Original articles
Multiple Primary Melanoma
Melanoma Primario Múltiple
J.R. Ferreresa,
, A. Morenob,1, J. Marcovala
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joseramonferreresriera@yahoo.es
Correspondence: Servicio de Dermatología, Hospital de Bellvitge, C/ Feixa Llarga, s/n, 08907 Hospitalet de Llobregat, Barcelona, Spain.
Correspondence: Servicio de Dermatología, Hospital de Bellvitge, C/ Feixa Llarga, s/n, 08907 Hospitalet de Llobregat, Barcelona, Spain.
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"apellidos" => "García-Patos" ] 12 => array:1 [ "colaborador" => "for the Spanish Psoriasis Group of the Spanish Academy of Dermatology and Venereology" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700861?idApp=UINPBA000044" "url" => "/15782190/0000010000000005/v1_201304241456/S1578219009700861/v1_201304241456/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Multiple Primary Melanoma" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "414" "paginaFinal" => "419" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.R. Ferreres, A. Moreno, J. Marcoval" "autores" => array:3 [ 0 => array:4 [ "nombre" => "J.R." "apellidos" => "Ferreres" "email" => array:1 [ 0 => "joseramonferreresriera@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Moreno" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn1" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Marcoval" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital de Bellvitge, C/ Feixa Llarga, s/n, 08907 Hospitalet de Llobregat, Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Melanoma Primario Múltiple" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-09-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84492" "palabras" => array:4 [ 0 => "multiple" 1 => "melanoma" 2 => "Mediterranean" 3 => "Spain" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84491" "palabras" => array:4 [ 0 => "múltiple" 1 => "melanoma" 2 => "mediterránea" 3 => "España" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">The risk of multiple melanoma is estimated to be between 1% and 8%, with the majority of studies being carried out on North American populations. Our objective was to determine the risk and the clinical-pathological features of multiple primary melanoma in a Spanish Mediterranean population.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective study of the medical records and the database of the Melanoma Unit of Hospital de Bellvitge, Barcelona, Spain, between 1988 and 2005.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We found 25 cases of multiple primary melanoma among 934 patients studied, representing a risk of 2.6% in our population of melanoma patients. In 50% of cases, the second melanoma appeared during the first year of follow-up. These subsequent lesions occurred at a different site from the initial lesion in 58% of cases. In the majority of cases, lesions in a single patient showed similar cytological and architectural features. However, we did observe marked interindividual variability in the histology of multiple primary melanomas.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">Although the risk of a second melanoma in our population appears to be lower than in North American populations, it is not negligible. Melanoma patients must therefore be followed up for life, not only for the risk of metastases but also for the risk of a new primary tumor. Complete examination of the skin must be performed at each visit.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">El riesgo de melanoma múltiple se cifra aproximadamente entre un 1 y un 8%. La mayoría de los estudios se basan en población anglosajona. Nuestro objetivo es determinar el riesgo y las características clínicas e histológicas de los melanomas múltiples en una población mediterránea.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos realizado un estudio retrospectivo a partir de las historias clínicas y la base de datos de la Unidad de Melanoma del Hospital de Bellvitge (Barcelona) de los pacientes con melanoma diagnosticados entre 1988 y 2005.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos encontrado 25 pacientes con melanoma primario múltiple de entre los 934 pacientes estudiados, siendo el riesgo del 2,6% para nuestra población de pacientes con melanoma. El 50% de segundos melanomas aparecieron dentro del primer año de seguimiento. En el 58% de los casos el siguiente melanoma apareció en un área distinta al anterior. En la mayoría de los casos las características histológicas se mantuvieron, por lo que se refiere a la citología y el tipo de distribución arquitectural en los distintos melanomas de un mismo paciente. No observamos similitud histológica y sí una gran variabilidad interindividual de los melanomas primarios múltiples de distintos pacientes.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque en la población mediterránea el riesgo de padecer un segundo melanoma parece ser menor que en los anglosajones, éste no es despreciable. Por dicho motivo, los pacientes con melanoma deben ser seguidos de por vida no sólo por el riesgo de metástasis, sino por el de aparición de otros nuevos primarios, debiéndose de explorar todo el tegumento cutáneo en cada visita.