Original articles
Therapeutic Effectiveness of Psoralen-U V-A Bath Therapy In Psoriasis
Eficacia Terapéutica del Baño-PUVA en Psoriasis
M.T. Rodríguez-Granadosa,
, M.J. Pereira-Rodríguezb, F.L. Vázquez-Vizosoc
Corresponding author
trgranados@mundo-r.com
Correspondence. Servicio de Dermatología. Complejo Hospitalario Universitario de Santiago de Compostela. Facultad de Medicina. Universidad de Compostela. 15707 Santiago de Compostela. A Coruña. Spain.
Correspondence. Servicio de Dermatología. Complejo Hospitalario Universitario de Santiago de Compostela. Facultad de Medicina. Universidad de Compostela. 15707 Santiago de Compostela. A Coruña. Spain.
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"apellidos" => "Rodríguez-Granados" "email" => array:1 [ 0 => "trgranados@mundo-r.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "M.J." "apellidos" => "Pereira-Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "F.L." "apellidos" => "Vázquez-Vizoso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología. Complejo Universitario Juan Canalejo. A Coruña" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Preventiva. Complejo Universitario Juan Canalejo. A Coruña" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Medicina Preventiva. Complexo Hospitalario de Pontevedra. Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence. Servicio de Dermatología. Complejo Hospitalario Universitario de Santiago de Compostela. Facultad de Medicina. Universidad de Compostela. 15707 Santiago de Compostela. A Coruña. Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eficacia Terapéutica del Baño-PUVA en Psoriasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-07-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84417" "palabras" => array:5 [ 0 => "psoriasis" 1 => "photosensitivity" 2 => "photochemotherapy" 3 => "psoralen-UV-A bath therapy" 4 => "therapeutic effectiveness" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84418" "palabras" => array:5 [ 0 => "psoriasis" 1 => "fotosensibilidad" 2 => "fotoquimioterapia" 3 => "baño-PUVA" 4 => "eficacia terapéutica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">The use of psoralen baths with long-wave UV radiation, known as PUVA bath therapy, is useful in the treatment of psoriasis. The therapy is not associated with systemic adverse effects and the dose of UV-A radiation administered is lower. The objectives of this study aimed to identify the variables that influence the effectiveness of PUVA bath therapy and the duration of remission, as well as to determine factors that predict relapse. It also aimed to assess the effectiveness of a protocol using the minimal phototoxic dose and to compare two concentrations of 8-methoxypsoralen.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Two hundred nine patients with moderate-severe plaque psoriasis attended between 1994 and 2000 were included in the study. The characteristics and therapeutic outcomes of the sample were recorded. Survival curves were plotted for the disease-free interval after a good response to treatment. A proportional hazard model was used to assess the factors that influence the duration of remission.