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Quinacrine in the Treatment of Cutaneous Lupus Erythematosus: Practical Aspects and a Case Series
Aspectos Prácticos de la Quinacrina Como Tratamiento del Lupus Eritematoso Cutáneo: Serie de Casos
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Zaragoza, A. Pérez, J.L. Sánchez, V. Oliver, L. Martínez, V. Alegre" "autores" => array:6 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Zaragoza" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Pérez" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "Sánchez" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Oliver" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Martínez" ] 5 => array:2 [ "nombre" => "V." "apellidos" => "Alegre" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010705795?idApp=UINPBA000044" "url" => "/15782190/0000010100000001/v1_201304241512/S1578219010705795/v1_201304241512/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Quinacrine in the Treatment of Cutaneous Lupus Erythematosus: Practical Aspects and a Case Series" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "54" "paginaFinal" => "58" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "B. González-Sixto, I. García-Doval, R. Oliveira, C. Posada, M.A. García-Cruz, M. Cruces" "autores" => array:6 [ 0 => array:4 [ "nombre" => "B." "apellidos" => "González-Sixto" "email" => array:1 [ 0 => "bgonsix@aedv.esn" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "García-Doval" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "R." "apellidos" => "Oliveira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Posada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "M.A." "apellidos" => "García-Cruz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "M." "apellidos" => "Cruces" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Enfermedades Autoinmunes, Servicio de Dermatología, Complejo Hospitalario de Pontevedra, Pontevedra, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Farmacia, Complejo Hospitalario de Pontevedra, Pontevedra, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aspectos Prácticos de la Quinacrina Como Tratamiento del Lupus Eritematoso Cutáneo: Serie de Casos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-12-17" "fechaAceptado" => "2009-07-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84666" "palabras" => array:4 [ 0 => "Cutaneous lupus erythematosus" 1 => "Antimalarials" 2 => "Quinacrine" 3 => "Adverse effect" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84667" "palabras" => array:4 [ 0 => "Lupus eritematoso cutáneo" 1 => "Antimaláricos" 2 => "Quinacrina" 3 => "Efecto secundario" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Hydroxychloroquine and chloroquine are antimalarials used as first-line treatment of cutaneous lupus. Quinacrine is not often employed by Spanish physicians due to a lack of information about its use and the fact that it is not marketed in Spain. It is effective in monotherapy or in combination therapy with other antimalarials. One of the advantages of quinacrine over chloroquine and hydroxychloroquine is that it does not appear to cause retinal toxicity.</p><p class="elsevierStyleSimplePara elsevierViewall">Quinacrine is used as second-line therapy in patients with pre-existing eye problems that contraindicate treatment with chloroquine or hydroxychloroquine (after evaluation of which drug has the better risk-benefit relationship), and in combination therapy with other antimalarials in patients with resistance or only a partial response to chloroquine or hydroxychloroquine.</p><p class="elsevierStyleSimplePara elsevierViewall">We report 8 cases of patients with cutaneous lupus who received treatment with quinacrine in monotherapy or in combination with other antimalarials. Lesions resolved in 5 patients and improved in 3. Therapy had to be withdrawn in 1 patient due to an exacerbation of his psoriasis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Los antimaláricos de primera elección en el tratamiento del lupus cutáneo son la hidroxicloroquina (hydroxychloroquine) y la cloroquina (chloroquine). La quinacrina (Qn) se emplea poco, fundamentalmente por la ausencia de información sobre su utilización y por no estar comercializada en España. Es eficaz en combinación con otros antimaláricos y en monoterapia. La quinacrine parece carecer de toxicidad retiniana y ésta es una de sus ventajas sobre la chloroquine y la hydroxychloroquine.