouracil&#46;<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">125</span></a> Case reports of SMs from carcinomas of unknown origin treated with cisplatin&#44; gemcitabine&#44; vinorelbine&#44; and paclitaxel have also been published&#46;<a class="elsevierStyleCrossRefs" href="#bib0630"><span class="elsevierStyleSup">126&#44;127</span></a> Determination of the expression of certain molecules such as EGF&#44; Her-2&#47;neu kinase&#44; and c-kit tyrosine kinase is very important as it will provide possible targets for systemic therapy&#46; In addition&#44; drugs targeted against stromal function and angiogenesis could prove useful&#46;<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">128</span></a>The palliative treatment of SMs includes adequate management of the pain&#44; pruritus&#44; possible bacterial superinfection&#44; and&#44; in some cases&#44; of the unpleasant smell that these lesions can produce&#46;<a class="elsevierStyleCrossRefs" href="#bib0645"><span class="elsevierStyleSup">129&#8211;132</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusions</span><p id="par0195" class="elsevierStylePara elsevierViewall">The majority of tumor recurrences are diagnosed on the basis of a detailed medical history and complete physical examination&#44; combined with the relevant imaging studies&#46; As SMs are usually asymptomatic&#44; active screening is essential&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">SMs can play a crucial role in alerting the physician to a possible tumor recurrence or may even be the first sign of previously unknown tumor&#46; The site and distribution of the skin lesions can suggest the organ of origin&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Histological and immunohistochemical study of SMs is required in order to identify the primary tumor&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">Early detection of SMs is essential in order to start appropriate treatment&#46; Although strong scientific evidence of a survival benefit is lacking&#44; case reports and certain preliminary publications would suggest that early diagnosis improves life expectancy&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflicts of Interest</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "identificador" => "xres295324"
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          "titulo" => "Keywords"
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          "titulo" => "Introduction"
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        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Etiology and Pathogenesis"
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        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Epidemiology"
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          "identificador" => "sec0020"
          "titulo" => "Clinical Presentation"
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        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Specific Clinical Forms of SMs"
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        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Differential Diagnosis"
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        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Diagnosis"
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        11 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Prognosis"
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          "titulo" => "Treatment"
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          "identificador" => "sec0050"
          "titulo" => "Conclusions"
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          "identificador" => "sec0055"
          "titulo" => "Conflicts of Interest"
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          "identificador" => "xack69009"
          "titulo" => "Acknowledgments"
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        16 => array:1 [
          "titulo" => "References"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2011-12-06"
    "fechaAceptado" => "2012-06-02"
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          "clase" => "keyword"
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          "palabras" => array:6 [
            0 => "Cutaneous metastases"
            1 => "Metastatic cascade"
            2 => "Nodule"
            3 => "Dissemination"
            4 => "Metastatic pattern"
            5 => "Immunohistochemistry"
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          "palabras" => array:6 [
            0 => "Met&#225;stasis cut&#225;neas"
            1 => "Cascada metast&#225;sica"
            2 => "N&#243;dulo"
            3 => "Diseminaci&#243;n"
            4 => "Patrones metast&#225;sicos"
            5 => "Inmunohistoqu&#237;mica"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous metastases are relatively rare in clinical practice and their diagnosis requires a high index of suspicion because clinical findings can be subtle&#46; These metastases reveal the presence of disseminated malignant disease and can lead to the diagnosis of unsuspected internal tumors or the spread or recurrence of an already diagnosed tumor&#46; Early recognition of cutaneous metastases can facilitate prompt and accurate diagnosis resulting in early treatment&#59; however&#44; they are generally indicative of a poor prognosis&#46; Some tumors have a predilection to metastasize to specific areas&#46; Recognition of these patterns provides essential information that can guide the search for the underlying tumor&#46;</p>"
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      "es" => array:2 [