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Therapeutic outcomes were better in patients with greater photosensitivity (p = 0.03). Application of the minimal phototoxic dose protocol was not associated with greater phototoxicity during treatment. The median duration of remission was 7 months. Those patients who had previously undergone oral PUVA therapy and those who did not achieve a substantial reduction in the psoriasis area and severity index (PASI) score were at greater risk of relapse.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">A lower final PASI extended the lesion-free period.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">El baño de psoralenos (P) e irradiación con ultravioleta de onda larga (UVA), conocido como baño-PUVA, es útil en el tratamiento de la psoriasis con la ausencia de efectos adversos sistémicos y una menor dosis de UVA administrada. El objetivo de este trabajo es identificar las variables que influyen en la efectividad del tratamiento con baño-PUVA y el período de remisión, así como determinar aquellas que permitan predecir la recidiva; valorar la efectividad de la prueba de fototoxicidad cutánea(DFM), y comparar dos concentraciones del 8-metoxipsoraleno (8-MOP).</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 209 pacientes afectos de psoriasis en placas moderada-grave visitados en el período 1994-2000. Se realizó un estudio descriptivo de las características y resultados terapéuticos de lamuestra estudiada, y un estudio de supervivencia valorando el tiempo libre de enfermedad tras una buena respuesta al tratamiento. El análisis 0de riesgos proporcionales permitió evaluar qué factores influyeron en el período de remisión.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes con mayor fotosensibilidad mostraron los mejores resultados terapéuticos (p = 0,03). El protocolo en que se realizó la DFM no supuso más fototoxicidad durante el tratamiento. La duración del período de remisión fue de 7 meses en el 50% de los pacientes. Aquellos pacientes que previamente realizaron terapia PUVA oral, y los que no consiguieron una reducción importante del <span class="elsevierStyleItalic">Psoriasis Area and Severity Index</span> (PASI), condicionaron un mayor riesgo de recidiva.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Un PASI final reducido incrementa la duración del tiempo libre de lesiones.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">This article is the result of the doctoral thesis of María Teresa Rodríguez Granados, “Therapeutic Effectiveness of Psoralen-UV-A Bath in Psoriasis: First Study in the Autonomous Community of Galicia, Spain.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:39 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 1 | 3 | 4 |
| 2024 October | 73 | 33 | 106 |
| 2024 September | 65 | 24 | 89 |
| 2024 August | 102 | 60 | 162 |
| 2024 July | 66 | 32 | 98 |
| 2024 June | 62 | 27 | 89 |
| 2024 May | 63 | 32 | 95 |
| 2024 April | 65 | 31 | 96 |
| 2024 March | 56 | 37 | 93 |
| 2024 February | 47 | 36 | 83 |
| 2024 January | 46 | 33 | 79 |
| 2023 December | 55 | 38 | 93 |
| 2023 November | 53 | 39 | 92 |
| 2023 October | 40 | 26 | 66 |
| 2023 September | 51 | 26 | 77 |
| 2023 August | 26 | 17 | 43 |
| 2023 July | 27 | 40 | 67 |
| 2023 June | 40 | 40 | 80 |
| 2023 May | 36 | 30 | 66 |
| 2023 April | 17 | 25 | 42 |
| 2023 March | 29 | 24 | 53 |
| 2023 February | 35 | 25 | 60 |
| 2023 January | 32 | 29 | 61 |
| 2022 December | 56 | 41 | 97 |
| 2022 November | 41 | 23 | 64 |
| 2022 October | 23 | 27 | 50 |
| 2022 September | 25 | 32 | 57 |
| 2022 August | 22 | 34 | 56 |
| 2022 July | 12 | 31 | 43 |
| 2022 June | 19 | 29 | 48 |
| 2022 May | 31 | 37 | 68 |
| 2022 April | 44 | 50 | 94 |
| 2022 March | 37 | 58 | 95 |
| 2022 February | 17 | 37 | 54 |
| 2022 January | 30 | 35 | 65 |
| 2021 December | 16 | 54 | 70 |
| 2021 November | 31 | 44 | 75 |
| 2021 October | 23 | 44 | 67 |
| 2021 September | 19 | 41 | 60 |
| 2021 August | 23 | 24 | 47 |
| 2021 July | 51 | 31 | 82 |
| 2021 June | 14 | 49 | 63 |
| 2021 May | 39 | 44 | 83 |
| 2021 April | 40 | 60 | 100 |
| 2021 March | 54 | 21 | 75 |
| 2021 February | 57 | 32 | 89 |
| 2021 January | 23 | 23 | 46 |
| 2020 December | 26 | 15 | 41 |
| 2020 November | 19 | 22 | 41 |
| 2020 October | 15 | 9 | 24 |
| 2020 September | 19 | 14 | 33 |
| 2020 August | 24 | 30 | 54 |
| 2020 July | 23 | 6 | 29 |
| 2020 June | 42 | 33 | 75 |
| 2020 May | 20 | 34 | 54 |
| 2020 April | 41 | 24 | 65 |
| 2020 March | 48 | 21 | 69 |
| 2020 February | 7 | 2 | 9 |
| 2020 January | 0 | 10 | 10 |
| 2019 December | 0 | 11 | 11 |
| 2019 November | 0 | 1 | 1 |
| 2019 July | 0 | 1 | 1 |
| 2019 June | 0 | 4 | 4 |
| 2019 May | 1 | 37 | 38 |
| 2019 April | 0 | 1 | 1 |
| 2019 March | 0 | 5 | 5 |
| 2019 February | 0 | 5 | 5 |
| 2018 September | 0 | 3 | 3 |
| 2018 August | 0 | 1 | 1 |
| 2018 June | 0 | 3 | 3 |
| 2018 April | 0 | 1 | 1 |
| 2018 March | 1 | 1 | 2 |
| 2018 February | 8 | 4 | 12 |
| 2018 January | 13 | 3 | 16 |
| 2017 December | 16 | 9 | 25 |
| 2017 November | 15 | 4 | 19 |
| 2017 October | 15 | 9 | 24 |
| 2017 September | 12 | 7 | 19 |
| 2017 August | 14 | 9 | 23 |
| 2017 July | 24 | 2 | 26 |
| 2017 June | 43 | 17 | 60 |
| 2017 May | 40 | 12 | 52 |
| 2017 April | 28 | 8 | 36 |
| 2017 March | 31 | 9 | 40 |
| 2017 February | 8 | 7 | 15 |
| 2017 January | 13 | 7 | 20 |
| 2016 December | 25 | 8 | 33 |
| 2016 November | 19 | 7 | 26 |
| 2016 October | 29 | 11 | 40 |
| 2016 September | 30 | 5 | 35 |
| 2016 August | 28 | 5 | 33 |
| 2016 July | 18 | 5 | 23 |
| 2016 June | 18 | 11 | 29 |
| 2016 May | 9 | 3 | 12 |
| 2016 April | 9 | 0 | 9 |
| 2016 March | 9 | 0 | 9 |
| 2016 February | 8 | 3 | 11 |
| 2016 January | 6 | 1 | 7 |
| 2015 December | 7 | 3 | 10 |
| 2015 November | 10 | 1 | 11 |
| 2015 October | 10 | 3 | 13 |
| 2015 September | 9 | 4 | 13 |
| 2015 August | 14 | 4 | 18 |
| 2015 July | 35 | 6 | 41 |
| 2015 June | 41 | 6 | 47 |
| 2015 May | 70 | 12 | 82 |
| 2015 April | 38 | 6 | 44 |
| 2015 March | 35 | 18 | 53 |
| 2015 February | 38 | 10 | 48 |
| 2015 January | 28 | 9 | 37 |
| 2014 December | 24 | 11 | 35 |
| 2014 November | 20 | 15 | 35 |
| 2014 October | 29 | 20 | 49 |
| 2014 September | 27 | 16 | 43 |
| 2014 August | 31 | 20 | 51 |
| 2014 July | 41 | 23 | 64 |
| 2014 June | 47 | 12 | 59 |
| 2014 May | 50 | 21 | 71 |
| 2014 April | 46 | 13 | 59 |
| 2014 March | 58 | 14 | 72 |
| 2014 February | 50 | 24 | 74 |
| 2014 January | 41 | 13 | 54 |
| 2013 December | 30 | 8 | 38 |
| 2013 November | 28 | 13 | 41 |
| 2013 October | 25 | 13 | 38 |
| 2013 September | 32 | 26 | 58 |
| 2013 August | 21 | 32 | 53 |
| 2013 July | 37 | 21 | 58 |
| 2013 June | 24 | 19 | 43 |
| 2013 May | 29 | 28 | 57 |
| 2013 April | 17 | 36 | 53 |
| 2013 March | 28 | 25 | 53 |
| 2013 February | 47 | 15 | 62 |
| 2013 January | 12 | 5 | 17 |
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