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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The incidence of melanoma is currently increasing worldwide&#46; One of the factors influencing disease prognosis is the presence of regional lymph node metastases&#46; Sentinel lymph node biopsy attempts to identify subclinical lymph node metastasis as a prognostic factor in the disease&#46; The aim of this study was to analyze differences between patients with melanoma for whom positive or negative results were obtained in sentinel lymph node biopsy and to assess the impact of the technique on disease prognosis&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Sentinel lymph node biopsy was carried out in patients with melanoma of the following characteristics&#58; Breslow thickness &#8805;1mm&#44; Breslow thickness &#60;1mm with ulceration&#44; Clark level IV&#8211;V&#44; or regression&#46; Lymphadenectomy was performed in patients with positive sentinel node biopsy&#46; Data were also collected on the following variables&#58; sex&#44; age&#44; skin phototype&#44; site and type of melanoma&#44; Breslow thickness&#44; Clark level&#44; ulceration&#44; regression&#44; cancer stage at diagnosis&#44; TNM classification&#44; change in cancer stage during follow-up&#44; and death due to melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Positive sentinel node biopsies were recorded in 19&#46;44&#37; of patients&#46; Positive results were associated with the following variables&#58; nodular melanoma &#40;crude odds ratio &#91;ORc&#93; compared with superficial spreading melanoma&#44; 3&#46;44&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;33&#8211;8&#46;90&#41;&#59; Breslow thickness &#62;2&#46;0&#44; for a thickness of 2&#46;1&#8211;4&#46;0 &#40;ORc&#44; 21&#46;12&#59; 95&#37; CI&#44; 2&#46;60&#8211;172&#46;03&#41; and for a thickness &#62;4&#46;0 &#40;ORc&#44; 23&#46;25&#59; 95&#37; CI&#44; 2&#46;44&#8211;221&#46;73&#41;&#59; Clark level IV &#40;ORc&#44; 8&#46;73&#59; 95&#37; CI&#44; 1&#46;03&#8211;74&#46;12&#41;&#59; ulceration &#40;ORc&#44; 4&#46;86&#59; 95&#37; CI&#44; 1&#46;58&#8211;14&#46;90&#41;&#59; T3 &#40;ORc&#44; 4&#46;20&#59; 95&#37; CI&#44; 1&#46;52&#8211;11&#46;63&#41; and T4 &#40;ORc&#44; 4&#46;67&#59; 95&#37; CI&#44; 1&#46;27&#8211;17&#46;15&#41; in the TNM classification&#59; change in cancer stage during follow-up &#40;ORc&#44; 7&#46;20&#59; 95&#37; CI&#44; 2&#46;25&#8211;22&#46;99&#41;&#59; and death due to melanoma &#40;ORc&#44; 8&#46;67&#59; 95&#37; CI&#44; 3&#46;62&#8211;96&#46;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">These results confirm the prognostic importance of sentinel lymph node biopsy&#44; which facilitates identification of patients with a greater tendency towards disease progression and death due to melanoma&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Actualmente existe un aumento mundial de la incidencia de melanoma&#46; Su pron&#243;stico depende entre otros factores de la existencia de met&#225;stasis en los ganglios linf&#225;ticos regionales&#46; La realizaci&#243;n de la biopsia del ganglio centinela persigue la identificaci&#243;n de met&#225;stasis ganglionares subcl&#237;nicas como factor pron&#243;stico de la enfermedad&#46; El presente estudio tiene por objetivo estudiar las diferencias entre los pacientes con melanoma&#44; positivos y negativos a la biopsia del ganglio centinela&#44; y analizar el impacto de esta t&#233;cnica en su pron&#243;stico&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; biopsia