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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 9-year-old girl with a history of obesity came to our clinic for evaluation of pruritic skin lesions that had appeared over 3 months earlier on the trunk and limbs&#46; She had not received any pharmacological treatments or vaccinations and no infections or family history of skin diseases were reported&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">We observed flat&#44; pink polygonal papules and plaques with fine superficial scaling in the form of whitish lines&#46; These lesions affected the ankles&#44; upper limbs&#44; trunk &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; and palms and soles &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; In addition&#44; the fingernails showed longitudinal ridges and some of them showed fraying of the distal edges&#46; There was no involvement of the scalp or mucous membranes&#46; A Koebner phenomenon was observed on scratched skin&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Histology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histology revealed acanthosis&#44; hypergranulosis&#44; and lichenoid infiltrate with marked damage to basal keratinocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Additional Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">Laboratory tests &#40;routine blood and urine tests&#44; biochemistry&#44; and hepatitis serology&#41; revealed no pathological findings&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">What is your diagnosis&#63;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Childhood lichen planus&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was treated with oral antihistamines and medium-potency topical corticosteroids for 2 weeks and subsequently with a 0&#46;1&#37; tacrolimus ointment&#46; In 2 months she achieved complete remission&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">Lichen planus&#44; first described by Wilson in 1869&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> is a chronic inflammatory dermatosis that affects the skin&#44; mucous membranes&#44; and skin appendages and is more common in adults&#46; Cases of this disease in children account for 1&#8211;4&#37; of the total&#44; although the incidence appears to be higher in darkly pigmented races&#46; Lichen planus affects men and women equally and is extremely rare in children under 4 years of age&#46; In the literature there are very few reports of childhood lichen planus with involvement of palms and soles&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The typical presentation of lichen planus is as small&#44; flat&#44; violaceous polygonal papules that cause severe itching&#46; The lesions appear as a symmetrical eruption that may be generalized or affect a few areas&#46; They are located mainly on the anterior face of the wrists&#44; the backs of the hands&#44; 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which is uncommon in adults&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> is even more uncommon in children&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a> Recently&#44; Handa and Sahoo<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> found 2 cases &#40;2&#46;3&#37;&#41; of lichen planus with involvement of palms and soles in their study of 87 children with lichen planus&#46; On the palms and soles the lesions do not have the typical clinical presentation of lichen planus&#44; so diagnosis is difficult&#46; Furthermore&#44; Wickham striae are not observed&#44; probably because of the greater thickness of the stratum corneum&#46; However&#44; the histopathologic characteristics are similar to those of other locations&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Cases for Diagnosis
Generalized Eruption in a Child
Erupción generalizada en una niña
N. Martía,
Corresponding author
nuriamarfa@hotmail.com

Corresponding author.
, C. Monteagudob, V. Alonsoa
a Servicio de Dermatología, Hospital Nisa 9 de Octubre, Valencia, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Clínico de Valencia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 9-year-old girl with a history of obesity came to our clinic for evaluation of pruritic skin lesions that had appeared over 3 months earlier on the trunk and limbs&#46; She had not received any pharmacological treatments or vaccinations and no infections or family history of skin diseases were reported&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">We observed flat&#44; pink polygonal papules and plaques with fine superficial scaling in the form of whitish lines&#46; These lesions affected the ankles&#44; upper limbs&#44; trunk &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; and palms and soles &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; In addition&#44; the fingernails showed longitudinal ridges and some of them showed fraying of the distal edges&#46; There was no involvement of the scalp or mucous membranes&#46; A Koebner phenomenon was observed on scratched skin&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Histology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histology revealed acanthosis&#44; hypergranulosis&#44; and lichenoid infiltrate with marked damage to basal keratinocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Additional Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">Laboratory tests &#40;routine blood and urine tests&#44; biochemistry&#44; and hepatitis serology&#41; revealed no pathological findings&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">What is your diagnosis&#63;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Childhood lichen planus&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was treated with oral antihistamines and medium-potency topical corticosteroids for 2 weeks and subsequently with a 0&#46;1&#37; tacrolimus ointment&#46; In 2 months she achieved complete remission&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">Lichen planus&#44; first described by Wilson in 1869&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> is a chronic inflammatory dermatosis that affects the skin&#44; mucous membranes&#44; and skin appendages and is more common in adults&#46; Cases of this disease in children account for 1&#8211;4&#37; of the total&#44; although the incidence appears to be higher in darkly pigmented races&#46; Lichen planus affects men and women equally and is extremely rare in children under 4 years of age&#46; In the literature there are very few reports of childhood lichen planus with involvement of palms and soles&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The typical presentation of lichen planus is as small&#44; flat&#44; violaceous polygonal papules that cause severe itching&#46; The lesions appear as a symmetrical eruption that may be generalized or affect a few areas&#46; They are located mainly on the anterior face of the wrists&#44; the backs of the hands&#44; the lumbar region&#44; and the pretibial area&#44; with exceptional involvement of the face&#44; scalp&#44; and palms and soles&#46; In children the lesions are frequently eruptive and involvement of the trunk is more frequent than in adults&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Cases of lichen planus occurring after hepatitis B vaccination have been reported&#46; In these cases the lesions usually appear a median of 40 days after vaccination&#46; They tend to start on the limbs and cases with a bullous component are not infrequent&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The duration of the disease varies from a few weeks to several years&#46; Although lichen planus is usually a skin disease without other systemic involvement&#44; it can sometimes be associated with autoimmune diseases and chronic hepatitis&#44; especially hepatitis C virus in some areas where it has a high prevalence&#44; such as Spain&#44; Italy&#44; and France&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Involvement of palms and soles&#44; which is uncommon in adults&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> is even more uncommon in children&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a> Recently&#44; Handa and Sahoo<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> found 2 cases &#40;2&#46;3&#37;&#41; of lichen planus with involvement of palms and soles in their study of 87 children with lichen planus&#46; On the palms and soles the lesions do not have the typical clinical presentation of lichen planus&#44; so diagnosis is difficult&#46; Furthermore&#44; Wickham striae are not observed&#44; probably because of the greater thickness of the stratum corneum&#46; However&#44; the histopathologic characteristics are similar to those of other locations&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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