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Contact Sensitization to Euxyl K400
Sensibilización de Contacto al Euxyl K-400
M.T. Bordel-Gómeza,
, A. Miranda-Romerob
Corresponding author
matebordel@yahoo.es
Correspondence: Servicio de Dermatología, Hospital Virgen de la Concha, Avda. Requejo, 35, 9022 Zamora, Spain.
Correspondence: Servicio de Dermatología, Hospital Virgen de la Concha, Avda. Requejo, 35, 9022 Zamora, Spain.
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"apellidos" => "Brufau" ] 13 => array:2 [ "nombre" => "E." "apellidos" => "Herrera" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700447?idApp=UINPBA000044" "url" => "/15782190/0000010000000003/v1_201304241451/S1578219009700447/v1_201304241451/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Contact Sensitization to Euxyl K400" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "204" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.T. Bordel-Gómez, A. Miranda-Romero" "autores" => array:2 [ 0 => array:4 [ "nombre" => "M.T." "apellidos" => "Bordel-Gómez" "email" => array:1 [ 0 => "matebordel@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Miranda-Romero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Complejo Asistencial Virgen de la Concha, Zamora" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Clínico Universitario de Valladolid, Facultad de Medicina, Valladolid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Virgen de la Concha, Avda. Requejo, 35, 9022 Zamora, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Sensibilización de Contacto al Euxyl K-400" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-04-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84430" "palabras" => array:4 [ 0 => "contact allergic dermatitis" 1 => "Euxyl K400" 2 => "methyldibromo glutaronitrile" 3 => "2-phenoxyethanol" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84429" "palabras" => array:4 [ 0 => "dermatitis alérgica de contacto" 1 => "Euxyl K-400" 2 => "metildibromo glutaronitrilo" 3 => "2-fenoxietanol" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Euxyl K400 is a widely used preservative in cosmetics, topical drugs, cutting fluids, etc. This antimicrobial product has two active components—methyldibromo glutaronitrile (MDGN), also known as 1,2-dibromo-2,4-dicyanobutane, and 2-phenoxyethanol, in a proportion of 1 to 4.The aim of this study was to assess the prevalence of sensitization to this preservative in cases in our dermatology department over a 5-year period. We also assessed the prevalence of sensitization to the two active components of Euxyl K400 and calculated the agreement with sensitization to Euxyl K400.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">In this retrospective study, we analyzed the medical records of 1,092 patients attended in our skin allergy unit between January 2000 and December 2005.We undertook testing with a standard battery that included, in addition to the allergens recommended by the Spanish Group for Research Into Dermatitis and Skin Allergies (GEIDAC), 0.3% MDGN and 1% 2-phenoxyethanol in Vaseline (Trolab<span class="elsevierStyleSup">®</span>).</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Only 15 patients developed a positive reaction to Euxyl K400. Of these, 11 were positive to MDGN and 2 to phenoxyethanol. Sensitization to Euxyl K400 was significantly more common in men. The agreement between sensitization to Euxyl K400 and MDGN was good (Kp = 0.68), whereas agreement between Euxyl K400 and phenoxyethanol was poor (Kp = 0.23).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of Euxyl K400 sensitization in this study was 1.4%. Most cases of Euxyl K400 sensitization were associated with the MDGN component, as indicated by the good agreement between the two substances.