Original article
Sentinel Node Biopsy as a Prognostic Factor in Cutaneous Melanoma
Biopsia del Ganglio Centinela como Factor Pronóstico en el Melanoma Cutáneo
J.A. Avilés-Izquierdo
, P. Lázaro-Ochaita
Corresponding author
dermaviles@yahoo.es
Correspondence: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo, 46, 28007 Madrid, Spain.
Correspondence: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo, 46, 28007 Madrid, Spain.
Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Arranz-Sánchez, Á. Pizarro, J.L. Valencia-Delfa, M. Villeta-López, M.J. González-Beato, M. Mayor-Arenal, M. Casado-Jiménez" "autores" => array:7 [ 0 => array:2 [ "nombre" => "D.M." "apellidos" => "Arranz-Sánchez" ] 1 => array:2 [ "nombre" => "Á." "apellidos" => "Pizarro" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "Valencia-Delfa" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Villeta-López" ] 4 => array:2 [ "nombre" => "M.J." "apellidos" => "González-Beato" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Mayor-Arenal" ] 6 => array:2 [ "nombre" => "M." "apellidos" => "Casado-Jiménez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701040?idApp=UINPBA000044" "url" => "/15782190/0000010000000006/v1_201304241459/S1578219009701040/v1_201304241459/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Sentinel Node Biopsy as a Prognostic Factor in Cutaneous Melanoma" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "486" "paginaFinal" => "492" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.A. Avilés-Izquierdo, P. Lázaro-Ochaita" "autores" => array:2 [ 0 => array:4 [ "nombre" => "J.A." "apellidos" => "Avilés-Izquierdo" "email" => array:1 [ 0 => "dermaviles@yahoo.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Lázaro-Ochaita" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo, 46, 28007 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Biopsia del Ganglio Centinela como Factor Pronóstico en el Melanoma Cutáneo" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-11-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84521" "palabras" => array:4 [ 0 => "melanoma" 1 => "sentinel node biopsy" 2 => "epidemiology" 3 => "survival" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84522" "palabras" => array:4 [ 0 => "melanoma" 1 => "ganglio centinela" 2 => "epidemiología" 3 => "supervivencia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of sentinel node biopsy (SNB) is to identify subclinical lymph node metastases using a procedure with minimal morbidity, establish more accurate staging in patients with melanoma, determine prognosis, and choose the most suitable treatment in each patient.</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To analyze the outcomes of SNB in patients with cutaneous melanoma, and the impact of this procedure on survival.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Information was gathered retrospectively on all patients in whom this procedure was performed at Hospital General Universitario Gregorio Marañón, Madrid, Spain, over an 11-year period (1997-2007). Descriptive epidemiological analysis of the variables and survival analysis were performed.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Sentinel node invasion by melanoma was present in 42 of 238 patients (17.6%). Tumor thickness and nodular melanomas were associated with the presence of lymph node micrometastases. There were no differences in overall survival, but disease-free survival was significantly lower in patients with a positive SNB, who also had a higher melanoma-related mortality.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Detection of lymph node micrometastases by sentinel node biopsy is a marker of tumor aggressiveness and an important prognostic factor in melanoma patients. Information from SNB permits better staging and determines the diagnostic and therapeutic approach in these patients.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La biopsia del ganglio centinela (BGC) persigue la identificación de metástasis ganglionares subclínicas con una morbilidad mínima, una estadificación más precisa de los pacientes con melanoma, estimar el pronóstico de estos pacientes y adoptar el tratamiento más adecuado en cada caso.