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                      "titulo" => "Birt-Hogg-Dub&#233; syndrome&#58; mapping of a novel hereditary neoplasia gene to chromosome 17p12-q11&#46;2"
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Case reports
Birt-Hogg-Dubé Syndrome in a Patient With Cutaneous Symptoms and a c.1429 C>T; p.R477X Mutation in Exon 12 of the Folliculin Gene
Síndrome de Birt-Hogg-Dubé, en un Paciente con Clínica Cutánea y Mutación en el Exón 12 del Gen BHD: c.1429 C> T; p.R477X
I. Fuertes
Corresponding author
tressoles8113@hotmail.com

Correspondencia: Servicio de Dermatología, Hospital Clínic, C/Villarroel, 170, 08036 Barcelona, Spain.
, J.M. Mascaró-Galy, J. Ferrando
Servicio de Dermatología, Hospital Clínic, Universidad de Barcelona, Barcelona, Spain
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        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Birt-Hogg-Dub&#233; syndrome is an autosomal dominant genodermatosis characterized by the presence of fibrofolliculomas&#44; renal cancer&#44; pulmonary cysts&#44; and spontaneous pneumothorax&#46; Recently&#44; the folliculin gene responsible for this process has been identified&#44; located on the short arm of chromosome 17&#46; We present the case of a 49-year-old man with multiple whitish papules on the face&#44; neck&#44; and retroauricular area&#46; Histology was compatible with fibrofolliculoma and genetic study showed a pathogenic mutation of the folliculin gene&#46;</p>"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de Birt-Hogg-Dub&#233; es una genodermatosis de herencia autos&#243;mica dominantecaracterizada por la presencia de fibrofoliculomas&#44; c&#225;ncer renal&#44; quistes pulmonares y pneumot&#243;rax espont&#225;neo&#46; Recientemente ha sido identificado el gen FCLN&#44; responsable de este proceso&#44; localizado en el brazo corto del cromosoma 17&#46; Presentamos el caso de un var&#243;n de 49 a&#241;os&#44; con m&#250;ltiples p&#225;pulas blanquecinas en la cara&#44; el cuello y el &#225;rea retroauricular&#46; La histolog&#237;a fue compatible con fibrofoliculoma y el estudio gen&#233;tico demostr&#243; una mutaci&#243;n patog&#233;nica en el gen FCLN&#46;</p>"
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