Original Article
Adverse Reactions During Biological Therapy for Psoriasis: Results of a Survey of the Spanish Psoriasis Group
Efectos Adversos Observados Durante la Terapia Biológica en la Psoriasis. Resultados de una Encuesta al Grupo Español de Psoriasis
M. Sánchez-Regañaa,
, E. Dilméa, Ll. Puigb, X. Bordasc, J.M. Carrascosa,d, M. Ferrane, P. Herranzf, M. García-Bustinduyg, J.L. López Estebaranzh, M. Alsinai, M.A. Rodríguezj, M. Riberad, E. Fernández-Lópezk, J.C. Morenol, I. Belinchón Romerom, D. Vidaln
Corresponding author
a Hospital Universitari Sagrat Cor, Barcelona, Spain
b Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
c Hospital Universitari de Bellvitge, Barcelona, Spain
d Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
e Hospital del Mar, Barcelona, Spain
f Hospital Universitario la Paz, Madrid, Spain
g Hospital Universitario de Canarias, La Laguna, Tenerife, Spain
h Fundación Hospital Alcorcón, Madrid, Spain
i Hospital Clínic, Barcelona, Spain
j Hospital de León, León, Spain
k Hospital Universitario de Salamanca, Salamanca, Spain
l Hospital Universitario Reina Sofía, Córdoba, Spain
m Hospital General Universitario de Alicante, Alicante, Spain
n Hospital Dos de Maig, Barcelona, Spain
Ver másRead
5912
Timeswas read the article
2521
Total PDF
3391
Total HTML
Share statistics
array:23 [ "pii" => "S1578219010706028" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70602-8" "estado" => "S300" "fechaPublicacion" => "2010-03-01" "aid" => "70602" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2010;101:156-63" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2306 "formatos" => array:3 [ "EPUB" => 47 "HTML" => 1401 "PDF" => 858 ] ] "itemSiguiente" => array:18 [ "pii" => "S157821901070603X" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70603-X" "estado" => "S300" "fechaPublicacion" => "2010-03-01" "aid" => "70603" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2010;101:164-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2047 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 1314 "PDF" => 689 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Leishmaniasis and Rheumatoid Nodulosis in a Patient With HIV Infection" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "164" "paginaFinal" => "167" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Leishmaniasis y Nodulosis Reumatoide en Paciente con Infección por el Virus de la Inmunodeficiencia Humana" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. García-Río, E. Daudén, M. Ballestero-Díez, J. Fraga, A. García-Díez" "autores" => array:5 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "García-Río" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Daudén" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Ballestero-Díez" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Fraga" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "García-Díez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901070603X?idApp=UINPBA000044" "url" => "/15782190/0000010100000002/v1_201304241515/S157821901070603X/v1_201304241515/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219010706016" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70601-6" "estado" => "S300" "fechaPublicacion" => "2010-03-01" "aid" => "70601" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2010;101:151-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2032 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 1307 "PDF" => 681 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Production of Interleukin 8 by Circulating CLA<span class="elsevierStyleSup">+</span> T Cells With Skin Tropism in Patients With Psoriasis and in Healthy Controls" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "151" "paginaFinal" => "155" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Producción preferente de IL-8 por linfocitos T CLA<span class="elsevierStyleSup">+</span> circulantes con tropismo cutáneo en pacientes con psoriasis y en sujetos sanos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Ferran, A.B. Galván, A. Giménez-Arnau, R.M. Pujol, L.F. Santamaría-Babia" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Ferran" ] 1 => array:2 [ "nombre" => "A.B." "apellidos" => "Galván" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Giménez-Arnau" ] 3 => array:2 [ "nombre" => "R.M." "apellidos" => "Pujol" ] 4 => array:2 [ "nombre" => "L.F." "apellidos" => "Santamaría-Babia" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706016?idApp=UINPBA000044" "url" => "/15782190/0000010100000002/v1_201304241515/S1578219010706016/v1_201304241515/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Adverse Reactions During Biological Therapy for Psoriasis: Results of a Survey of the Spanish Psoriasis Group" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "156" "paginaFinal" => "163" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Sánchez-Regaña, E. Dilmé, Ll. Puig, X. Bordas, J.M. Carrascos, M. Ferran, P. Herranz, M. García-Bustinduy, J.L. López Estebaranz, M. Alsina, M.A. Rodríguez, M. Ribera, E. Fernández-López, J.C. Moreno, I. Belinchón Romero, D. Vidal" "autores" => array:16 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Sánchez-Regaña" "email" => array:1 [ 0 => "ez.reg@terra.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Dilmé" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Ll." "apellidos" => "Puig" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "X." "apellidos" => "Bordas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "J.M." "apellidos" => "Carrascos" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] 5 => array:3 [ "nombre" => "M." "apellidos" => "Ferran" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] ] ] 6 => array:3 [ "nombre" => "P." "apellidos" => "Herranz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff6" ] ] ] 7 => array:3 [ "nombre" => "M." "apellidos" => "García-Bustinduy" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff7" ] ] ] 8 => array:3 [ "nombre" => "J.L." "apellidos" => "López Estebaranz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff8" ] ] ] 9 => array:3 [ "nombre" => "M." "apellidos" => "Alsina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">i</span>" "identificador" => "aff9" ] ] ] 10 => array:3 [ "nombre" => "M.A." "apellidos" => "Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">j</span>" "identificador" => "aff10" ] ] ] 11 => array:3 [ "nombre" => "M." "apellidos" => "Ribera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] 12 => array:3 [ "nombre" => "E." "apellidos" => "Fernández-López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">k</span>" "identificador" => "aff11" ] ] ] 13 => array:3 [ "nombre" => "J.C." "apellidos" => "Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">l</span>" "identificador" => "aff12" ] ] ] 14 => array:3 [ "nombre" => "I." "apellidos" => "Belinchón Romero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">m</span>" "identificador" => "aff13" ] ] ] 15 => array:3 [ "nombre" => "D." "apellidos" => "Vidal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">n</span>" "identificador" => "aff14" ] ] ] ] "afiliaciones" => array:14 [ 0 => array:3 [ "entidad" => "Hospital Universitari Sagrat Cor, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Hospital Universitari de Bellvitge, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] 4 => array:3 [ "entidad" => "Hospital del Mar, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] 5 => array:3 [ "entidad" => "Hospital Universitario la Paz, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff6" ] 6 => array:3 [ "entidad" => "Hospital Universitario de Canarias, La Laguna, Tenerife, Spain" "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff7" ] 7 => array:3 [ "entidad" => "Fundación Hospital Alcorcón, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff8" ] 8 => array:3 [ "entidad" => "Hospital Clínic, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">i</span>" "identificador" => "aff9" ] 9 => array:3 [ "entidad" => "Hospital de León, León, Spain" "etiqueta" => "<span class="elsevierStyleSup">j</span>" "identificador" => "aff10" ] 10 => array:3 [ "entidad" => "Hospital Universitario de Salamanca, Salamanca, Spain" "etiqueta" => "<span class="elsevierStyleSup">k</span>" "identificador" => "aff11" ] 11 => array:3 [ "entidad" => "Hospital Universitario Reina Sofía, Córdoba, Spain" "etiqueta" => "<span class="elsevierStyleSup">l</span>" "identificador" => "aff12" ] 12 => array:3 [ "entidad" => "Hospital General Universitario de Alicante, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">m</span>" "identificador" => "aff13" ] 13 => array:3 [ "entidad" => "Hospital Dos de Maig, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">n</span>" "identificador" => "aff14" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectos Adversos Observados Durante la Terapia Biológica en la Psoriasis. Resultados