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Analizar los resultados obtenidos con esta técnica en pacientes con melanoma cutáneo y el impacto de la misma en su supervivencia.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se obtuvieron de forma retrospectiva los datos referentes a todos los pacientes a los que se les realizó esta técnica en el Hospital General Universitario Gregorio Marañón de Madrid durante 11 años (1997-2007). Se realizó un estudio epidemiológico descriptivo y un estudio analítico del impacto en la supervivencia.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En 42 de 238 casos (17,6%) se encontró afectación del ganglio centinela por melanoma. El espesor tumoral y el tipo histológico nodular se asociaron a la presencia de micrometástasis ganglionares. Aunque el resultado del ganglio centinela no se asoció con una mayor supervivencia global, el tiempo libre de enfermedad fue significativamente inferior en los pacientes con ganglio centinela positivo, que además presentaron una mayor tasa de mortalidad por melanoma.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La detección de micrometástasis ganglionares gracias a la BGC supone un marcador de agresividad y un importante factor pronóstico en los pacientes con melanoma. La información que nos aporta esta técnica nos permite una mejor estadificación, determinando la actitud diagnóstica y terapéutica a seguir en estos pacientes.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Gershenwald" 1 => "W. Thompson" 2 => "P.F. Mansfield" 3 => "J.E. Lee" 4 => "M.I. Colome" 5 => "C.H. Tseng" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1999.17.3.976" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1999" "volumen" => "17" "paginaInicial" => "976" "paginaFinal" => "983" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10071292" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reliability of lymphoscintigraphy in indicating the number of sentinel nodes in melanoma patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Jansen" 1 => "O.E. Nieweg" 2 => "A.E. Kapteijn" 3 => "R.A. Valdés Olmos" 4 => "S.H. Muller" 5 => "C.A. Hoefnagel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2000" "volumen" => "7" "paginaInicial" => "624" "paginaFinal" => "630" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11005562" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small cell melanoma and ulceration as predictors of positive sentinel lymph node in malignant melanoma patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.A. Cuéllar" 1 => "A. Vilalta" 2 => "R. Rull" 3 => "S. Vidal-Sicart" 4 => "J. Palou" 5 => "P.J. Ventura" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Melanoma Res" "fecha" => "2004" "volumen" => "14" "paginaInicial" => "277" "paginaFinal" => "282" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15305158" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of sentinel node metastasis in patients with thin primary melanoma (< or = 1 mm) with vertical growth phase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Bedrosian" 1 => "M.B. Faries" 2 => "D. Guerry 4th" 3 => "R. Elenitsas" 4 => "L. Schuchter" 5 => "R. Mick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2000" "volumen" => "7" "paginaInicial" => "262" "paginaFinal" => "267" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10819365" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multivariate analysis of the relationship between survival and the microstage of primary melanoma by Clark level and Breslow thickness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.L. Morton" 1 => "D.G. Davtyan" 2 => "L.A. Wanek" 3 => "L.J. Foshag" 4 => "A.J. Cochran" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1993" "volumen" => "71" "paginaInicial" => "3737" "paginaFinal" => "3743" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8490924" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sentinel node biopsy: not only a staging tool?