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ATP-binding Cassette Transporter ABCB5 Gene is Expressed with Variability in Malignant Melanoma
Expresión variable del gen ABCB5 de las transportadoras de casetes de unión a ATP en el melanoma maligno
I. Vásquez-Moctezumaa, M.A. Meraz-Ríosb, C.G. Villanueva-Lópeza, M. Magañac, R. Martínez-Maciasd, D.J. Sánchez-Gonzáleze, F. García-Sierraf, N.E. Herrera-Gonzáleza,
Corresponding author
a Escuela Superior de Medicina, Instituto Politécnico Nacional, México DF, México
b Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México DF, México
c Hospital General de México, Universidad Nacional Autónoma de México (UNAM), México DF, México
d Unidad de Oncología, Hospital General de México, México DF, México
e Escuela Médico Militar, Universidad de Falcan (UDEFA), México DF, México
f Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México DF, México
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Incidence of melanoma varies according to geographic region and genetic background. Epidemiological studies indicate that acral melanoma (AM) is among the most common melanomas in the Mexican population. While extensive studies have identified genes associated with melanoma, little is known about the genes involved in the pathogenesis of AM.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To compare the gene expression patterns between primary melanoma and normal skin.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We used 10 samples of fresh acral melanomas and normal skin for the study of differential gene expression and 22 samples of melanoma for <span class="elsevierStyleItalic">in situ</span> hybridization.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We first identified a gene that was present in a sample of AM and absent in normal skin. DNA sequencing of this differentially expressed gene revealed that it corresponded to ABCB5, a gene recently implicated in the regulation of progenitor cell fusion. Furthermore, we detected ABCB5 expression in other melanoma specimens by RT-PCR. We showed that nine out of ten melanomas were positive for ABCB5 while only one melanoma and normal skin samples were negative. All ABCB5 expressing melanomas had variable gene expression according to <span class="elsevierStyleItalic">in situ</span> hybridization studies, suggesting that the ABCB5 gene may be differentially regulated by individual melanomas.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The ABCB5 gene may be related to the properties of chemoresistance and aggressiveness of melanoma. The high expression found in samples of acral melanoma may provide more insight on the pathogenesis of this common type of melanoma in the Mexican population, frequently associated with poor prognosis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El melanoma es una neoplasia maligna que presenta una elevada mortalidad y un alto riesgo de desarrollar metástasis. La incidencia de esta enfermedad varía en función de la región geográfica y el trasfondo genético. Estudios epidemiológicos indican que el melanoma acral es uno de los más comunes en la población mexicana. Hay una gran cantidad de estudios sobre genes asociados al melanoma, sin embargo, se sabe muy poco de los genes que se relacionan con el melanoma acral.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Comparar el patrón de expresión génica entre melanomas acrales primarios y piel sana.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se utilizaron muestras en fresco de 10 lesiones de melanoma acral y piel sana para el estudio de expresión diferencial de genes y 22 muestras de melanoma para la hibridación <span class="elsevierStyleItalic">in situ.</span></p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Identificamos un gen que estaba presente en una muestra de melanoma acral y ausente en la piel normal. La secuenciación de este gen reveló que correspondía al gen ABCB5, recientemente implicado en la regulación de la fusión de células progenitoras. Al realizar RT-PCR de otros melanomas se detectó la expresión de este gen: 9 de 10 melanomas fueron positivos para ABCB5. Todos los melanomas tuvieron una expresión variable de ABCB5 detectado por hibridación <span class="elsevierStyleItalic">in situ,</span> lo cual sugiere que el gen puede ser regulado diferencialmente en melanomas individuales.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El gen ABCB5 podría estar relacionado con las propiedades de resistencia a la quimioterapia y la agresividad del melanoma. La elevada expresión encontrada en las muestras de melanoma acral podría ayudar a la mejor comprensión de la patogenia de esta forma frecuente de melanoma en la población mexicana, que se asocia generalmente con un peor pronóstico.