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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Acrodermatitis enteropathica &#40;AE&#41; is a rare autosomal recessively inherited disease caused by alterations in zinc absorption in the digestive tract&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> Although it was first described in 1942 by Danbolt and Closs&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> it was not until 1973 that Moynahan and Barnes<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> identified its association with low plasma zinc levels&#46; It is estimated to affect 1 in 500<span class="elsevierStyleHsp" style=""></span>000 children&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Clinically&#44; it is characterized by acral and periorificial dermatitis&#44; alopecia&#44; and diarrhea&#44; although this triad of symptoms only occurs in 20&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> AE usually appears days or weeks after birth in bottle-fed infants&#44; or shortly after discontinuing breastfeeding in exclusively breastfed infants&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Here we describe the case of a full-term male infant who was diagnosed with AE&#46; The only remarkable finding in his history was neonatal indirect hyperbilirubinemia&#46; The patient&#44; who had been exclusively breastfed since birth&#44; developed cutaneous lesions on the scalp&#44; around the mouth&#44; and in the diaper area at 3 months of age&#46; Additionally&#44; his parents reported that he was more irritable at night&#46; He had received various treatments for the cutaneous lesions&#44; including topical and systemic antibiotics&#44; topical antifungal drugs&#44; and topical corticosteroids&#44; but showed no improvement&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Skin examination revealed scaly&#44; erythematous plaques with well-demarcated edges and psoriasiform morphology&#44; and some honey-colored crusts covering zones of erosion&#46; The plaques were located on the face&#44; predominantly in the perioral&#44; perinasal&#44; and frontal areas &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#44; as well as on the scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41; and on the neck&#44; buttocks&#44; and intergluteal cleft &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; Additionally&#44; several isolated plaques with similar characteristics were observed on the thighs and on the dorsal surfaces of fingers and toes&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A serum zinc test showed clearly deficient levels of zinc &#40;9<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#59; normal range&#44; 70&#8211;120<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; supporting the suspected diagnosis of AE&#46; Normal zinc levels in maternal milk ruled out an AE-like eruption&#46; After confirming the diagnosis of AE&#44; zinc sulfite treatment was started at a dosage of 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#59; this led to rapid resolution of the cutaneous lesions and an improvement in irritability&#46; Currently&#44; after 2 years of treatment&#44; the child shows normal growth parameters for his age&#44; has had no recurrence of the symptoms&#44; and has normal serum zinc levels&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The first symptom is usually acral and periorificial dermatitis and only more advanced cases present the classic triad of alopecia&#44; diarrhea&#44; and skin lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The disease is characterized by low levels of serum zinc&#44; caused by deficient absorption of this metal in the digestive tract&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It is now known that this zinc deficiency is due to a defect in the AE gene &#40;<span class="elsevierStyleItalic">SLC39A4&#41;</span> located on the 8q24 chromosome&#44; which encodes Zip4&#44; a zinc transporter in the cells of the small intestine&#44; and primarily in the jejunum&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinically&#44; scaly erythematous plaques with psoriasiform morphology&#44; distributed symmetrically in acral and periorificial areas&#44; are frequently observed&#46; Other symptoms include vesiculobullous lesions&#44; alopecia&#44; onychodystrophy&#44; onycholysis&#44; pachyonychia&#44; stomatitis&#44; cheilitis&#44; blepharitis&#44; photophobia&#44; and conjunctivitis&#46; When diagnosis is delayed&#44; patients can develop advanced disease&#44; characterized by increased morbidity and mortality&#59; conditions include growth and mental retardation&#44; irritability&#44; slow wound healing&#44; immunity alterations&#44; hypogonadism&#44; and anemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Zinc deficiency can have either a genetic or an acquired origin&#46; The genetic form is classically known as AE and&#44; as mentioned above&#44; is caused by a genetically determined defect in zinc absorption&#46; The acquired forms are clinically similar to classic AE&#46; Three basic causes are known&#58; &#40;a&#41; zinc deficiency in maternal milk&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> also known as lactogenic acrodermatitis&#59; &#40;b&#41; a complete lack of zinc in the parenteral nutrition&#59; and &#40;c&#41; the presence of other malabsorption syndromes&#44; 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substantiating the diagnosis&#46; It is advisable to begin treatment as soon as possible&#44; since delaying it can have severe consequences&#44; including death&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">AE usually presents after discontinuation of breastfeeding due to the fact that full-term newborns gain sufficient zinc stores during the last 10 weeks of pregnancy&#46; Furthermore&#44; maternal milk normally contains sufficient zinc for infant development&#46; However&#44; on rare occasions&#44; AE can also occur in full-term infants who have been exclusively breastfed&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> as was the case for our patient&#46; It is important to exclude zinc deficiency in maternal milk in such cases&#44; since this condition requires a much shorter treatment than AE&#44; which must be treated and monitored throughout life&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p></span>"
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Case and Research Letter
Acrodermatitis Enteropathica in a Breast-Fed Infant
Acrodermatitis enteropática en bebé alimentado con lactancia materna
E. Gutiérrez-González
Corresponding author
egutgon@hotmail.com

Corresponding author.
