Oral Leukoplakia: Clinical, Histopathologic, and Molecular Features and Therapeutic Approach

array:23 ["pii" => "S1578219009701490" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70149-0" "estado" => "S300" "fechaPublicacion" => "2009-10-01" "aid" => "70149" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:669-84" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 9574 "formatos" => array:3 [ "EPUB" => 34 "HTML" => 2688 "PDF" => 6852 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219009701507" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70150-7" "estado" => "S300" "fechaPublicacion" => "2009-10-01" "aid" => "70150" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:685-92" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2439 "formatos" => array:3 [ "EPUB" => 39 "HTML" => 1383 "PDF" => 1017 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Original articles" "titulo" => "Occupational Dermatoses: Cross-Cultural Adaptation of the Nordic Occupational Skin Questionnaire (NOSQ-2002) From English to Spanish and Catalan" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "685" "paginaFinal" => "692" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatosis Profesionales. Adaptación Transcultural del Cuestionario Nordic Occupational Skin Questionnaire (NOSQ-2002) del Inglés al Castellano y al Catalán" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "N. Sala-Sastre, M. Herdman, L. Navarro, M. de la Prada, R. Pujol, C. Serra, J. Alonso, M.A. Flyvholm, A.M. Giménez-Arnau" "autores" => array:9 [ 0 => array:2 [ "nombre" => "N." "apellidos" => "Sala-Sastre" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Herdman" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Navarro" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "de la Prada" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Pujol" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Serra" ] 6 => array:2 [ "nombre" => "J." "apellidos" => "Alonso" ] 7 => array:2 [ "nombre" => "M.A." "apellidos" => "Flyvholm" ] 8 => array:2 [ "nombre" => "A.M." "apellidos" => "Giménez-Arnau" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701507?idApp=UINPBA000044" "url" => "/15782190/0000010000000008/v1_201304241504/S1578219009701507/v1_201304241504/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009701489" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70148-9" "estado" => "S300" "fechaPublicacion" => "2009-10-01" "aid" => "70148" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:661-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2629 "formatos" => array:3 [ "EPUB" => 34 "HTML" => 1432 "PDF" => 1163 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Controversies in dermatology" "titulo" => "Complications in Dermatologic Surgery" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "661" "paginaFinal" => "668" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Complicaciones en Dermatología Quirúrgica" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Jiménez-Puya, C. Vázquez-Bayo, F. Gómez-García, J.C. Moreno-Giménez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Jiménez-Puya" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Vázquez-Bayo" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Gómez-García" ] 3 => array:2 [ "nombre" => "J.C." "apellidos" => "Moreno-Giménez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701489?idApp=UINPBA000044" "url" => "/15782190/0000010000000008/v1_201304241504/S1578219009701489/v1_201304241504/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Practical dermatology" "titulo" => "Oral Leukoplakia: Clinical, Histopathologic, and Molecular Features and Therapeutic Approach" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "669" "paginaFinal" => "684" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Martorell-Calatayud, R. Botella-Estrada, J.V. Bagán-Sebastián, O. Sanmartín-Jiménez, C. Guillén-Barona" "autores" => array:5 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Martorell-Calatayud" "email" => array:1 [ 0 => "antmarto@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "¿" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Botella-Estrada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "J.V." "apellidos" => "Bagán-Sebastián" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "O." "apellidos" => "Sanmartín-Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Guillén-Barona" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Fundación Instituto Valenciano de Oncología, Valencia, Spain" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Estomatología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain" "etiqueta" => "b" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Antonio Martorell Calatayud, C/ San José de la Montaña, n.° 14, puerta 11,` 46008 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La Leucoplasia Oral: Definición de Parámetros Clínicos, Histopatológicos y Moleculares y Actitud Terapéutica" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84573" "palabras" => array:4 [ 0 => "leukoplakia" 1 => "tobacco" 2 => "therapy" 3 => "risk of transformation" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84574" "palabras" => array:4 [ 0 => "leucoplasia" 1 => "tabaco" 2 => "terapia" 3 => "riesgo de transformación" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Dermatology departments are currently seeing an increase in the number of cases of oral diseases. Of note among the range of lesions covered by this broad area of knowledge is oral leukoplakia—the most common precancerous lesion and the most problematic in terms of both diagnosis and therapeutic management.In addition to defining leukoplakia, this review also establishes a differential diagnosis with the other most important oral diseases and analyzes the different clinical, histologic, and molecular features that can provide an indication of the risk of malignant transformation. Finally, a therapeutic algorithm is presented to help us optimize clinical management of the disease." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Actualmente existe un incremento del número de casos de patología oral en los servicios de Dermatología. Dentro de las diversas lesiones que forman parte de esta amplia área de conocimiento destacamos la leucoplasia oral, por ser la lesión mucosa precancerosa más frecuente y la que mayores problemas origina tanto en su diagnóstico como en su manejo terapéutico. En esta revisión, además de definir la leucoplasia, establecemos un diagnóstico diferencial con el resto de las patologías orales más importantes y analizamos los diversos parámetros clínicos, histológicos y moleculares que definen el riesgo de transformación maligna de esta patología. Finalmente se establece un algoritmo terapéutico que nos ayuda a optimizar su manejo clínico." ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:90 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer statistics, 2000" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.T. Greenlee" 1 => "T. Murray" 2 => "S. Bolden" 3 => "P.A. Wingo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "CA Cancer J Clin" "fecha" => "2000" "volumen" => "50" "paginaInicial" => "7" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10735013" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leucoqueratosis nicotínica del paladar" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Paricio-Rubio" 1 => "J. Revenga-Arranz" 2 => "T. Ramírez-Gasca" 3 => "P. Boned-Blas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2002" "volumen" => "93" "paginaInicial" => "38" "paginaFinal" => "41" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular genetics of premalignant oral lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.K. Mithani" 1 => "W.K. Mydlarz" 2 => "F.L. Grumbine" 3 => "I.M. Smith" 4 => "J.A. Califano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1601-0825.2006.01349.x" "Revista" => array:6 [ "tituloSerie" => "Oral Dis" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "126" "paginaFinal" => "133" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17305612" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular markers of the risk of oral cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.M. Lippman" 1 => "W.K. Hong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM200104263441710" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2001" "volumen" => "344" "paginaInicial" => "1323" "paginaFinal" => "1326" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11320393" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "World Health Organization: histological typing of cancer and precancer of the oral mucosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.J. Pindborg" 1 => "P. Reichart" 2 => "C.J. Smith" 3 => "I. Van der Waal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1997" "editorial" => "Springer-Verlag" "editorialLocalizacion" => "Berlin" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The evolution of predictive oncology and molecular-based therapy for oral cancer prevention" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Sudbø" 1 => "A. Reith" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.20896" "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2005" "volumen" => "115" "paginaInicial" => "339" "paginaFinal" => "345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15688375" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tobacco use and oral leucoplakia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Bánoczy" 1 => "Z. Gintner" 2 => "C. Dombi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dental Educ" "fecha" => "2001" "volumen" => "65" "paginaInicial" => "322" "paginaFinal" => "327" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leucoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn, 1935-1984" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.E. Bouquot" 1 => "L.H. Weiland" 2 => "L.T. Kurland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod" "fecha" => "1998" "volumen" => "65" "paginaInicial" => "199" "paginaFinal" => "207" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wieviele plattenepthelkarzinome der mundhöhle sind aus leukoplakien enstanden?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.K.H. Gundlach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dtch Z Mundokierfer-gesichts-Chir" "fecha" => "1992" "volumen" => "16" "paginaInicial" => "109" "paginaFinal" => "111" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Concomitant leucoplakia in patients with oral squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Schepman" 1 => "E.H. van der Meij" 2 => "l. Smeele" 3 => "I. van derl Waal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oral Dis" "fecha" => "1999" "volumen" => "5" "paginaInicial" => "206" "paginaFinal" => "209" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10483065" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal and appendageal tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.O. Duncan" 1 => "J.K. Geisse" 2 => "D.J. Leffel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Fitzpatrick's Dermatology in general medicine" "paginaInicial" => "1024" "paginaFinal" => "1026" "edicion" => "7th ed." "serieFecha" => "2007" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tobacco-induced changes in oral leukoplakic epithelium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.J. Pindborg" 1 => "J. Reibel" 2 => "B. Roed-Petersn" 3 => "F.S. Mehta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1980" "volumen" => "45" "paginaInicial" => "2330" "paginaFinal" => "2336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7189690" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mycotic infection in oral leukoplakia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Jepsen" 1 => "J.E. Winther" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Ondontol Scand" "fecha" => "1965" "volumen" => "23" "paginaInicial" => "239" "paginaFinal" => "256" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occurrence of candida in oral leukoplakias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Renstrup" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Pathol Microbiol Scand [B] Microbiol Immunol" "fecha" => "1970" "volumen" => "78" "paginaInicial" => "421" "paginaFinal" => "424" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Reibel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Rev Oral Biol Med" "fecha" => "2003" "volumen" => "14" "paginaInicial" => "47" "paginaFinal" => "62" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12764019" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus in oral premalignant lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Nielsen" 1 => "B. Norrild" 2 => "P. Vedtofte" 3 => "F. Praetorius" 4 => "J. Reibel" 5 => "P. Holmstrup" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Cancer B Oral Oncol" "fecha" => "1996" "volumen" => "32" "paginaInicial" => "264" "paginaFinal" => "270" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HPV-associated diseases of oral mucosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Praetorius" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "1997" "volumen" => "15" "paginaInicial" => "299" "paginaFinal" => "413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9167913" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus as a risk factor for oral squamous cell carcinoma: a metaanalysis, 1982-1997" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.S. Miller" 1 => "B.M. Johnstone" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/moe.2001.115392" "Revista" => array:6 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod" "fecha" => "2001" "volumen" => "91" "paginaInicial" => "622" "paginaFinal" => "635" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11402272" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case-control study of human papillomavirus and oropharyngeal cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. D'Souza" 1 => "A.R. Kreimer" 2 => "R. Viscidi" 3 => "M. Pawlita" 4 => "C. Fakhry" 5 => "W.M. Koch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa065497" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "paginaInicial" => "1944" "paginaFinal" => "1956" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17494927" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of association between proliferative verrucous leukoplakia and human papillomavirus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.V. Bagán" 1 => "Y. Jiménez" 2 => "J. Murillo" 3 => "C. Gavaldá" 4 => "R. Poveda" 5 => "C. Scully" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.joms.2005.12.066" "Revista" => array:6 [ "tituloSerie" => "J Oral Maxillofac Surg" "fecha" => "2007" "volumen" => "65" "paginaInicial" => "46" "paginaFinal" => "49" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17174763" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: A preliminary study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.V. Bagán" 1 => "Y. Jiménez" 2 => "J. Murillo" 3 => "R. Poveda" 4 => "J.M. Díaz" 5 => "C. Gavaldá" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Oral Patol Oral Cir Bucal" "fecha" => "2008" "volumen" => "13" "paginaInicial" => "E110" "paginaFinal" => "E113" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18223526" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How many mutations are required for tumorigenesis? Implications for human cancer data" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.J. Renan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mol Carcinog" "fecha" => "1993" "volumen" => "7" "paginaInicial" => "139" "paginaFinal" => "146" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8489711" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of heterozygosity: a potential tool in management of oral premalignant lesions?