Correspondence: Felipe Mardones Valdivieso, Departamento de Dermatología, Hospital Clínico, Universidad de Chile, Santos Dumont, 999, Santiago, Chile.
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"apellidos" => "Mardones" "email" => array:1 [ 0 => "fmardonesv@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "V." "apellidos" => "Zemelman" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "I." "apellidos" => "Sazunic" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Morales" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "K." 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"apellidos" => "Vargas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología, Hospital Clínico, Universidad de Chile, Santiago, Chile" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Instituto de Anatomía Patológica, Hospital Clínico, Universidad de Chile, Santiago, Chile" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Unidad de Análisis Celular Integral, Centro de Equipamiento y Servicio de Apoyo Tecnológico (CESAT), Facultad de Medicina, Universidad de Chile, Santiago, Chile" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Laboratorio Central de Inmunohistoquímica, S.A., Santiago, Chile" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Felipe Mardones Valdivieso, Departamento de Dermatología, Hospital Clínico, Universidad de Chile, Santos Dumont, 999, Santiago, Chile." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Células de Langerhans CD1a+ en la Epidermis Peritumoral del Carcinoma Basocelular" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-02-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84562" "palabras" => array:3 [ 0 => "basal cell carcinoma" 1 => "Langerhans cells" 2 => "density" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84561" "palabras" => array:3 [ 0 => "carcinoma basocelular" 1 => "células de Langerhans" 2 => "densidad" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma (BCC) is a common malignant tumor and its incidence has risen in recent decades. Research has shown the relationship between ultraviolet (UV) radiation, the skin immune system, and BCC. The role of Langerhans cells (LC) in the immune response to tumors has prompted research into LC density and morphology in response to UV radiation and BCC. However, the data are inconsistent due to differences in research methodology.</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To study the density and morphology of LCs in the peritumoral epidermis of BCC using immunohistochemistry and image processing software and compare the results with those from the epidermis overlying the tumor.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Twelve samples from patients with BCC were prepared with a CD1a stain. Areas of epidermis overlying and adjacent to the tumor were defined using light microscopy and the Image J image processing software. The LCs in each area were counted and the cell densities were calculated and compared. Morphological features of LCs were also evaluated in each epidermal area.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The results showed a lower density of LCs in the epidermis overlying the tumor than in the peritumoral epidermis (P<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). There were also differences in the size, shape, and dendritic pattern of the LCs between the epidermal areas.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The lower density and fewer morphological changes of LCs in the epidermis overlying BCC may give rise to alterations in the immune response to BCC. Digital image analysis is a reliable method for the morphometric evaluation of LCs.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">El carcinoma basocelular (CBC) es un tumor maligno frecuente y su incidencia ha aumentado en las últimas décadas. Investigaciones han demostrado la relación entre radiación ultravioleta (RUV), sistema inmune cutáneo y CBC. La función de las células de Langerhans (CL) en la respuesta inmuneantitumoral ha motivado la investigación de su densidad y morfología frente a la RUV y al CBC. Sin embargo, los resultados publicados presentan discordancias debido a diferencias en la metodología científica.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar la densidad y morfología de las CL en la epidermis peritumoral comparada con la epidermis supratumoral mediante inmunohistoquímica y un programa computacional de imágenes digitales.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Doce casos de CBC fueron teñidos con CD1a. Se utilizó microscopia óptica y el programa computacional Image J para calcular las áreas epidérmicas sobre el tumor y adyacente a él. Se contabilizaron el número de CL de cada área y se determinaron y compararon las densidades celulares. Finalmente, se analizó la morfología de las CL en ambas áreas epidérmicas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los resultados mostraron una menor densidad celular en la epidermis supratumoral respecto a la peritumoral (p < 0,05). Las CL entre ambas áreas presentaron diferencias en el tamaño, forma celular y patrón dendrítico.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p class="elsevierStyleSimplePara elsevierViewall">La menor densidad y alteraciones estructurales de las CL supratumorales podrían dar lugar a variaciones de la respuesta inmune en el CBC. El uso de tecnología de análisis de imágenes digitales sería un método fiable en el estudio morfométrico de las CL.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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2023 December | 53 | 22 | 75 |
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2023 October | 42 | 31 | 73 |
2023 September | 75 | 27 | 102 |
2023 August | 23 | 32 | 55 |
2023 July | 26 | 57 | 83 |
2023 June | 44 | 41 | 85 |
2023 May | 38 | 36 | 74 |
2023 April | 25 | 21 | 46 |
2023 March | 21 | 24 | 45 |
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2023 January | 25 | 45 | 70 |
2022 December | 33 | 38 | 71 |
2022 November | 11 | 26 | 37 |
2022 October | 19 | 30 | 49 |
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2022 August | 14 | 37 | 51 |
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2021 July | 25 | 39 | 64 |
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2020 December | 42 | 24 | 66 |
2020 November | 12 | 21 | 33 |
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2020 September | 37 | 10 | 47 |
2020 August | 12 | 14 | 26 |
2020 July | 10 | 6 | 16 |
2020 June | 32 | 19 | 51 |
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2019 December | 0 | 14 | 14 |
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2019 October | 0 | 5 | 5 |
2019 September | 0 | 2 | 2 |
2019 August | 0 | 5 | 5 |
2019 July | 0 | 8 | 8 |
2019 June | 0 | 7 | 7 |
2019 May | 0 | 46 | 46 |
2019 April | 0 | 9 | 9 |
2019 March | 0 | 7 | 7 |
2019 February | 0 | 5 | 5 |
2018 December | 0 | 5 | 5 |
2018 February | 18 | 3 | 21 |
2018 January | 27 | 4 | 31 |
2017 December | 23 | 9 | 32 |
2017 November | 32 | 3 | 35 |
2017 October | 20 | 7 | 27 |
2017 September | 24 | 6 | 30 |
2017 August | 39 | 15 | 54 |
2017 July | 19 | 9 | 28 |
2017 June | 45 | 13 | 58 |
2017 May | 44 | 8 | 52 |
2017 April | 24 | 12 | 36 |
2017 March | 30 | 22 | 52 |
2017 February | 30 | 9 | 39 |
2017 January | 16 | 6 | 22 |
2016 December | 44 | 8 | 52 |
2016 November | 54 | 9 | 63 |
2016 October | 35 | 15 | 50 |
2016 September | 52 | 18 | 70 |
2016 August | 51 | 4 | 55 |
2016 July | 43 | 4 | 47 |
2016 June | 18 | 9 | 27 |
2016 May | 10 | 6 | 16 |
2016 April | 20 | 12 | 32 |
2016 March | 14 | 7 | 21 |
2016 February | 9 | 12 | 21 |
2016 January | 6 | 8 | 14 |
2015 December | 12 | 6 | 18 |
2015 November | 17 | 10 | 27 |
2015 October | 14 | 8 | 22 |
2015 September | 24 | 8 | 32 |
2015 August | 20 | 3 | 23 |
2015 July | 61 | 6 | 67 |
2015 June | 38 | 7 | 45 |
2015 May | 86 | 16 | 102 |
2015 April | 48 | 11 | 59 |
2015 March | 32 | 11 | 43 |
2015 February | 22 | 11 | 33 |
2015 January | 35 | 14 | 49 |
2014 December | 30 | 15 | 45 |
2014 November | 22 | 7 | 29 |
2014 October | 32 | 12 | 44 |
2014 September | 28 | 8 | 36 |
2014 August | 40 | 24 | 64 |
2014 July | 46 | 19 | 65 |
2014 June | 51 | 10 | 61 |
2014 May | 54 | 16 | 70 |
2014 April | 55 | 15 | 70 |
2014 March | 69 | 13 | 82 |
2014 February | 54 | 14 | 68 |
2014 January | 54 | 14 | 68 |
2013 December | 42 | 15 | 57 |
2013 November | 29 | 14 | 43 |
2013 October | 29 | 17 | 46 |
2013 September | 30 | 17 | 47 |
2013 August | 20 | 13 | 33 |
2013 July | 28 | 24 | 52 |
2013 June | 30 | 13 | 43 |
2013 May | 28 | 9 | 37 |
2013 April | 23 | 22 | 45 |
2013 March | 33 | 20 | 53 |
2013 February | 26 | 15 | 41 |
2013 January | 8 | 3 | 11 |