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Lens" 1 => "M. Dawes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2004" "volumen" => "150" "paginaInicial" => "179" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14996086" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Características del melanoma en la población mexicana" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Magaña" 1 => "J. Cazarín" 2 => "L. Magaña" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermatol Dermatopathol (Méx)" "fecha" => "2001" "volumen" => "1" "paginaInicial" => "59" "paginaFinal" => "62" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular events in melanoma development and progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Meier" 1 => "K. Satyamoorthy" 2 => "M. Nesbit" 3 => "M.Y. Hsu" 4 => "B. Schittek" 5 => "C. Garbe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Front Biosci" "fecha" => "1998" "volumen" => "3" "paginaInicial" => "1005" "paginaFinal" => "1010" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classifying melanocytic tumors based on DNA copy number changes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Bastian" 1 => "A. Olshen" 2 => "P. LeBoit" 3 => "D. Pinkel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Pathol" "fecha" => "2003" "volumen" => "3" "paginaInicial" => "1765" "paginaFinal" => "1770" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intrinsic MDR-1 gene and P-glycoprotein expression in human melanoma cell lines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W. Berger" 1 => "L. Elbling" 2 => "M. Minai-Pour" 3 => "M. Vetterlein" 4 => "R. Pirker" 5 => "E.M. Kokoschka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "1994" "volumen" => "59" "paginaInicial" => "717" "paginaFinal" => "723" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7960246" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemical, cellular, and pharmacological aspects of the multidrug transporter" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Ambudkar" 1 => "S. Dey" 2 => "C. Hrycyna" 3 => "M. Ramachandra" 4 => "I. Pastan" 5 => "M.M. Gottesman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.pharmtox.39.1.361" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Pharmacol Toxicol" "fecha" => "1999" "volumen" => "39" "paginaInicial" => "361" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10331089" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Juliano" 1 => "V. Ling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Biochemical Biophysical Acta" "fecha" => "1976" "volumen" => "455" "paginaInicial" => "152" "paginaFinal" => "162" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of a multidrug-resistance gene in human tumors and tissues" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Fojo" 1 => "K. Ueda" 2 => "D. Slamon" 3 => "D.G. Poplack" 4 => "M.M. Gottesman" 5 => "I. Pastan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1978" "volumen" => "84" "paginaInicial" => "265" "paginaFinal" => "269" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2432605" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The human ATP-binding cassette (ABC) transporter superfamily" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Dean" 1 => "A. Rzhetsky" 2 => "R. Allikmets" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1101/gr.184901" "Revista" => array:6 [ "tituloSerie" => "Genome Res" "fecha" => "2001" "volumen" => "11" "paginaInicial" => "1156" "paginaFinal" => "1166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11435397" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multidrug resistance of DNA mediated transformants is linked to transfer of the human mdr1 gene" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Shen" 1 => "A. Fojo" 2 => "I. Roninson" 3 => "J.E. Chin" 4 => "R. Soffir" 5 => "I. Pastan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mol Cell Biol." "fecha" => "1986" "volumen" => "6" "paginaInicial" => "4039" "paginaFinal" => "4045" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3796599" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of cells initiating human melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Schatton" 1 => "G. Murphy" 2 => "N. Frank" 3 => "K. Yamaura" 4 => "A.M. Waaga-Gasser" 5 => "M. Gasser" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nature06489" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "2008" "volumen" => "451" "paginaInicial" => "345" "paginaFinal" => "349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18202660" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of the one allele with P-glycoprotein expression and activity in vivo" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Hoffmeyer" 1 => "O. Burk" 2 => "O. Von Ritcher" 3 => "H.P. Arnold" 4 => "J. Brockmóller" 5 => "A. Johne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.050585397" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "2000" "volumen" => "97" "paginaInicial" => "3473" "paginaFinal" => "3478" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10716719" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Apoptosis and melanoma chemoresistance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Soengas" 1 => "S. Lowe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.onc.1207590" "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "3138" "paginaFinal" => "3151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15094763" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Liang" 1 => "A. Pardee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1992" "volumen" => "257" "paginaInicial" => "967" "paginaFinal" => "971" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1354393" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "REN display, a rapid and efficient method for nonradioactive differential display and mRNA isolation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Lohmann" 1 => "H. Schickle" 2 => "T. Bosch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biotechniques" "fecha" => "1995" "volumen" => "18" "paginaInicial" => "200" "paginaFinal" => "202" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7727113" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Frank" 1 => "S. Pendse" 2 => "P. Lapchak" 3 => "A. Margaryan" 4 => "D. Shlain" 5 => "C. Doeing" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/jbc.M308700200" "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "2003" "volumen" => "278" "paginaInicial" => "47156" "paginaFinal" => "47165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12960149" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Huang" 1 => "P. Anderle" 2 => "K. Bussey" 3 => "C. Barbacioru" 4 => "U. Shankavaram" 5 => "Z. Dai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/0008-5472.CAN-03-3884" "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "2004" "volumen" => "64" "paginaInicial" => "4294" "paginaFinal" => "4301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15205344" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Kurebayashi" 1 => "T. Otsuki" 2 => "H. Kunisue" 3 => "K. Tanaka" 4 => "S. Yamamoto" 5 => "H. Sonoo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2000" "volumen" => "6" "paginaInicial" => "512" "paginaFinal" => "518" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10690532" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acral lentiginous melanoma: a challenge for early diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Maia" 1 => "C. Russo" 2 => "N. Ferrari" 3 => "M.C.S.A. Ribeiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Bras Dermatol" "fecha" => "2003" "volumen" => "78" "paginaInicial" => "553" "paginaFinal" => "560" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The importance of race and ethnic background in biomedical research and clinical practice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.E. Gonzalez" 1 => "E. Ziv" 2 => "N. Coyle" 3 => "S.L. Gomez" 4 => "H. Tang" 5 => "A.J. Karter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMsb025007" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2003" "volumen" => "348" "paginaInicial" => "1170" "paginaFinal" => "1175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12646676" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Race and genomics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Cooper" 1 => "J. Kaufman" 2 => "R. Ward" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "2003" "volumen" => "248" "paginaInicial" => "1166" "paginaFinal" => "1170" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B. Bastian" 1 => "P. LeBoit" 2 => "H. Hamm" 3 => "E.B. Brocker" 4 => "D. Pinkel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1998" "volumen" => "58" "paginaInicial" => "2170" "paginaFinal" => "2175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9605762" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomic approaches to skin cancer diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Bastian" 1 => "P. LeBoit" 2 => "D. Pinkel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2001" "volumen" => "137" "paginaInicial" => "1507" "paginaFinal" => "1511" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11708957" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutation of the B-RAF gene in human cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Davies" 1 => "G.R. Bignell" 2 => "C. Cox" 3 => "P. Stephens" 4 => "S. Edkins" 5 => "S. Clegg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nature00766" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "2002" "volumen" => "417" "paginaInicial" => "949" "paginaFinal" => "954" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12068308" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Determinants