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Zhang" 1 => "M.P. Rosin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Oral Pathol Med" "fecha" => "2001" "volumen" => "30" "paginaInicial" => "513" "paginaFinal" => "520" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11555152" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The influence of resection and aneuploidy on mortality in oral leukoplakia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Sudbø" 1 => "S.M. Lippman" 2 => "J.J. Lee" 3 => "L. Mao" 4 => "W. Kildal" 5 => "A. Sudbø" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa033374" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "1405" "paginaFinal" => "1413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15070790" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of localized treatment in reducing risk of progression of low-grade oral dysplasia: molecular evidence of incomplete resection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Zhang" 1 => "C.F. Poh" 2 => "W.L. Lam" 3 => "J.B. Epstein" 4 => "X. Cheng" 5 => "X. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oral Oncol" "fecha" => "2001" "volumen" => "37" "paginaInicial" => "505" "paginaFinal" => "512" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11435177" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Curfman GD, Morrissey S, Drazen JM. Retraction of: “Sudbø J et al. DNA content as a prognostic marker inpatients with oral leukoplakia. N Engl J Med. 2001;344:1270-8 and Sudbø J et al. The influence of resection and aneuploidy on mortality in oral leukoplakia. N Engl J Med2004;350:1405-13.” N Engl J Med. 2006;355:1927." ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.S. Greenblatt" 1 => "W.P. Bennet" 2 => "M. Hollstein" 3 => "C.C. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1994" "volumen" => "54" "paginaInicial" => "4855" "paginaFinal" => "4878" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8069852" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p53 and oral precancer – a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Warnakulasuriya" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Oral oncology" "paginaInicial" => "93" "paginaFinal" => "96" "serieFecha" => "1998" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "P53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I.B. Cruz" 1 => "P.J. Snijders" 2 => "C.J. Meijer" 3 => "B.J. Braakhuis" 4 => "G.B. Snow" 5 => "J.M. Walboomers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1096-9896(199804)184:4<360::AID-PATH1263>3.0.CO;2-H" "Revista" => array:6 [ "tituloSerie" => "J Pathol" "fecha" => "1998" "volumen" => "184" "paginaInicial" => "360" "paginaFinal" => "368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9664901" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TP53 mutations and survival in squamouscell carcinoma of the head and neck" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Poeta" 1 => "J. Manola" 2 => "M.A. Goldwasser" 3 => "A. Forastiere" 4 => "N. Benoit" 5 => "J.A. Califano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa073770" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "357" "paginaInicial" => "2552" "paginaFinal" => "2561" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18094376" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human telomerase catalytic subunit gene re-expression is an early event in oral carcinogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Luzar" 1 => "M. Poljak" 2 => "I.J. Marin" 3 => "A. Eberlinc" 4 => "U. Klopcic" 5 => "N. Gale" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2559.2004.01892.x" "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "2004" "volumen" => "45" "paginaInicial" => "13" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15228439" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tissue distribution of histo-blood group antigens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Ravn" 1 => "E. Dabelsteen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "APMIS" "fecha" => "2000" "volumen" => "108" "paginaInicial" => "1" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10698081" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ABO blood group antigens in oral mucosa. What is new?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Dabelsteen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Oral Pathol Med" "fecha" => "2002" "volumen" => "31" "paginaInicial" => "65" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11896825" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of genes and molecular pathways involved in the progression of premalignant oral epithelia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.G. Banerjee" 1 => "I. Bhattacharyya" 2 => "J.K. Vishwanatha" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1535-7163.MCT-05-0033" "Revista" => array:6 [ "tituloSerie" => "Mol Cancer Ther" "fecha" => "2005" "volumen" => "4" "paginaInicial" => "865" "paginaFinal" => "875" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15956244" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Altered expression of epithelial cell surface glycoconjugates and intermediate filaments at the margins of mucosal wounds" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Dabelsteen" 1 => "B. Gron" 2 => "U. Mandel" 3 => "I. Mackenzie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.1998.00346.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "1998" "volumen" => "111" "paginaInicial" => "592" "paginaFinal" => "597" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9764838" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Site variation of keratin expression in human oral epithelia-an immunocytochemical study on individual keratins" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.R. Morgan" 1 => "I.M. Leigh" 2 => "P.E. Purkis" 3 => "I.D. Gardner" 4 => "G.N.P. van Muijen" 5 => "E.B. Lane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Epithelia" "fecha" => "1987" "volumen" => "1" "paginaInicial" => "33" "paginaFinal" => "43" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene expression of differentiation-specific keratins in oral epithelial dysplasia and squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.K. Bloor" 1 => "S.V. Seddon" 2 => "P.R. Morga" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oral Oncol" "fecha" => "2001" "volumen" => "37" "paginaInicial" => "251" "paginaFinal" => "261" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11287279" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of alpha(v)beta 6 integrin in oral leukoplakia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Hamidi" 1 => "T. Salo" 2 => "T. Kainulainen" 3 => "J. Epstein" 4 => "K. Lerner" 5 => "H. Larjava" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1054/bjoc.1999.1130" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "2000" "volumen" => "82" "paginaInicial" => "1433" "paginaFinal" => "1440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10780523" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of CD44s, CD44v5, CD44v6 and CD44v7-8in betel quid chewing-associated oral premalignant lesions and squamous cell carcinomas in Taiwan" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.Y. Kuo" 1 => "S.J. Cheng" 2 => "H.M. Chen" 3 => "S.H. Kok" 4 => "L.J. Hahn" 5 => "C.P. Chiang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Oral Pathol Med" "fecha" => "1998" "volumen" => "27" "paginaInicial" => "428" "paginaFinal" => "433" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9790096" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of granulocyte colony stimulating factor receptor and platelet-derived endothelial cell growth factor in oral and oropharyngeal precancerous lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Sunaga" 1 => "S. Fujieda" 2 => "H. Tsuzuki" 3 => "K. Asamoto" 4 => "M. Fukuda" 5 => "H. Saito" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anticancer Res" "fecha" => "2001" "volumen" => "21" "paginaInicial" => "2901" "paginaFinal" => "2906" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11712784" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of TGF-and EFGR expression in oral leukoplakia and oral submucous fibrosis by quantitative immunohistochemistry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Sirinivasan" 1 => "S.D. Jewell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oral Oncol" "fecha" => "2001" "volumen" => "61" "paginaInicial" => "284" "paginaFinal" => "292" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alterations of Rb pathway components are frequent events in patients with oral epithelial dysplasia and predict clinical outcome in patients with squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Soni" 1 => "J. Kaur" 2 => "A. Kumar" 3 => "N. Chakravarti" 4 => "M. Mathur" 5 => "S. Bahadur" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000086970" "Revista" => array:6 [ "tituloSerie" => "Oncology" "fecha" => "2005" "volumen" => "68" "paginaInicial" => "314" "paginaFinal" => "325" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16020958" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dysregulated cyclin D1 expression early in head and neck tumorigenesis: In vivo evidence for an association with subsequent gene amplification" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.G. Izzo" 1 => "V.A. Papadimitrakopoulou" 2 => "X.Q. Li" 3 => "H. Ibarquen" 4 => "J.S. Lee" 5 => "J.Y. Ro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.onc.1202153" "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "1998" "volumen" => "17" "paginaInicial" => "2313" "paginaFinal" => "2322" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9811462" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overexpression of matrix metalloproteinase-1 and -9 mRNA is associated with progression of oral dysplasia to cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.C. Jordan" 1 => "M. Macabeo-Ong" 2 => "C.H. Shiboski" 3 => "N. Dekker" 4 => "D.G. Ginzinger" 5 => "D.T. Wong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1078-0432.CCR-04-0656" "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2004" "volumen" => "10" "paginaInicial" => "6460" "paginaFinal" => "6465" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15475433" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased EMMPRIN (CD147) expression during oral carcinogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Vigneswaran" 1 => "S. Beckers" 2 => "S. Waigel" 3 => "J. Mensah" 4 => "J. Wu" 5 => "J. Mo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.yexmp.2005.09.011" "Revista" => array:6 [ "tituloSerie" => "Exp Mol Pathol" "fecha" => "2006" "volumen" => "80" "paginaInicial" => "147" "paginaFinal" => "159" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16310185" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression and prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Arora" 1 => "J. Kaur" 2 => "C. Sharma" 3 => "M. Mathur" 4 => "S. Bahadur" 5 => "N.K. Shukla" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1078-0432.CCR-04-0572" "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2005" "volumen" => "11" "paginaInicial" => "2272" "paginaFinal" => "2284" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15788677" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral white lesions with special reference to precancerous and tobaccorelated lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994. International Collaborative Group on Oral White Lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Axéll" 1 => "J.J. Pindborg" 2 => "C.J. Smith" 3 => "I. van der Waal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Oral Pathol Med" "fecha" => "1996" "volumen" => "25" "paginaInicial" => "49" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8667255" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral leukoplakia and malignant transformation. A follow up study of 257 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Silverman Jr" 1 => "M. Gorsky" 2 => "F. Lozada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1984" "volumen" => "53" "paginaInicial" => "563" "paginaFinal" => "568" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6537892" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant transformation in oral leucoplakia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.O. Lind" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Dent Res" "fecha" => "1987" "volumen" => "95" "paginaInicial" => "449" "paginaFinal" => "455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3480564" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An epidemiologic assessment of cancer risk in oral precancerous lesions in India with special reference to nodular leukoplakia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.C. Gupta" 1 => "R.B. Bhonsle" 2 => "P.R. Murti" 3 => "D.K. Daftary" 4 => "F.S. Mehta" 5 => "J.J. Pindborg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1989" "volumen" => "63" "paginaInicial" => "2247" "paginaFinal" => "2252" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2720574" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proliferative verrucous leukoplakia. A long-term study of thirty patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.S. Hansen" 1 => "J.A. Olson" 2 => "S.J. Silverman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod" "fecha" => "1985" "volumen" => "60" "paginaInicial" => "285" "paginaFinal" => "298" ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proliferative verrucous leukoplakia: a follow up study of 54 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Silverman Jr" 1 => "M. Gorsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod" "fecha" => "1968" "volumen" => "84" "paginaInicial" => "154" "paginaFinal" => "157" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9269017" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Verrucous hyperplasia or verrucous carcinoma. An analysis of 27 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.J. Slootweg" 1 => "H. Müller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Maxillofac Surg" "fecha" => "1983" "volumen" => "11" "paginaInicial" => "13" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6572683" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The clinical features and risk of malignant transformation in sublingual keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I.R. Kramer" 1 => "N. el-Labban" 2 => "K.W. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nr Dent J" "fecha" => "1978" "volumen" => "144" "paginaInicial" => "171" "paginaFinal" => "180" ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The permeability of human oral mucosa and skin to water" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.A. Lesh" 1 => "C.A. Squier" 2 => "A. Cruchley" 3 => "D.M. Williams" 4 => "P. Speight" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Dent Res" "fecha" => "1989" "volumen" => "68" "paginaInicial" => "1345" "paginaFinal" => "1349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2476469" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral leukoplakia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.J. Sciubba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Rev Oral Biol Med" "fecha" => "1995" "volumen" => "6" "paginaInicial" => "147" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7548621" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiologic and histologic study of oral cancer and leucoplasia among 50,915 villagers in India" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.S. Mehta" 1 => "J.J. Pindborg" 2 => "P.C. Gupta" 3 => "D.K. Daftary" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1996" "volumen" => "24" "paginaInicial" => "832" "paginaFinal" => "849" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4898206" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occurrence of epithelial dysplasia in oral leukoplakia. Analysis and follow-up study of 12 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Bánóczy" 1 => "A. Csiba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod" "fecha" => "1976" "volumen" => "42" "paginaInicial" => "766" "paginaFinal" => "774" ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leucoplakia revisited. A clinicopathologic study 3256 oral leukoplakias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.A. Waldron" 1 => "W.G. Shafer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1975" "volumen" => "36" "paginaInicial" => "1386" "paginaFinal" => "1392" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant transformation and natural history of oral leucoplakia in 57,518 workers on Gujarat, India" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer" "fecha" => "1976" "volumen" => "38" "paginaInicial" => "563" "paginaFinal" => "568" ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leucoplakia, dysplasia and malignant transformation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod" "fecha" => "1996" "volumen" => "82" "paginaInicial" => "117" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant transformation of oral leukoplakia: a follow up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oral Oncol" "fecha" => "1998" "volumen" => "34" "paginaInicial" => "270" "paginaFinal" => "275" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib63" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Observer agreement in the grading of oral epithelial dysplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Community Dent Oral Epidemiol" "fecha" => "2003" "volumen" => "31" "paginaInicial" => "300" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib64" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Observations on the clinical characteristics of oral lesions showing histologic epithelial dysplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod" "fecha" => "1972" "volumen" => "33" "paginaInicial" => "389" "paginaFinal" => "399" ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib65" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Follow up studies in oral leukoplakia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Maxillofac Surg" "fecha" => "1977" "volumen" => "5" "paginaInicial" => "69" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib66" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow up study of Indian villagers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Community Dent Oral Epidemiol" "fecha" => "1980" "volumen" => "6" "paginaInicial" => "283" "paginaFinal" => "333" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib67" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Potentially malignant oral lesions in northern Ireland: a 20-year population-based perspective of malignant transformation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oral Dis" "fecha" => "2001" "volumen" => "7" "paginaInicial" => "18" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib68" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benign alveolar ridge keratosis (oral lichen simplex chronicus): A distinct clinicopathologic entity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2007.07.011" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2008" "volumen" => "58" "paginaInicial" => "151" "paginaFinal" => "157" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib69" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is alveolar ridge keratosis a true leukoplakia?: A clinicopathologic comparison of 2,153 lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Dent Assoc" "fecha" => "2007" "volumen" => "138" "paginaInicial" => "641" "paginaFinal" => "651" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib70" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interventions for treating oral leukoplakia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2006" ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib71" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of oral epithelial dysplasia: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tripleo.2006.10.015" "Revista" => array:6 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod" "fecha" => "2007" "volumen" => "103" "numero" => "Suppl" "paginaInicial" => "S19" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib72" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2002" "volumen" => "8" "paginaInicial" => "314" "paginaFinal" => "346" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib73" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predicting cancer development in oral leukoplakia: ten years of translational research" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2000" "volumen" => "6" "paginaInicial" => "1702" "paginaFinal" => "1710" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib74" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "2003" "volumen" => "63" "paginaInicial" => "1727" "paginaFinal" => "1730" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib75" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemoprevention: an essential approach to controlling cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Nat Rev Cancer" "fecha" => "2002" "paginaInicial" => "537" "paginaFinal" => "543" ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib76" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cyclooxigenasae-2 (COX-2) expression in high risk premalignant lessions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oral Oncol" "fecha" => "2003" "volumen" => "39" "paginaInicial" => "497" "paginaFinal" => "505" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib77" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Suppression of prostaglandin E2 receptor subtype EP2 by PPAR-gamma ligand inhibits human lung carcinoma cell growth" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochem Biophys Res Commun" "fecha" => "2004" "volumen" => "314" "paginaInicial" => "1093" "paginaFinal" => "1099" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib78" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of epidermal growth factor receptor in head and neck squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Oncol Rep" "fecha" => "2003" "volumen" => "5" "paginaInicial" => "140" "paginaFinal" => "146" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib79" "etiqueta" => "79." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differential expression of epidermal growth factor receptor inhuman head and neck cancers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Head Neck" "fecha" => "1998" "volumen" => "20" "paginaInicial" => "320" "paginaFinal" => "327" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib80" "etiqueta" => "80." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early maskers of carcinogenesis in head and neck cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1993" "volumen" => "53" "paginaInicial" => "3579" "paginaFinal" => "3584" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib81" "etiqueta" => "81." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "1998" "volumen" => "4" "paginaInicial" => "13" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib82" "etiqueta" => "82." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads for prolonged survival in a murine model of oral cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2003" "volumen" => "9" "paginaInicial" => "3183" "paginaFinal" => "3189" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib83" "etiqueta" => "83." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combinatorial chemoprevention of intestinal neoplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/79534" "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "2000" "volumen" => "6" "paginaInicial" => "1024" "paginaFinal" => "1028" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib84" "etiqueta" => "84." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bcp.2003.12.014" "Revista" => array:6 [ "tituloSerie" => "Biochem Pharmacol" "fecha" => "2004" "volumen" => "67" "paginaInicial" => "1469" "paginaFinal" => "1478" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib85" "etiqueta" => "85." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bjc.6601505" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "2004" "volumen" => "90" "paginaInicial" => "224" "paginaFinal" => "229" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 85 => array:3 [ "identificador" => "bib86" "etiqueta" => "86." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence forcyclooxygenase-2-independent mechanism in celecoxibmediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "2004" "volumen" => "64" "paginaInicial" => "1369" "paginaFinal" => "1376" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 86 => array:3 [ "identificador" => "bib87" "etiqueta" => "87." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3-phosphoinositide-dependent protein kinase l/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "2004" "volumen" => "64" "paginaInicial" => "1444" "paginaFinal" => "1451" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 87 => array:3 [ "identificador" => "bib88" "etiqueta" => "88." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/mc.20232" "Revista" => array:6 [ "tituloSerie" => "Mol Carcinog" "fecha" => "2006" "volumen" => "45" "paginaInicial" => "447" "paginaFinal" => "454" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 88 => array:3 [ "identificador" => "bib89" "etiqueta" => "89." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early de novo gene expression is required for 15-deoxy-Delta 12, 14-prostaglandin J2-induced apoptosis in breast cancer cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/jbc.C100339200" "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "2001" "volumen" => "276" "paginaInicial" => "47131" "paginaFinal" => "47135" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 89 => array:3 [ "identificador" => "bib90" "etiqueta" => "90." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1997" "volumen" => "272" "paginaInicial" => "3406" "paginaFinal" => "3410" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000008/v1_201304241504/S1578219009701490/v1_201304241504/en/main.assets" "Apartado" => array:4 [ "identificador" => "6151" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Practical Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000008/v1_201304241504/S1578219009701490/v1_201304241504/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701490?idApp=UINPBA000044"]

