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Practical dermatology
Clinical Guidelines for the Diagnosis and Treatment of Dermatitis Herpetiformis
Guía clínica de diagnóstico y tratamiento de la dermatitis herpetiforme
J.E. Herrero-González
Departamento de Dermatología, Hospital del Mar, Parc de Salut Mar, Institut Municipal d’Investigació Mèdica, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Dermatitis herpetiformis is an autoimmune blistering disease that appears as a cutaneous manifestation of gluten intolerance&#46; It is one of a group of disorders that have gluten sensitivity in common&#44; including celiac disease and gluten ataxia&#46; Patients with dermatitis herpetiformis present with a pruritic papulovesicular rash on extensor surfaces and on the buttocks&#46; Immunological studies demonstrate the presence of specific immunoglobulin &#40;Ig&#41; A antiendomysial and antitransglutaminase antibodies&#46; The finding of granular deposits of IgA along the dermal-epidermal junction is pathognomonic of dermatitis herpetiformis&#46; Treatment of dermatitis herpetiformis is based on a life-long&#44; strict gluten-free diet&#44; which improves all clinical aspects of gluten sensitivity&#44; and dapsone&#44; a drug that is only effective for the skin manifestations&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La dermatitis herpetiforme es una enfermedad ampollosa autoinmune que aparece como expresi&#243;n cut&#225;nea de la intolerancia al gluten&#46; Forma parte de un abanico de patolog&#237;as que tienen en com&#250;n la sensibilidad a este componente&#44; entre las cuales se encuentra la celiaqu&#237;a y la ataxia por gluten&#46; Los pacientes con dermatitis herpetiforme presentan una erupci&#243;n papulovesicular pruriginosa de predominio en superficies de extensi&#243;n y nalgas&#46; El estudio inmunol&#243;gico demuestra la presencia de anticuerpos espec&#237;ficos IgA antiendomisio y antitransglutaminasa&#46; El hallazgo de dep&#243;sitos granulares de IgA en la uni&#243;n dermoepid&#233;rmica es patognom&#243;nico de la dermatitis herpetiforme&#46; El tratamiento se basa en dos pilares&#58; mantener indefinidamente una dieta estricta libre de este componente &#40;la cual mejora todas las formas cl&#237;nicas de la sensibilidad al gluten&#41; y la dapsona&#44; f&#225;rmaco que es eficaz solo para las manifestaciones cut&#225;neas&#46;</p>"
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Idiomas
Actas Dermo-Sifiliográficas
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