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Sánchez, J. Nova" "autores" => array:2 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Sánchez" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Nova" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731013000604" "doi" => "10.1016/j.ad.2013.01.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000604?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013001753?idApp=UINPBA000044" "url" => "/15782190/0000010400000008/v1_201309240048/S1578219013001753/v1_201309240048/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S157821901300173X" "issn" => "15782190" "doi" => "10.1016/j.adengl.2012.10.012" "estado" => "S300" "fechaPublicacion" => "2013-10-01" "aid" => "747" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "article" "crossmark" => 0 "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2013;104:654-66" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 14994 "formatos" => array:3 [ "EPUB" => 47 "HTML" => 11590 "PDF" => 3357 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Update on the Classification and Treatment of Localized Scleroderma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "654" "paginaFinal" => "666" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Actualización en la clasificación y el tratamiento de la esclerodermia localizada" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1696 "Ancho" => 840 "Tamanyo" => 200417 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Generalized morphea. A, Multiple plaques of swollen, indurated, shiny skin. The plaques have become confluent and affect practically all the skin of the trunk and limbs. B, Erosions and scabs on the plaques on the distal areas of the lower limbs. Two biopsies taken from this patient revealed changes consistent with morphea in one and with lichen sclerosus et atrophicus in the other.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Bielsa Marsol" "autores" => array:1 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Bielsa Marsol" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731012004772" "doi" => "10.1016/j.ad.2012.10.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004772?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901300173X?idApp=UINPBA000044" "url" => "/15782190/0000010400000008/v1_201309240048/S157821901300173X/v1_201309240048/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Controversies in Dermatology</span>" "titulo" => "Is Bone Marrow Biopsy Always Indicated in Patients With Primary Cutaneous Marginal Zone B-Cell Lymphoma?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "667" "paginaFinal" => "671" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Muniesa, B. Hernández-Machín" "autores" => array:2 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Muniesa" "email" => array:1 [ 0 => "cristinamuniesa@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "Hernández-Machín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de Viladecans, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Nuestra Señora de Los Reyes, El Hierro, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Está siempre indicada la biopsia de médula ósea en los pacientes con linfoma primario cutáneo de células B de la zona marginal?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 644 "Ancho" => 950 "Tamanyo" => 95078 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Isolated nodule on the arm of a patient with primary cutaneous marginal zone B-cell lymphoma.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Primary cutaneous marginal zone B-cell lymphoma (MZL), or extranodal MZL of the mucosa-associated lymphoid tissue (MALT) type, is an indolent B-cell lymphoma that first manifests on the skin with no extracutaneous involvement at the time of diagnosis. It is one of the main subtypes of cutaneous B-cell lymphoma.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Clinically, primary cutaneous MZL presents as isolated or multiple infiltrated plaques or nodules that are often found on the trunk or proximal part of the extremities (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). These lymphomas affect middle-aged patients and tend to be somewhat more frequent in men. Although this tumor has an indolent course and is usually confined to the skin, relapses are common at the initial sites, distant sites, or both. In very rare cases, extracutaneous involvement is seen at diagnosis or during the course of the disease; other MALT sites (digestive tract, salivary glands, thyroid, breast, lung, and orbit), lymph nodes, or bone marrow may be affected. Nevertheless, prognosis is generally excellent, with a 5-year survival rate close to 100%.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–7</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Staging of Primary Cutaneous MZL</span><p id="par0010" class="elsevierStylePara elsevierViewall">In order to rule out potential systemic disease, the initial workup in suspected primary cutaneous MZL should include a clinical history and meticulous physical examination (detection of B symptoms, complete skin inspection, and palpation of lymph nodes and viscera). The staging study should include a laboratory workup with peripheral blood smear (formula and count), standard biochemical profile with levels of lactate dehydrogenase and β<span class="elsevierStyleInf">2</span>-microglobulin, and serological tests for hepatitis C virus, human herpesvirus 8, cytomegalovirus, Epstein-Barr virus, and <span class="elsevierStyleItalic">Borrelia burgdorferi</span>. A computed tomography scan of the thorax, abdomen, and pelvis should be performed. Pioneering studies in this field also proposed systematic inclusion of bone marrow biopsy in the initial staging.