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las met&#225;stasis cut&#225;neas son relativamente raras en la pr&#225;ctica cl&#237;nica&#46; Su diagn&#243;stico requiere un alto &#237;ndice de sospecha&#44; pues los hallazgos cl&#237;nicos pueden ser sutiles&#46; Las met&#225;stasis cut&#225;neas ponen de manifiesto la presencia de un tumor maligno diseminado y pueden permitir el diagn&#243;stico de neoplasias internas no conocida o indicar la diseminaci&#243;n o recurrencia de otras ya diagnosticadas&#46; Su reconocimiento temprano puede llevar a un diagn&#243;stico preciso y r&#225;pido&#44; con el consiguiente tratamiento oportuno&#44; aunque en la mayor&#237;a de los casos son indicativas de un pron&#243;stico infausto&#46; Algunos tumores tienen predilecci&#243;n por metastatizar en &#225;reas espec&#237;ficas&#46; El reconocimiento de esos patrones es esencial para dirigir la b&#250;squeda del tumor subyacente&#46;</p>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Fern&#225;ndez-Ant&#243;n Mart&#237;nez MC&#44; Parra-Blanco V&#44; Avil&#233;s Izquierdo JA&#44; Su&#225;rez Fern&#225;ndez RM&#46; Met&#225;stasis cut&#225;neas de origen visceral&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;841&#8211;853&#46;</p>"
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        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">This review is part of the introduction to the doctoral thesis entitled Met&#225;stasis cut&#225;neas&#58; estudio descriptivo cl&#237;nico-histopatol&#243;gico de las met&#225;stasis cut&#225;neas de neoplasias viscerales&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Pathogenesis of skin metastases&#46; Diagram that compares the classical model of metastasis production with the most recent hypotheses&#46; Source&#58; S&#225;nchez-Garc&#237;a I&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a></p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Skin metastases can manifest as primary or secondary skin lesions&#46; A&#44; Metastasis from a gastric adenocarcinoma&#46; Papule of 7<span class="elsevierStyleHsp" style=""></span>mm diameter on the abdomen&#46; B&#44; Metastasis from an adenocarcinoma of the ovary presenting as a plaque&#46; C&#44; Metastasis from a urothelial carcinoma of the bladder presenting as a nodule&#46; D&#44; Metastasis from an adenocarcinoma of the breast&#46; The lesion started as a macule over the mastectomy scar&#46; E&#44; Ulcerated infiltrated plaque corresponding to a metastasis from an adenocarcinoma of the lung&#46;</p>"
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Unusual skin metastases&#46; A&#44; Zosteriform metastases from a ductal adenocarcinoma of the breast&#46; Clusters of infiltrated papules&#44; some confluent and some ulcerated&#44; in a metameric distribution&#46; B&#44; Umbilical metastasis &#40;Sister Mary Joseph&#39;s nodule&#41;&#59; multiple&#44; confluent&#44; ulcerated papules and nodules in the umbilical and periumbilical regions&#46; C&#44; Alopecia neoplastica&#46; Plaque of alopecia over a metastasis from a ductal adenocarcinoma of the breast in a woman&#46; D&#46; Subungual metastasis&#46; Metastasis from a squamous cell carcinoma of the lung presenting as a painful inflammatory nodule that deformed the distal phalanx of the second finger of the left hand&#46;</p>"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Histological images of skin metastases&#46; A&#44; Dermal metastasis from a poorly differentiated carcinoma of unknown origin&#46; Infiltration of the dermis by cords and nests of epithelioid cells &#40;hematoxylin-eosin&#44; original magnification x10&#41;&#46; B&#44; Dermal metastasis from a moderately differentiated adenocarcinoma of the pancreas&#46; Glandular lumens lined by a layer of epithelial cells can be seen between the dermal collagen bundles &#40;hematoxylin-eosin&#44; original magnification x10&#41;&#46;</p>"
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          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A&#44; Dermal metastasis from a carcinoma of the ovary&#46; Dilated dermal blood vessels occupied by atypical epithelial cells &#40;hematoxylin-eosin&#44; original magnification x20&#41;&#46; B&#44; Extensive dermal and vascular infiltration &#40;lymphangitis carcinomatosa&#41; by a poorly differentiated carcinoma&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Men&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#160;40 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MelanomaColon cancerLung cancer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Breast cancerCarcinoma of the colonOvarian cancer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62;&#160;40 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lung cancerColon cancerSquamous cell carcinoma of the oral cavityMelanoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carcinoma of the breastCarcinoma of the colonLung cancerCarcinoma of the ovaryMelanoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Frequency of Skin Metastases According to Age and Sex &#40;in Decreasing Frequency&#41;&#46;</p>"
