Letter to the Editor
Response to Comment on the Article «Cutaneous Vasculitis»
Réplica a: «Vasculitis cutáneas»
A. Pulido-Pérez, J.A. Avilés-Izquierdo, R. Suárez-Fernández
Corresponding author
Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Sais, A. Vidaller" "autores" => array:2 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Sais" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Vidaller" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S000173101200230X" "doi" => "10.1016/j.ad.2012.04.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101200230X?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002636?idApp=UINPBA000044" "url" => "/15782190/0000010300000008/v1_201304241323/S1578219012002636/v1_201304241323/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Response to Comment on the Article «Cutaneous Vasculitis»" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "755" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Pulido-Pérez, J.A. Avilés-Izquierdo, R. Suárez-Fernández" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Pulido-Pérez" ] 1 => array:2 [ "nombre" => "J.A." "apellidos" => "Avilés-Izquierdo" ] 2 => array:4 [ "nombre" => "R." "apellidos" => "Suárez-Fernández" "email" => array:1 [ 0 => "ricardosuarezfernandez@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Réplica a: «Vasculitis cutáneas»" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We appreciate the comments received after the publication of our article on cutaneous vasculitis in the April issue of <span class="elsevierStyleItalic">Actas Dermo-Sifiliográficas</span><a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and would like to add the following clarifications.<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1</span><p id="par0010" class="elsevierStylePara elsevierViewall">With respect to the presence of fever as a sign associated with vasculitic syndromes, we referenced an interesting study by Sais et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> published in <span class="elsevierStyleItalic">Archives of Dermatology</span> which analyzed prognostic factors in patients with a histopathologic diagnosis of cutaneous leukocytoclastic vasculitis. The authors reported the presence of fever in 31.6% of the 160 patients studied and systemic involvement (other than articular) in 20%. Multivariate analysis of their data identified fever as 1 of the risk factors for systemic vasculitis. Undoubtedly, as these findings show, fever would appear to be more often associated with extracutaneous involvement. However, our article only mentions the possibility of finding this prognostic indicator in systemic vasculitis and in syndromes affecting only the cutaneous vasculature. We make no reference to the risk associated with fever as a predictor of vasculitis with extracutaneous involvement or the relationship of this sign with the etiology of such syndromes.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2</span><p id="par0015" class="elsevierStylePara elsevierViewall">In our discussion of the treatment options for uncomplicated cutaneous vasculitis, colchicine is mentioned as 1 of the possible therapeutic alternatives when rest, nonsteroidal anti-inflammatory drugs, and antihistamines have proved ineffective. To date, the only prospective randomized controlled trial to assess the efficacy of colchicine in controlling cutaneous leukocytoclastic vasculitis enrolled 41 patients: 20 who were treated with colchicine, 20 controls, and 1 who withdrew owing to gastrointestinal intolerance.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The largest open study included 13 patients.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The controlled trial did not demonstrate a therapeutic effect in terms of a reduction in the number of lesions in the patients who had received colchicine, but the authors did suggest that the drug may have had a beneficial effect in a subgroup of patients who had a complete response and relapsed on cessation of colchicine therapy. The author of the open study reported complete response to treatment in 9 of the 13 patients and partial response in 3 more. He also referred to the fact that colchicine was effective in controlling the symptoms of recurrence after cessation of treatment.</p></li></ul></p><p id="par0020" class="elsevierStylePara elsevierViewall">Despite the limitations affecting the conclusions drawn from these studies, colchicine continues to be considered a valid alternative treatment for the control of selected cases of cutaneous vasculitis<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and is therefore described as a second- or third-line treatment in our review.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Pulido-Pérez A, Avilés-Izquierdo JA, Suárez-Fernández R. Réplica a: “Vasculitis cutáneas”. Actas Dermosifiliogr.2012;103:755.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vasculitis Cutáneas. Revisión" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Pulido-Pérez" 1 => "J.A. Avilés-Izquierdo" 2 => "R. Suárez-Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2011.06.001" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2012" "volumen" => "103" "paginaInicial" => "179" "paginaFinal" => "191" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21839977" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors in leukocytoclastic vasculitis: A clinicopathologic study of 160 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Sais" 1 => "A. Vidaller" 2 => "A. Jucglà" 3 => "O. Servitje" 4 => "E. Condom" 5 => "J. Peyrí" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1998" "volumen" => "134" "paginaInicial" => "309" "paginaFinal" => "315" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9521029" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Colchicine in the treatment of cutaneous leukocytoclastic vasculitis. Results of a prospective, randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Sais" 1 => "A. Vidaller" 2 => "A. Jucglà" 3 => "F. Gallardo" 4 => "J. Peyrí" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1995" "volumen" => "131" "paginaInicial" => "1399" "paginaFinal" => "1402" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7492128" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Colchicine is effective in controlling chronic cutaneous leukocytoclastic vasculitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.P. Callen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1985" "volumen" => "13" "paginaInicial" => "193" "paginaFinal" => "200" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4044947" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous vasculitis: diagnosis and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. Carlson" 1 => "L.F. Cavaliere" 2 => "J.M. Grant-Kels" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2006.07.007" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2006" "volumen" => "24" "paginaInicial" => "414" "paginaFinal" => "429" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16966021" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010300000008/v1_201304241323/S1578219012002624/v1_201304241323/en/main.assets" "Apartado" => array:4 [ "identificador" => "6208" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010300000008/v1_201304241323/S1578219012002624/v1_201304241323/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002624?idApp=UINPBA000044" ]
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