of B-RAF mutations in primary melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Maldonado" 1 => "J. Fridlyand" 2 => "H. Patel" 3 => "A.N. Jain" 4 => "K. Busam" 5 => "T. Kageshita" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2003" "volumen" => "95" "paginaInicial" => "1878" "paginaFinal" => "1890" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14679157" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer multidrug resistance: a reviewof recent drug discovery research" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Liscovitch" 1 => "Y. Lavie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Drugs" "fecha" => "2002" "volumen" => "5" "paginaInicial" => "349" "paginaFinal" => "355" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Principal expression of two mRNA isoforms, (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB5 in melanoma cells and melanocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Chen" 1 => "G. Szakács" 2 => "J. Annereau" 3 => "F. Rouzaud" 4 => "X.J. Liang" 5 => "J.C. Valencia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0749.2005.00214.x" "Revista" => array:6 [ "tituloSerie" => "Pigment Cell Res" "fecha" => "2005" "volumen" => "18" "paginaInicial" => "102" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15760339" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Frank" 1 => "A. Margaryan" 2 => "Y. Huang" 3 => "T. Schatton" 4 => "A.M. Waaga-Gasser" 5 => "M. Gasser" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/0008-5472.CAN-04-3327" "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "2005" "volumen" => "65" "paginaInicial" => "4320" "paginaFinal" => "4333" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15899824" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug resistance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Giaccone" 1 => "H. Pinedo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oncologist" "fecha" => "1996" "volumen" => "1" "paginaInicial" => "82" "paginaFinal" => "87" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10387972" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Weinstein" 1 => "S. Jakate" 2 => "J. Domínguez" 3 => "M. Lebovitz" 4 => "G. Koukoulis" 5 => "J. Kuszak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1991" "volumen" => "51" "paginaInicial" => "2720" "paginaFinal" => "2726" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1673639" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Chen" 1 => "J. Valencia" 2 => "B. Lai" 3 => "G. Zhang" 4 => "J.K. Paterson" 5 => "F. Rouzaud" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.0600213103" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "2006" "volumen" => "103" "paginaInicial" => "9903" "paginaFinal" => "9907" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16777967" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatopathologic variants of malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Perniciaro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Mayo Clin Proc" "fecha" => "1997" "volumen" => "3" "paginaInicial" => "273" "paginaFinal" => "279" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Significance of the small subtelomeric area of chromosome 1, (1p36.3) inthe progression of malignant melanoma: FISH deletion screening with YAC DNA probes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Poetsch" 1 => "C. Woenckhaus" 2 => "T. Dittberner" 3 => "M. Pambor" 4 => "G. Lorenz" 5 => "F.H. Herrmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Virchows Arch" "fecha" => "1999" "volumen" => "435" "paginaInicial" => "105" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10599308" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MDR1 polymorphisms predict the response to etoposide-cisplatin combination chemotherapy in small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Sohn" 1 => "S. Lee" 2 => "S. Lee" 3 => "E.J. Kim" 4 => "S.I. Cha" 5 => "Ch.H. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jjco/hyi231" "Revista" => array:6 [ "tituloSerie" => "Jpn J Clin Oncol" "fecha" => "2006" "volumen" => "36" "paginaInicial" => "137" "paginaFinal" => "141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16478794" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Duncan" 1 => "J. Deeds" 2 => "J. Hunter" 3 => "J. Shao" 4 => "L.M. Holmgren" 5 => "E.A. Woolf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1998" "volumen" => "58" "paginaInicial" => "1515" "paginaFinal" => "1520" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9537257" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic progression of metastatic melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Rodolfo" 1 => "M. Daniotti" 2 => "V. Vallacchi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.canlet.2004.06.049" "Revista" => array:6 [ "tituloSerie" => "Cancer Lett" "fecha" => "2004" "volumen" => "214" "paginaInicial" => "133" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15363539" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000004/v1_201304241521/S1578219010706454/v1_201304241521/en/main.assets" "Apartado" => array:4 [ "identificador" => "6255" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000004/v1_201304241521/S1578219010706454/v1_201304241521/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706454?idApp=UINPBA000044" ]