Statistics

Practical dermatology

Oral Leukoplakia: Clinical, Histopathologic, and Molecular Features and Therapeutic Approach

La Leucoplasia Oral: Definición de Parámetros Clínicos, Histopatológicos y Moleculares y Actitud Terapéutica

A. Martorell-Calatayuda,

Corresponding author

antmarto@hotmail.com

Correspondencia: Antonio Martorell Calatayud, C/ San José de la Montaña, n.° 14, puerta 11,` 46008 Valencia, Spain.

, R. Botella-Estradaa, J.V. Bagán-Sebastiánb, O. Sanmartín-Jiméneza, C. Guillén-Baronaa

a Servicio de Dermatología, Fundación Instituto Valenciano de Oncología, Valencia, Spain

b Servicio de Estomatología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain

Read

19188

Times
was read the article

14167

Total PDF

5021

Total HTML

Share statistics

 array:23 [
  "pii" => "S1578219009701490"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(09)70149-0"
  "estado" => "S300"
  "fechaPublicacion" => "2009-10-01"
  "aid" => "70149"
  "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
  "copyrightAnyo" => "2009"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2009;100:669-84"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 9574
    "formatos" => array:3 [
      "EPUB" => 34
      "HTML" => 2688
      "PDF" => 6852
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219009701507"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70150-7"
    "estado" => "S300"
    "fechaPublicacion" => "2009-10-01"
    "aid" => "70150"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100:685-92"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2439
      "formatos" => array:3 [
        "EPUB" => 39
        "HTML" => 1383
        "PDF" => 1017
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>"
      "titulo" => "Occupational Dermatoses&#58; Cross-Cultural Adaptation of the Nordic Occupational Skin Questionnaire &#40;NOSQ-2002&#41; From English to Spanish and Catalan"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "685"
          "paginaFinal" => "692"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Dermatosis Profesionales&#46; Adaptaci&#243;n Transcultural del Cuestionario Nordic Occupational Skin Questionnaire &#40;NOSQ-2002&#41; del Ingl&#233;s al Castellano y al Catal&#225;n"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "N&#46; Sala-Sastre, M&#46; Herdman, L&#46; Navarro, M&#46; de la Prada, R&#46; Pujol, C&#46; Serra, J&#46; Alonso, M&#46;A&#46; Flyvholm, A&#46;M&#46; Gim&#233;nez-Arnau"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Sala-Sastre"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Herdman"
            ]
            2 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Navarro"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "de la Prada"
            ]
            4 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Pujol"
            ]
            5 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Serra"
            ]
            6 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Alonso"
            ]
            7 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Flyvholm"
            ]
            8 => array:2 [
              "nombre" => "A&#46;M&#46;"
              "apellidos" => "Gim&#233;nez-Arnau"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701507?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000008/v1_201304241504/S1578219009701507/v1_201304241504/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219009701489"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70148-9"
    "estado" => "S300"
    "fechaPublicacion" => "2009-10-01"
    "aid" => "70148"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100:661-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2629
      "formatos" => array:3 [
        "EPUB" => 34
        "HTML" => 1432
        "PDF" => 1163
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Controversies in dermatology</span>"
      "titulo" => "Complications in Dermatologic Surgery"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "661"
          "paginaFinal" => "668"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Complicaciones en Dermatolog&#237;a Quir&#250;rgica"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Jim&#233;nez-Puya, C&#46; V&#225;zquez-Bayo, F&#46; G&#243;mez-Garc&#237;a, J&#46;C&#46; Moreno-Gim&#233;nez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Jim&#233;nez-Puya"
            ]
            1 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "V&#225;zquez-Bayo"
            ]
            2 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "G&#243;mez-Garc&#237;a"
            ]
            3 => array:2 [
              "nombre" => "J&#46;C&#46;"
              "apellidos" => "Moreno-Gim&#233;nez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701489?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000008/v1_201304241504/S1578219009701489/v1_201304241504/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Practical dermatology</span>"
    "titulo" => "Oral Leukoplakia&#58; Clinical&#44; Histopathologic&#44; and Molecular Features and Therapeutic Approach"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "669"
        "paginaFinal" => "684"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Martorell-Calatayud, R&#46; Botella-Estrada, J&#46;V&#46; Bag&#225;n-Sebasti&#225;n, O&#46; Sanmart&#237;n-Jim&#233;nez, C&#46; Guill&#233;n-Barona"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Martorell-Calatayud"
            "email" => array:1 [
              0 => "antmarto&#64;hotmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Botella-Estrada"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;V&#46;"
            "apellidos" => "Bag&#225;n-Sebasti&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "O&#46;"
            "apellidos" => "Sanmart&#237;n-Jim&#233;nez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Guill&#233;n-Barona"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Fundaci&#243;n Instituto Valenciano de Oncolog&#237;a&#44; Valencia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Estomatolog&#237;a&#44; Consorcio Hospital General Universitario de Valencia&#44; Valencia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondencia&#58; Antonio Martorell Calatayud&#44; C&#47; San Jos&#233; de la Monta&#241;a&#44; n&#46;&#176; 14&#44; puerta 11&#44;&#96; 46008 Valencia&#44; Spain&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "La Leucoplasia Oral&#58; Definici&#243;n de Par&#225;metros Cl&#237;nicos&#44; Histopatol&#243;gicos y Moleculares y Actitud Terap&#233;utica"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84573"
          "palabras" => array:4 [
            0 => "leukoplakia"
            1 => "tobacco"
            2 => "therapy"
            3 => "risk of transformation"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84574"
          "palabras" => array:4 [
            0 => "leucoplasia"
            1 => "tabaco"
            2 => "terapia"
            3 => "riesgo de transformaci&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Dermatology departments are currently seeing an increase in the number of cases of oral diseases&#46; Of note among the range of lesions covered by this broad area of knowledge is oral leukoplakia&#8212;the most common precancerous lesion and the most problematic in terms of both diagnosis and therapeutic management&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">In addition to defining leukoplakia&#44; this review also establishes a differential diagnosis with the other most important oral diseases and analyzes the different clinical&#44; histologic&#44; and molecular features that can provide an indication of the risk of malignant transformation&#46; Finally&#44; a therapeutic algorithm is presented to help us optimize clinical management of the disease&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Actualmente existe un incremento del n&#250;mero de casos de patolog&#237;a oral en los servicios de Dermatolog&#237;a&#46; Dentro de las diversas lesiones que forman parte de esta amplia &#225;rea de conocimiento destacamos la leucoplasia oral&#44; por ser la lesi&#243;n mucosa precancerosa m&#225;s frecuente y la que mayores problemas origina tanto en su diagn&#243;stico como en su manejo terap&#233;utico&#46; En esta revisi&#243;n&#44; adem&#225;s de definir la leucoplasia&#44; establecemos un diagn&#243;stico diferencial con el resto de las patolog&#237;as orales m&#225;s importantes y analizamos los diversos par&#225;metros cl&#237;nicos&#44; histol&#243;gicos y moleculares que definen el riesgo de transformaci&#243;n maligna de esta patolog&#237;a&#46; Finalmente se establece un algoritmo terap&#233;utico que nos ayuda a optimizar su manejo cl&#237;nico&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:90 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer statistics&#44; 2000"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;T&#46; Greenlee"
                            1 => "T&#46; Murray"
                            2 => "S&#46; Bolden"
                            3 => "P&#46;A&#46; Wingo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "CA Cancer J Clin"
                        "fecha" => "2000"
                        "volumen" => "50"
                        "paginaInicial" => "7"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10735013"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leucoqueratosis nicot&#237;nica del paladar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Paricio-Rubio"
                            1 => "J&#46; Revenga-Arranz"
                            2 => "T&#46; Ram&#237;rez-Gasca"
                            3 => "P&#46; Boned-Blas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2002"
                        "volumen" => "93"
                        "paginaInicial" => "38"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular genetics of premalignant oral lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;K&#46; Mithani"
                            1 => "W&#46;K&#46; Mydlarz"
                            2 => "F&#46;L&#46; Grumbine"
                            3 => "I&#46;M&#46; Smith"
                            4 => "J&#46;A&#46; Califano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1601-0825.2006.01349.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Dis"
                        "fecha" => "2007"
                        "volumen" => "13"
                        "paginaInicial" => "126"
                        "paginaFinal" => "133"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17305612"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular markers of the risk of oral cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;M&#46; Lippman"
                            1 => "W&#46;K&#46; Hong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200104263441710"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2001"
                        "volumen" => "344"
                        "paginaInicial" => "1323"
                        "paginaFinal" => "1326"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11320393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "World Health Organization&#58; histological typing of cancer and precancer of the oral mucosa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;J&#46; Pindborg"
                            1 => "P&#46; Reichart"
                            2 => "C&#46;J&#46; Smith"
                            3 => "I&#46; Van der Waal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1997"
                        "editorial" => "Springer-Verlag"
                        "editorialLocalizacion" => "Berlin"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The evolution of predictive oncology and molecular-based therapy for oral cancer prevention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Sudb&#248;"
                            1 => "A&#46; Reith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ijc.20896"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2005"
                        "volumen" => "115"
                        "paginaInicial" => "339"
                        "paginaFinal" => "345"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15688375"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tobacco use and oral leucoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; B&#225;noczy"
                            1 => "Z&#46; Gintner"
                            2 => "C&#46; Dombi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dental Educ"
                        "fecha" => "2001"
                        "volumen" => "65"
                        "paginaInicial" => "322"
                        "paginaFinal" => "327"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leucoplakia and carcinoma in situ synchronously associated with invasive oral&#47;oropharyngeal carcinoma in Rochester&#44; Minn&#44; 1935-1984"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;E&#46; Bouquot"
                            1 => "L&#46;H&#46; Weiland"
                            2 => "L&#46;T&#46; Kurland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "1998"
                        "volumen" => "65"
                        "paginaInicial" => "199"
                        "paginaFinal" => "207"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Wieviele plattenepthelkarzinome der mundh&#246;hle sind aus leukoplakien enstanden&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46;K&#46;H&#46; Gundlach"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dtch Z Mundokierfer-gesichts-Chir"
                        "fecha" => "1992"
                        "volumen" => "16"
                        "paginaInicial" => "109"
                        "paginaFinal" => "111"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Concomitant leucoplakia in patients with oral squamous cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Schepman"
                            1 => "E&#46;H&#46; van der Meij"
                            2 => "l&#46; Smeele"
                            3 => "I&#46; van derl Waal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Dis"
                        "fecha" => "1999"
                        "volumen" => "5"
                        "paginaInicial" => "206"
                        "paginaFinal" => "209"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10483065"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal and appendageal tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;O&#46; Duncan"
                            1 => "J&#46;K&#46; Geisse"
                            2 => "D&#46;J&#46; Leffel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Fitzpatrick&#39;s Dermatology in general medicine"
                        "paginaInicial" => "1024"
                        "paginaFinal" => "1026"
                        "edicion" => "7th ed&#46;"
                        "serieFecha" => "2007"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tobacco-induced changes in oral leukoplakic epithelium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;J&#46; Pindborg"
