Review article
Histopathology of the More Common Viral Skin Infections
Histopatología de las infecciones víricas cutáneas más frecuentes
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Giménez-Arnau" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.F." "apellidos" => "Silvestre" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Mercader" ] 2 => array:2 [ "nombre" => "A.M." "apellidos" => "Giménez-Arnau" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706193?idApp=UINPBA000044" "url" => "/15782190/0000010100000003/v1_201304241518/S1578219010706193/v1_201304241518/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S157821901070617X" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70617-X" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "70617" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Actas Dermosifiliogr. 2010;101:197-200" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2499 "formatos" => array:3 [ "EPUB" => 40 "HTML" => 1361 "PDF" => 1098 ] ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>" "titulo" => "Antioxidants in Photoprotection: Do They Really Work?" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "197" "paginaFinal" => "200" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Antioxidantes en fotoprotección, ¿realmente funcionan?" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.V. De Gálvez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "M.V." "apellidos" => "De Gálvez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901070617X?idApp=UINPBA000044" "url" => "/15782190/0000010100000003/v1_201304241518/S157821901070617X/v1_201304241518/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Histopathology of the More Common Viral Skin Infections" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "216" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L. Requena, C. Requena" "autores" => array:2 [ 0 => array:4 [ "nombre" => "L." "apellidos" => "Requena" "email" => array:1 [ 0 => "lrequena@fjd.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Requena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Histopatología de las infecciones víricas cutáneas más frecuentes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-07-18" "fechaAceptado" => "2009-07-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84732" "palabras" => array:7 [ 0 => "Histopathology" 1 => "Viral infections" 2 => "Skin" 3 => "Herpesvirus" 4 => "Cytomegalovirus" 5 => "Papillomavirus" 6 => "Parapoxvirus" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84733" "palabras" => array:7 [ 0 => "Histopatología" 1 => "Infecciones víricas" 2 => "Piel" 3 => "Herpes virus" 4 => "Citomegalovirus" 5 => "Papilomavirus" 6 => "Parapoxvirus" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We describe the histopathological characteristics of viral skin infections. Herpes simplex virus and varicella-zoster virus produce an intraepidermal vesicle with variable degrees of epithelial necrosis. Typical findings include keratinocytes with ballooned nuclei with a ground-glass appearance and giant multinucleated keratinocytes. In the endothelial cells of the dermal blood vessels, cytomegalovirus produces large eosinophilic nuclear inclusions surrounded by a clear halo. Human herpes virus 8 is etiologically associated with Kaposi sarcoma. In its early stages, this tumor contains blood vessels with a fine endothelium