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Essner" 1 => "A.J. Cochran" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Recent Results Cancer Res" "fecha" => "2002" "volumen" => "160" "paginaInicial" => "133" "paginaFinal" => "148" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12079207" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sentinel node biopsy and selective dissection for melanoma nodal metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Belli" 1 => "L. Lenisa" 2 => "C. Clemente" 3 => "G. Tragni" 4 => "L. Mascheroni" 5 => "G. Gallino" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Tumori" "fecha" => "1998" "volumen" => "84" "paginaInicial" => "24" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9619709" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immediate or delayed dissection of regional nodes inpatients with melanoma of the trunk: a randomised trial. WHO Melanoma Programme" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Cascinelli" 1 => "A. Morabito" 2 => "M. Santinami" 3 => "R.M. MacKie" 4 => "F. Belli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1998" "volumen" => "351" "paginaInicial" => "793" "paginaFinal" => "796" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9519951" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphatic mapping and sentinel lymphadenectomy for breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.C. Kelley" 1 => "N. Hansen" 2 => "K.M. McMasters" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjsurg.2003.10.028" "Revista" => array:6 [ "tituloSerie" => "Am J Surg" "fecha" => "2004" "volumen" => "188" "paginaInicial" => "49" "paginaFinal" => "61" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15219485" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Value of sentinel lymphadenectomy in head and neck cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.A. Werner" 1 => "A.A. Dünne" 2 => "B.J. Folz" 3 => "R. Moll" 4 => "T. Behr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2004" "volumen" => "11" "numero" => "3 Suppl" "paginaInicial" => "267S" "paginaFinal" => "270S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15023766" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Invasive penile carcinoma: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Micali" 1 => "M.R. Nasca" 2 => "D. Innocenzi" 3 => "R.A. Schwartz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2004" "volumen" => "30" "paginaInicial" => "311" "paginaFinal" => "320" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14871226" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sentinel node in gastric cancer surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Carlini" 1 => "F. Carboni" 2 => "M. Petric" 3 => "R. Santoro" 4 => "F. Guadagni" 5 => "F. Marandino" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Clin Cancer Res" "fecha" => "2002" "volumen" => "21" "paginaInicial" => "469" "paginaFinal" => "473" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12636091" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of colon and rectal cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Blumberg" 1 => "R.K. Ramanathan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Gastroenterol" "fecha" => "2002" "volumen" => "34" "paginaInicial" => "15" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11743241" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sentinel node mapping in lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.J. Liptay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2004" "volumen" => "11" "numero" => "3 Suppl" "paginaInicial" => "271S" "paginaFinal" => "274S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15023767" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reassessing the role of lymphatic mapping and sentinel lymphadenectomy in the management of cutaneous malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.E. Perrott" 1 => "L.F. Glass" 2 => "D.S. Reintgen" 3 => "N.A. Fenske" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2003" "volumen" => "49" "paginaInicial" => "567" "paginaFinal" => "588" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14512901" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sentinel lymph node biopsy for melanoma: how many radioactive nodes should be removed?