NoveltIes in dermatology
New Therapies Targeting the Genetic Mutations Responsible for Different Types of Melanoma
Diferentes alteraciones genéticas causan diferentes melanomas y nuevas posibilidades terapéuticas
R. Botella-Estrada
, O. Sanmartín Jiménez
Corresponding author
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain
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"apellidos" => "Botella-Estrada" "email" => array:1 [ 0 => "rbotellaes@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "O." "apellidos" => "Sanmartín Jiménez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Diferentes alteraciones genéticas causan diferentes melanomas y nuevas posibilidades terapéuticas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-12-29" "fechaAceptado" => "2010-01-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84762" "palabras" => array:6 [ 0 => "Melanoma" 1 => "MAPK" 2 => "BRAF" 3 => "KIT" 4 => "Sorafenib" 5 => "Imatinib" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84763" "palabras" => array:6 [ 0 => "Melanoma" 1 => "MAPK" 2 => "BRAF" 3 => "KIT" 4 => "Sorafenib" 5 => "Imatinib" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">A number of molecular alterations have been described for melanoma. Melanomas with BRAF mutations tend to be located in areas of intermittent sun exposure, whereas melanomas with KIT mutations mostly appear in acral areas, the mucosa, and areas of chronic sun exposure. Sorafenib, a BRAF inhibitor, has a cytostatic effect on most melanomas with mutations affecting the mitogen-activated protein kinase (MAPK) pathway, and is also capable of triggering apoptosis in a small subgroup of these melanomas. By inhibiting KIT, imatinib has a cytostatic and cytotoxic effect on melanomas with KIT mutations, and probably has the same effect on another subgroup of melanomas with other as yet imperfectly understood KIT mutations. For therapy to be effective, agents should be selected according to the pathways associated with the genetic mutations present in the melanoma.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Se han descrito diversas alteraciones moleculares en el melanoma. Los melanomas con mutaciones de BRAF suelen localizarse en zonas con exposición solar intermitente mientras que las alteraciones genéticas de KIT ocurren con mayor frecuencia en los melanomas acrales, mucosos y en los que se localizan en áreas con exposición solar crónica. Sorafenib, un inhibidor de BRAF, tiene un efecto citostático en la mayoría de los melanomas con mutaciones en la vía MAP cinasa, aunque en un pequeño subgrupo de estos melanomas es también capaz de promover la apoptosis. Imatinib, a través de la inhibición de KIT, posee un efecto citostático y citotóxico en aquellos melanomas con mutaciones de KIT, y probablemente en otro subgrupo de melanomas con otras alteraciones genéticas de KIT aún no perfectamente definidas. Para que estos tratamientos sean efectivos es imprescindible que se hayan seleccionado adecuadamente los pacientes, estableciéndose la existencia de alteraciones genéticas en la vía sobre la que se va a actuar.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:44 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A single-institution validation of the AJCC staging system for stage IV melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.B. Neuman" 1 => "A. Patel" 2 => "N. Ishill" 3 => "C. Hanlon" 4 => "M.S. Brady" 5 => "A.C. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 19 | 25 |
| 2024 October | 75 | 51 | 126 |
| 2024 September | 73 | 31 | 104 |
| 2024 August | 94 | 57 | 151 |
| 2024 July | 58 | 44 | 102 |
| 2024 June | 65 | 32 | 97 |
| 2024 May | 57 | 29 | 86 |
| 2024 April | 55 | 25 | 80 |
| 2024 March | 61 | 32 | 93 |
| 2024 February | 44 | 24 | 68 |
