Original Article
Nail Psoriasis in Individuals With Psoriasis Vulgaris: A Study of 661 Patients
Psoriasis ungueal: estudio en 661 pacientes con psoriasis vulgar
S. Armestoa,b, A. Estevec, P. Coto-Segurac, M. Drakea, C. Galachec, J. Martínez-Borrad, J. Santos-Juanesce,
Corresponding author
a Servicio de Dermatología, Hospital Universitario Marqués de Valdecilla, Santander, Spain
b Departamento de Medicina, Facultad de Medicina, Universidad de Santander, Santander, Spain
c Servicio de Dermatología, Hospital Universitario Central de Asturias, Asturias, Spain
d Servicio de Inmunología, Hospital Universitario Central de Asturias, Asturias, Spain
e Departamento de Medicina, Facultad de Medicina, Universidad de Oviedo, Asturias, Spain
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Nevertheless, few epidemiological studies have reported the characteristics of patients with nail psoriasis. Here we describe the epidemiology of nail psoriasis and the main characteristics of affected patients.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We undertook a prospective case-control study at Hospital Universitario Marqués de Valdecilla and Hospital Universitario Central de Asturias in Spain between January 2007 and December 2009.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Of a total of 661 patients included, 47.4% were diagnosed with nail psoriasis, which was 13.5% more prevalent in men. The group of patients with nail disease had more severe psoriasis (12.82 vs 8.22 points on the psoriasis area and severity index) and a longer disease duration (20.30 vs 13.94 years), and included a larger percentage of patients with psoriatic arthritis (29.7% vs 11.5%), a positive family history of the disease (53.7% vs 42.8%), and a body mass index greater than 30 (31.6% vs 23.9%). A larger percentage of the patients with nail disease had early-onset psoriasis (74.1% vs 65.5%) and fewer were carriers of the human lymphocyte antigen Cw*0602 allele (33% vs 50.3%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nail disease is frequent in psoriasis and is associated with greater severity of psoriasis and a larger number of comorbidities.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La psoriasis ungueal afecta a un número importante de pacientes con psoriasis. No obstante, son raros los estudios epidemiológicos que recojan las características de estos individuos. Describimos la epidemiología y principales características de los pacientes con psoriasis ungueal.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se trata de un estudio prospectivo de casos y controles realizado en el Hospital Universitario Marqués de Valdecilla y Hospital Universitario Central de Asturias entre enero de 2007 y diciembre de 2009.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">De un total de 661 pacientes la psoriasis ungueal fue diagnosticada en el 47,4% de los pacientes. La prevalencia fue 13,5 puntos mayor en hombres que en mujeres. Los pacientes con afectación ungueal presentan mayor severidad de la enfermedad (PASI 12,82 vs 8,22), mayor duración de la misma (20,30 vs 13,94 años), incidencia superior de artropatía psoriática (29,7% vs 11,5%), mayor frecuencia de antecedentes familiares positivos (53,7% vs 42,8%) y mayor proporción de obesidad IMC > 30 (31,6 vs 23,9%). La psoriasis en el grupo con afectación ungueal se inicia de forma precoz (74,1 vs 65,5%) y se asocia con menor frecuencia a Cw*0602 (33 vs 50,3%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La afectación ungueal es una manifestación frecuente en los pacientes con psoriasis y se asocia a mayor gravedad de la enfermedad y mayor número de comorbilidades.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patientsan analysis of 1019 HLA-C and HLA-B-typed patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. 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Ogilvie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000316177" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2010" "volumen" => "221" "paginaInicial" => "23" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20733312" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010200000005/v1_201304241545/S1578219011708198/v1_201304241545/en/main.assets" "Apartado" => array:4 [ "identificador" => "6256" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000005/v1_201304241545/S1578219011708198/v1_201304241545/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011708198?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 15 | 7 | 22 |
