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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Melanomas arising in areas with comparable levels of sun exposure have been shown to have similar genetic profiles&#46; The aim of this study was to characterize the clinical features of melanoma patients according to the pattern of sun exposure&#58; chronic&#44; intermittent&#44; or none&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">From our melanoma database&#44; we selected 789 consecutive patients with melanoma diagnosed in our center since January 2000&#46; Epidemiologic data&#44; phenotype&#44; and personal and family history of cancer were retrieved&#46; The observed frequency of each variable was compared&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Most melanoma patients presented tumors on areas exposed intermittently to sunlight&#46; In addition&#44; these patients presented higher numbers of common and atypical melanocytic <span class="elsevierStyleItalic">nevi</span> and the melanoma very frequently arose in a pre-existing <span class="elsevierStyleItalic">nevus</span>&#46; The second largest group was formed by patients with tumors on areas chronically exposed to sun and that had all the clinical lesions &#40;solar lentigines and actinic keratoses&#41; and epidemiologic characteristics typical of these areas&#46; Finally&#44; patients with melanomas on areas not exposed to sun were older&#44; as occurred in the group with chronic exposure&#44; and the diagnosis was made at more advanced stages of the disease&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">There are many patients who did not fit these patterns of melanoma development&#46; Clinical and biological characterization is therefore necessary to determine alternative pathways of development in order to establish specific preventive measures&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha observado que los melanomas tienen un perfil gen&#233;tico similar seg&#250;n el patr&#243;n de exposici&#243;n al sol del &#225;rea cut&#225;nea donde asientan&#46; El objetivo de este estudio ha sido caracterizar desde el punto de vista cl&#237;nico los pacientes con melanoma seg&#250;n su patr&#243;n de exposici&#243;n al sol&#58; cr&#243;nico&#44; intermitente y ausencia de exposici&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 789 pacientes con melanoma diagnosticados en nuestro centro de forma consecutiva desde enero del a&#241;o 2000 a partir de la base de datos de melanoma&#46; Se obtuvieron los datos referentes a las caracter&#237;sticas epidemiol&#243;gicas&#44; fenot&#237;picas y los antecedentes personales y familiares de c&#225;ncer&#46; Se compararon las frecuencias observadas de cada una de las variables estudiadas&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se observ&#243; que la mayor&#237;a de los pacientes tienen los melanomas en localizaciones expuestas al sol de forma intermitente&#46; Adem&#225;s&#44; estos pacientes tienen m&#225;s nevus melanoc&#237;ticos tanto comunes como at&#237;picos y su melanoma se asocia con una elevada frecuencia a un nevus preexistente&#46; Por otra parte&#44; el segundo grupo en n&#250;mero est&#225; constituido por el grupo de pacientes con melanomas en &#225;reas cut&#225;neas expuestas al sol de forma cr&#243;nica que presentaron todas las lesiones &#40;lentigos solares y queratosis act&#237;nicas&#41; y antecedentes t&#237;picos de esta localizaci&#243;n&#46; Finalmente&#44; el grupo de melanomas que se presenta en &#225;reas de piel no expuestas al sol tiene&#44; al igual que el anterior&#44; una edad de diagn&#243;stico mayor y se diagnostican en fases avanzadas de la enfermedad&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La presencia de un elevado n&#250;mero de pacientes que no sigue ninguno de los patrones mencionados suscita la necesidad de caracterizarlos cl&#237;nica y biol&#243;gicamente para conocer v&#237;as alternativas de desarrollo de un melanoma&#44; y as&#237; poder establecer medidas preventivas adecuadas&#46;</p>"
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Original article
Clinical and Epidemiologic Profile of Melanoma Patients According To Sun Exposure Of The Tumor Site
Perfil Clínico y Epidemiológico de los Pacientes con Melanoma Cutáneo Según el Grado de Exposición Solar de la Localización del Melanoma
E. Nagore
Corresponding author
eduyame@meditex.es

Correspondence: Servicio de Dermatología, Fundación Instituto Valenciano de Oncología, C/ Profesor Beltrán Báguena 8, 46009 Valencia, Spain.