</p>" ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara">Although Dr Abelardo Moreno passed away during the preparation of this manuscript, he was involved in the histologic evaluation of the multiple melanomas analyzed and in the drafting of the manuscript until the very last moment.</p>" "identificador" => "fn1" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Melanoma Study Group of the Mayo Clinic Cancer Center" "etal" => true "autores" => array:6 [ 0 => "S.N. Markovic" 1 => "L.A. Erickson" 2 => "R.D. Rao" 3 => "R.H. Weenig" 4 => "B.A. Pockaj" 5 => "A. Bardia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4065/82.3.364" "Revista" => array:6 [ "tituloSerie" => "Mayo Clin Proc" "fecha" => "2007" "volumen" => "82" "paginaInicial" => "364" "paginaFinal" => "380" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17352373" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolución del melanoma maligno cutáneo en los últimos 19 años en un hospital terciario de la cuenca mediterránea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Marcoval" 1 => "A. Moreno" 2 => "A. Torras" 3 => "E. Baumann" 4 => "J. Graells" 5 => "M.I. Gallego" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "464" "paginaFinal" => "468" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18558054" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiología del melanoma en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Sáenz" 1 => "J. Conejo-Mir" 2 => "A. Cayuela" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2005" "volumen" => "96" "paginaInicial" => "411" "paginaFinal" => "418" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476268" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Día del Euromelanoma. Resultados en España de las campañas de 2000, 2001 y 2002" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Conejo-Mir" 1 => "J. Bravo" 2 => "J.L. Díaz-Pérez" 3 => "J. Fernández-Herrera" 4 => "C. Guillén" 5 => "R. Martí" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2005" "volumen" => "96" "paginaInicial" => "217" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476371" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Características sociodemográficas del cáncer cutáneo en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Pérez-Suárez" 1 => "A. Guerra-Tapia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "119" "paginaFinal" => "126" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18346433" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efectividad del programa educativo escolar «SolSano» para la prevención del cáncer de piel" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Gilaberte Calzada" 1 => "M.P. Teruel Melero" 2 => "C. Pardos Martínez" 3 => "A. Pueyo Ascaso" 4 => "D. Doste Larrull" 5 => "C. Coscojuela Santaliestra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2002" "volumen" => "93" "paginaInicial" => "313" "paginaFinal" => "319" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Propuesta de protocolo para elinforme histológico del tumor primario de los pacientes con un melanoma cutáneo del Grupo de Trabajo para el Melanoma Cutáneo de la Comunidad Valenciana" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Nagore" 1 => "C. Monteagudo" 2 => "M.I. Pinazo" 3 => "R. Botella-Estrada" 4 => "V. Oliver" 5 => "J. Bañuls" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2007" "volumen" => "98" "paginaInicial" => "459" "paginaFinal" => "465" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17669299" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mapeo linfático y biopsia del ganglio centinela en el melanoma cutáneo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Lázaro Ochaíta" 1 => "A. Bittini Copano" 2 => "C. Bueno Marco" 3 => "J.L. Escat Cortés" 4 => "M. Lecona Echevarría" 5 => "S. Pérez Santos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2001" "volumen" => "92" "paginaInicial" => "319" "paginaFinal" => "333" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pronóstico del melanoma cutáneo según el servicio quirúrgico: estudio comparativo en un hospital de tercer nivel" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Avilés" 1 => "P. Lázaro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2006" "volumen" => "97" "paginaInicial" => "247" "paginaFinal" => "252" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16801017" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current therapy for cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T.M. Johnson" 1 => "J.W. Smith 2nd" 2 => "B.R. Nelson" 3 => "A. Chang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1995" "volumen" => "32" "paginaInicial" => "689" "paginaFinal" => "707" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7722012" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Second cancer following cutaneous melanoma and cancers of the brain, thyroid, connective tissue, bone, and eye in Connecticut, 1935-82" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.A. Tucker" 1 => "J.D. Boice Jr" 2 => "D.A. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Natl Cancer Inst Monogr" "fecha" => "1985" "volumen" => "68" "paginaInicial" => "161" "paginaFinal" => "189" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4088297" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple primary melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.M. Johnson" 1 => "T. Hamilton" 2 => "L. Lowe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1998" "volumen" => "39" "paginaInicial" => "422" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9738776" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple primary melanoma: two-year results from a population-based study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Titus-Ernstoff" 1 => "A.E. Perry" 2 => "S.K. Spencer" 3 => "J. Gibson" 4 => "J. Ding" 5 => "B. Cole" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.142.4.433" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2006" "volumen" => "142" "paginaInicial" => "433" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16618861" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of the CDKN2A locus in patients with multiple primary melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Puig" 1 => "J. Malvehy" 2 => "C. Badenas" 3 => "A. Ruiz" 4 => "D. Jiménez" 5 => "F. Cuellar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2005.08.034" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "3043" "paginaFinal" => "3051" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15860862" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of the CDKN2A and CDK4 genes and HLA-DR and HLA-DQ alleles in two Spanish familial melanoma kindreds" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Nagore" 1 => "J. Climent" 2 => "M.D. Planelles" 3 => "E. Ledesma" 4 => "F. Rubio-Moscardó" 5 => "J.M. Fortea" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2000" "volumen" => "80" "paginaInicial" => "440" "paginaFinal" => "442" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11243640" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The importance of self-examination in the earliest diagnosis of multiple primary cutaneous melanomas: a report of 47 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.M. Manganoni" 1 => "C. Farisoglio" 2 => "G. Tucci" 3 => "F. Facchetti" 4 => "P.G. Calzavara Pinton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2007.02263.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2007" "volumen" => "21" "paginaInicial" => "1333" "paginaFinal" => "1336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17958838" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple primary melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.J. Stam-Posthuma" 1 => "C. van Duinen" 2 => "E. Scheffer" 3 => "J. Vink" 4 => "W. Bergman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2001" "volumen" => "44" "paginaInicial" => "22" "paginaFinal" => "27" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11148472" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predisposición genética en el melanoma cutáneo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Avilés" 1 => "P. Lázaro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2006" "volumen" => "97" "paginaInicial" => "229" "paginaFinal" => "240" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16801015" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A population-based analysis of risk factors for a second primary cutaneous melanoma among melanoma survivors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W.B. Goggins" 1 => "H. Tsao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.11116" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2003" "volumen" => "97" "paginaInicial" => "639" "paginaFinal" => "643" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12548605" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Second primary tumors in patients with cutaneous malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Bhatia" 1 => "L. Estrada-Batres" 2 => "T. Maryon" 3 => "M. Bogue" 4 => "D. Chu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1999" "volumen" => "86" "paginaInicial" => "2014" "paginaFinal" => "2020" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10570426" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple primary cutaneous melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Kang" 1 => "R.L. Barnhill" 2 => "M.C. Mihm Jr" 3 => "A.J. Sober" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1992" "volumen" => "70" "paginaInicial" => "1911" "paginaFinal" => "1916" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1525766" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio dermoscópico del melanoma maligno cutáneo: análisis descriptivo de 45 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. de Troya-Martín" 1 => "N. Blázquez-Sánchez" 2 => "I. Fernández-Canedo" 3 => "M. Frieyro-Elicegui" 4 => "R. Fúnez-Liébana" 5 => "F. Rivas-Ruiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "44" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18206086" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplicaciones clínicas de la microscopía confocal de reflectancia en el manejo de los tumores cutáneos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "ActasDermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "528" "paginaFinal" => "531" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000005/v1_201304241456/S1578219009700873/v1_201304241456/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000005/v1_201304241456/S1578219009700873/v1_201304241456/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700873?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 2 | 4 |