passing through the dermal collagen bundles. In the plaque and nodular stages, the vessel lumens are more clearly visible and there is a progressive increase in the number of neoplastic spindle cells with a low degree of pleomorphism and atypia, and occasional mitoses. The infiltrate is made up of lymphocytes and plasma cells. Contagious ecthyma and milker's nodule give rise to an acanthotic epidermis with ballooned keratinocytes containing eosinophilic cytoplasmic viral inclusions. Molluscum contagiosum shows lobules of epithelium that open onto the epidermal surface and characteristic inclusion bodies. Acanthosis, papillomatosis, and hyperkeratosis are observed in common warts, with confluence of the epidermal ridges in the center of the lesion and koilocytes.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">En este trabajo describimos las características histopatológicas de las infecciones víricas cutáneas. El herpes simple y el virus varicela-zóster producen una vesícula intraepidérmica con grados variables de necrosis epitelial. Son característicos los queratinocitos con núcleos balonizados con aspecto de vidrio esmerilado y los queratinocitos gigantes multinucleados. El citomegalovirus produce grandes inclusiones nucleares eosinófilas rodeadas de un halo claro en los endotelios de los vasos dérmicos. El herpes virus tipo 8 se relaciona etiológicamente con el sarcoma de Kaposi, que en sus fases iniciales muestra luces vasculares de endotelios finos disecando los haces de colágeno dérmicos. En las fases en placa y nodular las luces vasculares son más visibles, aumenta progresivamente el número de células fusiformes tumorales con discreto grado de atipia y pleomorfismo y algunas mitosis. El infiltrado se compone de linfocitos y células plasmáticas. El orf y el nódulo de los ordeñadores inducen una epidermis acantósica con queratinocitos balonizados que contienen inclusiones víricas citoplasmáticas eosinófilas. El molusco contagioso muestra lóbulos de epitelio abiertos a la superficie epidérmica con característicos cuerpos de inclusión. En las verrugas vulgares aparece acantosis, papilomatosis e hiperqueratosis, con confluencia de las crestas epidérmicas hacia el centro de la lesión y coilocitos.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:103 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The histopathologic evolution of recurrent herpes simplex labialis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.C. Huff" 1 => "G.G. Krueger" 2 => "J.C. Overall" 3 => "J. Copeland" 4 => "S.L. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 6 | 13 |
| 2024 October | 111 | 55 | 166 |
| 2024 September | 110 | 59 | 169 |
| 2024 August | 175 | 70 | 245 |
| 2024 July | 129 | 79 | 208 |
| 2024 June | 107 | 44 | 151 |
| 2024 May | 98 | 58 | 156 |
| 2024 April | 95 | 63 | 158 |
| 2024 March | 98 | 36 | 134 |
| 2024 February | 71 | 43 | 114 |
| 2024 January | 63 | 39 | 102 |
| 2023 December | 81 | 43 | 124 |
| 2023 November | 84 | 44 | 128 |
| 2023 October | 81 | 44 | 125 |
| 2023 September | 79 | 34 | 113 |
| 2023 August | 53 | 27 | 80 |
| 2023 July | 53 | 55 | 108 |
| 2023 June | 72 | 54 | 126 |
| 2023 May | 43 | 35 | 78 |
| 2023 April | 36 | 41 | 77 |
| 2023 March | 40 | 46 | 86 |
| 2023 February | 36 | 32 | 68 |
| 2023 January | 33 | 37 | 70 |
| 2022 December | 41 | 52 | 93 |
| 2022 November | 25 | 42 | 67 |