de una Encuesta al Grupo Español de Psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-04-05" "fechaAceptado" => "2009-08-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84698" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Biologic agents" 2 => "Survey" 3 => "Safety" 4 => "Adverse reactions" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84699" "palabras" => array:5 [ 0 => "Psoriasis" 1 => "Biológicos" 2 => "Encuesta" 3 => "Seguridad" 4 => "Efectos adversos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Biologic therapies have been a major breakthrough in the treatment of psoriasis because they are more selective and have a better short-term and medium-term safety profile. There are reliable data to support both the efficacy and the safety of these drugs. However, it is always useful to report the clinical experience of dermatologists who are experts in the use of biologic agents to treat psoriasis, particularly with regard to their safety.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We present the results of a survey administered to the members of Spanish Psoriasis Group and based on a series of questions referring to the clinical safety of these agents. A total of 988 patients treated with efalizumab, infliximab, etanercept, and adalimumab were reported by 15 members of the group.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">There was a particularly high proportion of reactions (34%) to infliximab infusions. Blood test abnormalities were detected in 13.25% of patients and infections in 12.24%, with one case of pulmonary tuberculosis. Attention is drawn to the adverse effects profile of efalizumab: de novo arthritis in 5.8% and rebound in 20.9% of patients.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">The safety data provided by our study should be taken into account in view of the large number of patients recruited by dermatologists experienced in the use of this type of therapy.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La terapia biológica ha representado un avance muy importante en el tratamiento de la psoriasis, al tratarse de una generación de fármacos más selectivos y con mejor perfil de seguridad a corto y medio plazo. Existen datos sólidos a favor de la eficacia de cada uno de estos fármacos, así como de su seguridad. A pesar de ello, siempre es útil aportar la experiencia clínica de dermatólogos expertos en el tratamiento de la psoriasis con biológicos, en especial en lo referente a su seguridad.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se realizó una encuesta a los miembros del Grupo Español de Psoriasis (GEP) basada en una serie de ítems relativos a aspectos referentes a la seguridad clínica de estos fármacos, cuyos resultados se presentan en este artículo. Un total de 988 pacientes tratados con efalizumab, etanercept, infliximab y adalimumab fueron recogidos por parte de 15 miembros del GEP.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Entre los resultados obtenidos destaca la elevada proporción de reacciones a infliximab (34%). Se observaron alteraciones analíticas en el 13,25% de los pacientes e infecciones en el 12,24%, con un único caso de tuberculosis pulmonar. Es de destacar el perfil de efectos secundarios de efalizumab: artritis <span class="elsevierStyleItalic">de novo</span> en el 5,8% y rebote en el 20,9%.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p class="elsevierStyleSimplePara elsevierViewall">Los datos de seguridad aportados por nuestro trabajo deben tenerse en consideración, habida cuenta del importante número de pacientes reclutados por un grupo de dermatólogos expertos en el manejo de este tipo de fármacos.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nuevos tratamientos en la psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Ferrándiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2007" "volumen" => "129" "paginaInicial" => "377" "paginaFinal" => "378" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis causes as much disability as other major medical diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.R. Rapp" 1 => "S.R. Feldman" 2 => "M.L. Exum" 3 => "A.B. Fleisxe" 4 => "D.M. Reboussin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "41" "numero" => "3 Pt 1" "paginaInicial" => "401" "paginaFinal" => "407" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10459113" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biological therapies in the systemic management of psoriasis; International Consensus Conference" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W. Sterry" 1 => "J. Baker" 2 => "W.H. Boehncke" 3 => "J.D. Bos" 4 => "S. Chimenti" 5 => "E. Christophers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2004.06269.