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.M. McMasters" 1 => "D.S. Reintgen" 2 => "M.I. Ross" 3 => "S.L. Wong" 4 => "J.E. Gershenwald" 5 => "D.N. Krag" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2001" "volumen" => "8" "paginaInicial" => "192" "paginaFinal" => "197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11314933" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mapeo linfático y biopsia del ganglio centinela en el melanoma cutáneo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Lázaro Ochaita" 1 => "Á. Bittini Copano" 2 => "C. Bueno Marco" 3 => "J.L. Escat Cortés" 4 => "M. Lecona Echevarría" 5 => "S. Pérez Santos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2001" "volumen" => "92" "paginaInicial" => "319" "paginaFinal" => "333" "itemHostRev" => array:3 [ "pii" => "S0140673699061553" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphadenectomy in the management of stage I malignant melanoma: a prospective randomized study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.H. Sim" 1 => "W.F. Taylor" 2 => "D.J. Pritchard" 3 => "E.H. Soule" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mayo Clin Proc" "fecha" => "1986" "volumen" => "61" "paginaInicial" => "697" "paginaFinal" => "705" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3747613" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morbidity following prophylactic and therapeutic lymph node dissection for melanoma–a comparison" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Ingvar" 1 => "C. Erichsen" 2 => "P.E. Jonsson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Tumori" "fecha" => "1984" "volumen" => "70" "paginaInicial" => "529" "paginaFinal" => "533" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6531796" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between preoperative lympho scintigraphy and metastatic nodal disease sites in362 patients with cutaneous melanomas of the head and neck" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.H. De Wilt" 1 => "J.F. Thompson" 2 => "R.F. Uren" 3 => "V.S. Ka" 4 => "R.A. Scolyer" 5 => "W.H. McCarthy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "2004" "volumen" => "239" "paginaInicial" => "544" "paginaFinal" => "552" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15024316" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La biopsia del ganglio centinela: su papel diagnóstico y pronóstico en el melanoma maligno" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Mangas" 1 => "C. Paradelo" 2 => "J. Rex" 3 => "C. Ferrándiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Derm-Sif" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "331" "paginaFinal" => "348" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of sentinel lymphadenectomy in thin invasive cutaneous melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.J. Bleicher" 1 => "R. Essner" 2 => "L.J. Foshag" 3 => "L.A. Wanek" 4 => "D.L. Morton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2003.06.123" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "1326" "paginaFinal" => "1331" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12663722" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sentinel lymph node biopsy has no benefit for patients with primary cutaneous melanoma metastatic to a lymph node: an assertion based on comprehensive, critical analysis: part I" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N.S. Medalie" 1 => "A.B. Ackerman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2003" "volumen" => "25" "paginaInicial" => "399" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14501289" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "¿Por qué la biopsia del ganglio centinela no aumenta la supervivencia en pacientes con melanoma?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Pizarro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Derm-Sif" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "323" "paginaFinal" => "330" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sentinel lymph node biopsy in melanoma patients with clinically negative regional lymph nodes–one institution's experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Z.I. Nowecki" 1 => "P. Rutkowski" 2 => "A. Nasierowska-Guttmejer" 3 => "W. Ruka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.cmr.0000056207.78713.8b" "Revista" => array:6 [ "tituloSerie" => "Melanoma Res" "fecha" => "2003" "volumen" => "13" "paginaInicial" => "35" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12569283" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000006/v1_201304241459/S1578219009701052/v1_201304241459/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000006/v1_201304241459/S1578219009701052/v1_201304241459/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701052?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 2 | 6 |