del ganglio centinela a los pacientes con melanomas de espesor Breslow &#8805; 1 mm o con Breslow &#60; 1 mm y ulceraci&#243;n&#44; nivel de Clark IV&#8211;V o regresi&#243;n&#46; Aquellos con biopsia positiva fueron sometidos a linfadenectom&#237;a&#46; Adem&#225;s&#44; se recogieron las siguientes variables&#58; sexo&#44; edad&#44; fototipo&#44; localizaci&#243;n y tipo de melanoma&#44; niveles Breslow y Clark&#44; ulceraci&#243;n&#44; regresi&#243;n&#44; estadio inicial&#44; TNM&#44; cambio de estadio y fallecimiento por melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El 19&#44;44&#37; de los pacientes present&#243; ganglios positivos&#46; Esta positividad se present&#243; asociada con el melanoma nodular &#40;odds ratio cruda &#91;ORc&#93;&#58; 3&#44;44&#59; intervalo de confianza al 95&#37; &#91;IC 95&#37;&#93;&#58; 1&#44;33&#8211;8&#44;90&#41; con respecto al melanoma de extensi&#243;n superficial Breslow superior a 2&#44;0 &#40;nivel 2&#44;1&#8211;4&#44;0&#58; ORc&#58; 21&#44;14&#59; IC 95&#37;&#58; 2&#44;60&#8211;172&#44;03&#44; nivel &#62; 4&#44;0&#58; ORc&#58; 23&#44;25&#59; IC 95&#37;&#58; 2&#44;44&#8211;221&#44;73&#41;&#44; nivel Clark IV &#40;ORc&#58; 8&#44;73&#59; IC 95&#37; 1&#44;03&#8211;74&#44;12&#41;&#44; ulceraci&#243;n &#40;ORc&#58; 4&#44;86&#59; IC 95&#37;&#58; 1&#44;58&#8211;14&#44;90&#41;&#44; estadios T3 y T4 &#40;T3&#58; ORc&#58; 4&#44;20&#59; IC 95&#37;&#58; 1&#44;52&#8211;11&#44;63&#59; T4&#58; ORc&#58; 4&#44;67&#59; IC 95&#37; 1&#44;27&#8211;17&#44;15&#41;&#44; cambio de estadio &#40;ORc&#58; 7&#44;20&#59; IC 95&#37;&#58; 2&#44;25&#8211;22&#44;99&#41; y fallecimiento por melanoma &#40;ORc&#58; 8&#44;67&#59; IC 95&#37;&#58; 3&#44;62&#8211;96&#44;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estos resultados confirman la importancia pron&#243;stica de la biopsia del ganglio centinela&#44; que permite identificar a los pacientes con mayor tendencia a la progresi&#243;n de la enfermedad y fallecimiento por melanoma&#46;</p>"
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Original article
Sentinel Lymph Node Biopsy in Patients With Melanoma
La técnica del ganglio centinela en pacientes con melanoma
L. Tomás-Mallebreraa, R. Rojo-Españaa, A. Marquina-Vilaa, N. Gimeno-Clementeb,c, M.M. Morales-Suárez-Varelab,c,d,
Corresponding author
maria.m.morales@uv.es

Corresponding author.
a Servicio de Dermatología, Hospital Universitario Dr. Peset, Valencia, Spain
b CIBER Epidemiología y Salud Pública (CIBERESP), Spain
c Unidad de Salud Pública, Higiene y Sanidad Ambiental, Departamento de Medicina Preventiva y Salud Pública, Ciencias de la Alimentación, Toxicología y Medicina Legal, Universidad de Valencia, Spain
d Fundación de la Comunidad Valenciana para la Investigación, Hospital Universitario Dr. Peset, Valencia, Spain
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The incidence of melanoma is currently increasing worldwide&#46; One of the factors influencing disease prognosis is the presence of regional lymph node metastases&#46; Sentinel lymph node biopsy attempts to identify subclinical lymph node metastasis as a prognostic factor in the disease&#46; The aim of this study was to analyze differences between patients with melanoma for whom positive or negative results were obtained in sentinel lymph node biopsy and to assess the impact of the technique on disease prognosis&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Sentinel lymph node biopsy was carried out in patients with melanoma of the following characteristics&#58; Breslow thickness &#8805;1mm&#44; Breslow thickness &#60;1mm with ulceration&#44; Clark level IV&#8211;V&#44; or regression&#46; Lymphadenectomy was performed in patients with positive sentinel node biopsy&#46; Data were also collected on the following variables&#58; sex&#44; age&#44; skin phototype&#44; site and type of melanoma&#44; Breslow thickness&#44; Clark level&#44; ulceration&#44; regression&#44; cancer stage at diagnosis&#44; TNM classification&#44; change in cancer stage during follow-up&#44; and death due to melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Positive sentinel node biopsies were recorded in 19&#46;44&#37; of patients&#46; Positive results were associated with the following variables&#58; nodular melanoma &#40;crude odds ratio &#91;ORc&#93; compared with superficial spreading melanoma&#44; 3&#46;44&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;33&#8211;8&#46;90&#41;&#59; Breslow thickness &#62;2&#46;0&#44; for a thickness of 2&#46;1&#8211;4&#46;0 &#40;ORc&#44; 21&#46;12&#59; 95&#37; CI&#44; 2&#46;60&#8211;172&#46;03&#41; and for a thickness &#62;4&#46;0 &#40;ORc&#44; 23&#46;25&#59; 95&#37; CI&#44; 2&#46;44&#8211;221&#46;73&#41;&#59; Clark level IV &#40;ORc&#44; 8&#46;73&#59; 95&#37; CI&#44; 1&#46;03&#8211;74&#46;12&#41;&#59; ulceration &#40;ORc&#44; 4&#46;86&#59; 95&#37; CI&#44; 1&#46;58&#8211;14&#46;90&#41;&#59; T3 &#40;ORc&#44; 4&#46;20&#59; 95&#37; CI&#44; 1&#46;52&#8211;11&#46;63&#41; and T4 &#40;ORc&#44; 4&#46;67&#59; 95&#37; CI&#44; 1&#46;27&#8211;17&#46;15&#41; in the TNM classification&#59; change in cancer stage during follow-up &#40;ORc&#44; 7&#46;20&#59; 95&#37; CI&#44; 2&#46;25&#8211;22&#46;99&#41;&#59; and death due to melanoma &#40;ORc&#44; 8&#46;67&#59; 95&#37; CI&#44; 3&#46;62&#8211;96&#46;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">These results confirm the prognostic importance of sentinel lymph node biopsy&#44; which facilitates identification of patients with a greater tendency towards disease progression and death due to melanoma&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Actualmente existe un aumento mundial de la incidencia de melanoma&#46; Su pron&#243;stico depende entre otros factores de la existencia de met&#225;stasis en los ganglios linf&#225;ticos regionales&#46; La realizaci&#243;n de la biopsia del ganglio centinela persigue la identificaci&#243;n de met&#225;stasis ganglionares subcl&#237;nicas como factor pron&#243;stico de la enfermedad&#46; El presente estudio tiene por objetivo estudiar las diferencias entre los pacientes con melanoma&#44; positivos y negativos a la biopsia del ganglio centinela&#44; y analizar el impacto de esta t&#233;cnica en su pron&#243;stico&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; biopsia del ganglio centinela a los pacientes con melanomas de espesor Breslow &#8805; 1 mm o con Breslow &#60; 1 mm y ulceraci&#243;n&#44; nivel de Clark IV&#8211;V o regresi&#243;n&#46; Aquellos con biopsia positiva fueron sometidos a linfadenectom&#237;a&#46; Adem&#225;s&#44; se recogieron las siguientes variables&#58; sexo&#44; edad&#44; fototipo&#44; localizaci&#243;n y tipo de melanoma&#44; niveles Breslow y Clark&#44; ulceraci&#243;n&#44; regresi&#243;n&#44; estadio inicial&#44; TNM&#44; cambio de estadio y fallecimiento por melanoma&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El 19&#44;44&#37; de los pacientes present&#243; ganglios positivos&#46; Esta positividad se present&#243; asociada con el melanoma nodular &#40;odds ratio cruda &#91;ORc&#93;&#58; 3&#44;44&#59; intervalo de confianza