| 2024 October | 71 | 53 | 124 |
| 2024 September | 89 | 24 | 113 |
| 2024 August | 123 | 62 | 185 |
| 2024 July | 81 | 32 | 113 |
| 2024 June | 80 | 39 | 119 |
| 2024 May | 75 | 33 | 108 |
| 2024 April | 58 | 25 | 83 |
| 2024 March | 60 | 37 | 97 |
| 2024 February | 54 | 36 | 90 |
| 2024 January | 55 | 44 | 99 |
| 2023 December | 77 | 34 | 111 |
| 2023 November | 75 | 47 | 122 |
| 2023 October | 63 | 33 | 96 |
| 2023 September | 52 | 26 | 78 |
| 2023 August | 42 | 28 | 70 |
| 2023 July | 57 | 48 | 105 |
| 2023 June | 51 | 30 | 81 |
| 2023 May | 34 | 29 | 63 |
| 2023 April | 32 | 19 | 51 |
| 2023 March | 33 | 22 | 55 |
| 2023 February | 20 | 20 | 40 |
| 2023 January | 31 | 29 | 60 |
| 2022 December | 37 | 56 | 93 |
| 2022 November | 25 | 35 | 60 |
| 2022 October | 22 | 14 | 36 |
| 2022 September | 27 | 49 | 76 |
| 2022 August | 35 | 39 | 74 |
| 2022 July | 43 | 29 | 72 |
| 2022 June | 22 | 28 | 50 |
| 2022 May | 27 | 43 | 70 |
| 2022 April | 43 | 42 | 85 |
| 2022 March | 44 | 58 | 102 |
| 2022 February | 26 | 50 | 76 |
| 2022 January | 36 | 57 | 93 |
| 2021 December | 30 | 47 | 77 |
| 2021 November | 30 | 53 | 83 |
| 2021 October | 28 | 57 | 85 |
| 2021 September | 19 | 47 | 66 |
| 2021 August | 16 | 42 | 58 |
| 2021 July | 27 | 32 | 59 |
| 2021 June | 49 | 40 | 89 |
| 2021 May | 30 | 24 | 54 |
| 2021 April | 75 | 43 | 118 |
| 2021 March | 63 | 18 | 81 |
| 2021 February | 65 | 31 | 96 |
| 2021 January | 36 | 18 | 54 |
| 2020 December | 30 | 22 | 52 |
| 2020 November | 28 | 20 | 48 |
| 2020 October | 22 | 21 | 43 |
| 2020 September | 24 | 20 | 44 |
| 2020 August | 18 | 23 | 41 |
| 2020 July | 25 | 14 | 39 |
| 2020 June | 25 | 31 | 56 |
| 2020 May | 28 | 27 | 55 |
| 2020 April | 24 | 24 | 48 |
| 2020 March | 32 | 30 | 62 |
| 2020 February | 1 | 8 | 9 |
| 2020 January | 0 | 4 | 4 |
| 2019 December | 0 | 12 | 12 |
| 2019 November | 0 | 1 | 1 |
| 2019 October | 0 | 2 | 2 |
| 2019 September | 0 | 5 | 5 |
| 2019 August | 0 | 4 | 4 |
| 2019 July | 0 | 4 | 4 |
| 2019 June | 0 | 9 | 9 |
| 2019 May | 0 | 45 | 45 |
| 2019 April | 0 | 3 | 3 |
| 2019 March | 0 | 12 | 12 |
| 2018 February | 12 | 4 | 16 |
| 2018 January | 23 | 8 | 31 |
| 2017 December | 20 | 6 | 26 |
| 2017 November | 33 | 4 | 37 |
| 2017 October | 23 | 6 | 29 |
| 2017 September | 25 | 1 | 26 |
| 2017 August | 52 | 10 | 62 |
| 2017 July | 29 | 6 | 35 |
| 2017 June | 37 | 13 | 50 |
| 2017 May | 35 | 4 | 39 |
| 2017 April | 33 | 3 | 36 |
| 2017 March | 41 | 4 | 45 |
| 2017 February | 27 | 7 | 34 |
| 2017 January | 21 | 10 | 31 |
| 2016 December | 35 | 2 | 37 |
| 2016 November | 38 | 17 | 55 |
| 2016 October | 29 | 16 | 45 |
| 2016 September | 34 | 4 | 38 |
| 2016 August | 50 | 5 | 55 |
| 2016 July | 32 | 12 | 44 |
| 2016 June | 10 | 8 | 18 |
| 2016 May | 4 | 0 | 4 |
| 2016 April | 3 | 6 | 9 |
| 2016 March | 4 | 6 | 10 |
| 2016 February | 7 | 1 | 8 |
| 2016 January | 10 | 0 | 10 |
| 2015 December | 15 | 5 | 20 |
| 2015 November | 12 | 0 | 12 |
| 2015 October | 3 | 0 | 3 |
| 2015 September | 7 | 4 | 11 |
| 2015 August | 11 | 4 | 15 |
| 2015 July | 19 | 7 | 26 |
| 2015 June | 36 | 3 | 39 |
| 2015 May | 75 | 8 | 83 |
| 2015 April | 44 | 7 | 51 |
| 2015 March | 24 | 5 | 29 |
| 2015 February | 34 | 8 | 42 |
| 2015 January | 24 | 7 | 31 |
| 2014 December | 40 | 8 | 48 |
| 2014 November | 28 | 12 | 40 |
| 2014 October | 42 | 16 | 58 |
| 2014 September | 25 | 7 | 32 |
| 2014 August | 29 | 16 | 45 |
| 2014 July | 36 | 15 | 51 |
| 2014 June | 34 | 12 | 46 |
| 2014 May | 48 | 8 | 56 |
| 2014 April | 55 | 11 | 66 |
| 2014 March | 35 | 14 | 49 |
| 2014 February | 44 | 19 | 63 |
| 2014 January | 40 | 8 | 48 |
| 2013 December | 41 | 16 | 57 |
| 2013 November | 30 | 28 | 58 |
| 2013 October | 27 | 19 | 46 |
| 2013 September | 29 | 21 | 50 |
| 2013 August | 32 | 29 | 61 |
| 2013 July | 35 | 46 | 81 |
| 2013 June | 22 | 25 | 47 |
| 2013 May | 4 | 20 | 24 |
| 2013 April | 4 | 19 | 23 |
| 2013 March | 8 | 12 | 20 |
| 2013 February | 5 | 14 | 19 |
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