Case report
Annular Plaques in the Skin Folds: 4 Cases of Lichen Planus Pigmentosus-Inversus
Placas Anulares en Grandes Pliegues: Cuatro Casos de Liquen Plano Pigmentoso-Inverso
A. Bennàssar
, A. Mas, M. Julià, P. Iranzo, J. Ferrando
Corresponding author
tbennassar@hotmail.com
Correspondence: Servicio de Dermatología, Hospital Clínic, C/ Villarroel, 170, 08036 Barcelona, Spain.
Correspondence: Servicio de Dermatología, Hospital Clínic, C/ Villarroel, 170, 08036 Barcelona, Spain.
Servicio de Dermatología, Hospital Clínic, Barcelona, Spain
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Bennàssar, A. Mas, M. Julià, P. Iranzo, J. Ferrando" "autores" => array:5 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Bennàssar" "email" => array:1 [ 0 => "tbennassar@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Mas" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Julià" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Iranzo" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Ferrando" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Clínic, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Clínic, C/ Villarroel, 170, 08036 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Placas Anulares en Grandes Pliegues: Cuatro Casos de Liquen Plano Pigmentoso-Inverso" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-11-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84532" "palabras" => array:3 [ 0 => "lichen planus" 1 => "lichen planus pigmentosus-inversus" 2 => "intertriginous location" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84531" "palabras" => array:3 [ 0 => "liquen plano" 1 => "liquen plano pigmentoso-inverso" 2 => "localización intertriginosa" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We report 4 patients with relatively asymptomatic, annular brownish plaques arising in the skin creases. The lesions had remained stable for months despite many topical treatments. Histological examination revealed an atrophic epidermis with a dermal lichenoid inflammatory infiltrate showing marked pigmentary incontinence. These clinical and pathological features were consistent with lichen planus pigmentosus-inversus, a rare, recently described variant of lichen planus, with only 10 cases reported to date. It has been suggested that the intensity and speed of onset of the inflammatory response could be modulated by keratinocyte surface markers, which could also determine the typical morphology of the lesions of this disease.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Describimos 4 pacientes que consultaron por placas paucisintomáticas anulares marronáceas localizadas en grandes pliegues. Dichas placas habían permanecido estables durante meses, a pesar de haber intentado múltiples tratamientos tópicos. Histológicamente se objetivó una epidermis atrófica, así como un inflamatorio liquenoide dérmico con marcada incontinencia de pigmento. Estos cuadros eran clínica e histológicamente compatibles con el diagnóstico de liquen plano pigmentoso-inverso (LPP-inv). El LPP-inv es una rara variedad de liquen plano recientemente descrita del que solamente se han comunicado con anterioridad 10 casos. Se ha postulado que la intensidad y la rapidez con que se establece la respuesta inflamatoria podría estar modulada por marcadores de la superficie de los queratinocitos, que a su vez determinaría la morfología típica de las lesiones de LPP-inv.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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