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        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:1 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Site of the Skin Metastases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Most Common Primary Tumors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Breast&#44; lung&#44; and kidney&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Neck&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Oral squamous cell carcinoma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Face&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oral squamous cell carcinoma&#44; renal cell&#44; and lung&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chest&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Breast and lung&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Abdomen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colon&#44; lung&#44; stomach&#44; breast&#44; and ovary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Umbilicus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stomach&#44; pancreas&#44; colon&#44; kidney&#44; ovary&#44; and breast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pelvis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lower abdomen&#44; groin&#44; or thigh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ovary and uterus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Limbs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Breast&#44; lung&#44; kidney&#44; and bowel&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Back&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lung&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab430528.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Most Common Primary Tumors Giving Rise to Skin Metastases According to the Site of the Metastases&#46;</p>"
        ]
      ]
      9 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Source&#58; Sarya et al&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">85</span></a> Abbreviations&#58; BCC&#44; basal cell carcinoma&#59; SCC&#44; squamous cell carcinoma&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Antibodies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">General Characteristics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Metastatic Carcinomas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Adnexal Tumors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Usefulness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Homolog of p53&#44; expressed in the basal cells of the skin and mucosas and in the myoepithelial cells of the breast&#44; salivary glands&#44; and prostatePositive in SCC at various sites&#44; urothelial carcinoma&#44; BCC&#44; adnexal tumors&#44; 30&#37; of lung cancers&#44; and some pancreatic&#44; biliary&#44; gastric&#44; ovarian&#44; breast&#44; hepatic&#44; renal&#44; colon&#44; and thymus cancers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative in the published literatureNegative in 25&#47;32&#44; positive in 2&#47;2 from urothelial tumors&#44; 2&#47;8 from lung tumors&#44; 1&#47;2 from gastric tumors&#44; and 2&#47;6 from carcinomas of the breast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Positive in all cases published in the literaturePositive in 24&#47;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Most useful markerHowever&#44; it should not be used alone&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">B72&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tumor-associated glycoprotein&#46; Expressed in many adenocarcinomas&#46; Useful to differentiate lung cancer from mesothelioma and in adnexal tumors of apocrine origin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Positive 26&#47;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative in 18&#47;25&#44; focally positive in 6&#47;25&#44; and diffusely positive in 1 mucinous carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Positivity useful in metastatic carcinomas that are positive for p63 and CK5&#47;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Calretinin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Calcium-binding protein expressed in mesothelial&#44; epithelial&#44; and stromal cells&#46; Used to differentiate adenocarcinoma from mesothelioma and in sex-cord stromal tumors of the testis and ovary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative in 23&#47;32&#44; positive in 9 &#40;pancreas&#44; lung&#44; breast sporadically&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Positive in 16&#47;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negativity useful in metastatic carcinomas that are positive for p63 and CK5&#47;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CK5&#47;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intermediate-sized cytokeratin expressed in the skin&#44; squamous mucosa&#44; myoepithelial cells of breast&#44; salivary glands&#44; and prostatePositive in SCC&#44; BCC&#44; thymoma&#44; salivary gland tumors&#44; biphasic mesothelioma&#44; and some urothelial&#44; pancreatic&#44; endometrial&#44; breast&#44; and ovarian tumors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative in the published literatureNegative in 14&#47;32&#44; positive in 18&#47;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Positive in the published literaturePositive in 25&#47;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Consistent expression in skin tumors&#46; Useful in the panel of markers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab430530.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Summary of the Immunohistochemical Markers Useful for the Differentiation Between Skin Metastases and Primary Skin Tumors&#44; and Synopsis of the Data Obtained in the Series by Sarya et al&#46;</p>"
        ]
      ]