| 2024 October | 66 | 40 | 106 |
| 2024 September | 64 | 46 | 110 |
| 2024 August | 92 | 66 | 158 |
| 2024 July | 64 | 50 | 114 |
| 2024 June | 63 | 37 | 100 |
| 2024 May | 47 | 36 | 83 |
| 2024 April | 55 | 31 | 86 |
| 2024 March | 65 | 41 | 106 |
| 2024 February | 64 | 42 | 106 |
| 2024 January | 52 | 46 | 98 |
| 2023 December | 38 | 36 | 74 |
| 2023 November | 30 | 47 | 77 |
| 2023 October | 51 | 39 | 90 |
| 2023 September | 37 | 43 | 80 |
| 2023 August | 25 | 20 | 45 |
| 2023 July | 38 | 46 | 84 |
| 2023 June | 37 | 35 | 72 |
| 2023 May | 39 | 30 | 69 |
| 2023 April | 30 | 37 | 67 |
| 2023 March | 30 | 45 | 75 |
| 2023 February | 21 | 34 | 55 |
| 2023 January | 34 | 42 | 76 |
| 2022 December | 33 | 41 | 74 |
| 2022 November | 12 | 28 | 40 |
| 2022 October | 16 | 32 | 48 |
| 2022 September | 15 | 43 | 58 |
| 2022 August | 17 | 43 | 60 |
| 2022 July | 16 | 51 | 67 |
| 2022 June | 14 | 36 | 50 |
| 2022 May | 27 | 53 | 80 |
| 2022 April | 32 | 43 | 75 |
| 2022 March | 32 | 61 | 93 |
| 2022 February | 27 | 41 | 68 |
| 2022 January | 28 | 38 | 66 |
| 2021 December | 27 | 47 | 74 |
| 2021 November | 28 | 47 | 75 |
| 2021 October | 35 | 54 | 89 |
| 2021 September | 20 | 52 | 72 |
| 2021 August | 15 | 27 | 42 |
| 2021 July | 29 | 41 | 70 |
| 2021 June | 24 | 36 | 60 |
| 2021 May | 18 | 26 | 44 |
| 2021 April | 53 | 91 | 144 |
| 2021 March | 72 | 17 | 89 |
| 2021 February | 65 | 21 | 86 |
| 2021 January | 41 | 6 | 47 |
| 2020 December | 44 | 16 | 60 |
| 2020 November | 28 | 12 | 40 |
| 2020 October | 18 | 5 | 23 |
| 2020 September | 40 | 24 | 64 |
| 2020 August | 29 | 20 | 49 |
| 2020 July | 25 | 3 | 28 |
| 2020 June | 31 | 22 | 53 |
| 2020 May | 21 | 26 | 47 |
| 2020 April | 27 | 19 | 46 |
| 2020 March | 27 | 26 | 53 |
| 2020 February | 2 | 4 | 6 |
| 2020 January | 0 | 6 | 6 |
| 2019 December | 0 | 6 | 6 |
| 2019 November | 0 | 2 | 2 |
| 2019 October | 0 | 2 | 2 |
| 2019 September | 0 | 4 | 4 |
| 2019 August | 0 | 4 | 4 |
| 2019 July | 0 | 3 | 3 |
| 2019 June | 0 | 7 | 7 |
| 2019 May | 1 | 99 | 100 |
| 2019 April | 0 | 47 | 47 |
| 2019 March | 0 | 9 | 9 |
| 2019 February | 0 | 13 | 13 |
| 2019 January | 0 | 5 | 5 |
| 2018 December | 0 | 1 | 1 |
| 2018 November | 0 | 1 | 1 |
| 2018 September | 0 | 2 | 2 |
| 2018 August | 0 | 12 | 12 |
| 2018 July | 0 | 10 | 10 |
| 2018 June | 0 | 8 | 8 |
| 2018 May | 0 | 6 | 6 |
| 2018 April | 0 | 9 | 9 |
| 2018 March | 0 | 10 | 10 |
| 2018 February | 15 | 8 | 23 |
| 2018 January | 22 | 19 | 41 |
| 2017 December | 15 | 13 | 28 |
| 2017 November | 19 | 13 | 32 |
| 2017 October | 19 | 15 | 34 |
| 2017 September | 14 | 21 | 35 |
| 2017 August | 19 | 18 | 37 |
| 2017 July | 14 | 30 | 44 |
| 2017 June | 20 | 43 | 63 |
| 2017 May | 12 | 22 | 34 |
| 2017 April | 15 | 22 | 37 |
| 2017 March | 19 | 34 | 53 |
| 2017 February | 20 | 37 | 57 |
| 2017 January | 14 | 20 | 34 |
| 2016 December | 30 | 7 | 37 |
| 2016 November | 25 | 11 | 36 |
| 2016 October | 23 | 22 | 45 |
| 2016 September | 25 | 17 | 42 |
| 2016 August | 22 | 16 | 38 |
| 2016 July | 17 | 18 | 35 |
| 2016 June | 7 | 11 | 18 |
| 2016 May | 11 | 6 | 17 |
| 2016 April | 6 | 7 | 13 |
| 2016 March | 6 | 16 | 22 |
| 2016 February | 4 | 16 | 20 |
| 2016 January | 11 | 13 | 24 |
| 2015 December | 8 | 11 | 19 |
| 2015 November | 10 | 15 | 25 |
| 2015 October | 8 | 9 | 17 |
| 2015 September | 9 | 5 | 14 |
| 2015 August | 13 | 7 | 20 |
| 2015 July | 40 | 14 | 54 |
| 2015 June | 28 | 8 | 36 |
| 2015 May | 70 | 19 | 89 |
| 2015 April | 33 | 18 | 51 |
| 2015 March | 30 | 16 | 46 |
| 2015 February | 30 | 22 | 52 |
| 2015 January | 8 | 13 | 21 |
| 2014 December | 29 | 15 | 44 |
| 2014 November | 20 | 13 | 33 |
| 2014 October | 28 | 14 | 42 |
| 2014 September | 21 | 15 | 36 |
| 2014 August | 26 | 22 | 48 |
| 2014 July | 29 | 21 | 50 |
| 2014 June | 35 | 8 | 43 |
| 2014 May | 48 | 13 | 61 |
| 2014 April | 42 | 15 | 57 |
| 2014 March | 46 | 22 | 68 |
| 2014 February | 31 | 12 | 43 |
| 2014 January | 33 | 20 | 53 |
| 2013 December | 37 | 7 | 44 |
| 2013 November | 28 | 25 | 53 |
| 2013 October | 24 | 25 | 49 |
| 2013 September | 29 | 24 | 53 |
| 2013 August | 17 | 27 | 44 |
| 2013 July | 40 | 29 | 69 |
| 2013 June | 27 | 37 | 64 |
| 2013 May | 31 | 24 | 55 |
| 2013 April | 26 | 20 | 46 |
| 2013 March | 34 | 17 | 51 |
| 2013 February | 29 | 11 | 40 |
| 2013 January | 8 | 3 | 11 |
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