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Bone Marrow Biopsy</span><p id="par0015" class="elsevierStylePara elsevierViewall">Bone marrow biopsy is an invasive diagnostic technique in which a small fragment of bone containing a small amount of bone marrow is extracted with a needle. The procedure is generally performed by hematologists, who usually take the sample from the iliac crest. Although local anesthesia is applied, the procedure is uncomfortable and may occasionally be painful. In some cases, the physician has to exert strong pressure when inserting the needle, and the patient may momentarily feel pain when the needle crosses the bone. The patient may also feel discomfort or pain in the general area, although this usually eases within a few hours with the help of ordinary analgesics. Other side effects include hematoma or bleeding at the puncture site and risk of local or bone infection, which is very unusual today given that the procedure is performed under aseptic conditions. Histologically, extranodal MZL does not have a specific pattern of infiltration, and nodular, interstitial, paratrabecular, diffuse, or sinusoidal patterns can be observed. The fact that a median of 5% of the medullary space is infiltrated by extranodal MZL sometimes creates a diagnostic challenge for the pathologist.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8–10</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Unlike splenic and nodal MZL, which tend to infiltrate bone marrow in 67% to 100% and 30% to 40% of cases, respectively, extranodal MZL infiltrates bone marrow much less commonly (in around 10% of cases).<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Primary Cutaneous MZL and Bone Marrow Involvement at Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Bone marrow involvement is uncommon at the time of diagnosis of primary cutaneous MZL. Moreover, in patients with this lymphoma, bone marrow is rarely the only tissue affected at diagnosis, and in the few cases in which early bone marrow involvement is found, patients usually also have secondary nodal or visceral disease, which is detected using other staging studies (usually computed tomography). Therefore, the need for bone marrow biopsy at diagnosis in all cases of suspected primary cutaneous MZL has lately come under debate. In a consensus proposal from the Cutaneous Lymphoma Task Force of the European Organization for Research and Treatment of Cancer (EORTC) and the International Society of Cutaneous Lymphomas, Kim et al.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> proposed a new TNM classification for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome. The report also listed recommended tests for initial staging of these lymphomas (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Of note, the proposal considers bone marrow biopsy essential in cases of lymphoma with a risk of extracutaneous dissemination and intermediate or aggressive behavior according to the World Health Organization (WHO)-EORTC classification (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>) (natural killer lymphoma; CD8<span class="elsevierStyleSup">+</span> T-cell lymphoma; γ/δ T-cell lymphoma; and diffuse large B-cell lymphoma, leg type). In contrast, in slow-growing lymphomas, including primary cutaneous MZL, primary cutaneous follicle center lymphoma (FCL), and CD30<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSup">+</span><span class="elsevierStyleHsp" style=""></span>T-cell anaplastic lymphoma, bone marrow biopsy is considered an option, unless the results of other staging tests are positive. After an exhaustive review of the literature, we found that very few articles<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12–15</span></a> specifically address bone marrow involvement at diagnosis in primary cutaneous MZL and that even fewer address the issue of whether bone marrow biopsy should be performed routinely in cases of primary cutaneous MZL. We found confirmation of the low frequency of early bone marrow involvement in primary cutaneous MZL<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12–14</span></a> and suggest that routine bone marrow biopsy would not be justified in the initial workup for these lymphomas. The most relevant article in this respect is that of Senff et al.,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> who reviewed 275 bone marrow biopsy results (193 primary cutaneous FCL and 82 primary cutaneous MZL) and found that the marrow was affected at diagnosis in 22 cases of primary cutaneous FCL (11%) and that this was the only sign of extracutaneous dissemination in only 9 of them. A positive bone-marrow biopsy was found in only 2 cases of primary cutaneous MZL (2%), and in only 1 of these cases was bone marrow involvement the only extracutaneous sign. However, other guidelines, including those of the Dutch-Belgian Hemato-Oncology Group, maintain bone marrow biopsy as part of routine staging in all patients with non-Hodgkin lymphoma.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> The criteria for performing bone marrow biopsy vary among the different clinical guidelines of the working groups. The literature suggests that a bone marrow biopsy is ordered by most groups (as reported in papers from the Netherlands,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Italy,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and Austria<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>) although these studies were performed before the 2007 consensus paper.