      10 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Primary Tumor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Immunohistochemical Markers<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Breast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CK7 &#40;&#43;&#41;&#44; CAM 5&#46;2 &#40;&#43;&#41;&#44; vimentin &#40;&#8722;&#41;&#44; TTF-1 &#40;&#8722;&#41;&#44; Ber-EP4 &#40;&#43;&#41;&#44; WT-1 &#40;&#8722;&#41;&#44; DPC4 &#40;&#8722;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adenocarcinoma of the lung&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CK7 &#40;&#43;&#41;&#44; CAM 5&#46;2 &#40;&#43;&#41;&#44; CEA &#40;&#43;&#41;&#44; Ber-EP4 &#40;&#43;&#41;&#44; WT-1 &#40;&#8722;&#41;&#44; DPC4 &#40;&#8722;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Colon and rectum&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CK20 &#40;&#43;&#41;&#44; CAM 5&#46;2 &#40;&#43;&#41;&#44; CK17 &#40;&#8722;&#41;&#44; CK19 &#40;&#43;&#41;&#44; CEA &#40;&#43;&#41;&#44; TTF-1 &#40;&#8722;&#41;&#44; Ber-EP4 &#40;&#43;&#41;&#44; S100 &#40;&#8722;&#41;&#44; WT-1 &#40;&#8722;&#41;&#44; DPC4 &#40;&#8722;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stomach&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAM 5&#46;2 &#40;&#43;&#41;&#44; vimentin &#40;&#8722;&#41;&#44; TTF-1 &#40;&#8722;&#41;&#44; ER &#40;&#8722;&#41;&#44; Ber-EP4 &#40;&#43;&#41;&#44; WT-1 &#40;&#8722;&#41;&#44; DPC4 &#40;&#8722;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prostate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CK7 &#40;&#8722;&#41;&#44; CK20 &#40;&#8722;&#41;&#44; CAM 5&#46;2 &#40;&#43;&#41;&#44; CD5&#47;6 &#40;&#8722;&#41;&#44; CK17 &#40;&#8722;&#41;&#44; CEA &#40;&#8722;&#41;&#44; vimentin &#40;&#8722;&#41;&#44; TTF-1 &#40;&#8722;&#41;&#44; ER &#40;&#8722;&#41;&#44; Ber-EP4 &#40;&#43;&#41;&#44; S100 &#40;&#8722;&#41;&#44; WT-1 &#40;&#8722;&#41;&#44; DPC4 &#40;&#8722;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pancreas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CK7 &#40;&#43;&#41;&#44; CAM 5&#46;2 &#40;&#43;&#41;&#44; vimentin &#40;&#8722;&#41;&#44; TTF-1 &#40;&#40;&#41;&#44; ER &#40;&#8722;&#41;&#44; Ber-EP4 &#40;&#43;&#41;&#44; S100 &#40;&#8722;&#41;&#44; WT-1 &#40;&#8722;&#41;&#44; DPC 4 &#40;&#43;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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          "identificador" => "bibs0005"
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            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastatic tumors"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Clinical Dermatology"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "serieFecha" => "1997"
                      ]
                    ]
                  ]
                ]
              ]
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            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do all roads lead to Rome&#63; Routes to metastasis development&#63;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ijc.26027"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2011"
                        "volumen" => "128"
                        "paginaInicial" => "2511"
                        "paginaFinal" => "2526"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor cells caught in the act of invading&#58; their strategy for enhanced cell motility"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.tcb.2005.01.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Trends Cell Biol"
                        "fecha" => "2005"
                        "volumen" => "15"
                        "paginaInicial" => "138"
                        "paginaFinal" => "145"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The lymph node as a bridgehead in the metastatic dissemination of tumors"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Recent Results Cancer Res"
                        "fecha" => "2000"
                        "volumen" => "157"
                        "paginaInicial" => "55"
                        "paginaFinal" => "81"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dissemination and growth of cancer cells in metastatic sites"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nrc865"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Cancer"
                        "fecha" => "2002"
                        "volumen" => "2"
                        "paginaInicial" => "563"
                        "paginaFinal" => "572"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous manifestations of internal malignancies"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2001"
                        "volumen" => "19"
                        "paginaInicial" => "290"
                        "paginaFinal" => "297"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastatic disease"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermalol"
                        "fecha" => "1995"
                        "volumen" => "33"
                        "paginaInicial" => "161"
                        "paginaFinal" => "182"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "El proceso metast&#225;tico &#40;<span class="elsevierStyleSmallCaps">ii</span>&#41;&#58; diseminaci&#243;n tumoral directa&#44; linf&#225;tica y hem&#225;tica"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "1999"
                        "volumen" => "90"
                        "paginaInicial" => "277"
                        "paginaFinal" => "290"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastases in internal malignancy"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Egypt Dermatol Online J"
                        "fecha" => "2007"
                        "volumen" => "3"
                        "paginaInicial" => "1"
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Met&#225;stasis cut&#225;nea inflamatoria como primer signo de recidiva de carcinoma escamoso de pulm&#243;n"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2008"
                        "volumen" => "99"
                        "paginaInicial" => "157"
                        "paginaFinal" => "159"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin involvement as the presenting sign of internal carcinoma&#58; a retrospective study of 7&#44;316 cancer patients"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1990"
