Spanish Evidence-Based Guidelines on the Treatment of Moderate to Severe Psoriasis with Biologic Agents

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It is associated with a marked decline in quality of life. A wide range of treatments are currently available, although surveys conducted before the advent of biologic agents reflected a strong degree of dissatisfaction with the treatments then available. Extensive scientific evidence has been gathered on the safety of biologic agents, and this has led to a review of the role of systemic treatment in general and has allowed new therapeutic goals and strategies to be contemplated in patients with moderate to severe psoriasis. In this new situation, there is a need for Spanish guidelines on the treatment of moderate to severe psoriasis with biologic agents, drafted by consensus among specialists and ratified by the Spanish Psoriasis Group of the Spanish Academy of Dermatology and Venereology (AEDV). These guidelines should be evidence-based with regard to the pharmacologic characteristics, mechanism of action, administration route and regimen, efficacy, contraindications, adverse effects, and cost estimates of biologic agents approved for the treatment of moderate to severe psoriasis in Spain." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "La psoriasis vulgar es una enfermedad cutánea inflamatoria, de curso habitualmente crónico, que afecta a un 1-2% de la población en los países occidentales industrializados, y produce una reducción marcada de la calidad de vida de los pacientes. Pese a la diversidad de tratamientos disponibles, las encuestas efectuadas antes del advenimiento de los agentes biológicos demuestran un alto grado de insatisfacción con respecto a los tratamientos disponibles. Se ha acumulado abundante evidencia científica con respecto a la eficacia y seguridad de los agentes biológicos, que ha llevado a revisar el papel del tratamiento sistémico en general y ha permitido contemplar nuevos objetivos y estrategias terapéuticas en los pacientes con psoriasis moderada a grave. En este contexto nuevo se hace necesario establecer, de forma consensuada por especialistas expertos y ratificada por los integrantes del Grupo Español de Psoriasis de la Academia Española de Dermatología y Venereología (AEDV), unas directrices para el tratamiento de la psoriasis moderada a grave con agentes biológicos, que incluyan información basada en la evidencia científica disponible acerca de las características farmacológicas, mecanismo de acción, vía y pautas de administración, eficacia, contraindicaciones, efectos adversos y estimaciones del coste de los agentes biológicos aprobados para el tratamiento de la psoriasis moderada a grave en España" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:120 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Consensus statement

Spanish Evidence-Based Guidelines on the Treatment of Moderate to Severe Psoriasis with Biologic Agents

Directrices Españolas Basadas en la Evidencia Para el Tratamiento de la Psorias is Moderada a Grave Cona Gentes Biológicos

L. Puiga,

Corresponding author

lpuig@santpau.cat

Correspondence: Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Maria Claret, 167, 08025 Barcelona, Spain.

, J.M. Carrascosab, E. Daudénc, J.L. Sánchez-Carazod, C. Ferrándizb, M. Sánchez-Regañae, M. García-Bustinduyf, X. Bordasg, J.C. Morenoh, J.M. Hernanzi, S. Laguardaj, V. García-Patosk, for the Spanish Psoriasis Group of the Spanish Academy of Dermatology and Venereology

a Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona

b Servicio de Dermatología. Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona

c Servicio de Dermatología, Hospital de la Princesa, Madrid

d Servicio de Dermatología, Hospital General de Valencia, Valencia

e Servicio de Dermatología, Hospital Universitari Sagrat Cor, Barcelona

f Servicio de Dermatología, Hospital Universitario de Canarias, Santa Cruz de Tenerife

g Servicio de Dermatología, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona

h Servicio de Dermatología, Hospital Universitario Reina Sofía, Córdoba

i Servicio de Dermatología, Hospital Infanta Leonor, Madrid

j Servicio de Dermatología, Hospital Casa de Salud de Valencia, Valencia

k Servicio de Dermatología, Hospital Universitari Vall d’Hebron, Barcelona, Spain

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Article information

ISSN: 15782190
Original language: English

DOI:10.1016/S1578-2190(09)70086-1

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2021 April	134	100	234
2021 March	104	49	153
2021 February	56	39	95
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2020 December	60	15	75
2020 November	35	26	61
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2020 September	42	20	62
2020 August	45	27	72
2020 July	40	16	56
2020 June	43	25	68
2020 May	40	47	87
2020 April	34	33	67
2020 March	38	22	60
2020 February	0	5	5
2020 January	0	6	6
2019 December	0	5	5
2019 October	0	5	5
2019 September	0	5	5
2019 August	1	6	7
2019 July	0	2	2
2019 June	0	4	4
2019 May	0	49	49
2019 April	0	27	27
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2019 February	1	6	7
2019 January	0	4	4
2018 June	0	1	1
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2017 September	32	20	52
2017 August	49	11	60
2017 July	34	12	46
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2017 March	40	5	45
2017 February	37	12	49
2017 January	28	13	41
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2016 November	26	5	31
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2016 September	39	6	45
2016 August	39	6	45
2016 July	38	13	51
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2016 April	7	2	9
2016 March	6	1	7
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2013 December	43	14	57
2013 November	29	16	45
2013 October	30	17	47
2013 September	34	23	57
2013 August	30	35	65
2013 July	40	29	69
2013 June	39	29	68
2013 May	33	15	48
2013 April	42	46	88
2013 March	38	30	68
2013 February	42	13	55
2013 January	10	6	16

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