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and along the dorsal midline a pinkish&#44; lobulated plaque with a shiny surface and rubbery consistency &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No lymphadenopathies were detected on palpation of the craniocervical region&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Additional tests</span><p id="par0015" class="elsevierStylePara elsevierViewall">The following tests were performed&#58; punch biopsy&#59; culture in Sabouraud&#39;s medium&#44; which was positive for <span class="elsevierStyleItalic">Candida albicans</span>&#59; and routine blood tests&#44; which were normal&#44; including negative HIV serology&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Histology</span><p id="par0020" class="elsevierStylePara elsevierViewall">On histology&#44; the mucosa exhibited marked acanthosis and papillomatosis&#44; as well as an increase in the mitotic activity of the basal layer&#44; with no alterations in cell polarity or maturation&#46; A moderate lymphohistiocytic interstitial infiltrate and vascular ectasia were observed in the chorion &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Periodic acid Schiff &#40;PAS&#41; and PAS diastase staining revealed no fungal structures&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Hypertrophic median rhomboid glossitis &#40;MRG&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Course</span><p id="par0035" class="elsevierStylePara elsevierViewall">Quitting smoking was recommended&#44; and this resulted in a significant improvement and a decrease in the size of the lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The patient was subsequently treated with fluconazole &#40;50&#160;mg&#47;12&#160;h by mouth&#41; for 14 days&#44; which led to some additional improvement&#46; Despite continued systemic antifungal treatment and replacement of the patient&#39;s dental prosthesis&#44; subsequent cultures were only transiently negative&#46; The patient was thus referred to the otolaryngology service for carbon-dioxide laser treatment of the residual lesion&#44; which resulted in complete resolution of the plaque with no recurrences after more than a year of follow-up&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">MRG is uncommon and probably underdiagnosed&#44; 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or &#8220;kissing lesion&#8221;&#44; is observed on the hard palate&#59; according to Brown and colleagues&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> this may be a marker of associated immunosuppression&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Diagnosis is clinical&#44; supported by a positive culture&#46; The most commonly isolated species is <span class="elsevierStyleItalic">Candida albicans</span>&#44; followed by <span class="elsevierStyleItalic">Candida glabrata</span>&#44; <span class="elsevierStyleItalic">Candida tropicalis</span>&#44; and <span class="elsevierStyleItalic">Candida parapsilosis</span>&#44; although up to 10&#37; of samples can contain 2 or more <span class="elsevierStyleItalic">Candida</span> species&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In some cases a biopsy may be required to rule out neoplasia&#46; PAS staining can be negative in up to 13&#37; of cases&#44; as <span class="elsevierStyleItalic">Candida</span> does not invade the epithelium and is lost during sample processing&#46; The principal differential diagnosis is with squamous cell carcinoma and Abrikossoff tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Barret and coworkers<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> observed a statistically significant association between moderate-severe epithelial dysplasia and the presence of fungi on staining with PAS&#59; they therefore recommend screening with this staining method in this type of lesion&#46; However&#44; those authors were unable to state whether <span class="elsevierStyleItalic">Candida</span> exerts a pathogenic effect in these cases or merely colonizes previously altered tissue&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Treatment is usually topical&#44; associated with the correction of predisposing factors&#59; 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Case for diagnosis
Linear Exophytic Tumor on the Dorsum of the Tongue
Tumoración exofítica y lineal en el dorso de la lengua
C. Meseguer-Yebraa,
Corresponding author
camesye@hotmail.com

Corresponding author.