                            1 => "J&#46; Reibel"
                            2 => "B&#46; Roed-Petersn"
                            3 => "F&#46;S&#46; Mehta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1980"
                        "volumen" => "45"
                        "paginaInicial" => "2330"
                        "paginaFinal" => "2336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7189690"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mycotic infection in oral leukoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Jepsen"
                            1 => "J&#46;E&#46; Winther"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Ondontol Scand"
                        "fecha" => "1965"
                        "volumen" => "23"
                        "paginaInicial" => "239"
                        "paginaFinal" => "256"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Occurrence of candida in oral leukoplakias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Renstrup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Pathol Microbiol Scand &#91;B&#93; Microbiol Immunol"
                        "fecha" => "1970"
                        "volumen" => "78"
                        "paginaInicial" => "421"
                        "paginaFinal" => "424"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis of oral pre-malignant lesions&#58; significance of clinical&#44; histopathological&#44; and molecular biological characteristics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Reibel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Rev Oral Biol Med"
                        "fecha" => "2003"
                        "volumen" => "14"
                        "paginaInicial" => "47"
                        "paginaFinal" => "62"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12764019"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus in oral premalignant lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Nielsen"
                            1 => "B&#46; Norrild"
                            2 => "P&#46; Vedtofte"
                            3 => "F&#46; Praetorius"
                            4 => "J&#46; Reibel"
                            5 => "P&#46; Holmstrup"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Cancer B Oral Oncol"
                        "fecha" => "1996"
                        "volumen" => "32"
                        "paginaInicial" => "264"
                        "paginaFinal" => "270"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "HPV-associated diseases of oral mucosa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Praetorius"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "1997"
                        "volumen" => "15"
                        "paginaInicial" => "299"
                        "paginaFinal" => "413"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9167913"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus as a risk factor for oral squamous cell carcinoma&#58; a metaanalysis&#44; 1982-1997"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;S&#46; Miller"
                            1 => "B&#46;M&#46; Johnstone"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/moe.2001.115392"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "2001"
                        "volumen" => "91"
                        "paginaInicial" => "622"
                        "paginaFinal" => "635"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11402272"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Case-control study of human papillomavirus and oropharyngeal cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; D&#39;Souza"
                            1 => "A&#46;R&#46; Kreimer"
                            2 => "R&#46; Viscidi"
                            3 => "M&#46; Pawlita"
                            4 => "C&#46; Fakhry"
                            5 => "W&#46;M&#46; Koch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa065497"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2007"
                        "volumen" => "356"
                        "paginaInicial" => "1944"
                        "paginaFinal" => "1956"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17494927"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of association between proliferative verrucous leukoplakia and human papillomavirus infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;V&#46; Bag&#225;n"
                            1 => "Y&#46; Jim&#233;nez"
                            2 => "J&#46; Murillo"
                            3 => "C&#46; Gavald&#225;"
                            4 => "R&#46; Poveda"
                            5 => "C&#46; Scully"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.joms.2005.12.066"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Maxillofac Surg"
                        "fecha" => "2007"
                        "volumen" => "65"
                        "paginaInicial" => "46"
                        "paginaFinal" => "49"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17174763"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma&#58; A preliminary study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;V&#46; Bag&#225;n"
                            1 => "Y&#46; Jim&#233;nez"
                            2 => "J&#46; Murillo"
                            3 => "R&#46; Poveda"
                            4 => "J&#46;M&#46; D&#237;az"
                            5 => "C&#46; Gavald&#225;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Oral Patol Oral Cir Bucal"
                        "fecha" => "2008"
                        "volumen" => "13"
                        "paginaInicial" => "E110"
                        "paginaFinal" => "E113"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18223526"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How many mutations are required for tumorigenesis&#63; Implications for human cancer data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;J&#46; Renan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Carcinog"
                        "fecha" => "1993"
                        "volumen" => "7"
                        "paginaInicial" => "139"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8489711"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Loss of heterozygosity&#58; a potential tool in management of oral premalignant lesions&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Zhang"
                            1 => "M&#46;P&#46; Rosin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Pathol Med"
                        "fecha" => "2001"
                        "volumen" => "30"
                        "paginaInicial" => "513"
                        "paginaFinal" => "520"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11555152"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The influence of resection and aneuploidy on mortality in oral leukoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Sudb&#248;"
                            1 => "S&#46;M&#46; Lippman"
                            2 => "J&#46;J&#46; Lee"
                            3 => "L&#46; Mao"
                            4 => "W&#46; Kildal"
                            5 => "A&#46; Sudb&#248;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa033374"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "1405"
                        "paginaFinal" => "1413"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15070790"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of localized treatment in reducing risk of progression of low-grade oral dysplasia&#58; molecular evidence of incomplete resection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Zhang"
                            1 => "C&#46;F&#46; Poh"
                            2 => "W&#46;L&#46; Lam"
                            3 => "J&#46;B&#46; Epstein"
                            4 => "X&#46; Cheng"
                            5 => "X&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Oncol"
                        "fecha" => "2001"
                        "volumen" => "37"
                        "paginaInicial" => "505"
                        "paginaFinal" => "512"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11435177"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Curfman GD&#44; Morrissey S&#44; Drazen JM&#46; Retraction of&#58; &#8220;Sudb&#248; J et al&#46; DNA content as a prognostic marker inpatients with oral leukoplakia&#46; N Engl J Med&#46; 2001&#59;344&#58;1270-8 and Sudb&#248; J et al&#46; The influence of resection and aneuploidy on mortality in oral leukoplakia&#46; N Engl J Med2004&#59;350&#58;1405-13&#46;&#8221; N Engl J Med&#46; 2006&#59;355&#58;1927&#46;"
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the p53 tumor suppressor gene&#58; clues to cancer etiology and molecular pathogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;S&#46; Greenblatt"
                            1 => "W&#46;P&#46; Bennet"
                            2 => "M&#46; Hollstein"
                            3 => "C&#46;C&#46; Harris"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1994"
                        "volumen" => "54"
                        "paginaInicial" => "4855"
                        "paginaFinal" => "4878"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8069852"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "p53 and oral precancer &#8211; a review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Warnakulasuriya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Oral oncology"
                        "paginaInicial" => "93"
                        "paginaFinal" => "96"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "P53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46;B&#46; Cruz"
                            1 => "P&#46;J&#46; Snijders"
                            2 => "C&#46;J&#46; Meijer"
                            3 => "B&#46;J&#46; Braakhuis"
                            4 => "G&#46;B&#46; Snow"
                            5 => "J&#46;M&#46; Walboomers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1096-9896(199804)184:4<360::AID-PATH1263>3.0.CO;2-H"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pathol"
                        "fecha" => "1998"
                        "volumen" => "184"
                        "paginaInicial" => "360"
                        "paginaFinal" => "368"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9664901"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TP53 mutations and survival in squamouscell carcinoma of the head and neck"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Poeta"
                            1 => "J&#46; Manola"
                            2 => "M&#46;A&#46; Goldwasser"
                            3 => "A&#46; Forastiere"
                            4 => "N&#46; Benoit"
                            5 => "J&#46;A&#46; Califano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa073770"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2007"
                        "volumen" => "357"
                        "paginaInicial" => "2552"
                        "paginaFinal" => "2561"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18094376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human telomerase catalytic subunit gene re-expression is an early event in oral carcinogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Luzar"
                            1 => "M&#46; Poljak"
                            2 => "I&#46;J&#46; Marin"
                            3 => "A&#46; Eberlinc"
                            4 => "U&#46; Klopcic"
                            5 => "N&#46; Gale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2559.2004.01892.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Histopathology"
                        "fecha" => "2004"
                        "volumen" => "45"
                        "paginaInicial" => "13"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15228439"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tissue distribution of histo-blood group antigens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46; Ravn"
                            1 => "E&#46; Dabelsteen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "APMIS"
                        "fecha" => "2000"
                        "volumen" => "108"
                        "paginaInicial" => "1"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10698081"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ABO blood group antigens in oral mucosa&#46; What is new&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Dabelsteen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Pathol Med"
                        "fecha" => "2002"
                        "volumen" => "31"
                        "paginaInicial" => "65"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11896825"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of genes and molecular pathways involved in the progression of premalignant oral epithelia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;G&#46; Banerjee"
                            1 => "I&#46; Bhattacharyya"
                            2 => "J&#46;K&#46; Vishwanatha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1535-7163.MCT-05-0033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Cancer Ther"
                        "fecha" => "2005"
                        "volumen" => "4"
                        "paginaInicial" => "865"
                        "paginaFinal" => "875"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15956244"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Altered expression of epithelial cell surface glycoconjugates and intermediate filaments at the margins of mucosal wounds"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Dabelsteen"
                            1 => "B&#46; Gron"
                            2 => "U&#46; Mandel"
                            3 => "I&#46; Mackenzie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.1998.00346.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1998"
                        "volumen" => "111"
                        "paginaInicial" => "592"
                        "paginaFinal" => "597"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9764838"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Site variation of keratin expression in human oral epithelia-an immunocytochemical study on individual keratins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;R&#46; Morgan"
                            1 => "I&#46;M&#46; Leigh"
                            2 => "P&#46;E&#46; Purkis"
                            3 => "I&#46;D&#46; Gardner"
                            4 => "G&#46;N&#46;P&#46; van Muijen"
                            5 => "E&#46;B&#46; Lane"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Epithelia"
                        "fecha" => "1987"
                        "volumen" => "1"
                        "paginaInicial" => "33"