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> On the other hand, Gerami et al.,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> from Chicago in the United States, reviewed 30 cases of primary cutaneous MZL and found that bone marrow biopsy was only performed in half.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Consequences of Performing or Not Performing Bone Marrow Biopsy in Primary Cutaneous MZL</span><p id="par0030" class="elsevierStylePara elsevierViewall">In patients with primary cutaneous MZL, not performing a bone marrow biopsy has very limited clinical consequences. If a patient with MZL has skin lesions at the time of initial staging (including those who have had a negative bone marrow biopsy), then the disease would be classed as primary cutaneous MZL according to the WHO-EORTC classification. However, if a distant tumor can be identified in the bone marrow biopsy or at another phase of staging, the classification would change to extranodal MZL with initial presentation on the skin and the corresponding MALT lymphoma. Lastly, if we do not perform a bone marrow biopsy and the other staging study results are negative, then, from a terminological point of view, we cannot class the disease as primary cutaneous MZL, but rather as extranodal MZL with skin lesions. Although the classification changes, the disease would still be considered slow-growing lymphoma, and treatment and prognosis would not vary substantially. Treatment of extranodal MZL with skin lesions and isolated involvement of the marrow is no different from that of primary cutaneous MZL. The treatment of choice in both cases is local radiotherapy delivered to the skin, although patients with extranodal MZL are more closely followed.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Furthermore, if, by definition, primary cutaneous MZL is limited to the skin at diagnosis, then diagnosis must be confirmed by staging study in order to rule out the presence of systemic lymphoma with secondary cutaneous manifestations. Consequently, if bone marrow biopsy is no longer to be routinely performed in these cases, then we cannot confirm a diagnosis of the primary cutaneous form, thus making it difficult to identify the pathogenetic differences between the different types of MALT lymphoma by localization, in terms of the translocations and antigenic stimuli involved in their development.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="par0040" class="elsevierStylePara elsevierViewall">In our opinion, bone marrow biopsy is necessary for the diagnosis and classification of cutaneous lymphoma from a theoretical viewpoint; from a clinical viewpoint, however, its contribution is limited, and, if it is not performed, very few cases with isolated involvement of bone marrow would go undiagnosed. We believe that more prospective studies with larger populations are necessary to explore the significance of isolated bone marrow involvement in patients diagnosed with primary cutaneous MZL, including the therapeutic implications and prognosis of this finding. Further study would allow us to decide whether routine bone marrow biopsy is or is not necessary in this type of lymphoma.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Ethical Disclosures</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Protection of human and animal subjects</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Data protection</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they followed their hospital's regulations regarding the publication of patient information and that written informed consent for voluntary participation was obtained for all patients.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Right to privacy and informed consent</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data are disclosed in this article.</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:2 [ "identificador" => "xres276233" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec258208" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres276232" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec258207" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Staging of Primary Cutaneous MZL" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Bone Marrow Biopsy" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Primary Cutaneous MZL and Bone Marrow Involvement at Diagnosis" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Consequences of Performing or Not Performing Bone Marrow Biopsy in Primary Cutaneous MZL" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conclusion" ] 10 => array:3 [ "identificador" => "sec0035" "titulo" => "Ethical Disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Data protection" ] 2 => array:2 [ "identificador" => "sec0050" "titulo" => "Right to privacy and informed consent" ] ] ] 11 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflicts of Interest" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-09-30" "fechaAceptado" => "2013-01-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec258208" "palabras" => array:3 [ 0 => "Primary cutaneous marginal zone B-cell lymphoma" 1 => "Bone marrow biopsy" 2 => "Extracutaneous involvement" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec258207" "palabras" => array:3 [ 0 => "Linfoma primario cutáneo de células B de la zona marginal" 1 => "Biopsia de médula ósea" 2 => "Afectación extracutánea" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bone marrow involvement at the time of diagnosis is uncommon in patients with primary cutaneous marginal zone B-cell lymphoma (PCMZL). Moreover, in these patients such involvement is rarely found in isolation on diagnosis. Typically the few patients with PCMZL who have early bone marrow involvement also present secondary nodal or visceral involvement, which is detected by other staging studies (usually computed tomography). In recent years, this has given rise to some debate about whether a bone marrow biopsy should be routinely performed in patients diagnosed with PCMZL in view of the good prognosis and low incidence of bone marrow infiltration and/or extracutaneous involvement in this type of lymphoma.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En los pacientes con linfoma primario cutáneo de células B de la zona marginal (LPCBZM), la afectación de la médula ósea en el momento del diagnóstico es poco frecuente. Además, es raro en estos pacientes detectar afectación de la médula ósea al diagnóstico de forma aislada. Los pocos casos de LPCBZM y afectación inicial de la médula ósea habitualmente presentan también afectación secundaria nodal o visceral que son detectadas con otras pruebas de estadificación (normalmente con la TAC). Por dicho motivo, en los últimos años ha sido tema de controversia si debe realizarse la biopsia de médula ósea al diagnóstico de forma sistemática en todos los casos de LPCBZM dado el buen pronóstico y la baja incidencia de infiltración medular y/o afectación extracutánea por parte de este tipo de linfoma.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Muniesa C, Hernández-Machín B. ¿Está siempre indicada la biopsia de médula ósea en los pacientes con linfoma primario cutáneo de células B de la zona marginal? Actas Dermosifiliogr. 2013;104:667–71.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 644 "Ancho" => 950 "Tamanyo" => 95078 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Isolated nodule on the arm of a patient with primary cutaneous marginal zone B-cell lymphoma.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: CT, computed tomography; EORTC, European Organization for Research and Treatment of Cancer; ISCL, International Society of Cutaneous Lymphomas; PET, positron emission tomography; WHO, World Health Organization.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Complete clinical history and physical examination</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Laboratory workup</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Complete blood count and biochemistry, including lactate dehydrogenase levels \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Whenever indicated, flow cytometric study of peripheral blood mononuclear cells \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Imaging studies</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CT scan of chest, abdomen, and pelvis with contrast; include CT or ultrasound of neck in cases of cervical lymph nodes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Whole-body PET scan (as alternative imaging study to contrast-enhanced CT scan) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Bone marrow biopsy and aspirate</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Required in cutaneous lymphomas with intermediate to aggressive clinical behavior according to the WHO-EORTC classification \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Should be considered in cutaneous lymphomas with indolent clinical behavior, but not required unless positive results are recorded in other staging studies \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab397384.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">ISCL/EORTC Recommendations on Initial Staging in Cutaneous Lymphomas Other Than Mycosis Fungoides/Sézary Syndrome.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: EORTC, European Organization for Research and Treatment of Cancer; WHO, World Health Organization.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Cutaneous T-Cell Lymphoma</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Indolent clinical behavior</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mycosis fungoides \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Folliculotropic mycosis fungoides \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pagetoid reticulosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Granulomatous slack skin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous anaplastic large cell lymphoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Lymphomatoid papulosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Subcutaneous panniculitis-like T-cell lymphoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous CD4<span class="elsevierStyleSup">+</span> small/medium-sized pleomorphic T-cell lymphoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Aggressive clinical behavior</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sézary syndrome \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous natural killer/T-cell lymphoma, nasal type \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous aggressive CD8<span class="elsevierStyleSup">+</span> T-cell lymphoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous γ/δ T-cell lymphoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous peripheral T-cell lymphoma, unspecified \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Cutaneous B-Cell Lymphoma</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Indolent clinical behavior</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous marginal zone B-cell lymphoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous follicle center B-cell lymphoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Intermediate clinical behavior</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous diffuse large B-cell lymphoma, leg type \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous diffuse large B-cell lymphoma, other \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Primary cutaneous intravascular large B-cell lymphoma \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab397385.