Correspondence: Servicio de Dermatología, Fundación Instituto Valenciano de Oncología, C/ Profesor Beltrán Báguena 8, 46009 Valencia, Spain.
was read the article
array:23 [ "pii" => "S1578219009700460" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70046-0" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "aid" => "70046" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:205-11" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2337 "formatos" => array:3 [ "EPUB" => 40 "HTML" => 1483 "PDF" => 814 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219009700472" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70047-2" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "aid" => "70047" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:212-21" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2438 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 1619 "PDF" => 776 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Therapeutic Effectiveness of Psoralen-U V-A Bath Therapy In Psoriasis" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "212" "paginaFinal" => "221" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eficacia Terapéutica del Baño-PUVA en Psoriasis" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.T. Rodríguez-Granados, M.J. Pereira-Rodríguez, F.L. Vázquez-Vizoso" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M.T." "apellidos" => "Rodríguez-Granados" ] 1 => array:2 [ "nombre" => "M.J." "apellidos" => "Pereira-Rodríguez" ] 2 => array:2 [ "nombre" => "F.L." "apellidos" => "Vázquez-Vizoso" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700472?idApp=UINPBA000044" "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700472/v1_201304241451/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009700459" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70045-9" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "aid" => "70045" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:201-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2978 "formatos" => array:3 [ "EPUB" => 41 "HTML" => 1862 "PDF" => 1075 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Contact Sensitization to Euxyl K400" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "204" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Sensibilización de Contacto al Euxyl K-400" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.T. Bordel-Gómez, A. Miranda-Romero" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M.T." "apellidos" => "Bordel-Gómez" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Miranda-Romero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700459?idApp=UINPBA000044" "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700459/v1_201304241451/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Clinical and Epidemiologic Profile of Melanoma Patients According To Sun Exposure Of The Tumor Site" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "205" "paginaFinal" => "211" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E. Nagore, R. Botella-Estrada, C. Requena, C. Serra-Guillén, A. Martorell, L. Hueso, B. Llombart, O. Sanmartín, C. Guillén" "autores" => array:9 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Nagore" "email" => array:1 [ 0 => "eduyame@meditex.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Botella-Estrada" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Requena" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Serra-Guillén" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Martorell" ] 5 => array:2 [ "nombre" => "L." "apellidos" => "Hueso" ] 6 => array:2 [ "nombre" => "B." "apellidos" => "Llombart" ] 7 => array:2 [ "nombre" => "O." "apellidos" => "Sanmartín" ] 8 => array:2 [ "nombre" => "C." "apellidos" => "Guillén" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Fundación Instituto Valenciano de Oncología, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Fundación Instituto Valenciano de Oncología, C/ Profesor Beltrán Báguena 8, 46009 Valencia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Perfil Clínico y Epidemiológico de los Pacientes con Melanoma Cutáneo Según el Grado de Exposición Solar de la Localización del Melanoma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-07-07" "PalabrasClave" => array:1 [ "en" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84413" "palabras" => array:3 [ 0 => "melanoma" 1 => "sun exposure" 2 => "epidemiology" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84414" "palabras" => array:3 [ 0 => "melanoma" 1 => "exposición solar" 2 => "epidemiología" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Melanomas arising in areas with comparable levels of sun exposure have been shown to have similar genetic profiles. The aim of this study was to characterize the clinical features of melanoma patients according to the pattern of sun exposure: chronic, intermittent, or none.