                        "paginaFinal" => "43"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gene expression of differentiation-specific keratins in oral epithelial dysplasia and squamous cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;K&#46; Bloor"
                            1 => "S&#46;V&#46; Seddon"
                            2 => "P&#46;R&#46; Morga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Oncol"
                        "fecha" => "2001"
                        "volumen" => "37"
                        "paginaInicial" => "251"
                        "paginaFinal" => "261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11287279"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of alpha&#40;v&#41;beta 6 integrin in oral leukoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Hamidi"
                            1 => "T&#46; Salo"
                            2 => "T&#46; Kainulainen"
                            3 => "J&#46; Epstein"
                            4 => "K&#46; Lerner"
                            5 => "H&#46; Larjava"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1054/bjoc.1999.1130"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Cancer"
                        "fecha" => "2000"
                        "volumen" => "82"
                        "paginaInicial" => "1433"
                        "paginaFinal" => "1440"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10780523"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of CD44s&#44; CD44v5&#44; CD44v6 and CD44v7-8in betel quid chewing-associated oral premalignant lesions and squamous cell carcinomas in Taiwan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;Y&#46; Kuo"
                            1 => "S&#46;J&#46; Cheng"
                            2 => "H&#46;M&#46; Chen"
                            3 => "S&#46;H&#46; Kok"
                            4 => "L&#46;J&#46; Hahn"
                            5 => "C&#46;P&#46; Chiang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Pathol Med"
                        "fecha" => "1998"
                        "volumen" => "27"
                        "paginaInicial" => "428"
                        "paginaFinal" => "433"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9790096"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of granulocyte colony stimulating factor receptor and platelet-derived endothelial cell growth factor in oral and oropharyngeal precancerous lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Sunaga"
                            1 => "S&#46; Fujieda"
                            2 => "H&#46; Tsuzuki"
                            3 => "K&#46; Asamoto"
                            4 => "M&#46; Fukuda"
                            5 => "H&#46; Saito"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Anticancer Res"
                        "fecha" => "2001"
                        "volumen" => "21"
                        "paginaInicial" => "2901"
                        "paginaFinal" => "2906"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11712784"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of TGF-and EFGR expression in oral leukoplakia and oral submucous fibrosis by quantitative immunohistochemistry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Sirinivasan"
                            1 => "S&#46;D&#46; Jewell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oral Oncol"
                        "fecha" => "2001"
                        "volumen" => "61"
                        "paginaInicial" => "284"
                        "paginaFinal" => "292"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alterations of Rb pathway components are frequent events in patients with oral epithelial dysplasia and predict clinical outcome in patients with squamous cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Soni"
                            1 => "J&#46; Kaur"
                            2 => "A&#46; Kumar"
                            3 => "N&#46; Chakravarti"
                            4 => "M&#46; Mathur"
                            5 => "S&#46; Bahadur"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000086970"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncology"
                        "fecha" => "2005"
                        "volumen" => "68"
                        "paginaInicial" => "314"
                        "paginaFinal" => "325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16020958"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dysregulated cyclin D1 expression early in head and neck tumorigenesis&#58; In vivo evidence for an association with subsequent gene amplification"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;G&#46; Izzo"
                            1 => "V&#46;A&#46; Papadimitrakopoulou"
                            2 => "X&#46;Q&#46; Li"
                            3 => "H&#46; Ibarquen"
                            4 => "J&#46;S&#46; Lee"
                            5 => "J&#46;Y&#46; Ro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.onc.1202153"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncogene"
                        "fecha" => "1998"
                        "volumen" => "17"
                        "paginaInicial" => "2313"
                        "paginaFinal" => "2322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9811462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Overexpression of matrix metalloproteinase-1 and -9 mRNA is associated with progression of oral dysplasia to cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Jordan"
                            1 => "M&#46; Macabeo-Ong"
                            2 => "C&#46;H&#46; Shiboski"
                            3 => "N&#46; Dekker"
                            4 => "D&#46;G&#46; Ginzinger"
                            5 => "D&#46;T&#46; Wong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1078-0432.CCR-04-0656"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "10"
                        "paginaInicial" => "6460"
                        "paginaFinal" => "6465"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15475433"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased EMMPRIN &#40;CD147&#41; expression during oral carcinogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Vigneswaran"
                            1 => "S&#46; Beckers"
                            2 => "S&#46; Waigel"
                            3 => "J&#46; Mensah"
                            4 => "J&#46; Wu"
                            5 => "J&#46; Mo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.yexmp.2005.09.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Mol Pathol"
                        "fecha" => "2006"
                        "volumen" => "80"
                        "paginaInicial" => "147"
                        "paginaFinal" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16310185"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stromelysin 3&#44; Ets-1&#44; and vascular endothelial growth factor expression in oral precancerous and cancerous lesions&#58; correlation with microvessel density&#44; progression and prognosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Arora"
                            1 => "J&#46; Kaur"
                            2 => "C&#46; Sharma"
                            3 => "M&#46; Mathur"
                            4 => "S&#46; Bahadur"
                            5 => "N&#46;K&#46; Shukla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1078-0432.CCR-04-0572"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2005"
                        "volumen" => "11"
                        "paginaInicial" => "2272"
                        "paginaFinal" => "2284"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15788677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral white lesions with special reference to precancerous and tobaccorelated lesions&#58; conclusions of an international symposium held in Uppsala&#44; Sweden&#44; May 18-21 1994&#46; International Collaborative Group on Oral White Lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Ax&#233;ll"
                            1 => "J&#46;J&#46; Pindborg"
                            2 => "C&#46;J&#46; Smith"
                            3 => "I&#46; van der Waal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Pathol Med"
                        "fecha" => "1996"
                        "volumen" => "25"
                        "paginaInicial" => "49"
                        "paginaFinal" => "54"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8667255"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib48"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral leukoplakia and malignant transformation&#46; A follow up study of 257 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Silverman Jr"
                            1 => "M&#46; Gorsky"
                            2 => "F&#46; Lozada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1984"
                        "volumen" => "53"
                        "paginaInicial" => "563"
                        "paginaFinal" => "568"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6537892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib49"
              "etiqueta" => "49&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant transformation in oral leucoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;O&#46; Lind"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Dent Res"
                        "fecha" => "1987"
                        "volumen" => "95"
                        "paginaInicial" => "449"
                        "paginaFinal" => "455"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3480564"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib50"
              "etiqueta" => "50&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An epidemiologic assessment of cancer risk in oral precancerous lesions in India with special reference to nodular leukoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;C&#46; Gupta"
                            1 => "R&#46;B&#46; Bhonsle"
                            2 => "P&#46;R&#46; Murti"
                            3 => "D&#46;K&#46; Daftary"
                            4 => "F&#46;S&#46; Mehta"
                            5 => "J&#46;J&#46; Pindborg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1989"
                        "volumen" => "63"
                        "paginaInicial" => "2247"
                        "paginaFinal" => "2252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2720574"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib51"
              "etiqueta" => "51&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proliferative verrucous leukoplakia&#46; A long-term study of thirty patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;S&#46; Hansen"
                            1 => "J&#46;A&#46; Olson"
                            2 => "S&#46;J&#46; Silverman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "1985"
                        "volumen" => "60"
                        "paginaInicial" => "285"
                        "paginaFinal" => "298"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib52"
              "etiqueta" => "52&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proliferative verrucous leukoplakia&#58; a follow up study of 54 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Silverman Jr"
                            1 => "M&#46; Gorsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "1968"
                        "volumen" => "84"
                        "paginaInicial" => "154"
                        "paginaFinal" => "157"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9269017"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib53"
              "etiqueta" => "53&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Verrucous hyperplasia or verrucous carcinoma&#46; An analysis of 27 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;J&#46; Slootweg"
                            1 => "H&#46; M&#252;ller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Maxillofac Surg"
                        "fecha" => "1983"
                        "volumen" => "11"
                        "paginaInicial" => "13"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6572683"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib54"
              "etiqueta" => "54&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The clinical features and risk of malignant transformation in sublingual keratosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "I&#46;R&#46; Kramer"
                            1 => "N&#46; el-Labban"
                            2 => "K&#46;W&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nr Dent J"
                        "fecha" => "1978"
                        "volumen" => "144"
                        "paginaInicial" => "171"
                        "paginaFinal" => "180"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib55"
              "etiqueta" => "55&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The permeability of human oral mucosa and skin to water"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;A&#46; Lesh"
                            1 => "C&#46;A&#46; Squier"
                            2 => "A&#46; Cruchley"
                            3 => "D&#46;M&#46; Williams"
                            4 => "P&#46; Speight"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dent Res"
                        "fecha" => "1989"
                        "volumen" => "68"
                        "paginaInicial" => "1345"
                        "paginaFinal" => "1349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2476469"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib56"
              "etiqueta" => "56&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral leukoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;J&#46; Sciubba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Rev Oral Biol Med"
                        "fecha" => "1995"
                        "volumen" => "6"
                        "paginaInicial" => "147"
                        "paginaFinal" => "160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7548621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib57"
              "etiqueta" => "57&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiologic and histologic study of oral cancer and leucoplasia among 50&#44;915 villagers in India"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46;S&#46; Mehta"
                            1 => "J&#46;J&#46; Pindborg"
                            2 => "P&#46;C&#46; Gupta"
                            3 => "D&#46;K&#46; Daftary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1996"
                        "volumen" => "24"
                        "paginaInicial" => "832"
                        "paginaFinal" => "849"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4898206"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib58"
              "etiqueta" => "58&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Occurrence of epithelial dysplasia in oral leukoplakia&#46; Analysis and follow-up study of 12 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; B&#225;n&#243;czy"