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2004" "volumen" => "151" "paginaInicial" => "3" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15548171" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673605673941" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term data in the treatment of psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Thaci" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08781.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "159" "numero" => "Suppl 2" "paginaInicial" => "18" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18700911" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia biológica y psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Gamo" 1 => "J.L. López -Estebaranz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2006" "volumen" => "97" "paginaInicial" => "1" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16540046" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Directrices españolas basadas en la evidencia para el tratamiento de la psoriasis moderada a grave con agentes biológicos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Puig" 1 => "J.M. Carrascosa" 2 => "E. Daudén" 3 => "J.L. Sánchez-Carazo" 4 => "C. Ferrándiz" 5 => "M. Sánchez-Regaña" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2009" "volumen" => "100" "paginaInicial" => "386" "paginaFinal" => "413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19558918" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efalizumab: results of a 3-year continuous dosing study for the long-term control of psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Leonardi" 1 => "A. Menter" 2 => "T. Hamilton" 3 => "I. Caro" 4 => "B. Xing" 5 => "A.B. Gottlieb" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08548.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "158" "paginaInicial" => "1107" "paginaFinal" => "1116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18373710" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term treatment of plaque psoriasis with efalizumab: an Italian experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Costanzo" 1 => "K. Peris" 2 => "M. Talamonti" 3 => "A. Di Cesare" 4 => "M. Concetta Fargnoli" 5 => "E. Botti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07765.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "numero" => "Suppl 2" "paginaInicial" => "17" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17371319" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Greek experience with efalizumab in psoriasis from a University Dermatologic Hospital" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Antoniou" 1 => "I. Stefanaki" 2 => "A. Stratigos" 3 => "G. Avgerinou" 4 => "P. Stavropoulos" 5 => "I. Potouridou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07764.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "numero" => "Suppl 2" "paginaInicial" => "12" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17371318" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efalizumab in routine use: a clinical experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Selenko-Gebauer" 1 => "F. Karlhoer" 2 => "G. Stingl" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07861.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "numero" => "Suppl 2" "paginaInicial" => "1" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17488399" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efalizumab in the treatment of chronic plaque psoriasis: experiences from the largest psoriasis treatment centre in Denmark" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Kragballe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.07763.