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">WHO-EORTC Classification of Primary Cutaneous Lymphomas.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "WHO-EORTC classification for cutaneous lymphomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Willemze" 1 => "E.S. Jaffe" 2 => "G. Burg" 3 => "L. Cerroni" 4 => "E. Berti" 5 => "S.H. Swerdlow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2004-09-3502" "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2005" "volumen" => "105" "paginaInicial" => "3768" "paginaFinal" => "3785" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15692063" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO classification (2008): Update and future directions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Turner" 1 => "L.M. Morton" 2 => "M.S. Linet" 3 => "C.A. Clarke" 4 => "M.E. Kadin" 5 => "C.M. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 14 | 19 | 33 |
2024 October | 86 | 79 | 165 |
2024 September | 83 | 56 | 139 |
2024 August | 122 | 97 | 219 |
2024 July | 119 | 49 | 168 |
2024 June | 104 | 42 | 146 |
2024 May | 86 | 52 | 138 |
2024 April | 102 | 47 | 149 |
2024 March | 91 | 53 | 144 |
2024 February | 129 | 57 | 186 |
2024 January | 114 | 52 | 166 |
2023 December | 99 | 66 | 165 |
2023 November | 98 | 63 | 161 |
2023 October | 94 | 75 | 169 |
2023 September | 77 | 74 | 151 |
2023 August | 81 | 26 | 107 |
2023 July | 113 | 55 | 168 |
2023 June | 126 | 27 | 153 |
2023 May | 112 | 35 | 147 |
2023 April | 87 | 26 | 113 |
2023 March | 103 | 38 | 141 |
2023 February | 89 | 24 | 113 |
2023 January | 97 | 42 | 139 |
2022 December | 103 | 49 | 152 |
2022 November | 43 | 26 | 69 |
2022 October | 40 | 19 | 59 |
2022 September | 45 | 36 | 81 |
2022 August | 49 | 40 | 89 |
2022 July | 51 | 35 | 86 |
2022 June | 52 | 43 | 95 |
2022 May | 57 | 70 | 127 |
2022 April | 79 | 41 | 120 |
2022 March | 85 | 62 | 147 |
2022 February | 68 | 34 | 102 |
2022 January | 71 | 49 | 120 |
2021 December | 51 | 40 | 91 |
2021 November | 73 | 43 | 116 |
2021 October | 68 | 52 | 120 |
2021 September | 60 | 52 | 112 |
2021 August | 56 | 31 | 87 |
2021 July | 41 | 40 | 81 |
2021 June | 88 | 21 | 109 |
2021 May | 54 | 33 | 87 |
2021 April | 187 | 61 | 248 |
2021 March | 91 | 25 | 116 |
2021 February | 67 | 51 | 118 |
2021 January | 73 | 21 | 94 |
2020 December | 56 | 23 | 79 |
2020 November | 40 | 30 | 70 |
2020 October | 40 | 18 | 58 |
2020 September | 62 | 11 | 73 |
2020 August | 57 | 25 | 82 |
2020 July | 41 | 18 | 59 |
2020 June | 47 | 26 | 73 |
2020 May | 31 | 26 | 57 |
2020 April | 46 | 28 | 74 |
2020 March | 37 | 22 | 59 |
2020 February | 5 | 4 | 9 |
2020 January | 4 | 8 | 12 |
2019 December | 8 | 8 | 16 |
2019 November | 4 | 1 | 5 |
2019 October | 0 | 2 | 2 |
2019 September | 8 | 3 | 11 |
2019 August | 4 | 2 | 6 |
2019 July | 4 | 2 | 6 |
2019 June | 6 | 13 | 19 |
2019 May | 5 | 47 | 52 |
2019 April | 2 | 13 | 15 |
2019 March | 2 | 9 | 11 |
2019 February | 2 | 2 | 4 |
2019 January | 4 | 2 | 6 |
2018 December | 1 | 5 | 6 |
2018 November | 3 | 0 | 3 |
2018 October | 3 | 0 | 3 |
2018 September | 5 | 0 | 5 |
2018 August | 0 | 4 | 4 |
2018 June | 0 | 2 | 2 |
2018 May | 0 | 4 | 4 |
2018 April | 0 | 1 | 1 |
2018 March | 21 | 4 | 25 |
2018 February | 72 | 6 | 78 |
2018 January | 93 | 6 | 99 |
2017 December | 77 | 8 | 85 |
2017 November | 77 | 10 | 87 |
2017 October | 65 | 9 | 74 |
2017 September | 79 | 10 | 89 |
2017 August | 82 | 16 | 98 |
2017 July | 82 | 11 | 93 |
2017 June | 74 | 19 | 93 |
2017 May | 81 | 19 | 100 |
2017 April | 66 | 10 | 76 |
2017 March | 73 | 15 | 88 |
2017 February | 53 | 16 | 69 |
2017 January | 47 | 9 | 56 |
2016 December | 85 | 7 | 92 |
2016 November | 94 | 11 | 105 |
2016 October | 127 | 7 | 134 |
2016 September | 200 | 11 | 211 |
2016 August | 205 | 14 | 219 |
2016 July | 87 | 12 | 99 |
2016 June | 8 | 7 | 15 |
2016 May | 9 | 7 | 16 |
2016 April | 6 | 4 | 10 |
2016 March | 4 | 14 | 18 |
2016 February | 4 | 16 | 20 |
2016 January | 8 | 19 | 27 |
2015 December | 17 | 3 | 20 |
2015 November | 5 | 2 | 7 |
2015 October | 8 | 15 | 23 |
2015 September | 2 | 2 | 4 |
2015 August | 4 | 1 | 5 |
2015 July | 147 | 11 | 158 |
2015 June | 66 | 10 | 76 |
2015 May | 84 | 14 | 98 |
2015 April | 76 | 7 | 83 |
2015 March | 81 | 0 | 81 |
2015 February | 71 | 3 | 74 |
2015 January | 54 | 3 | 57 |
2014 December | 67 | 6 | 73 |
2014 November | 63 | 7 | 70 |
2014 October | 72 | 3 | 75 |
2014 September | 54 | 1 | 55 |
2014 August | 54 | 4 | 58 |
2014 July | 66 | 6 | 72 |
2014 June | 59 | 4 | 63 |
2014 May | 61 | 6 | 67 |
2014 April | 57 | 3 | 60 |
2014 March | 51 | 5 | 56 |
2014 February | 38 | 2 | 40 |
2014 January | 39 | 7 | 46 |
2013 December | 29 | 8 | 37 |
2013 November | 3 | 5 | 8 |
2013 October | 3 | 5 | 8 |
2013 September | 0 | 2 | 2 |