                            1 => "A&#46; Csiba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "1976"
                        "volumen" => "42"
                        "paginaInicial" => "766"
                        "paginaFinal" => "774"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib59"
              "etiqueta" => "59&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leucoplakia revisited&#46; A clinicopathologic study 3256 oral leukoplakias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;A&#46; Waldron"
                            1 => "W&#46;G&#46; Shafer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1975"
                        "volumen" => "36"
                        "paginaInicial" => "1386"
                        "paginaFinal" => "1392"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib60"
              "etiqueta" => "60&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant transformation and natural history of oral leucoplakia in 57&#44;518 workers on Gujarat&#44; India"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1976"
                        "volumen" => "38"
                        "paginaInicial" => "563"
                        "paginaFinal" => "568"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib61"
              "etiqueta" => "61&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leucoplakia&#44; dysplasia and malignant transformation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "1996"
                        "volumen" => "82"
                        "paginaInicial" => "117"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib62"
              "etiqueta" => "62&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant transformation of oral leukoplakia&#58; a follow up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Oncol"
                        "fecha" => "1998"
                        "volumen" => "34"
                        "paginaInicial" => "270"
                        "paginaFinal" => "275"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib63"
              "etiqueta" => "63&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Observer agreement in the grading of oral epithelial dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Community Dent Oral Epidemiol"
                        "fecha" => "2003"
                        "volumen" => "31"
                        "paginaInicial" => "300"
                        "paginaFinal" => "305"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib64"
              "etiqueta" => "64&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Observations on the clinical characteristics of oral lesions showing histologic epithelial dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "1972"
                        "volumen" => "33"
                        "paginaInicial" => "389"
                        "paginaFinal" => "399"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib65"
              "etiqueta" => "65&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follow up studies in oral leukoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Maxillofac Surg"
                        "fecha" => "1977"
                        "volumen" => "5"
                        "paginaInicial" => "69"
                        "paginaFinal" => "75"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib66"
              "etiqueta" => "66&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow up study of Indian villagers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Community Dent Oral Epidemiol"
                        "fecha" => "1980"
                        "volumen" => "6"
                        "paginaInicial" => "283"
                        "paginaFinal" => "333"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib67"
              "etiqueta" => "67&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potentially malignant oral lesions in northern Ireland&#58; a 20-year population-based perspective of malignant transformation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Dis"
                        "fecha" => "2001"
                        "volumen" => "7"
                        "paginaInicial" => "18"
                        "paginaFinal" => "24"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib68"
              "etiqueta" => "68&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Benign alveolar ridge keratosis &#40;oral lichen simplex chronicus&#41;&#58; A distinct clinicopathologic entity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2007.07.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "151"
                        "paginaFinal" => "157"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib69"
              "etiqueta" => "69&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is alveolar ridge keratosis a true leukoplakia&#63;&#58; A clinicopathologic comparison of 2&#44;153 lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Dent Assoc"
                        "fecha" => "2007"
                        "volumen" => "138"
                        "paginaInicial" => "641"
                        "paginaFinal" => "651"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib70"
              "etiqueta" => "70&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interventions for treating oral leukoplakia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2006"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib71"
              "etiqueta" => "71&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of oral epithelial dysplasia&#58; a review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.tripleo.2006.10.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "2007"
                        "volumen" => "103"
                        "numero" => "Suppl"
                        "paginaInicial" => "S19"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib72"
              "etiqueta" => "72&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment and prevention of intraepithelial neoplasia&#58; an important target for accelerated new agent development"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2002"
                        "volumen" => "8"
                        "paginaInicial" => "314"
                        "paginaFinal" => "346"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib73"
              "etiqueta" => "73&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predicting cancer development in oral leukoplakia&#58; ten years of translational research"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2000"
                        "volumen" => "6"
                        "paginaInicial" => "1702"
                        "paginaFinal" => "1710"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib74"
              "etiqueta" => "74&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A genetic explanation of Slaughter&#39;s concept of field cancerization&#58; evidence and clinical implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2003"
                        "volumen" => "63"
                        "paginaInicial" => "1727"
                        "paginaFinal" => "1730"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib75"
              "etiqueta" => "75&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemoprevention&#58; an essential approach to controlling cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Nat Rev Cancer"
                        "fecha" => "2002"
                        "paginaInicial" => "537"
                        "paginaFinal" => "543"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib76"
              "etiqueta" => "76&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cyclooxigenasae-2 &#40;COX-2&#41; expression in high risk premalignant lessions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Oncol"
                        "fecha" => "2003"
                        "volumen" => "39"
                        "paginaInicial" => "497"
                        "paginaFinal" => "505"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib77"
              "etiqueta" => "77&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suppression of prostaglandin E2 receptor subtype EP2 by PPAR-gamma ligand inhibits human lung carcinoma cell growth"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem Biophys Res Commun"
                        "fecha" => "2004"
                        "volumen" => "314"
                        "paginaInicial" => "1093"
                        "paginaFinal" => "1099"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib78"
              "etiqueta" => "78&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of epidermal growth factor receptor in head and neck squamous cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Oncol Rep"
                        "fecha" => "2003"
                        "volumen" => "5"
                        "paginaInicial" => "140"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib79"
              "etiqueta" => "79&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential expression of epidermal growth factor receptor inhuman head and neck cancers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Head Neck"
                        "fecha" => "1998"
                        "volumen" => "20"
                        "paginaInicial" => "320"
                        "paginaFinal" => "327"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            79 => array:3 [
              "identificador" => "bib80"
              "etiqueta" => "80&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early maskers of carcinogenesis in head and neck cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1993"
                        "volumen" => "53"
                        "paginaInicial" => "3579"
                        "paginaFinal" => "3584"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            80 => array:3 [
              "identificador" => "bib81"
              "etiqueta" => "81&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "1998"
                        "volumen" => "4"
                        "paginaInicial" => "13"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            81 => array:3 [
              "identificador" => "bib82"
              "etiqueta" => "82&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads for prolonged survival in a murine model of oral cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2003"
                        "volumen" => "9"
                        "paginaInicial" => "3183"
                        "paginaFinal" => "3189"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            82 => array:3 [
              "identificador" => "bib83"
              "etiqueta" => "83&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Combinatorial chemoprevention of intestinal neoplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/79534"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Med"
                        "fecha" => "2000"
                        "volumen" => "6"
                        "paginaInicial" => "1024"
                        "paginaFinal" => "1028"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            83 => array:3 [
              "identificador" => "bib84"
              "etiqueta" => "84&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cyclooxygenase-2 &#40;COX-2&#41;-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bcp.2003.12.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem Pharmacol"
                        "fecha" => "2004"
                        "volumen" => "67"
                        "paginaInicial" => "1469"
                        "paginaFinal" => "1478"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            84 => array:3 [
              "identificador" => "bib85"
              "etiqueta" => "85&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.bjc.6601505"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Cancer"
                        "fecha" => "2004"
                        "volumen" => "90"
                        "paginaInicial" => "224"
                        "paginaFinal" => "229"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            85 => array:3 [
              "identificador" => "bib86"
              "etiqueta" => "86&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cyclooxygenase-2 promotes human cholangiocarcinoma growth&#58; evidence forcyclooxygenase-2-independent mechanism in celecoxibmediated induction of p21waf1&#47;cip1 and p27kip1 and cell cycle arrest"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "64"
                        "paginaInicial" => "1369"
                        "paginaFinal" => "1376"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            86 => array:3 [
              "identificador" => "bib87"
              "etiqueta" => "87&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "3-phosphoinositide-dependent protein kinase l&#47;Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2004"
                        "volumen" => "64"
                        "paginaInicial" => "1444"
                        "paginaFinal" => "1451"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            87 => array:3 [
              "identificador" => "bib88"
              "etiqueta" => "88&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mc.20232"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Carcinog"
                        "fecha" => "2006"
                        "volumen" => "45"
                        "paginaInicial" => "447"
                        "paginaFinal" => "454"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            88 => array:3 [
              "identificador" => "bib89"
              "etiqueta" => "89&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early de novo gene expression is required for 15-deoxy-Delta 12&#44; 14-prostaglandin J2-induced apoptosis in breast cancer cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.C100339200"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2001"
                        "volumen" => "276"
                        "paginaInicial" => "47131"
                        "paginaFinal" => "47135"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            89 => array:3 [
              "identificador" => "bib90"
              "etiqueta" => "90&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1997"
                        "volumen" => "272"
                        "paginaInicial" => "3406"
                        "paginaFinal" => "3410"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010000000008/v1_201304241504/S1578219009701490/v1_201304241504/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6151"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Practical Dermatology"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000008/v1_201304241504/S1578219009701490/v1_201304241504/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701490?idApp=UINPBA000044"
]