| 2024 October | 56 | 42 | 98 |
| 2024 September | 48 | 34 | 82 |
| 2024 August | 69 | 54 | 123 |
| 2024 July | 52 | 44 | 96 |
| 2024 June | 55 | 40 | 95 |
| 2024 May | 46 | 42 | 88 |
| 2024 April | 46 | 30 | 76 |
| 2024 March | 46 | 48 | 94 |
| 2024 February | 50 | 41 | 91 |
| 2024 January | 41 | 43 | 84 |
| 2023 December | 46 | 29 | 75 |
| 2023 November | 47 | 40 | 87 |
| 2023 October | 31 | 32 | 63 |
| 2023 September | 37 | 23 | 60 |
| 2023 August | 25 | 22 | 47 |
| 2023 July | 42 | 56 | 98 |
| 2023 June | 41 | 25 | 66 |
| 2023 May | 35 | 22 | 57 |
| 2023 April | 14 | 8 | 22 |
| 2023 March | 22 | 26 | 48 |
| 2023 February | 19 | 30 | 49 |
| 2023 January | 26 | 40 | 66 |
| 2022 December | 28 | 46 | 74 |
| 2022 November | 15 | 31 | 46 |
| 2022 October | 13 | 35 | 48 |
| 2022 September | 11 | 46 | 57 |
| 2022 August | 14 | 32 | 46 |
| 2022 July | 16 | 32 | 48 |
| 2022 June | 12 | 24 | 36 |
| 2022 May | 21 | 29 | 50 |
| 2022 April | 29 | 48 | 77 |
| 2022 March | 30 | 65 | 95 |
| 2022 February | 17 | 29 | 46 |
| 2022 January | 19 | 39 | 58 |
| 2021 December | 13 | 40 | 53 |
| 2021 November | 30 | 40 | 70 |
| 2021 October | 22 | 55 | 77 |
| 2021 September | 14 | 32 | 46 |
| 2021 August | 8 | 24 | 32 |
| 2021 July | 14 | 29 | 43 |
| 2021 June | 12 | 31 | 43 |
| 2021 May | 12 | 13 | 25 |
| 2021 April | 19 | 39 | 58 |
| 2021 March | 53 | 16 | 69 |
| 2021 February | 25 | 26 | 51 |
| 2021 January | 21 | 16 | 37 |
| 2020 December | 32 | 12 | 44 |
| 2020 November | 24 | 11 | 35 |
| 2020 October | 13 | 14 | 27 |
| 2020 September | 34 | 8 | 42 |
| 2020 August | 13 | 13 | 26 |
| 2020 July | 21 | 15 | 36 |
| 2020 June | 17 | 14 | 31 |
| 2020 May | 11 | 19 | 30 |
| 2020 April | 39 | 13 | 52 |
| 2020 March | 13 | 11 | 24 |
| 2020 February | 0 | 6 | 6 |
| 2020 January | 0 | 6 | 6 |
| 2019 December | 0 | 7 | 7 |
| 2019 September | 0 | 1 | 1 |
| 2019 June | 0 | 2 | 2 |
| 2019 May | 1 | 44 | 45 |
| 2019 March | 0 | 7 | 7 |
| 2019 February | 0 | 5 | 5 |
| 2018 November | 0 | 1 | 1 |
| 2018 October | 0 | 1 | 1 |
| 2018 June | 0 | 1 | 1 |
| 2018 February | 9 | 3 | 12 |
| 2018 January | 16 | 3 | 19 |
| 2017 December | 17 | 5 | 22 |
| 2017 November | 14 | 2 | 16 |
| 2017 October | 12 | 4 | 16 |
| 2017 September | 19 | 3 | 22 |
| 2017 August | 23 | 7 | 30 |
| 2017 July | 23 | 3 | 26 |
| 2017 June | 31 | 6 | 37 |
| 2017 May | 27 | 4 | 31 |
| 2017 April | 23 | 7 | 30 |
| 2017 March | 24 | 5 | 29 |
| 2017 February | 11 | 5 | 16 |
| 2017 January | 9 | 9 | 18 |
| 2016 December | 21 | 9 | 30 |
| 2016 November | 27 | 6 | 33 |
| 2016 October | 25 | 15 | 40 |
| 2016 September | 28 | 5 | 33 |
| 2016 August | 24 | 4 | 28 |
| 2016 July | 18 | 4 | 22 |
| 2016 June | 13 | 5 | 18 |
| 2016 May | 6 | 6 | 12 |
| 2016 April | 9 | 23 | 32 |
| 2016 March | 5 | 2 | 7 |
| 2016 February | 6 | 2 | 8 |
| 2016 January | 7 | 1 | 8 |
| 2015 December | 9 | 0 | 9 |
| 2015 November | 10 | 1 | 11 |
| 2015 October | 7 | 3 | 10 |
| 2015 September | 3 | 3 | 6 |
| 2015 August | 12 | 4 | 16 |
| 2015 July | 43 | 5 | 48 |
| 2015 June | 42 | 6 | 48 |
| 2015 May | 60 | 20 | 80 |
| 2015 April | 33 | 7 | 40 |
| 2015 March | 22 | 10 | 32 |
| 2015 February | 29 | 11 | 40 |
| 2015 January | 31 | 16 | 47 |
| 2014 December | 16 | 4 | 20 |
| 2014 November | 16 | 11 | 27 |
| 2014 October | 34 | 10 | 44 |
| 2014 September | 32 | 11 | 43 |
| 2014 August | 34 | 22 | 56 |
| 2014 July | 49 | 17 | 66 |
| 2014 June | 41 | 10 | 51 |
| 2014 May | 31 | 17 | 48 |
| 2014 April | 37 | 11 | 48 |
| 2014 March | 39 | 19 | 58 |
| 2014 February | 23 | 14 | 37 |
| 2014 January | 28 | 12 | 40 |
| 2013 December | 26 | 7 | 33 |
| 2013 November | 32 | 16 | 48 |
| 2013 October | 25 | 10 | 35 |
| 2013 September | 44 | 16 | 60 |
| 2013 August | 30 | 37 | 67 |
| 2013 July | 62 | 29 | 91 |
| 2013 June | 28 | 38 | 66 |
| 2013 May | 27 | 18 | 45 |
| 2013 April | 43 | 33 | 76 |
| 2013 March | 40 | 26 | 66 |
| 2013 February | 29 | 11 | 40 |
| 2013 January | 7 | 3 | 10 |
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