, S. Córdoba-Guijarrob, J. Borbujob
a Sección de Dermatología, Complejo Asistencial de Zamora, Zamora, Spain
b Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Madrid, Spain
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        "titulo" => "Tumoraci&#243;n exof&#237;tica y lineal en el dorso de la lengua"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 68-year-old man who presented with a 10-year history of a growth on the dorsum of the tongue&#46; The lesion was asymptomatic&#44; had not been previously treated&#44; and had grown slowly and progressively&#46; The patient had no relevant past medical history&#44; smoked 20 cigarettes a day&#44; used a dental prosthesis that he removed at night&#44; and was undergoing treatment with nystatin mouthwashes &#40;after meals&#41; and omeprazole &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Examination revealed a coated tongue&#44; and along the dorsal midline a pinkish&#44; lobulated plaque with a shiny surface and rubbery consistency &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No lymphadenopathies were detected on palpation of the craniocervical region&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Additional tests</span><p id="par0015" class="elsevierStylePara elsevierViewall">The following tests were performed&#58; punch biopsy&#59; culture in Sabouraud&#39;s medium&#44; which was positive for <span class="elsevierStyleItalic">Candida albicans</span>&#59; and routine blood tests&#44; which were normal&#44; including negative HIV serology&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Histology</span><p id="par0020" class="elsevierStylePara elsevierViewall">On histology&#44; the mucosa exhibited marked acanthosis and papillomatosis&#44; as well as an increase in the mitotic activity of the basal layer&#44; with no alterations in cell polarity or maturation&#46; A moderate lymphohistiocytic interstitial infiltrate and vascular ectasia were observed in the chorion &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Periodic acid Schiff &#40;PAS&#41; and PAS diastase staining revealed no fungal structures&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Hypertrophic median rhomboid glossitis &#40;MRG&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Course</span><p id="par0035" class="elsevierStylePara elsevierViewall">Quitting smoking was recommended&#44; and this resulted in a significant improvement and a decrease in the size of the lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The patient was subsequently treated with fluconazole &#40;50&#160;mg&#47;12&#160;h by mouth&#41; for 14 days&#44; which led to some additional improvement&#46; Despite continued systemic antifungal treatment and replacement of the patient&#39;s dental prosthesis&#44; subsequent cultures were only transiently negative&#46; The patient was thus referred to the otolaryngology service for carbon-dioxide laser treatment of the residual lesion&#44; which resulted in complete resolution of the plaque with no recurrences after more than a year of follow-up&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">MRG is uncommon and probably underdiagnosed&#44; and for many years was considered to be a malformation&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It manifests as a clearly defined&#44; rhomboid-shaped&#44; atrophic or globular erythematous plaque&#44; which appears on the midline of the dorsum of the tongue&#46; It most commonly affects men&#44; smokers&#44; and diabetics&#44; and the response to antifungal therapy is variable&#46; Several hypotheses have been proposed to explain why the infection in MRG manifests in such a localized manner&#46; According to Whitaker and coworkers&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> the affected region lies on the hard palate during deglutition&#44; phonation&#44; and rest&#44; thus reducing its exposure to the the action of the saliva&#46; Other authors propose that blood flow in this region is reduced compared with the rest of the tongue&#46; In some cases an opposing erythematous plaque&#44; or &#8220;kissing lesion&#8221;&#44; is observed on the hard palate&#59; according to Brown and colleagues&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> this may be a marker of associated immunosuppression&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Diagnosis is clinical&#44; supported by a positive culture&#46; The most commonly isolated species is <span class="elsevierStyleItalic">Candida albicans</span>&#44; followed by <span class="elsevierStyleItalic">Candida glabrata</span>&#44; <span class="elsevierStyleItalic">Candida tropicalis</span>&#44; and <span class="elsevierStyleItalic">Candida parapsilosis</span>&#44; although up to 10&#37; of samples can contain 2 or more <span class="elsevierStyleItalic">Candida</span> species&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In some cases a biopsy may be required to rule out neoplasia&#46; PAS staining can be negative in up to 13&#37; of cases&#44; as <span class="elsevierStyleItalic">Candida</span> does not invade the epithelium and is lost during sample processing&#46; The principal differential diagnosis is with squamous cell carcinoma and Abrikossoff tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Barret and coworkers<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> observed a statistically significant association between moderate-severe epithelial dysplasia and the presence of fungi on staining with PAS&#59; they therefore recommend screening with this staining method in this type of lesion&#46; However&#44; those authors were unable to state whether <span class="elsevierStyleItalic">Candida</span> exerts a pathogenic effect in these cases or merely colonizes previously altered tissue&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Treatment is usually topical&#44; associated with the correction of predisposing factors&#59; combined topical and oral therapy is reserved for highly recurrent infections or immunosuppressed patients&#46; Surgical treatment may be useful in cases of persistent exophytic lesions&#44; for which medical treatments are of limited effectiveness&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "texto" => "<p id="par0060" class="elsevierStylePara elsevierViewall">We would like to thank Dr&#46; &#193;ngel Casta&#241;o Pascual of the Pathology Department of Hospital Universitario de Fuenlabrada for his help with the histological study in this case&#46;</p>"
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Article information
ISSN: 15782190
Original language: English
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Idiomas
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