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "numero" => "Suppl 2" "paginaInicial" => "7" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17371317" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etanercept monotherapy in patients with psoriasis: A summary of safety, based on an integrated multistudy database" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.B. Gottlieb" 1 => "C.L. Leonardi" 2 => "B.S. Goffe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2005.10.053" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2006" "volumen" => "54" "paginaInicial" => "S92" "paginaFinal" => "S100" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16488335" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term safety and efficacy of 50 mg of etanercept twice weekly in patients with psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Tyring" 1 => "K.B. Gorgon" 2 => "Y. Poulin" 3 => "R.G. Langley" 4 => "A.B. Gottlieb" 5 => "M. Dunn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.143.6.719" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2007" "volumen" => "143" "paginaInicial" => "719" "paginaFinal" => "726" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17576937" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparación de la eficacia y seguridad del tratamiento continuo e intermitente con etanercept en pacientes con psoriasis moderada a grave durante 54 semanas: estudio CRYSTEL" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.P. Ortonne" 1 => "C. Griffiths" 2 => "E. Daudén" 3 => "R. Strohal" 4 => "D. Robertson" 5 => "R. Pedersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Expert Rev Dermatol" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "657" "paginaFinal" => "666" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Ko" 1 => "A.B. Gottlieb" 2 => "J.F. Kerbleski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dermatol Treat" "fecha" => "2009" "volumen" => "20" "paginaInicial" => "100" "paginaFinal" => "108" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations for the long-term treatment of psoriasis with infliximab: a dermatology expert group consensus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Reich" 1 => "C. Griffiths" 2 => "J. Barber" 3 => "S. Chimenti" 4 => "E. Daudén" 5 => "A. Giannetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000149970" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2008" "volumen" => "217" "paginaInicial" => "268" "paginaFinal" => "275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18685261" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reacciones a la infusión de infliximab en pacientes dermatológicos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Puig" 1 => "E. Sáez" 2 => "M.J. Lozano" 3 => "X. Bordas" 4 => "J.M. Carrascosa" 5 => "F. Gallardo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2009" "volumen" => "100" "paginaInicial" => "103" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19445874" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biologic therapies for psoriasis: practical experience in a UK tertiary referral centre" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.B. Warren" 1 => "B.C. Brown" 2 => "D. Lavery" 3 => "D.M. Ashcroft" 4 => "C.E.M. Griffiths" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08865.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "160" "paginaInicial" => "162" "paginaFinal" => "169" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18808412" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety results from the comparative study of adalimumab (HUMIRA) versus methotrexate versus placebo in psoriasis patients (CHAMPION)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.H. Saurat" 1 => "G. Stingl" 2 => "L. Dubertret" 3 => "K. Papp" 4 => "R.G. Langley" 5 => "J.P. Ortonne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2007.08315.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "158" "paginaInicial" => "558" "paginaFinal" => "566" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18047523" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical response to adalimumab treatment in patients with moderate to severe psoriasis: double-blind, randomized controlled trial and open-label extension study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.B. Gordon" 1 => "R.G. Langley" 2 => "C. Leonardi" 3 => "D. Toth" 4 => "M.A. Menter" 5 => "S. Kang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2006.05.027" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2006" "volumen" => "55" "paginaInicial" => "598" "paginaFinal" => "606" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17010738" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000002/v1_201304241515/S1578219010706028/v1_201304241515/en/main.assets" "Apartado" => array:4 [ "identificador" => "6252" "tipo" => "SECCION" "fr" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "fr" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000002/v1_201304241515/S1578219010706028/v1_201304241515/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010706028?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 7 | 13 |
