Original articles
Retrospective, Descriptive, Observational Study of Treatment of Multiple Actinic Keratoses With Topical Methyl Aminolevulinate and Red Light: Results in Clinical Practice and Correlation With Fluorescence Imaging
Estudio Retrospectivo, Descriptivo y Observacional del Tratamiento de Queratosis Actínicas Múltiples con Metilaminolevulinato Tópico y Luz Roja: Resultados en la Práctica Clínica y Correlación con la Imagen de Fluorescencia
Read
5974
Timeswas read the article
2792
Total PDF
3182
Total HTML
Share statistics
array:23 [ "pii" => "S1578219008703664" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70366-4" "estado" => "S300" "fechaPublicacion" => "2008-12-01" "aid" => "70366" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:779-87" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2398 "formatos" => array:3 [ "EPUB" => 40 "HTML" => 1369 "PDF" => 989 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219008703676" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70367-6" "estado" => "S300" "fechaPublicacion" => "2008-12-01" "aid" => "70367" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:788-94" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3160 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 1469 "PDF" => 1648 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Sensitization to Acrylates Caused by Artificial Acrylic Nails: Review of 15 Cases" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "788" "paginaFinal" => "794" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Sensibilización a Acrilatos por Uñas Artificiales Acrílicas. Revisión de 15 Casos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Roche, J. de la Cuadra, V. Alegre" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Roche" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "de la Cuadra" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Alegre" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703676?idApp=UINPBA000044" "url" => "/15782190/0000009900000010/v1_201304241444/S1578219008703676/v1_201304241444/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219008703652" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70365-2" "estado" => "S300" "fechaPublicacion" => "2008-12-01" "aid" => "70365" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:772-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2925 "formatos" => array:3 [ "EPUB" => 35 "HTML" => 1543 "PDF" => 1347 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Practical dermatology</span>" "titulo" => "Strategies for Getting Published in High-Impact Dermatology Journals" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "772" "paginaFinal" => "778" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estrategias Para Publicar en Revistas de Dermatología de Impacto" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Pulido" "autores" => array:1 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Pulido" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703652?idApp=UINPBA000044" "url" => "/15782190/0000009900000010/v1_201304241444/S1578219008703652/v1_201304241444/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Retrospective, Descriptive, Observational Study of Treatment of Multiple Actinic Keratoses With Topical Methyl Aminolevulinate and Red Light: Results in Clinical Practice and Correlation With Fluorescence Imaging" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "779" "paginaFinal" => "787" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Fernández-Guarino, A. Harto, M. Sánchez-Ronco, B. Pérez-García, A. Marquet, P. Jaén" "autores" => array:6 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Fernández-Guarino" "email" => array:1 [ 0 => "montsefdez@msn.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Harto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Sánchez-Ronco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "B." "apellidos" => "Pérez-García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Marquet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "P." "apellidos" => "Jaén" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento de Ciencias Sanitarias y Médico-Sociales, Facultad de Medicina, Universidad de Alcalá de Henares, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Hospital Ramón y Cajal, Carretera de Colmenar km. 9.100, 28034 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio Retrospectivo, Descriptivo y Observacional del Tratamiento de Queratosis Actínicas Múltiples con Metilaminolevulinato Tópico y Luz Roja: Resultados en la Práctica Clínica y Correlación con la Imagen de Fluorescencia" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-04-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84350" "palabras" => array:5 [ 0 => "photodynamic therapy" 1 => "actinic keratosis" 2 => "methyl aminolevulinate" 3 => "red light" 4 => "fluorescence diagnosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84349" "palabras" => array:5 [ 0 => "terapia fotodinámica" 1 => "queratosis actínicas" 2 => "metilaminolevulinato" 3 => "luz roja" 4 => "diagnóstico de fluorescencia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Actinic keratosis (AK) is one of the most common skin diseases seen in clinical practice. In the last 5 years, several studies assessing the efficacy of photodynamic therapy in the treatment of multiple AKs have been published.