, R. Botella-Estrada, C. Requena, C. Serra-Guillén, A. Martorell, L. Hueso, B. Llombart, O. Sanmartín, C. Guillén
Servicio de Dermatología, Fundación Instituto Valenciano de Oncología, Valencia, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Melanomas arising in areas with comparable levels of sun exposure have been shown to have similar genetic profiles&#46; The aim of this study was to characterize the clinical features of melanoma patients according to the pattern of sun exposure&#58; chronic&#44; intermittent&#44; or none&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">From our melanoma database&#44; we selected 789 consecutive patients with melanoma diagnosed in our center since January 2000&#46; Epidemiologic data&#44; phenotype&#44; and personal and family history of cancer were retrieved&#46; The observed frequency of each variable was compared&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Most melanoma patients presented tumors on areas exposed intermittently to sunlight&#46; In addition&#44; these patients presented higher numbers of common and atypical melanocytic <span class="elsevierStyleItalic">nevi</span> and the melanoma very frequently arose in a pre-existing <span class="elsevierStyleItalic">nevus</span>&#46; The second largest group was formed by patients with tumors on areas chronically exposed to sun and that had all the clinical lesions &#40;solar lentigines and actinic keratoses&#41; and epidemiologic characteristics typical of these areas&#46; Finally&#44; patients with melanomas on areas not exposed to sun were older&#44; as occurred in the group with chronic exposure&#44; and the diagnosis was made at more advanced stages of the disease&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">There are many patients who did not fit these patterns of melanoma development&#46; Clinical and biological characterization is therefore necessary to determine alternative pathways of development in order to establish specific preventive measures&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha observado que los melanomas tienen un perfil gen&#233;tico similar seg&#250;n el patr&#243;n de exposici&#243;n al sol del &#225;rea cut&#225;nea donde asientan&#46; El objetivo de este estudio ha sido caracterizar desde el punto de vista cl&#237;nico los pacientes con melanoma seg&#250;n su patr&#243;n de exposici&#243;n al sol&#58; cr&#243;nico&#44; intermitente y ausencia de exposici&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 789 pacientes con melanoma diagnosticados en nuestro centro de forma consecutiva desde enero del a&#241;o 2000 a partir de la base de datos de melanoma&#46; Se obtuvieron los datos referentes a las caracter&#237;sticas epidemiol&#243;gicas&#44; fenot&#237;picas y los antecedentes personales y familiares de c&#225;ncer&#46; Se compararon las frecuencias observadas de cada una de las variables estudiadas&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se observ&#243; que la mayor&#237;a de los pacientes tienen los melanomas en localizaciones expuestas al sol de forma intermitente&#46; Adem&#225;s&#44; estos pacientes tienen m&#225;s nevus melanoc&#237;ticos tanto comunes como at&#237;picos y su melanoma se asocia con una elevada frecuencia a un nevus preexistente&#46; Por otra parte&#44; el segundo grupo en n&#250;mero est&#225; constituido por el grupo de pacientes con melanomas en &#225;reas cut&#225;neas expuestas al sol de forma cr&#243;nica que presentaron todas las lesiones &#40;lentigos solares y queratosis act&#237;nicas&#41; y antecedentes t&#237;picos de esta localizaci&#243;n&#46; Finalmente&#44; el grupo de melanomas que se presenta en &#225;reas de piel no expuestas al sol tiene&#44; al igual que el anterior&#44; una edad de diagn&#243;stico mayor y se diagnostican en fases avanzadas de la enfermedad&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La presencia de un elevado n&#250;mero de pacientes que no sigue ninguno de los patrones mencionados suscita la necesidad de caracterizarlos cl&#237;nica y biol&#243;gicamente para conocer v&#237;as alternativas de desarrollo de un melanoma&#44; y as&#237; poder establecer medidas preventivas adecuadas&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
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        0 => array:1 [
          "bibliografiaReferencia" => array:15 [
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                      "autores" => array:1 [
                        0 => array:2 [
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                            0 => "Y&#46; Cohen"
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                            0 => "S&#46; Gandini"
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                      "titulo" => "Melanocytic nevi&#44; solar keratoses&#44; and divergent pathways to cutaneous melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;C&#46; Whiteman"
                            1 => "P&#46; Watt"
                            2 => "D&#46;M&#46; Purdie"
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                          ]
                        ]
                      ]
                    ]
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            ]
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                      "titulo" => "Epidemiology of melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "D&#46;C&#46; Whiteman"
                            1 => "C&#46;A&#46; Whiteman"
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                          ]
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                          ]
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            ]
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            0 => "S&#46; Gandini"
                            1 => "F&#46; Sera"
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                          ]
                        ]
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                        "fecha" => "2005"
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                        ]
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                    ]
                  ]
                ]
              ]
            ]
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "P&#46; Carli"
                            1 => "D&#46; Massi"
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                          ]
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                    ]
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                ]
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            ]
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Marks"
                            1 => "A&#46;P&#46; Dorevitch"
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                          ]
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                          ]
                        ]
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                    ]
                  ]
                ]
              ]
            ]
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            0 => "P&#46;M&#46; Pollock"
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                            2 => "K&#46;S&#46; Hansen"
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;C&#46; Whiteman"
                            1 => "P&#46;G&#46; Parsons"
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Article information
ISSN: 15782190
Original language: English
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