                        "volumen" => "22"
                        "paginaInicial" => "19"
                        "paginaFinal" => "26"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patterns of cutaneous metastasis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1972"
                        "volumen" => "105"
                        "paginaInicial" => "862"
                        "paginaFinal" => "868"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastases of internal malignancies"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0378-6323.60548"
                      "Revista" => array:7 [
                        "tituloSerie" => "Indian J Dermatol Venereol Leprol"
                        "fecha" => "2010"
                        "volumen" => "76"
                        "paginaInicial" => "125"
                        "paginaFinal" => "131"
                        "link" => array:1 [ …1]
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastatic tumors of the skin"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1972"
                        "volumen" => "29"
                        "paginaInicial" => "1298"
                        "paginaFinal" => "1307"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastasis mechanisms"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Biochim Biophys Acta"
                        "fecha" => "1796"
                        "volumen" => "2009"
                        "paginaInicial" => "293"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastases from internal carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1966"
                        "volumen" => "19"
                        "paginaInicial" => "162"
                        "paginaFinal" => "168"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin metastases in cancer patients"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Cutis"
                        "fecha" => "1987"
                        "volumen" => "39"
                        "paginaInicial" => "119"
                        "paginaFinal" => "121"
                        "link" => array:1 [ …1]
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Complex networks orchestrate epithelial-mesenchymal transitions"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nrm1835"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Mol Cell Biol"
                        "fecha" => "2006"
                        "volumen" => "7"
                        "paginaInicial" => "131"
                        "paginaFinal" => "142"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatic and skin metastases after laparoscopic radical prostatectomy for prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Gastrointestin Liver"
                        "fecha" => "2007"
                        "volumen" => "16"
                        "paginaInicial" => "333"
                        "paginaFinal" => "335"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastasis of pleural mesothelioma&#58; two cases"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Dermatol Venereol"
                        "fecha" => "2003"
                        "volumen" => "130"
                        "paginaInicial" => "455"
                        "paginaFinal" => "459"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-09-4442"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2010"
                        "volumen" => "70"
                        "paginaInicial" => "6071"
                        "paginaFinal" => "6082"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathogenesis of cancer metastasis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1979"
                        "volumen" => "283"
                        "paginaInicial" => "139"
                        "paginaFinal" => "146"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Ras branch of small GTPases&#58; Ras family members don&#8217;t fall far from the tree"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Curr Opin Cell Biol"
                        "fecha" => "2000"
                        "volumen" => "12"
                        "paginaInicial" => "157"
                        "paginaFinal" => "165"
                        "link" => array:1 [ …1]
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The mitogen activated protein kinase signal transduction pathway&#58; From the cell surface to the nucleus"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Signal"
                        "fecha" => "1994"
                        "volumen" => "6"
                        "paginaInicial" => "581"
                        "paginaFinal" => "589"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ras oncogenes in human cancer&#58; A review"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1989"
                        "volumen" => "49"
                        "paginaInicial" => "4682"
                        "paginaFinal" => "4689"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibitors of the ras oncogene as therapeutic targets"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hematol Oncol Clin North Am"
                        "fecha" => "2002"
                        "volumen" => "16"
                        "paginaInicial" => "1065"
                        "paginaFinal" => "1088"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular mechanisms of tumor metastasis and angiogenesis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Langenbecks Arch Surg"
                        "fecha" => "1999"
                        "volumen" => "384"