Article information

ISSN: 15782190
Original language: English

DOI:10.1016/S1578-2190(09)70149-0

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	5	20	25
2024 October	60	219	279
2024 September	86	233	319
2024 August	128	223	351
2024 July	79	231	310
2024 June	93	236	329
2024 May	86	351	437
2024 April	64	174	238
2024 March	64	196	260
2024 February	60	248	308
2024 January	59	245	304
2023 December	67	253	320
2023 November	68	372	440
2023 October	51	272	323
2023 September	52	266	318
2023 August	47	161	208
2023 July	69	211	280
2023 June	65	190	255
2023 May	65	199	264
2023 April	29	126	155
2023 March	23	111	134
2023 February	21	104	125
2023 January	30	116	146
2022 December	35	121	156
2022 November	16	83	99
2022 October	16	107	123
2022 September	24	120	144
2022 August	11	79	90
2022 July	14	81	95
2022 June	10	101	111
2022 May	28	108	136
2022 April	32	190	222
2022 March	32	178	210
2022 February	26	129	155
2022 January	27	111	138
2021 December	29	87	116
2021 November	48	101	149
2021 October	35	110	145
2021 September	36	94	130
2021 August	34	68	102
2021 July	28	78	106
2021 June	36	71	107
2021 May	33	42	75
2021 April	50	99	149
2021 March	62	42	104
2021 February	59	39	98
2021 January	36	33	69
2020 December	21	26	47
2020 November	16	23	39
2020 October	29	23	52
2020 September	15	27	42
2020 August	18	25	43
2020 July	21	23	44
2020 June	23	47	70
2020 May	18	34	52
2020 April	23	30	53
2020 March	21	26	47
2020 February	0	5	5
2020 January	1	4	5
2019 December	0	15	15
2019 November	0	6	6
2019 October	0	7	7
2019 September	0	14	14
2019 August	0	10	10
2019 July	0	9	9
2019 June	0	8	8
2019 May	0	51	51
2019 April	0	17	17
2019 March	0	7	7
2019 February	0	3	3
2019 January	0	2	2
2018 November	0	2	2
2018 July	1	0	1
2018 June	0	2	2
2018 May	0	6	6
2018 April	0	83	83
2018 March	3	28	31
2018 February	28	111	139
2018 January	27	130	157
2017 December	39	182	221
2017 November	40	181	221
2017 October	25	162	187
2017 September	32	98	130
2017 August	48	113	161
2017 July	41	164	205
2017 June	49	178	227
2017 May	57	182	239
2017 April	38	140	178
2017 March	54	199	253
2017 February	29	194	223
2017 January	24	125	149
2016 December	37	213	250
2016 November	40	199	239
2016 October	51	172	223
2016 September	76	240	316
2016 August	127	128	255
2016 July	48	107	155
2016 June	13	79	92
2016 May	11	96	107
2016 April	8	1	9
2016 March	2	13	15
2016 February	4	11	15
2016 January	10	11	21
2015 December	6	10	16
2015 November	14	6	20
2015 October	10	5	15
2015 September	10	7	17
2015 August	9	1	10
2015 July	51	185	236
2015 June	62	89	151
2015 May	97	112	209
2015 April	64	163	227
2015 March	42	230	272
2015 February	49	235	284
2015 January	46	183	229
2014 December	58	203	261
2014 November	39	181	220
2014 October	71	173	244
2014 September	77	118	195
2014 August	67	135	202
2014 July	71	102	173
2014 June	68	78	146
2014 May	60	68	128
2014 April	74	15	89
2014 March	78	33	111
2014 February	77	41	118
2014 January	51	31	82
2013 December	50	30	80
2013 November	50	33	83
2013 October	41	62	103
2013 September	41	68	109
2013 August	38	80	118
2013 July	48	78	126
2013 June	39	69	108
2013 May	48	91	139
2013 April	42	87	129
2013 March	36	83	119
2013 February	33	56	89
2013 January	8	5	13

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter