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Experience in the Treatment of Cutaneous In-Transit Melanoma Metastases and Satellitosis With Intralesional Interleukin-2
Esperiencia en el Tratamiento de Satelitosis y Metástasis Cutáneas en Tránsuito de Melanoma con Interleucina 2 Intralesional
L.A. Dehesa, J. Vilar-Alejo, P. Valerón-Almazán, G. Carretero
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gcarher@gobiernodecanarias.org
Correspondence: Servicio de Dermatología. Hospital Universitario de Gran Canaria Dr. Negrín. Barranco de La Ballena, s/n. 35012 Las Palmas de Gran Canaria, Spain.
Correspondence: Servicio de Dermatología. Hospital Universitario de Gran Canaria Dr. Negrín. Barranco de La Ballena, s/n. 35012 Las Palmas de Gran Canaria, Spain.
Servicio de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
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Carretero" "autores" => array:4 [ 0 => array:2 [ "nombre" => "L.A." "apellidos" => "Dehesa" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Vilar-Alejo" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Valerón-Almazán" ] 3 => array:4 [ "nombre" => "G." "apellidos" => "Carretero" "email" => array:1 [ 0 => "gcarher@gobiernodecanarias.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología. Hospital Universitario de Gran Canaria Dr. Negrín. Barranco de La Ballena, s/n. 35012 Las Palmas de Gran Canaria, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Esperiencia en el Tratamiento de Satelitosis y Metástasis Cutáneas en Tránsuito de Melanoma con Interleucina 2 Intralesional" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-10-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84538" "palabras" => array:4 [ 0 => "interleukin 2" 1 => "malignant melanoma" 2 => "cutaneous metastasis" 3 => "intralesional therapy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84537" "palabras" => array:4 [ 0 => "interleucina 2" 1 => "melanoma maligno" 2 => "metástasis cutáneas" 3 => "terapia intralesional" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Although metastatic melanoma has a poor prognosis, cutaneous metastases represent a special case given their ready accessibility, making it possible for dermatologists to apply local treatment. We report our experience with intralesional treatment with interleukin (IL) 2 in 7 patients with cutaneous metastases from malignant melanoma.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A total of 244 lesions in 7 patients with satellitosis and/or cutaneous metastases from malignant melanoma were treated with intralesional IL-2 twice a week. The maximum dose in each patient ranged from 3 to 18 million units per session, according to the number and size of lesions.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Complete or partial remission was achieved in almost all lesions (95.9% and 3.7%, respectively). Only 1 lesion (0.4%)—the largest and located subcutaneously—did not respond to intralesional treatment and required alcoholization and subsequent surgical removal to achieve cure. All partial responses occurred in subcutaneous lesions larger than 2 cm. Treatment was well tolerated with only a few mild side effects (grade 1-2).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">IL-2 may be an effective and well-tolerated treatment option in patients with satellitosis and cutaneous metastases from melanoma. Lesions smaller than 2 cm and located in the epidermis or superficial dermis respond better than those larger than 2 cm or located in the subcutaneous cellular tissue. More studies are necessary to establish appropriate doses and regimens.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">A pesar del mal pronóstico del melanoma metastásico, las metástasis cutáneas constituyen un grupo especial por su fácil accesibilidad que lo hace susceptible al abordaje local por parte del dermatólogo. Describimos nuestra experiencia de tratamiento intralesional con interleucina 2 (IL-2) en 7 pacientes con metástasis cutáneas de melanoma maligno.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Un total de 244 lesiones en 7 pacientes con satelitosis y/o metástasis cutáneas de melanoma maligno han sido tratadas con IL-2 intralesional administrada dos veces a la semana. Las dosis máximas por pacientes variaron entre los 3 y 18 millones de unidades/sesión, en función del número y tamaño de las lesiones.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se han obtenido remisiones completas (95,9%) o parciales (3,7%) en la gran mayoría de lesiones tratadas, una sola lesión (0,4%), de localización subcutánea y de mayor tamaño, no respondió al tratamiento intralesional y precisó de alcoholización y posterior extirpación quirúrgica para su resolución. Todas las respuestas parciales se observaron en lesiones de localización subcutánea y mayores de 2 cm. El tratamiento fue bien tolerado, con escasos efectos secundarios de intensidad leve (grado 1-2).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La IL-2 puede ser una buena opción para el tratamiento de pacientes con satelitosis y metástasis cutáneas de melanoma con elevada eficacia y escasos efectos secundarios. Las lesiones menores de 2 cm y localizadas en epidermis o dermis superficial responden mejor que las mayores de 2 cm o localizadas en el tejido celular subcutáneo. Son necesarios más estudios para establecer las dosis y pautas de tratamiento adecuadas.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2022 January | 26 | 48 | 74 |
| 2021 December | 24 | 48 | 72 |
| 2021 November | 30 | 46 | 76 |
| 2021 October | 38 | 54 | 92 |
| 2021 September | 27 | 44 | 71 |
| 2021 August | 23 | 35 | 58 |
| 2021 July | 15 | 37 | 52 |
| 2021 June | 25 | 29 | 54 |
| 2021 May | 21 | 18 | 39 |
| 2021 April | 42 | 80 | 122 |
| 2021 March | 39 | 17 | 56 |
| 2021 February | 50 | 25 | 75 |
| 2021 January | 30 | 21 | 51 |
| 2020 December | 41 | 15 | 56 |
| 2020 November | 28 | 13 | 41 |
| 2020 October | 15 | 11 | 26 |
| 2020 September | 26 | 16 | 42 |
| 2020 August | 31 | 17 | 48 |
| 2020 July | 27 | 13 | 40 |
| 2020 June | 20 | 20 | 40 |
| 2020 May | 20 | 18 | 38 |
| 2020 April | 25 | 9 | 34 |
| 2020 March | 20 | 21 | 41 |
| 2020 February | 0 | 3 | 3 |
| 2020 January | 0 | 8 | 8 |
| 2019 December | 0 | 9 | 9 |
| 2019 November | 0 | 2 | 2 |
| 2019 September | 0 | 5 | 5 |
| 2019 July | 0 | 16 | 16 |
| 2019 June | 0 | 6 | 6 |
| 2019 May | 0 | 49 | 49 |
| 2019 April | 0 | 3 | 3 |
| 2019 March | 0 | 5 | 5 |
| 2019 February | 0 | 3 | 3 |
| 2018 April | 0 | 1 | 1 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 15 | 7 | 22 |
| 2018 January | 21 | 5 | 26 |
| 2017 December | 17 | 11 | 28 |
| 2017 November | 23 | 12 | 35 |
| 2017 October | 16 | 8 | 24 |
| 2017 September | 19 | 16 | 35 |
| 2017 August | 29 | 15 | 44 |
| 2017 July | 31 | 10 | 41 |
| 2017 June | 24 | 41 | 65 |
| 2017 May | 21 | 18 | 39 |
| 2017 April | 35 | 19 | 54 |
| 2017 March | 46 | 33 | 79 |
| 2017 February | 28 | 22 | 50 |
| 2017 January | 29 | 20 | 49 |
| 2016 December | 41 | 21 | 62 |
| 2016 November | 14 | 16 | 30 |
| 2016 October | 31 | 22 | 53 |
| 2016 September | 38 | 21 | 59 |
| 2016 August | 39 | 23 | 62 |
| 2016 July | 33 | 19 | 52 |
| 2016 June | 13 | 13 | 26 |
| 2016 May | 13 | 19 | 32 |
| 2016 April | 7 | 22 | 29 |
| 2016 March | 9 | 25 | 34 |
| 2016 February | 7 | 25 | 32 |
| 2016 January | 4 | 26 | 30 |
| 2015 December | 10 | 21 | 31 |
| 2015 November | 10 | 1 | 11 |
| 2015 October | 10 | 30 | 40 |
| 2015 September | 7 | 19 | 26 |
| 2015 August | 14 | 8 | 22 |
| 2015 July | 40 | 24 | 64 |
| 2015 June | 41 | 39 | 80 |
| 2015 May | 80 | 37 | 117 |
| 2015 April | 29 | 29 | 58 |
| 2015 March | 30 | 20 | 50 |
| 2015 February | 24 | 35 | 59 |
| 2015 January | 31 | 29 | 60 |
| 2014 December | 28 | 20 | 48 |
| 2014 November | 22 | 18 | 40 |
| 2014 October | 27 | 17 | 44 |
| 2014 September | 33 | 18 | 51 |
| 2014 August | 31 | 26 | 57 |
| 2014 July | 43 | 35 | 78 |
| 2014 June | 28 | 8 | 36 |
| 2014 May | 45 | 13 | 58 |
| 2014 April | 48 | 8 | 56 |
| 2014 March | 49 | 27 | 76 |
| 2014 February | 43 | 26 | 69 |
| 2014 January | 37 | 18 | 55 |
| 2013 December | 36 | 13 | 49 |
| 2013 November | 30 | 18 | 48 |
| 2013 October | 39 | 30 | 69 |
| 2013 September | 33 | 29 | 62 |
| 2013 August | 28 | 45 | 73 |
| 2013 July | 38 | 91 | 129 |
| 2013 June | 27 | 45 | 72 |
| 2013 May | 30 | 42 | 72 |
| 2013 April | 29 | 37 | 66 |
| 2013 March | 32 | 28 | 60 |
| 2013 February | 26 | 13 | 39 |
| 2013 January | 9 | 3 | 12 |
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