Review article
Congenital Epidermolysis Bullosa: A Review
Epidermólisis Ampollosa Congénita : Revisión del Tema
C. Siañez-González, R. Pezoa-Jares, J.C. Salas-Alanis
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salas999@hotmail.com
doctor@juliosalas.com
Correspondence: Otomí #206, Colonia Azteca. Cd. Guadalupe. Nuevo León, 67150 Mexico.
doctor@juliosalas.com
Correspondence: Otomí #206, Colonia Azteca. Cd. Guadalupe. Nuevo León, 67150 Mexico.
Escuela de Medicina del Instituto Tecnológico y de Estudios Superiores de Monterrey, Nuevo León, Mexico
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"apellidos" => "Salas-Alanis" "email" => array:2 [ 0 => "salas999@hotmail.com" 1 => "doctor@juliosalas.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Escuela de Medicina del Instituto Tecnológico y de Estudios Superiores de Monterrey, Nuevo León, Mexico" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Otomí #206, Colonia Azteca. Cd. Guadalupe. Nuevo León, 67150 Mexico." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Epidermólisis Ampollosa Congénita : Revisión del Tema" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-04-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84626" "palabras" => array:3 [ 0 => "epidermolysis bullosa" 1 => "molecular biology" 2 => "treatment" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84625" "palabras" => array:3 [ 0 => "epidermólisis ampollosa" 1 => "biología molecular" 2 => "tratamiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Epidermolysis bullosa is a group of hereditary diseases affecting 1 in 17 000 live births worldwide. It consists of blistering of the skin and mucous membranes in response to minimal trauma. The disorder seriously affects the patient's quality of life. Diagnosis is based on immunofluorescence mapping and electron microscopy. Treatment is symptomatic, although new cellular and molecular therapies are currently under investigation. This review covers aspects of the molecular biology, clinical presentation, diagnosis, and treatment of epidermolysis bullosa relevant to improving the care for affected patients.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La epidermólisis ampollosa (EA) engloba un grupo de enfermedades hereditarias que afectan a uno de cada 17.000 nacidos vivos en el mundo. Consiste en la formación de ampollas ante el menor traumatismo que afectan a la piel y a las mucosas. Esta enfermedad empeora seriamente la calidad de vida. El diagnóstico se realiza principalmente por mapeo por inmunofluorescencia y microscopía electrónica. El tratamiento es sintomático, aunque se están investigando nuevas terapias celulares y moleculares. Esta revisión presentará información relevante sobre la biología molecular, la sintomatología clínica, el diagnóstico y el tratamiento de la EA, con la clara intención de proporcionar un mejor cuidado a los pacientes que padecen esta enfermedad.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:66 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermolysis bullosa in Mexico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Uitto" 1 => "L. 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| 2024 October | 89 | 113 | 202 |
| 2024 September | 98 | 73 | 171 |
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| 2024 April | 74 | 115 | 189 |
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| 2023 December | 60 | 93 | 153 |
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| 2023 October | 88 | 145 | 233 |
| 2023 September | 49 | 136 | 185 |
| 2023 August | 36 | 164 | 200 |
| 2023 July | 49 | 255 | 304 |
| 2023 June | 56 | 193 | 249 |
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| 2021 December | 53 | 183 | 236 |
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| 2021 October | 74 | 137 | 211 |
| 2021 September | 49 | 105 | 154 |
| 2021 August | 44 | 96 | 140 |
| 2021 July | 45 | 99 | 144 |
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| 2021 May | 38 | 85 | 123 |
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| 2021 February | 64 | 76 | 140 |
| 2021 January | 56 | 42 | 98 |
| 2020 December | 48 | 61 | 109 |
| 2020 November | 59 | 49 | 108 |
| 2020 October | 72 | 31 | 103 |
| 2020 September | 53 | 31 | 84 |
| 2020 August | 41 | 34 | 75 |
| 2020 July | 38 | 25 | 63 |
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| 2020 January | 0 | 22 | 22 |
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| 2019 October | 0 | 6 | 6 |
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| 2019 August | 0 | 11 | 11 |
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| 2019 April | 0 | 50 | 50 |
| 2019 March | 0 | 17 | 17 |
| 2019 February | 0 | 15 | 15 |
| 2019 January | 0 | 1 | 1 |
| 2018 December | 0 | 5 | 5 |
| 2018 September | 0 | 27 | 27 |
| 2018 August | 0 | 43 | 43 |
| 2018 July | 0 | 26 | 26 |
| 2018 June | 0 | 14 | 14 |
| 2018 May | 0 | 41 | 41 |
| 2018 April | 0 | 45 | 45 |
| 2018 March | 2 | 62 | 64 |
| 2018 February | 28 | 59 | 87 |
| 2018 January | 31 | 64 | 95 |
| 2017 December | 20 | 46 | 66 |
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| 2016 July | 31 | 38 | 69 |
| 2016 June | 12 | 27 | 39 |
| 2016 May | 6 | 30 | 36 |
| 2016 April | 4 | 31 | 35 |
| 2016 March | 5 | 33 | 38 |
| 2016 February | 10 | 1 | 11 |
| 2016 January | 7 | 29 | 36 |
| 2015 December | 5 | 28 | 33 |
| 2015 November | 11 | 46 | 57 |
| 2015 October | 3 | 38 | 41 |
| 2015 September | 7 | 22 | 29 |
| 2015 August | 18 | 18 | 36 |
| 2015 July | 41 | 26 | 67 |
| 2015 June | 24 | 26 | 50 |
| 2015 May | 70 | 52 | 122 |
| 2015 April | 26 | 49 | 75 |
| 2015 March | 29 | 43 | 72 |
| 2015 February | 28 | 40 | 68 |
| 2015 January | 30 | 42 | 72 |
| 2014 December | 40 | 29 | 69 |
| 2014 November | 23 | 46 | 69 |
| 2014 October | 30 | 54 | 84 |
| 2014 September | 29 | 23 | 52 |
| 2014 August | 39 | 27 | 66 |
| 2014 July | 36 | 18 | 54 |
| 2014 June | 42 | 13 | 55 |
| 2014 May | 42 | 20 | 62 |
| 2014 April | 38 | 15 | 53 |
| 2014 March | 54 | 49 | 103 |
| 2014 February | 37 | 44 | 81 |
| 2014 January | 42 | 50 | 92 |
| 2013 December | 34 | 33 | 67 |
| 2013 November | 26 | 50 | 76 |
| 2013 October | 28 | 62 | 90 |
| 2013 September | 25 | 77 | 102 |
| 2013 August | 33 | 142 | 175 |
| 2013 July | 53 | 65 | 118 |
| 2013 June | 29 | 69 | 98 |
| 2013 May | 25 | 99 | 124 |
| 2013 April | 33 | 68 | 101 |
| 2013 March | 31 | 53 | 84 |
| 2013 February | 18 | 20 | 38 |
| 2013 January | 2 | 4 | 6 |
Show all