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| 2024 July | 67 | 59 | 126 |
| 2024 June | 70 | 39 | 109 |
| 2024 May | 61 | 35 | 96 |
| 2024 April | 63 | 37 | 100 |
| 2024 March | 52 | 41 | 93 |
| 2024 February | 53 | 41 | 94 |
| 2024 January | 44 | 45 | 89 |
| 2023 December | 52 | 38 | 90 |
| 2023 November | 43 | 31 | 74 |
| 2023 October | 75 | 46 | 121 |
| 2023 September | 38 | 30 | 68 |
| 2023 August | 31 | 29 | 60 |
| 2023 July | 40 | 53 | 93 |
| 2023 June | 37 | 26 | 63 |
| 2023 May | 31 | 23 | 54 |
| 2023 April | 27 | 32 | 59 |
| 2023 March | 22 | 57 | 79 |
| 2023 February | 20 | 53 | 73 |
| 2023 January | 34 | 39 | 73 |
| 2022 December | 31 | 52 | 83 |
| 2022 November | 16 | 38 | 54 |
| 2022 October | 17 | 19 | 36 |
| 2022 September | 14 | 39 | 53 |
| 2022 August | 19 | 33 | 52 |
| 2022 July | 17 | 31 | 48 |
| 2022 June | 19 | 28 | 47 |
| 2022 May | 19 | 42 | 61 |
| 2022 April | 36 | 48 | 84 |
| 2022 March | 39 | 53 | 92 |
| 2022 February | 23 | 27 | 50 |
| 2022 January | 22 | 41 | 63 |
| 2021 December | 25 | 46 | 71 |
| 2021 November | 27 | 53 | 80 |
| 2021 October | 37 | 51 | 88 |
| 2021 September | 23 | 54 | 77 |
| 2021 August | 30 | 37 | 67 |
| 2021 July | 24 | 35 | 59 |
| 2021 June | 17 | 27 | 44 |
| 2021 May | 29 | 30 | 59 |
| 2021 April | 56 | 47 | 103 |
| 2021 March | 83 | 33 | 116 |
| 2021 February | 57 | 23 | 80 |
| 2021 January | 27 | 15 | 42 |
| 2020 December | 20 | 16 | 36 |
| 2020 November | 20 | 25 | 45 |
| 2020 October | 16 | 5 | 21 |
| 2020 September | 30 | 14 | 44 |
| 2020 August | 27 | 21 | 48 |
| 2020 July | 19 | 13 | 32 |
| 2020 June | 24 | 20 | 44 |
| 2020 May | 40 | 20 | 60 |
| 2020 April | 22 | 23 | 45 |
| 2020 March | 16 | 16 | 32 |
| 2020 February | 2 | 3 | 5 |
| 2020 January | 0 | 4 | 4 |
| 2019 December | 0 | 10 | 10 |
| 2019 November | 0 | 2 | 2 |
| 2019 October | 0 | 4 | 4 |
| 2019 September | 0 | 3 | 3 |
| 2019 August | 0 | 3 | 3 |
| 2019 July | 0 | 7 | 7 |
| 2019 June | 0 | 7 | 7 |
| 2019 May | 0 | 43 | 43 |
| 2019 April | 0 | 11 | 11 |
| 2019 March | 0 | 7 | 7 |
| 2019 February | 0 | 10 | 10 |
| 2019 January | 0 | 1 | 1 |
| 2018 December | 0 | 7 | 7 |
| 2018 September | 0 | 2 | 2 |
| 2018 August | 0 | 11 | 11 |
| 2018 July | 0 | 5 | 5 |
| 2018 June | 0 | 6 | 6 |
| 2018 May | 0 | 3 | 3 |
| 2018 April | 0 | 3 | 3 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 11 | 5 | 16 |
| 2018 January | 16 | 8 | 24 |
| 2017 December | 15 | 7 | 22 |
| 2017 November | 12 | 7 | 19 |
| 2017 October | 13 | 10 | 23 |
| 2017 September | 12 | 3 | 15 |
| 2017 August | 22 | 8 | 30 |
| 2017 July | 12 | 17 | 29 |
| 2017 June | 24 | 20 | 44 |
| 2017 May | 19 | 10 | 29 |
| 2017 April | 21 | 8 | 29 |
| 2017 March | 15 | 30 | 45 |
| 2017 February | 20 | 8 | 28 |
| 2017 January | 9 | 10 | 19 |
| 2016 December | 30 | 14 | 44 |
| 2016 November | 26 | 11 | 37 |
| 2016 October | 20 | 6 | 26 |
| 2016 September | 22 | 6 | 28 |
| 2016 August | 19 | 10 | 29 |
| 2016 July | 18 | 4 | 22 |
| 2016 June | 14 | 4 | 18 |
| 2016 May | 6 | 5 | 11 |
| 2016 April | 12 | 8 | 20 |
| 2016 March | 5 | 7 | 12 |
| 2016 February | 10 | 7 | 17 |
| 2016 January | 13 | 3 | 16 |
| 2015 December | 11 | 1 | 12 |
| 2015 November | 9 | 6 | 15 |
| 2015 October | 15 | 8 | 23 |
| 2015 September | 18 | 2 | 20 |
| 2015 August | 12 | 2 | 14 |
| 2015 July | 21 | 6 | 27 |
| 2015 June | 11 | 7 | 18 |
| 2015 May | 34 | 9 | 43 |
| 2015 April | 24 | 11 | 35 |
| 2015 March | 17 | 7 | 24 |
| 2015 February | 22 | 9 | 31 |
| 2015 January | 11 | 11 | 22 |
| 2014 December | 12 | 19 | 31 |
| 2014 November | 7 | 16 | 23 |
| 2014 October | 15 | 12 | 27 |
| 2014 September | 11 | 11 | 22 |
| 2014 August | 13 | 15 | 28 |
| 2014 July | 18 | 22 | 40 |
| 2014 June | 22 | 11 | 33 |
| 2014 May | 23 | 21 | 44 |
| 2014 April | 23 | 9 | 32 |
| 2014 March | 34 | 23 | 57 |
| 2014 February | 20 | 25 | 45 |
| 2014 January | 22 | 21 | 43 |
| 2013 December | 24 | 10 | 34 |
| 2013 November | 18 | 15 | 33 |
| 2013 October | 10 | 16 | 26 |
| 2013 September | 20 | 24 | 44 |
| 2013 August | 27 | 23 | 50 |
| 2013 July | 19 | 44 | 63 |
| 2013 June | 15 | 29 | 44 |
| 2013 May | 21 | 27 | 48 |
| 2013 April | 21 | 28 | 49 |
| 2013 March | 23 | 28 | 51 |
| 2013 February | 11 | 19 | 30 |
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