                        "paginaInicial" => "133"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "General mechanisms of metastasis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1997"
                        "volumen" => "80"
                        "paginaInicial" => "1529"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Axis of evil&#58; molecular mechanisms of cancer metastasis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.onc.1206757"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncogene"
                        "fecha" => "2003"
                        "volumen" => "22"
                        "paginaInicial" => "6524"
                        "link" => array:1 [ …1]
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The crossroads of oncogenesis and metastasis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2009"
                        "volumen" => "15"
                        "paginaInicial" => "297"
                        "paginaFinal" => "299"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastases in carcinoma&#59; analysis of 1000 autopsied cases"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1950"
                        "volumen" => "3"
                        "paginaInicial" => "74"
                        "paginaFinal" => "85"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastases&#46; Clinical pathological review"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Med Chil"
                        "fecha" => "1996"
                        "volumen" => "124"
                        "paginaInicial" => "1519"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastases in patients with metastatic carcinoma&#58; A retrospective study of 4020 patients"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1993"
                        "volumen" => "29"
                        "paginaInicial" => "228"
                        "paginaFinal" => "236"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastases&#58; a metaanalysis of data"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.SMJ.0000053676.73249.E5"
                      "Revista" => array:6 [
                        "tituloSerie" => "South Med J"
                        "fecha" => "2003"
                        "volumen" => "96"
                        "paginaInicial" => "164"
                        "paginaFinal" => "167"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastatic Patterns of Cancers&#58; Results From a Large Autopsy Study"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Pathol Lab Med"
                        "fecha" => "2008"
                        "volumen" => "6"
                        "paginaInicial" => "931 L 939"
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Non-hematopoietic cutaneous metastases in children and adolescents&#58; thirty years experience at St&#46; Jude Children&#39;s Research Hospital"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2000"
                        "volumen" => "27"
                        "paginaInicial" => "485"
                        "paginaFinal" => "492"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Met&#225;stasis cut&#225;nea por carcinoma pancre&#225;tico como primera manifestaci&#243;n cl&#237;nica"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2010"
                        "volumen" => "101"
                        "paginaInicial" => "93"
                        "paginaFinal" => "95"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Met&#225;stasis cut&#225;neas generalizadas como forma de presentaci&#243;n de un adenocarcinoma g&#225;strico"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2007"
                        "volumen" => "98"
                        "paginaInicial" => "213"
                        "paginaFinal" => "218"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A study of 70 cases of cutaneous metastases from internal carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastatic cancer of the skin"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [ …4]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous manifestations of malignant disease"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [ …7]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastasis of a radiation associated thyroid medullary carcinoma"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03349501"
                      "Revista" => array:5 [ …5]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastasis from follicular carcinoma of the thyroid gland"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/thy.1993.3.235"
                      "Revista" => array:5 [ …5]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous infiltration by cancer"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2007.01.034"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastatic tumors to the nail unit&#58; subungueal metastases"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "N&#243;dulo umbilical"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous lesions of metastatic visceral malignancy mimicking pyogenic granuloma"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinoma erysipelatoides from squamous cell carcinoma of unknown origin"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1368-5031.2005.00588.x"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Met&#225;stasis cut&#225;nea inflamatoria como primer signo de recidiva de carcinoma escamoso de pulm&#243;n"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastases from carcinoma breast&#58; the common and the rare"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0378-6323.55395"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Narrative review&#58; diseases that masquerade as infection cellulitis"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [ …7]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastases&#8211;carcinoma en cuirasse"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammatory metastatic carcinoma&#46; Carcinoma erysipelatoides"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bilateral thoracic zosteroid spreading marginate telangiectasia &#8211; probably a variety of carcinoma erysipelatoides &#8211; associated with unilateral mammary carcinoma&#44; and better termed carcinoma telangiectaticum"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Telangiectatic metastatic breast carcinoma preceded by en cuirasse metastatic breast carcinoma"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2004.06140.x"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recognizing malignant skin changes following breast cancer"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [ …7]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bilateral thoracic zosteroid spreading marginate telangiectasia&#8211;probably a variant of carcinoma telangiectatum"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
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            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Zosteriform cutaneous metastases&#58; a literature meta-analysis and a clinical report of three melanoma cases"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1524-4725.2009.01241.x"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Met&#225;stasis cut&#225;neas de adenocarcinoma de recto con distribuci&#243;n herpetiforme"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [ …7]
                    ]
                  ]
                ]
              ]
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            59 => array:3 [
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              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Zosteriform metastasis&#58; case presentation and review of the literature"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
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            60 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous malignancies mimicking herpes zoster"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
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                ]
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            61 => array:3 [
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                0 => array:2 [
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                    0 => array:1 [
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                      "titulo" => "Dermal and subcutaneous tumors"
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                    0 => array:1 [
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                      "titulo" => "Metastatic breast carcinoma mimicking granular cell tumor"
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                    0 => array:1 [
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                      "titulo" => "Cutaneous metastasis from hepatocellular carcinoma resembling pyogenic granuloma"
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                    0 => array:1 [
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                    0 => array:1 [
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                      "titulo" => "Inflammatory carcinoma masquerading as erythema annulare centrifugum"
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                    0 => array:1 [
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                    0 => array:1 [
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                      "titulo" => "The significance of cutaneous metastasis from visceral tumors diagnosed by fine-needle aspiration biopsy"
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                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                    0 => array:1 [
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                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                    0 => array:1 [
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                    0 => array:2 [
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        "texto" => "<p id="par0220" class="elsevierStylePara elsevierViewall">We would like to thank Dr Concepci&#243;n Rom&#225;n Curto&#44; author of the doctoral thesis &#8220;Tumores cutaneous metast&#225;sicos&#46; <span class="elsevierStyleItalic">Estudio clinic&#44; histol&#243;gico y ultraestructural</span>&#8221; for her help and Dr Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Professor of Medicine&#44; Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Facultad de Medicina&#44; Universidad Complutense&#44; in Madrid&#44; Spain&#44; for his inestimable collaboration&#46;</p>"
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Article information

ISSN: 15782190
Original language: English

DOI:10.1016/j.adengl.2012.06.031

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2020 December	34	28	62
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2020 August	42	25	67
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2020 June	41	23	64
2020 May	34	20	54
2020 April	33	17	50
2020 March	38	24	62
2020 February	2	2	4
2020 January	3	4	7
2019 December	8	2	10
2019 November	4	0	4
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2019 September	5	0	5
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2019 July	4	1	5
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2019 May	10	8	18
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2018 February	199	3	202
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