</p><p class="elsevierStyleSimplePara elsevierViewall">Se utiliza cuando existen alteraciones oculares previas al tratamiento que contraindican el uso de otros antimaláricos (al valorar la opción con mejor relación riesgo-beneficio), y en tratamiento combinado con otros antimaláricos en pacientes resistentes o parcialmente respondedores a chloroquine o hydroxychloroquine.</p><p class="elsevierStyleSimplePara elsevierViewall">Presentamos una serie de 8 casos de pacientes con lupus cutáneo que han recibido tratamiento con quinacrine en monoterapia o combinada con otros antimaláricos, se obtuvo resolución de las lesiones en 5 pacientes y mejoría de éstas en 3 pacientes. En uno de los pacientes fue necesario suspender el tratamiento por la aparición de un brote de psoriasis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of lupus erythematosus with mepacrine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Page" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1951" "volumen" => "2" "paginaInicial" => "755" "paginaFinal" => "758" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2571008" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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| 2021 March | 53 | 34 | 87 |
| 2021 February | 78 | 32 | 110 |
| 2021 January | 40 | 16 | 56 |
| 2020 December | 31 | 10 | 41 |
| 2020 November | 32 | 20 | 52 |
| 2020 October | 44 | 20 | 64 |
| 2020 September | 27 | 19 | 46 |
| 2020 August | 17 | 27 | 44 |
| 2020 July | 29 | 12 | 41 |
| 2020 June | 25 | 24 | 49 |
| 2020 May | 42 | 25 | 67 |
| 2020 April | 26 | 17 | 43 |
| 2020 March | 13 | 18 | 31 |
| 2020 February | 4 | 15 | 19 |
| 2020 January | 0 | 4 | 4 |
| 2019 December | 0 | 9 | 9 |
| 2019 November | 0 | 5 | 5 |
| 2019 October | 0 | 4 | 4 |
| 2019 September | 0 | 2 | 2 |
| 2019 August | 0 | 1 | 1 |
| 2019 July | 0 | 6 | 6 |
| 2019 June | 0 | 11 | 11 |
| 2019 May | 1 | 51 | 52 |
| 2019 March | 0 | 3 | 3 |
| 2019 February | 0 | 2 | 2 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 13 | 6 | 19 |
| 2018 January | 20 | 4 | 24 |
| 2017 December | 20 | 8 | 28 |
| 2017 November | 18 | 5 | 23 |
| 2017 October | 14 | 4 | 18 |
| 2017 September | 38 | 6 | 44 |
| 2017 August | 52 | 9 | 61 |
| 2017 July | 30 | 4 | 34 |
| 2017 June | 26 | 14 | 40 |
| 2017 May | 13 | 9 | 22 |
| 2017 April | 16 | 8 | 24 |
| 2017 March | 16 | 12 | 28 |
| 2017 February | 13 | 8 | 21 |
| 2017 January | 14 | 6 | 20 |
| 2016 December | 23 | 15 | 38 |
| 2016 November | 26 | 8 | 34 |
| 2016 October | 27 | 12 | 39 |
| 2016 September | 29 | 14 | 43 |
| 2016 August | 35 | 10 | 45 |
| 2016 July | 38 | 9 | 47 |
| 2016 June | 6 | 12 | 18 |
| 2016 May | 9 | 10 | 19 |
| 2016 April | 4 | 0 | 4 |
| 2016 March | 2 | 1 | 3 |
| 2016 February | 9 | 3 | 12 |
| 2016 January | 12 | 2 | 14 |
| 2015 December | 10 | 0 | 10 |
| 2015 November | 12 | 2 | 14 |
| 2015 October | 8 | 11 | 19 |
| 2015 September | 2 | 3 | 5 |
| 2015 August | 9 | 4 | 13 |
| 2015 July | 29 | 26 | 55 |
| 2015 June | 37 | 11 | 48 |
| 2015 May | 71 | 25 | 96 |
| 2015 April | 42 | 29 | 71 |
| 2015 March | 31 | 32 | 63 |
| 2015 February | 41 | 18 | 59 |
| 2015 January | 35 | 16 | 51 |
| 2014 December | 27 | 13 | 40 |
| 2014 November | 27 | 18 | 45 |
| 2014 October | 33 | 19 | 52 |
| 2014 September | 28 | 19 | 47 |
| 2014 August | 28 | 24 | 52 |
| 2014 July | 39 | 22 | 61 |
| 2014 June | 26 | 11 | 37 |
| 2014 May | 41 | 15 | 56 |
| 2014 April | 31 | 12 | 43 |
| 2014 March | 47 | 22 | 69 |
| 2014 February | 28 | 14 | 42 |
| 2014 January | 33 | 23 | 56 |
| 2013 December | 31 | 15 | 46 |
| 2013 November | 26 | 25 | 51 |
| 2013 October | 23 | 29 | 52 |
| 2013 September | 31 | 22 | 53 |
| 2013 August | 19 | 28 | 47 |
| 2013 July | 39 | 31 | 70 |
| 2013 June | 23 | 36 | 59 |
| 2013 May | 18 | 31 | 49 |
| 2013 April | 25 | 32 | 57 |
| 2013 March | 26 | 34 | 60 |
| 2013 February | 11 | 13 | 24 |
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