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">From our melanoma database, we selected 789 consecutive patients with melanoma diagnosed in our center since January 2000. Epidemiologic data, phenotype, and personal and family history of cancer were retrieved. The observed frequency of each variable was compared.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Most melanoma patients presented tumors on areas exposed intermittently to sunlight. In addition, these patients presented higher numbers of common and atypical melanocytic <span class="elsevierStyleItalic">nevi</span> and the melanoma very frequently arose in a pre-existing <span class="elsevierStyleItalic">nevus</span>. The second largest group was formed by patients with tumors on areas chronically exposed to sun and that had all the clinical lesions (solar lentigines and actinic keratoses) and epidemiologic characteristics typical of these areas. Finally, patients with melanomas on areas not exposed to sun were older, as occurred in the group with chronic exposure, and the diagnosis was made at more advanced stages of the disease.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">There are many patients who did not fit these patterns of melanoma development. Clinical and biological characterization is therefore necessary to determine alternative pathways of development in order to establish specific preventive measures.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha observado que los melanomas tienen un perfil genético similar según el patrón de exposición al sol del área cutánea donde asientan. El objetivo de este estudio ha sido caracterizar desde el punto de vista clínico los pacientes con melanoma según su patrón de exposición al sol: crónico, intermitente y ausencia de exposición.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 789 pacientes con melanoma diagnosticados en nuestro centro de forma consecutiva desde enero del año 2000 a partir de la base de datos de melanoma. Se obtuvieron los datos referentes a las características epidemiológicas, fenotípicas y los antecedentes personales y familiares de cáncer. Se compararon las frecuencias observadas de cada una de las variables estudiadas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se observó que la mayoría de los pacientes tienen los melanomas en localizaciones expuestas al sol de forma intermitente. Además, estos pacientes tienen más nevus melanocíticos tanto comunes como atípicos y su melanoma se asocia con una elevada frecuencia a un nevus preexistente. Por otra parte, el segundo grupo en número está constituido por el grupo de pacientes con melanomas en áreas cutáneas expuestas al sol de forma crónica que presentaron todas las lesiones (lentigos solares y queratosis actínicas) y antecedentes típicos de esta localización. Finalmente, el grupo de melanomas que se presenta en áreas de piel no expuestas al sol tiene, al igual que el anterior, una edad de diagnóstico mayor y se diagnostican en fases avanzadas de la enfermedad.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La presencia de un elevado número de pacientes que no sigue ninguno de los patrones mencionados suscita la necesidad de caracterizarlos clínica y biológicamente para conocer vías alternativas de desarrollo de un melanoma, y así poder establecer medidas preventivas adecuadas.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.N. Crowson" 1 => "C.M. Magro" 2 => "R.L. Barnhill" 3 => "M.C. Mihm Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Cutaneous melanoma" "paginaInicial" => "171" "paginaFinal" => "208" "edicion" => "4th ed" "serieFecha" => "2003" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.C. Bastian" 1 => "M. Kashani-Sabet" 2 => "H. Hamm" 3 => "T. Godfrey" 4 => "D.H. Moore 2nd" 5 => "E.B. Bröcker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "2000" "volumen" => "60" "paginaInicial" => "1968" "paginaFinal" => "1973" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10766187" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Determinants of BRAF mutations in primary melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.L. Maldonado" 1 => "J. Fridlyand" 2 => "H. Patel" 3 => "A.N. Jain" 4 => "K. Busam" 5 => "T. Kageshita" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2003" "volumen" => "95" "paginaInicial" => "1878" "paginaFinal" => "1890" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14679157" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exon 15 BRAF mutations are uncommon in melanomas arising in non-sun-exposed sites" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Cohen" 1 => "E. Rosenbaum" 2 => "S. Begum" 3 => "D. Goldenberg" 4 => "C. Esche" 5 => "O. Lavie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin CancerRes" "fecha" => "2004" "volumen" => "10" "paginaInicial" => "3444" "paginaFinal" => "3447" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distinct sets of genetic alterations in melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.A. Curtin" 1 => "J. Fridlyand" 2 => "T. Kageshita" 3 => "H.N. Patel" 4 => "K.J. Busam" 5 => "H. Kutzner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa050092" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2005" "volumen" => "353" "paginaInicial" => "2135" "paginaFinal" => "2147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16291983" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Gandini" 1 => "F. Sera" 2 => "M.S. Cattaruzza" 3 => "P. Pasquini" 4 => "D. Abeni" 5 => "P. Boyle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejca.2004.10.015" "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "28" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15617989" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.C. Whiteman" 1 => "P. Watt" 2 => "D.M. Purdie" 3 => "M.C. Hughes" 4 => "N.K. Hayward" 5 => "A.C. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2003" "volumen" => "95" "paginaInicial" => "806" "paginaFinal" => "812" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12783935" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Marks" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2000" "volumen" => "25" "paginaInicial" => "459" "paginaFinal" => "463" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11044179" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.C. Whiteman" 1 => "C.A. Whiteman" 2 => "A.C. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Causes Control" "fecha" => "2001" "volumen" => "12" "paginaInicial" => "69" "paginaFinal" => "82" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11227927" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sun exposure, pigmentary traits, and risk of cutaneous malignant melanoma: a case-control study in a Mediterranean population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.M. Rodenas" 1 => "M. Delgado-Rodríguez" 2 => "M.T. Herranz" 3 => "J. Tercedor" 4 => "S. Serrano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Causes Control" "fecha" => "1996" "volumen" => "7" "paginaInicial" => "275" "paginaFinal" => "283" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8740740" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Gandini" 1 => "F. Sera" 2 => "M.S. Cattaruzza" 3 => "P. Pasquini" 4 => "O. Picconi" 5 => "P. Boyle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejca.2004.10.016" "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "45" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15617990" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous melanoma histologically associated with a nevus and melanoma de novo have a different profile of risk: results from a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Carli" 1 => "D. Massi" 2 => "M. Santucci" 3 => "A. Biggeri" 4 => "B. Giannotti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "40" "paginaInicial" => "549" "paginaFinal" => "557" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10188672" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Do all melanomas come from «moles»? A study of the histological association between melanocytic naevi and melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Marks" 1 => "A.P. Dorevitch" 2 => "G. Mason" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Australas J Dermatol" "fecha" => "1990" "volumen" => "31" "paginaInicial" => "77" "paginaFinal" => "80" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2095738" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High frequency of BRAF mutations in nevi" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.M. Pollock" 1 => "U.L. Harper" 2 => "K.S. Hansen" 3 => "L.M. Yudt" 4 => "M. Stark" 5 => "C.M. Robbins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng1054" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2003" "volumen" => "33" "paginaInicial" => "19" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12447372" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p53 expression and risk factors for cutaneous melanoma: a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.C. Whiteman" 1 => "P.G. Parsons" 2 => "A.C. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "1998" "volumen" => "77" "paginaInicial" => "843" "paginaFinal" => "848" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9714052" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700460/v1_201304241451/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000003/v1_201304241451/S1578219009700460/v1_201304241451/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700460?idApp=UINPBA000044" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 4 | 2 | 6 |
2024 October | 55 | 52 | 107 |
2024 September | 58 | 36 | 94 |
2024 August | 72 | 60 | 132 |
2024 July | 43 | 30 | 73 |
2024 June | 49 | 35 | 84 |
2024 May | 49 | 28 | 77 |
2024 April | 48 | 34 | 82 |
2024 March | 45 | 40 | 85 |
2024 February | 40 | 35 | 75 |
2024 January | 39 | 45 | 84 |
2023 December | 50 | 37 | 87 |
2023 November | 49 | 43 | 92 |
2023 October | 38 | 32 | 70 |
2023 September | 27 | 48 | 75 |
2023 August | 27 | 13 | 40 |
2023 July | 34 | 49 | 83 |
2023 June | 25 | 21 | 46 |
2023 May | 29 | 20 | 49 |
2023 April | 18 | 19 | 37 |
2023 March | 20 | 18 | 38 |
2023 February | 26 | 17 | 43 |
2023 January | 28 | 24 | 52 |
2022 December | 30 | 35 | 65 |
2022 November | 22 | 28 | 50 |
2022 October | 13 | 26 | 39 |
2022 September | 13 | 37 | 50 |
2022 August | 17 | 36 | 53 |
2022 July | 23 | 37 | 60 |
2022 June | 15 | 28 | 43 |
2022 May | 23 | 59 | 82 |
2022 April | 28 | 53 | 81 |
2022 March | 23 | 62 | 85 |
2022 February | 18 | 25 | 43 |
2022 January | 18 | 51 | 69 |
2021 December | 20 | 54 | 74 |
2021 November | 24 | 71 | 95 |
2021 October | 22 | 39 | 61 |
2021 September | 22 | 46 | 68 |
2021 August | 14 | 29 | 43 |
2021 July | 25 | 35 | 60 |
2021 June | 19 | 32 | 51 |
2021 May | 36 | 34 | 70 |
2021 April | 53 | 47 | 100 |
2021 March | 64 | 20 | 84 |
2021 February | 69 | 21 | 90 |
2021 January | 32 | 15 | 47 |
2020 December | 16 | 12 | 28 |
2020 November | 12 | 14 | 26 |
2020 October | 24 | 7 | 31 |
2020 September | 21 | 8 | 29 |
2020 August | 19 | 22 | 41 |
2020 July | 12 | 6 | 18 |
2020 June | 14 | 23 | 37 |
2020 May | 27 | 22 | 49 |
2020 April | 14 | 19 | 33 |
2020 March | 14 | 19 | 33 |
2020 February | 2 | 1 | 3 |
2020 January | 0 | 5 | 5 |
2019 December | 0 | 11 | 11 |
2019 November | 0 | 1 | 1 |
2019 October | 0 | 4 | 4 |
2019 September | 0 | 1 | 1 |
2019 July | 0 | 8 | 8 |
2019 May | 0 | 41 | 41 |
2019 March | 0 | 3 | 3 |
2019 February | 0 | 3 | 3 |
2018 May | 0 | 6 | 6 |
2018 April | 0 | 2 | 2 |
2018 February | 6 | 3 | 9 |
2018 January | 13 | 4 | 17 |
2017 December | 18 | 7 | 25 |
2017 November | 11 | 4 | 15 |
2017 October | 11 | 2 | 13 |
2017 September | 18 | 2 | 20 |
2017 August | 24 | 11 | 35 |
2017 July | 35 | 7 | 42 |
2017 June | 39 | 7 | 46 |
2017 May | 25 | 5 | 30 |
2017 April | 29 | 11 | 40 |
2017 March | 25 | 27 | 52 |
2017 February | 13 | 8 | 21 |
2017 January | 11 | 8 | 19 |
2016 December | 21 | 5 | 26 |
2016 November | 19 | 4 | 23 |
2016 October | 21 | 14 | 35 |
2016 September | 27 | 8 | 35 |
2016 August | 17 | 6 | 23 |
2016 July | 21 | 4 | 25 |
2016 June | 13 | 8 | 21 |
2016 May | 6 | 3 | 9 |
2016 April | 5 | 2 | 7 |
2016 March | 11 | 16 | 27 |
2016 February | 14 | 16 | 30 |
2016 January | 5 | 16 | 21 |
2015 December | 9 | 17 | 26 |
2015 November | 10 | 13 | 23 |
2015 October | 9 | 10 | 19 |
2015 September | 5 | 7 | 12 |
2015 August | 19 | 4 | 23 |
2015 July | 38 | 13 | 51 |
2015 June | 34 | 11 | 45 |
2015 May | 48 | 13 | 61 |
2015 April | 27 | 17 | 44 |
2015 March | 25 | 3 | 28 |
2015 February | 16 | 12 | 28 |
2015 January | 16 | 8 | 24 |
2014 December | 24 | 7 | 31 |
2014 November | 21 | 17 | 38 |
2014 October | 39 | 19 | 58 |
2014 September | 27 | 13 | 40 |
2014 August | 39 | 18 | 57 |
2014 July | 41 | 21 | 62 |
2014 June | 54 | 13 | 67 |
2014 May | 46 | 16 | 62 |
2014 April | 38 | 8 | 46 |
2014 March | 47 | 20 | 67 |
2014 February | 45 | 17 | 62 |
2014 January | 34 | 16 | 50 |
2013 December | 34 | 7 | 41 |
2013 November | 24 | 15 | 39 |
2013 October | 29 | 18 | 47 |
2013 September | 35 | 17 | 52 |
2013 August | 19 | 23 | 42 |
2013 July | 29 | 22 | 51 |
2013 June | 25 | 22 | 47 |
2013 May | 22 | 13 | 35 |
2013 April | 30 | 33 | 63 |
2013 March | 27 | 20 | 47 |
2013 February | 28 | 11 | 39 |
2013 January | 12 | 7 | 19 |