| 2022 October | 20 | 22 | 42 |
| 2022 September | 24 | 46 | 70 |
| 2022 August | 20 | 43 | 63 |
| 2022 July | 26 | 34 | 60 |
| 2022 June | 35 | 39 | 74 |
| 2022 May | 89 | 47 | 136 |
| 2022 April | 64 | 50 | 114 |
| 2022 March | 49 | 52 | 101 |
| 2022 February | 71 | 46 | 117 |
| 2022 January | 52 | 56 | 108 |
| 2021 December | 36 | 43 | 79 |
| 2021 November | 54 | 46 | 100 |
| 2021 October | 54 | 53 | 107 |
| 2021 September | 44 | 55 | 99 |
| 2021 August | 67 | 40 | 107 |
| 2021 July | 45 | 39 | 84 |
| 2021 June | 46 | 30 | 76 |
| 2021 May | 38 | 35 | 73 |
| 2021 April | 110 | 52 | 162 |
| 2021 March | 90 | 27 | 117 |
| 2021 February | 76 | 48 | 124 |
| 2021 January | 44 | 22 | 66 |
| 2020 December | 45 | 20 | 65 |
| 2020 November | 38 | 23 | 61 |
| 2020 October | 23 | 10 | 33 |
| 2020 September | 28 | 11 | 39 |
| 2020 August | 41 | 19 | 60 |
| 2020 July | 31 | 11 | 42 |
| 2020 June | 42 | 29 | 71 |
| 2020 May | 44 | 26 | 70 |
| 2020 April | 30 | 21 | 51 |
| 2020 March | 33 | 23 | 56 |
| 2020 February | 5 | 5 | 10 |
| 2020 January | 0 | 7 | 7 |
| 2019 December | 0 | 11 | 11 |
| 2019 November | 0 | 3 | 3 |
| 2019 October | 0 | 4 | 4 |
| 2019 September | 0 | 4 | 4 |
| 2019 August | 0 | 4 | 4 |
| 2019 July | 0 | 8 | 8 |
| 2019 June | 0 | 14 | 14 |
| 2019 May | 0 | 53 | 53 |
| 2019 April | 0 | 47 | 47 |
| 2019 March | 0 | 16 | 16 |
| 2019 February | 0 | 13 | 13 |
| 2019 January | 0 | 8 | 8 |
| 2018 April | 1 | 0 | 1 |
| 2018 March | 7 | 0 | 7 |
| 2018 February | 35 | 4 | 39 |
| 2018 January | 26 | 3 | 29 |
| 2017 December | 36 | 5 | 41 |
| 2017 November | 45 | 4 | 49 |
| 2017 October | 40 | 3 | 43 |
| 2017 September | 34 | 10 | 44 |
| 2017 August | 56 | 13 | 69 |
| 2017 July | 60 | 7 | 67 |
| 2017 June | 58 | 19 | 77 |
| 2017 May | 73 | 12 | 85 |
| 2017 April | 48 | 10 | 58 |
| 2017 March | 51 | 37 | 88 |
| 2017 February | 53 | 14 | 67 |
| 2017 January | 31 | 7 | 38 |
| 2016 December | 54 | 15 | 69 |
| 2016 November | 47 | 23 | 70 |
| 2016 October | 47 | 26 | 73 |
| 2016 September | 64 | 32 | 96 |
| 2016 August | 63 | 16 | 79 |
| 2016 July | 30 | 20 | 50 |
| 2016 June | 12 | 21 | 33 |
| 2016 May | 9 | 24 | 33 |
| 2016 April | 2 | 5 | 7 |
| 2016 March | 6 | 7 | 13 |
| 2016 February | 2 | 10 | 12 |
| 2016 January | 8 | 8 | 16 |
| 2015 December | 10 | 7 | 17 |
| 2015 November | 14 | 9 | 23 |
| 2015 October | 2 | 1 | 3 |
| 2015 September | 5 | 2 | 7 |
| 2015 August | 10 | 7 | 17 |
| 2015 July | 52 | 54 | 106 |
| 2015 June | 44 | 33 | 77 |
| 2015 May | 92 | 37 | 129 |
| 2015 April | 43 | 26 | 69 |
| 2015 March | 51 | 25 | 76 |
| 2015 February | 67 | 23 | 90 |
| 2015 January | 45 | 30 | 75 |
| 2014 December | 62 | 26 | 88 |
| 2014 November | 41 | 19 | 60 |
| 2014 October | 46 | 35 | 81 |
| 2014 September | 50 | 21 | 71 |
| 2014 August | 45 | 18 | 63 |
| 2014 July | 65 | 20 | 85 |
| 2014 June | 51 | 14 | 65 |
| 2014 May | 58 | 19 | 77 |
| 2014 April | 62 | 20 | 82 |
| 2014 March | 71 | 30 | 101 |
| 2014 February | 40 | 14 | 54 |
| 2014 January | 51 | 26 | 77 |
| 2013 December | 49 | 17 | 66 |
| 2013 November | 24 | 23 | 47 |
| 2013 October | 31 | 24 | 55 |
| 2013 September | 48 | 43 | 91 |
| 2013 August | 37 | 37 | 74 |
| 2013 July | 40 | 45 | 85 |
| 2013 June | 25 | 25 | 50 |
| 2013 May | 42 | 16 | 58 |
| 2013 April | 36 | 28 | 64 |
| 2013 March | 28 | 22 | 50 |
| 2013 February | 27 | 17 | 44 |
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