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">I</span>El Euxyl K-400 es un conservante muy utilizado en cosméticos, medicamentos de uso tópico, fluidos de corte, etc. Este producto antimicrobiano consta de dos componentes activos: metildibromoglutaronitrilo (MDGN), también llamado 1,2-dibromo-2,4-dicianobutano, y 2-fenoxietanol, en una proporción 1:4. El objetivo de este estudio fue evaluar la prevalencia de sensibilización a este conservante en nuestro departamento de Dermatología, en un período de 5 años. Evaluamos también la prevalencia de sensibilización de los dos componentes del Euxyl K-400 y calculamos la concordancia entre dichas sensibilizaciones.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos realizado un estudio retrospectivo analizando las historias clínicas de 1.092 pacientes estudiados en nuestra unidad de Alergia Cutánea desde enero de 2000 hasta diciembre de 2005. Realizamos pruebas con una batería estándar que contenía, además de todos los alérgenos recomendados por el Grupo Español de Investigación en Dermatitis y Alergia Cutánea (GEIDAC), el MDGN al 0,3% y el 2-fenoxietanol al 1% en vaselina (Trolab<span class="elsevierStyleSup">®</span>).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Solo 15 pacientes presentaron positividad al Euxyl K-400, de los que 11 fueron positivos al MDGN y 2 al fenoxietanol. La sensibilización al Euxyl K-400 fue significativamente superior en los hombres. La concordancia entre la sensibilización al Euxyl K-400 y el MDGN fue buena (Kp = 0,68), mientras que la concordancia entre el Euxyl K-400 y el fenoxietanol solo fue regular (Kp = 0,23).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La prevalencia de sensibilización al Euxyl K-400 en nuestro estudio fue de 1,4%. La mayoría de las sensibilizaciones al Euxyl K-400 se debe al componente MDGN, hecho corroborado en nuestro trabajo, en el que se observa una buena concordancia entre ambos alérgenos<span class="elsevierStyleItalic">.</span></p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Johansen" 2 => "S.C. Rastogi" 3 => "T. Menné" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.0105-1873.2005.00478.x" "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2005" "volumen" => "52" "paginaInicial" => "6" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15701121" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Methyldibromoglutaronitrile is an important contact allergen in The Netherlands" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.C. De Groot" 1 => "P.A. de Cock" 2 => "P.J. Coenraads" 3 => "C.J. van Ginkel" 4 => "B.A. Jagtman" 5 => "T. van Joost" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1996" "volumen" => "34" "paginaInicial" => "118" "paginaFinal" => "120" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8681539" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational allergic contact dermatitis to methyldibromoglutaronitrile in hand degreasing toilet paper" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.E. Marcano" 1 => "F. Heras" 2 => "L. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 8 | 10 |
| 2024 October | 60 | 55 | 115 |
| 2024 September | 66 | 45 | 111 |
| 2024 August | 82 | 54 | 136 |
| 2024 July | 57 | 42 | 99 |
| 2024 June | 56 | 38 | 94 |
| 2024 May | 45 | 37 | 82 |
| 2024 April | 67 | 31 | 98 |
| 2024 March | 49 | 42 | 91 |
| 2024 February | 58 | 50 | 108 |
| 2024 January | 43 | 44 | 87 |
| 2023 December | 38 | 56 | 94 |
| 2023 November | 43 | 66 | 109 |
| 2023 October | 30 | 41 | 71 |
| 2023 September | 31 | 34 | 65 |