| 2024 October | 109 | 43 | 152 |
| 2024 September | 86 | 17 | 103 |
| 2024 August | 97 | 49 | 146 |
| 2024 July | 69 | 30 | 99 |
| 2024 June | 57 | 23 | 80 |
| 2024 May | 52 | 22 | 74 |
| 2024 April | 51 | 24 | 75 |
| 2024 March | 45 | 39 | 84 |
| 2024 February | 49 | 43 | 92 |
| 2024 January | 37 | 39 | 76 |
| 2023 December | 50 | 29 | 79 |
| 2023 November | 50 | 25 | 75 |
| 2023 October | 43 | 25 | 68 |
| 2023 September | 34 | 21 | 55 |
| 2023 August | 27 | 18 | 45 |
| 2023 July | 36 | 41 | 77 |
| 2023 June | 38 | 19 | 57 |
| 2023 May | 30 | 20 | 50 |
| 2023 April | 21 | 20 | 41 |
| 2023 March | 25 | 26 | 51 |
| 2023 February | 25 | 19 | 44 |
| 2023 January | 32 | 18 | 50 |
| 2022 December | 28 | 40 | 68 |
| 2022 November | 19 | 32 | 51 |
| 2022 October | 18 | 20 | 38 |
| 2022 September | 20 | 36 | 56 |
| 2022 August | 25 | 27 | 52 |
| 2022 July | 11 | 35 | 46 |
| 2022 June | 15 | 28 | 43 |
| 2022 May | 28 | 32 | 60 |
| 2022 April | 27 | 46 | 73 |
| 2022 March | 34 | 56 | 90 |
| 2022 February | 17 | 29 | 46 |
| 2022 January | 25 | 41 | 66 |
| 2021 December | 20 | 33 | 53 |
| 2021 November | 27 | 48 | 75 |
| 2021 October | 18 | 51 | 69 |
| 2021 September | 24 | 50 | 74 |
| 2021 August | 28 | 32 | 60 |
| 2021 July | 29 | 34 | 63 |
| 2021 June | 28 | 40 | 68 |
| 2021 May | 36 | 28 | 64 |
| 2021 April | 42 | 59 | 101 |
| 2021 March | 58 | 31 | 89 |
| 2021 February | 48 | 21 | 69 |
| 2021 January | 44 | 18 | 62 |
| 2020 December | 19 | 16 | 35 |
| 2020 November | 27 | 19 | 46 |
| 2020 October | 26 | 20 | 46 |
| 2020 September | 15 | 10 | 25 |
| 2020 August | 35 | 20 | 55 |
| 2020 July | 23 | 11 | 34 |
| 2020 June | 20 | 22 | 42 |
| 2020 May | 29 | 17 | 46 |
| 2020 April | 30 | 20 | 50 |
| 2020 March | 28 | 24 | 52 |
| 2020 February | 0 | 3 | 3 |
| 2020 January | 0 | 6 | 6 |
| 2019 December | 0 | 11 | 11 |
| 2019 November | 0 | 4 | 4 |
| 2019 October | 0 | 3 | 3 |
| 2019 September | 0 | 5 | 5 |
| 2019 August | 0 | 5 | 5 |
| 2019 July | 0 | 11 | 11 |
| 2019 June | 0 | 13 | 13 |
| 2019 May | 0 | 42 | 42 |
| 2019 April | 0 | 12 | 12 |
| 2019 March | 0 | 9 | 9 |
| 2019 February | 0 | 5 | 5 |
| 2019 January | 1 | 1 | 2 |
| 2018 December | 0 | 3 | 3 |
| 2018 November | 0 | 8 | 8 |
| 2018 September | 1 | 0 | 1 |
| 2018 May | 0 | 1 | 1 |
| 2018 April | 0 | 6 | 6 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 8 | 3 | 11 |
| 2018 January | 20 | 6 | 26 |
| 2017 December | 13 | 5 | 18 |
| 2017 November | 21 | 3 | 24 |
| 2017 October | 26 | 14 | 40 |
| 2017 September | 15 | 11 | 26 |
| 2017 August | 29 | 5 | 34 |
| 2017 July | 26 | 4 | 30 |
| 2017 June | 22 | 12 | 34 |
| 2017 May | 19 | 13 | 32 |
| 2017 April | 14 | 6 | 20 |
| 2017 March | 18 | 17 | 35 |
| 2017 February | 32 | 11 | 43 |
| 2017 January | 17 | 11 | 28 |
| 2016 December | 45 | 6 | 51 |
| 2016 November | 24 | 7 | 31 |
| 2016 October | 29 | 14 | 43 |
| 2016 September | 33 | 12 | 45 |
| 2016 August | 24 | 7 | 31 |
| 2016 July | 19 | 8 | 27 |
| 2016 June | 20 | 5 | 25 |
| 2016 May | 7 | 4 | 11 |
| 2016 April | 4 | 7 | 11 |
| 2016 March | 5 | 9 | 14 |
| 2016 February | 9 | 9 | 18 |
| 2016 January | 6 | 1 | 7 |
| 2015 December | 10 | 0 | 10 |
| 2015 November | 9 | 1 | 10 |
| 2015 October | 10 | 4 | 14 |
| 2015 September | 8 | 3 | 11 |
| 2015 August | 13 | 2 | 15 |
| 2015 July | 26 | 6 | 32 |
| 2015 June | 23 | 3 | 26 |
| 2015 May | 52 | 15 | 67 |
| 2015 April | 23 | 8 | 31 |
| 2015 March | 23 | 12 | 35 |
| 2015 February | 19 | 6 | 25 |
| 2015 January | 13 | 9 | 22 |
| 2014 December | 19 | 22 | 41 |
| 2014 November | 14 | 17 | 31 |
| 2014 October | 36 | 16 | 52 |
| 2014 September | 26 | 11 | 37 |
| 2014 August | 19 | 14 | 33 |
| 2014 July | 30 | 19 | 49 |
| 2014 June | 50 | 17 | 67 |
| 2014 May | 42 | 16 | 58 |
| 2014 April | 38 | 6 | 44 |
| 2014 March | 46 | 20 | 66 |
| 2014 February | 36 | 10 | 46 |
| 2014 January | 42 | 15 | 57 |
| 2013 December | 36 | 9 | 45 |
| 2013 November | 33 | 24 | 57 |
| 2013 October | 20 | 17 | 37 |
| 2013 September | 27 | 20 | 47 |
| 2013 August | 22 | 23 | 45 |
| 2013 July | 32 | 24 | 56 |
| 2013 June | 28 | 30 | 58 |
| 2013 May | 15 | 22 | 37 |
| 2013 April | 13 | 27 | 40 |
| 2013 March | 24 | 36 | 60 |
| 2013 February | 17 | 15 | 32 |
Show all