</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">We aimed to assess the clinical outcomes of photodynamic therapy in patients with multiple AKs and the correlation of those outcomes with fluorescence imaging.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">In this retrospective, descriptive, observational study of 57 patients treated in our hospital with photodynamic therapy for multiple AKs, we recorded age, sex, and lesion site (face, scalp, and dorsum of the hands). All patients were treated in the same way: methyl aminolevulinic acid (Metvix<span class="elsevierStyleSup">®</span>) was applied for 3 hours and the skin then irradiated with red light at 630 nm, 37 J/cm<span class="elsevierStyleSup">2</span>, for 7.5 minutes (Aktilite<span class="elsevierStyleSup">®</span>). The response, remission duration, tolerance, number of sessions, and fluorescence images were recorded by site. The χ<span class="elsevierStyleSup">2</span> test was used to assess between-site differences and the correlation between fluorescence imaging and clinical response.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The greatest improvements were obtained for facial lesions; these required fewer sessions and remission lasted longer than lesions at other sites. The treatment was best tolerated on the dorsum of the hands. The fluorescence area and the reduction in intensity on applying treatment were found to be strongly and significantly correlated with the extent of clinical response.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Overall, the outcomes of treatment of multiple AKs with photodynamic therapy are better for the face than for the scalp and dorsum of the hands. Fluorescence imaging may be an effective tool for predicting response to treatment.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Las queratosis actínicas (QA) son una de las patologías cutáneas más frecuentes en la práctica clínica. En los últimos 5 años se han publicado varios estudios que evaluaban la eficacia de la terapia fotodinámica (TFD) en el tratamiento de múltiples QA.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar los resultados de la TFD de múltiples QA por localizaciones y su correlación con la imagen de fluorescencia.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Realizamos un estudio retrospectivo, descriptivo y observacional de los pacientes tratados por múltiples QA con TFD en nuestro hospital. Se describe la edad, el sexo y la localización de las lesiones (cara, cuero cabelludo y dorso de las manos) de los 57 pacientes. Se trató a todos los pacientes usando los mismos parámetros: ácido metilaminolevulínico (MAL, Metvix<span class="elsevierStyleSup">®</span>) ocluido tres horas e irradiación con luz roja de 630 nm, 37 J/cm<span class="elsevierStyleSup">2</span>, 7,5 minutos (Aktilite<span class="elsevierStyleSup">®</span>). Se describe la respuesta, período de remisión, tolerancia, número de sesiones y la fluorescencia según localizaciones. Con la prueba Chi-cua-drado se evalúan las diferencias entre localizaciones y la correlación de la imagen de fluorescencia con la respuesta clínica.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En la cara se obtiene mayor grado de mejoría, se requieren menor número de sesiones y mayores períodos de remisión que en el resto de las localizaciones. El dorso de las manos es la zona mejor tolerada. Existe una correlación alta y significativa entre el área de fluorescencia y su disminución al aplicar el tratamiento, con el grado de respuesta clínica.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los resultados en el tratamiento de múltiples QA con TFD son mejores, globalmente, en la cara que en el cuero cabelludo y en el dorso de manos. El diagnóstico de fluorescencia puede ser una herramienta eficaz para predecir la respuesta al tratamiento.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia fotodinámica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.P. Golman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "1.ª ed." "fecha" => "2006" "editorial" => "Editorial Elsevier" "editorialLocalizacion" => "Madrid" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The risk of progression to invasive disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.G. Glogau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2000" "volumen" => "42" "numero" => "Pt 2" "paginaInicial" => "23" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10607353" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia fotodinámica en Dermatología" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Gilaberte" 1 => "C. Serra-Guillén" 2 => "M.E. de las Heras" 3 => "R. Ruiz-Rodríguez" 4 => "M. Fernández-Lorente" 5 => "C. Benvenuto-Andrade" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2006" "volumen" => "97" "paginaInicial" => "83" "paginaFinal" => "102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16595110" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia fotodinámica en dermatología" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Marquet" 1 => "M. Fernández-Guarino" 2 => "B. Pérez-García" 3 => "A. Harto" 4 => "P. Jaén" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatología Práctica" "fecha" => "2006" "volumen" => "14" "paginaInicial" => "30" "paginaFinal" => "35" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between ppIX and fluorescence diagnosis in psoriasis and actinic keratoses