, A. Álvarez-Pérez, M. Loureiro, D. Sánchez-Aguilar, J. Toribio
Departamento de Dermatología, Complejo Hospitalario Universitario, Facultad de Medicina, Santiago de Compostela, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Acrodermatitis enteropathica &#40;AE&#41; is a rare autosomal recessively inherited disease caused by alterations in zinc absorption in the digestive tract&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> Although it was first described in 1942 by Danbolt and Closs&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> it was not until 1973 that Moynahan and Barnes<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> identified its association with low plasma zinc levels&#46; It is estimated to affect 1 in 500<span class="elsevierStyleHsp" style=""></span>000 children&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Clinically&#44; it is characterized by acral and periorificial dermatitis&#44; alopecia&#44; and diarrhea&#44; although this triad of symptoms only occurs in 20&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> AE usually appears days or weeks after birth in bottle-fed infants&#44; or shortly after discontinuing breastfeeding in exclusively breastfed infants&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Here we describe the case of a full-term male infant who was diagnosed with AE&#46; The only remarkable finding in his history was neonatal indirect hyperbilirubinemia&#46; The patient&#44; who had been exclusively breastfed since birth&#44; developed cutaneous lesions on the scalp&#44; around the mouth&#44; and in the diaper area at 3 months of age&#46; Additionally&#44; his parents reported that he was more irritable at night&#46; He had received various treatments for the cutaneous lesions&#44; including topical and systemic antibiotics&#44; topical antifungal drugs&#44; and topical corticosteroids&#44; but showed no improvement&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Skin examination revealed scaly&#44; erythematous plaques with well-demarcated edges and psoriasiform morphology&#44; and some honey-colored crusts covering zones of erosion&#46; The plaques were located on the face&#44; predominantly in the perioral&#44; perinasal&#44; and frontal areas &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#44; as well as on the scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41; and on the neck&#44; buttocks&#44; and intergluteal cleft &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; Additionally&#44; several isolated plaques with similar characteristics were observed on the thighs and on the dorsal surfaces of fingers and toes&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A serum zinc test showed clearly deficient levels of zinc &#40;9<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#59; normal range&#44; 70&#8211;120<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41;&#44; supporting the suspected diagnosis of AE&#46; Normal zinc levels in maternal milk ruled out an AE-like eruption&#46; After confirming the diagnosis of AE&#44; zinc sulfite treatment was started at a dosage of 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#59; this led to rapid resolution of the cutaneous lesions and an improvement in irritability&#46; Currently&#44; after 2 years of treatment&#44; the child shows normal growth parameters for his age&#44; has had no recurrence of the symptoms&#44; and has normal serum zinc levels&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The first symptom is usually acral and periorificial dermatitis and only more advanced cases present the classic triad of alopecia&#44; diarrhea&#44; and skin lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The disease is characterized by low levels of serum zinc&#44; caused by deficient absorption of this metal in the digestive tract&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It is now known that this zinc deficiency is due to a defect in the AE gene &#40;<span class="elsevierStyleItalic">SLC39A4&#41;</span> located on the 8q24 chromosome&#44; which encodes Zip4&#44; a zinc transporter in the cells of the small intestine&#44; and primarily in the jejunum&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinically&#44; scaly erythematous plaques with psoriasiform morphology&#44; distributed symmetrically in acral and periorificial areas&#44; are frequently observed&#46; Other symptoms include vesiculobullous lesions&#44; alopecia&#44; onychodystrophy&#44; onycholysis&#44; pachyonychia&#44; stomatitis&#44; cheilitis&#44; blepharitis&#44; photophobia&#44; and conjunctivitis&#46; When diagnosis is delayed&#44; patients can develop advanced disease&#44; characterized by increased morbidity and mortality&#59; conditions include growth and mental retardation&#44; irritability&#44; slow wound healing&#44; immunity alterations&#44; hypogonadism&#44; and anemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Zinc deficiency can have either a genetic or an acquired origin&#46; The genetic form is classically known as AE and&#44; as mentioned above&#44; is caused by a genetically determined defect in zinc absorption&#46; The acquired forms are clinically similar to classic AE&#46; Three basic causes are known&#58; &#40;a&#41; zinc deficiency in maternal milk&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> also known as lactogenic acrodermatitis&#59; &#40;b&#41; a complete lack of zinc in the parenteral nutrition&#59; and &#40;c&#41; the presence of other malabsorption syndromes&#44; such as Crohn disease and celiac disease&#44; in which absorption is compromised&#44; or metabolic disorders associated with a deficit of other trace elements besides zinc&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Diagnosis is primarily clinical&#44; but it is important to acquire data that support the diagnosis &#40;e&#46;g&#46;&#44; low serum zinc levels&#41; and to exclude other causes&#44; such as malnutrition&#44; zinc deficiency in maternal milk&#44; and other metabolic alterations&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> While histopathologic findings are not specific&#44; they can be useful for a preliminary diagnosis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Characteristically&#44; zinc replacement therapy at a dosage of 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> leads to rapid improvement and resolution of signs and symptoms&#44; substantiating the diagnosis&#46; It is advisable to begin treatment as soon as possible&#44; since delaying it can have severe consequences&#44; including death&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">AE usually presents after discontinuation of breastfeeding due to the fact that full-term newborns gain sufficient zinc stores during the last 10 weeks of pregnancy&#46; Furthermore&#44; maternal milk normally contains sufficient zinc for infant development&#46; However&#44; on rare occasions&#44; AE can also occur in full-term infants who have been exclusively breastfed&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> as was the case for our patient&#46; It is important to exclude zinc deficiency in maternal milk in such cases&#44; since this condition requires a much shorter treatment than AE&#44; which must be treated and monitored throughout life&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p></span>"
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Article information
ISSN: 15782190
Original language: English
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