| 2024 January | 53 | 32 | 85 |
| 2023 December | 59 | 24 | 83 |
| 2023 November | 57 | 33 | 90 |
| 2023 October | 73 | 27 | 100 |
| 2023 September | 48 | 29 | 77 |
| 2023 August | 36 | 17 | 53 |
| 2023 July | 59 | 69 | 128 |
| 2023 June | 39 | 25 | 64 |
| 2023 May | 45 | 27 | 72 |
| 2023 April | 40 | 16 | 56 |
| 2023 March | 18 | 18 | 36 |
| 2023 February | 26 | 29 | 55 |
| 2023 January | 44 | 28 | 72 |
| 2022 December | 47 | 38 | 85 |
| 2022 November | 20 | 27 | 47 |
| 2022 October | 29 | 19 | 48 |
| 2022 September | 25 | 32 | 57 |
| 2022 August | 22 | 33 | 55 |
| 2022 July | 14 | 26 | 40 |
| 2022 June | 14 | 32 | 46 |
| 2022 May | 24 | 32 | 56 |
| 2022 April | 57 | 39 | 96 |
| 2022 March | 70 | 38 | 108 |
| 2022 February | 48 | 30 | 78 |
| 2022 January | 69 | 32 | 101 |
| 2021 December | 24 | 44 | 68 |
| 2021 November | 23 | 44 | 67 |
| 2021 October | 42 | 53 | 95 |
| 2021 September | 62 | 40 | 102 |
| 2021 August | 52 | 36 | 88 |
| 2021 July | 22 | 35 | 57 |
| 2021 June | 22 | 22 | 44 |
| 2021 May | 33 | 32 | 65 |
| 2021 April | 68 | 37 | 105 |
| 2021 March | 63 | 36 | 99 |
| 2021 February | 63 | 27 | 90 |
| 2021 January | 39 | 14 | 53 |
| 2020 December | 33 | 16 | 49 |
| 2020 November | 31 | 20 | 51 |
| 2020 October | 38 | 30 | 68 |
| 2020 September | 42 | 15 | 57 |
| 2020 August | 37 | 19 | 56 |
| 2020 July | 16 | 14 | 30 |
| 2020 June | 21 | 22 | 43 |
| 2020 May | 8 | 11 | 19 |
| 2020 April | 23 | 24 | 47 |
| 2020 March | 11 | 20 | 31 |
| 2020 February | 2 | 5 | 7 |
| 2020 January | 0 | 11 | 11 |
| 2019 December | 0 | 5 | 5 |
| 2019 November | 0 | 2 | 2 |
| 2019 October | 0 | 1 | 1 |
| 2019 September | 0 | 4 | 4 |
| 2019 August | 0 | 2 | 2 |
| 2019 July | 0 | 2 | 2 |
| 2019 June | 0 | 3 | 3 |
| 2019 May | 1 | 39 | 40 |
| 2019 April | 0 | 1 | 1 |
| 2019 March | 0 | 4 | 4 |
| 2019 February | 0 | 4 | 4 |
| 2018 March | 0 | 3 | 3 |
| 2018 February | 13 | 1 | 14 |
| 2018 January | 16 | 5 | 21 |
| 2017 December | 11 | 8 | 19 |
| 2017 November | 16 | 1 | 17 |
| 2017 October | 18 | 4 | 22 |
| 2017 September | 13 | 8 | 21 |
| 2017 August | 21 | 6 | 27 |
| 2017 July | 23 | 3 | 26 |
| 2017 June | 22 | 6 | 28 |
| 2017 May | 23 | 12 | 35 |
| 2017 April | 28 | 7 | 35 |
| 2017 March | 26 | 3 | 29 |
| 2017 February | 21 | 6 | 27 |
| 2017 January | 16 | 5 | 21 |
| 2016 December | 30 | 5 | 35 |
| 2016 November | 18 | 6 | 24 |
| 2016 October | 25 | 10 | 35 |
| 2016 September | 25 | 4 | 29 |
| 2016 August | 21 | 9 | 30 |
| 2016 July | 18 | 5 | 23 |
| 2016 June | 11 | 8 | 19 |
| 2016 May | 10 | 9 | 19 |
| 2016 April | 6 | 3 | 9 |
| 2016 March | 1 | 8 | 9 |
| 2016 February | 5 | 1 | 6 |
| 2016 January | 10 | 7 | 17 |
| 2015 December | 7 | 1 | 8 |
| 2015 November | 7 | 10 | 17 |
| 2015 October | 8 | 6 | 14 |
| 2015 September | 10 | 4 | 14 |
| 2015 August | 15 | 3 | 18 |
| 2015 July | 31 | 6 | 37 |
| 2015 June | 37 | 4 | 41 |
| 2015 May | 52 | 7 | 59 |
| 2015 April | 29 | 6 | 35 |
| 2015 March | 29 | 8 | 37 |
| 2015 February | 26 | 14 | 40 |
| 2015 January | 27 | 10 | 37 |
| 2014 December | 22 | 4 | 26 |
| 2014 November | 19 | 5 | 24 |
| 2014 October | 29 | 12 | 41 |
| 2014 September | 29 | 10 | 39 |
| 2014 August | 42 | 16 | 58 |
| 2014 July | 40 | 24 | 64 |
| 2014 June | 39 | 6 | 45 |
| 2014 May | 39 | 14 | 53 |
| 2014 April | 31 | 8 | 39 |
| 2014 March | 34 | 12 | 46 |
| 2014 February | 51 | 13 | 64 |
| 2014 January | 40 | 7 | 47 |
| 2013 December | 31 | 12 | 43 |
| 2013 November | 29 | 17 | 46 |
| 2013 October | 29 | 15 | 44 |
| 2013 September | 40 | 19 | 59 |
| 2013 August | 29 | 19 | 48 |
| 2013 July | 36 | 27 | 63 |
| 2013 June | 26 | 15 | 41 |
| 2013 May | 18 | 16 | 34 |
| 2013 April | 30 | 16 | 46 |
| 2013 March | 26 | 14 | 40 |
| 2013 February | 17 | 13 | 30 |
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