| 2023 August | 22 | 32 | 54 |
| 2023 July | 27 | 68 | 95 |
| 2023 June | 25 | 37 | 62 |
| 2023 May | 33 | 41 | 74 |
| 2023 April | 19 | 45 | 64 |
| 2023 March | 21 | 32 | 53 |
| 2023 February | 26 | 28 | 54 |
| 2023 January | 22 | 44 | 66 |
| 2022 December | 34 | 56 | 90 |
| 2022 November | 19 | 41 | 60 |
| 2022 October | 19 | 29 | 48 |
| 2022 September | 12 | 48 | 60 |
| 2022 August | 19 | 50 | 69 |
| 2022 July | 12 | 36 | 48 |
| 2022 June | 20 | 31 | 51 |
| 2022 May | 32 | 51 | 83 |
| 2022 April | 44 | 61 | 105 |
| 2022 March | 27 | 62 | 89 |
| 2022 February | 30 | 37 | 67 |
| 2022 January | 34 | 60 | 94 |
| 2021 December | 27 | 50 | 77 |
| 2021 November | 45 | 53 | 98 |
| 2021 October | 59 | 54 | 113 |
| 2021 September | 45 | 51 | 96 |
| 2021 August | 25 | 43 | 68 |
| 2021 July | 25 | 39 | 64 |
| 2021 June | 28 | 29 | 57 |
| 2021 May | 22 | 41 | 63 |
| 2021 April | 38 | 31 | 69 |
| 2021 March | 67 | 24 | 91 |
| 2021 February | 54 | 40 | 94 |
| 2021 January | 35 | 28 | 63 |
| 2020 December | 15 | 16 | 31 |
| 2020 November | 29 | 26 | 55 |
| 2020 October | 16 | 7 | 23 |
| 2020 September | 31 | 5 | 36 |
| 2020 August | 35 | 23 | 58 |
| 2020 July | 24 | 18 | 42 |
| 2020 June | 29 | 27 | 56 |
| 2020 May | 30 | 33 | 63 |
| 2020 April | 34 | 25 | 59 |
| 2020 March | 27 | 28 | 55 |
| 2020 February | 6 | 7 | 13 |
| 2020 January | 0 | 8 | 8 |
| 2019 December | 0 | 11 | 11 |
| 2019 November | 0 | 4 | 4 |
| 2019 October | 0 | 2 | 2 |
| 2019 September | 0 | 3 | 3 |
| 2019 August | 0 | 2 | 2 |
| 2019 July | 0 | 5 | 5 |
| 2019 June | 0 | 6 | 6 |
| 2019 May | 0 | 42 | 42 |
| 2019 April | 0 | 2 | 2 |
| 2019 March | 0 | 7 | 7 |
| 2019 February | 0 | 5 | 5 |
| 2018 April | 0 | 5 | 5 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 9 | 4 | 13 |
| 2018 January | 31 | 6 | 37 |
| 2017 December | 17 | 8 | 25 |
| 2017 November | 20 | 9 | 29 |
| 2017 October | 16 | 13 | 29 |
| 2017 September | 21 | 7 | 28 |
| 2017 August | 25 | 18 | 43 |
| 2017 July | 32 | 4 | 36 |
| 2017 June | 36 | 17 | 53 |
| 2017 May | 18 | 20 | 38 |
| 2017 April | 29 | 10 | 39 |
| 2017 March | 25 | 8 | 33 |
| 2017 February | 16 | 9 | 25 |
| 2017 January | 17 | 16 | 33 |
| 2016 December | 43 | 10 | 53 |
| 2016 November | 34 | 12 | 46 |
| 2016 October | 31 | 27 | 58 |
| 2016 September | 60 | 21 | 81 |
| 2016 August | 54 | 22 | 76 |
| 2016 July | 37 | 9 | 46 |
| 2016 June | 15 | 12 | 27 |
| 2016 May | 10 | 2 | 12 |
| 2016 April | 7 | 21 | 28 |
| 2016 March | 6 | 1 | 7 |
| 2016 February | 12 | 20 | 32 |
| 2016 January | 6 | 24 | 30 |
| 2015 December | 6 | 13 | 19 |
| 2015 November | 14 | 22 | 36 |
| 2015 October | 8 | 19 | 27 |
| 2015 September | 8 | 18 | 26 |
| 2015 August | 19 | 7 | 26 |
| 2015 July | 31 | 13 | 44 |
| 2015 June | 48 | 14 | 62 |
| 2015 May | 63 | 21 | 84 |
| 2015 April | 28 | 22 | 50 |
| 2015 March | 32 | 27 | 59 |
| 2015 February | 24 | 11 | 35 |
| 2015 January | 28 | 8 | 36 |
| 2014 December | 26 | 6 | 32 |
| 2014 November | 24 | 18 | 42 |
| 2014 October | 45 | 24 | 69 |
| 2014 September | 40 | 29 | 69 |
| 2014 August | 42 | 19 | 61 |
| 2014 July | 56 | 22 | 78 |
| 2014 June | 54 | 11 | 65 |
| 2014 May | 53 | 16 | 69 |
| 2014 April | 49 | 12 | 61 |
| 2014 March | 64 | 21 | 85 |
| 2014 February | 50 | 19 | 69 |
| 2014 January | 43 | 14 | 57 |
| 2013 December | 46 | 8 | 54 |
| 2013 November | 30 | 15 | 45 |
| 2013 October | 35 | 24 | 59 |
| 2013 September | 32 | 17 | 49 |
| 2013 August | 25 | 20 | 45 |
| 2013 July | 33 | 43 | 76 |
| 2013 June | 23 | 19 | 42 |
| 2013 May | 20 | 22 | 42 |
| 2013 April | 27 | 30 | 57 |
| 2013 March | 21 | 21 | 42 |
| 2013 February | 35 | 9 | 44 |
| 2013 January | 53 | 3 | 56 |
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