al 95&#37; &#91;IC 95&#37;&#93;&#58; 1&#44;33&#8211;8&#44;90&#41; con respecto al melanoma de extensi&#243;n superficial Breslow superior a 2&#44;0 &#40;nivel 2&#44;1&#8211;4&#44;0&#58; ORc&#58; 21&#44;14&#59; IC 95&#37;&#58; 2&#44;60&#8211;172&#44;03&#44; nivel &#62; 4&#44;0&#58; ORc&#58; 23&#44;25&#59; IC 95&#37;&#58; 2&#44;44&#8211;221&#44;73&#41;&#44; nivel Clark IV &#40;ORc&#58; 8&#44;73&#59; IC 95&#37; 1&#44;03&#8211;74&#44;12&#41;&#44; ulceraci&#243;n &#40;ORc&#58; 4&#44;86&#59; IC 95&#37;&#58; 1&#44;58&#8211;14&#44;90&#41;&#44; estadios T3 y T4 &#40;T3&#58; ORc&#58; 4&#44;20&#59; IC 95&#37;&#58; 1&#44;52&#8211;11&#44;63&#59; T4&#58; ORc&#58; 4&#44;67&#59; IC 95&#37; 1&#44;27&#8211;17&#44;15&#41;&#44; cambio de estadio &#40;ORc&#58; 7&#44;20&#59; IC 95&#37;&#58; 2&#44;25&#8211;22&#44;99&#41; y fallecimiento por melanoma &#40;ORc&#58; 8&#44;67&#59; IC 95&#37;&#58; 3&#44;62&#8211;96&#44;15&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estos resultados confirman la importancia pron&#243;stica de la biopsia del ganglio centinela&#44; que permite identificar a los pacientes con mayor tendencia a la progresi&#243;n de la enfermedad y fallecimiento por melanoma&#46;</p>"
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Article information
ISSN: 15782190
Original language: English
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2022 October 25 15 40
2022 September 20 37 57
2022 August 22 43 65
2022 July 15 35 50
2022 June 24 32 56
2022 May 30 49 79
2022 April 37 38 75
2022 March 36 55 91
2022 February 21 32 53
2022 January 20 50 70
2021 December 41 47 88
2021 November 29 51 80
2021 October 28 56 84
2021 September 23 57 80
2021 August 30 43 73
2021 July 18 35 53
2021 June 27 48 75
2021 May 33 39 72
2021 April 58 50 108
2021 March 77 37 114
2021 February 62 29 91
2021 January 34 26 60
2020 December 31 15 46
2020 November 22 36 58
2020 October 20 16 36
2020 September 20 12 32
2020 August 30 26 56
2020 July 28 13 41
2020 June 30 33 63
2020 May 20 23 43
2020 April 22 30 52
2020 March 18 24 42
2020 February 3 0 3
2020 January 0 11 11
2019 December 0 5 5
2019 November 0 1 1
2019 September 0 2 2
2019 July 0 1 1
2019 June 0 5 5
2019 May 1 41 42
2019 April 0 7 7
2019 March 0 5 5
2019 February 0 3 3
2018 March 0 1 1
2018 February 13 4 17
2018 January 14 2 16
2017 December 21 7 28
2017 November 14 4 18
2017 October 12 3 15
2017 September 16 4 20
2017 August 25 7 32
2017 July 16 3 19
2017 June 21 8 29
2017 May 16 6 22
2017 April 15 2 17
2017 March 16 4 20
2017 February 14 9 23
2017 January 19 1 20
2016 December 18 14 32
2016 November 13 7 20
2016 October 9 20 29
2016 September 16 10 26
2016 August 30 4 34
2016 July 25 4 29
2016 June 10 0 10
2016 May 8 5 13
2016 April 7 0 7
2016 March 10 0 10
2016 February 2 2 4
2016 January 7 1 8
2015 December 10 2 12
2015 November 4 0 4
2015 October 8 1 9
2015 September 8 4 12
2015 August 13 4 17
2015 July 28 12 40
2015 June 28 9 37
2015 May 58 15 73
2015 April 36 10 46
2015 March 49 8 57
2015 February 20 6 26
2015 January 18 12 30
2014 December 13 5 18
2014 November 11 4 15
2014 October 29 13 42
2014 September 20 7 27
2014 August 30 20 50
2014 July 36 25 61
2014 June 49 6 55
2014 May 35 16 51
2014 April 29 8 37
2014 March 39 21 60
2014 February 19 17 36
2014 January 34 12 46
2013 December 26 11 37
2013 November 19 13 32
2013 October 20 17 37
2013 September 31 14 45
2013 August 13 19 32
2013 July 23 23 46
2013 June 19 22 41
2013 May 14 18 32
2013 April 25 15 40
2013 March 27 18 45
2013 February 11 10 21
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?