using a digital fluorescence imaging system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T. Smits" 1 => "C. Robles" 2 => "P.E. Van Erp" 3 => "P.C. Van der Kerhof" 4 => "M.J. Gerritsen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Book of Abstracts of the Annual Meeting of the European Society for Photodynamic Therapy" "paginaInicial" => "57" "conferencia" => "Italy, Brescia" "serieFecha" => "2005" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.A. Olsen" 1 => "L. Abernethy" 2 => "C. Kulp-Shorten" 3 => "J.P. Callen" 4 => "S.D. Glazer" 5 => "A. Huntley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1991" "volumen" => "5" "paginaInicial" => "738" "paginaFinal" => "743" "itemHostRev" => array:3 [ "pii" => "S0015028206046735" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia fotodinámica: nuevas indicaciones" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Fernández-Guarino" 1 => "I. García-Morales" 2 => "A. Harto" 3 => "C. Montull" 4 => "B. Pérez-García" 5 => "P. Jaén" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2007" "volumen" => "98" "paginaInicial" => "377" "paginaFinal" => "395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17663928" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix<span class="elsevierStyleSup">®</span>) in actinic keratosis on the face and scalp" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Tarstedt" 1 => "I. Rosdahl" 2 => "B. Berne" 3 => "K. Svanberg" 4 => "A.M. Wennberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/00015550510032887" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2005" "volumen" => "85" "paginaInicial" => "424" "paginaFinal" => "428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16159735" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.M. Szeimies" 1 => "S. Barrer" 2 => "S. Radakovic-Fijan" 3 => "A. Tanew" 4 => "P.G. Calzavara-Pinton" 5 => "C. Zane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2002" "volumen" => "47" "paginaInicial" => "258" "paginaFinal" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12140473" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy with topical methyl aminolevulinate (Metvix<span class="elsevierStyleSup">®</span>) is effective and safe in the treatment of actinic keratosis: results of a prospective randomized trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.M. Pariser" 1 => "N.J. Lowe" 2 => "D.M. Stewar" 3 => "M.T. Jarratt" 4 => "A.W. Lucky" 5 => "R.J. Pariser" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mjd.2003.49" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2003" "volumen" => "48" "paginaInicial" => "227" "paginaFinal" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12582393" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1552526008029841" "estado" => "S300" "issn" => "15525260" ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraindividual right-left comparison of topical methyl-aminolevulinate-photodynamic therapy (MAL-PDT) and cryotherapy in subjects with actinic keratosis: a multicentre, randomized controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Morton" 1 => "S. Campbell" 2 => "G. Gupta" 3 => "S. Keohane" 4 => "J. Lear" 5 => "I. Zaki" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07470.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2006" "volumen" => "155" "paginaInicial" => "1029" "paginaFinal" => "1036" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17034536" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix<span class="elsevierStyleSup">®</span>) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Freeman" 1 => "C. Vinciullo" 2 => "D. Francis" 3 => "L. Spelman" 4 => "R. Nguyen" 5 => "P. Fergin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dermatol Treat" "fecha" => "2003" "volumen" => "14" "paginaInicial" => "99" "paginaFinal" => "106" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy for actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.B. Ericson" 1 => "C. Sandberg" 2 => "B. Stenquist" 3 => "F. Gudmundson" 4 => "M. Karlsson" 5 => "A.M. Ros" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2004.06211.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2004" "volumen" => "151" "paginaInicial" => "1204" "paginaFinal" => "1212" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15606516" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000009900000010/v1_201304241444/S1578219008703664/v1_201304241444/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000010/v1_201304241444/S1578219008703664/v1_201304241444/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703664?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 6 | 11 |
| 2024 October | 59 | 66 | 125 |
| 2024 September | 56 | 28 | 84 |
| 2024 August | 114 | 66 | 180 |
| 2024 July | 67 | 44 | 111 |
| 2024 June | 69 | 31 | 100 |
| 2024 May | 62 | 42 | 104 |
| 2024 April | 49 | 33 | 82 |
| 2024 March | 57 | 46 | 103 |
| 2024 February | 52 | 34 | 86 |
| 2024 January | 45 | 42 | 87 |
| 2023 December | 35 | 52 | 87 |
| 2023 November | 38 | 37 | 75 |
| 2023 October | 32 | 31 | 63 |
| 2023 September | 40 | 24 | 64 |
| 2023 August | 34 | 22 | 56 |
| 2023 July | 37 | 51 | 88 |
| 2023 June | 40 | 24 | 64 |
| 2023 May | 41 | 21 | 62 |
| 2023 April | 19 | 22 | 41 |
| 2023 March | 27 | 16 | 43 |
| 2023 February | 25 | 14 | 39 |
| 2023 January | 31 | 29 | 60 |
| 2022 December | 34 | 32 | 66 |
| 2022 November | 14 | 22 | 36 |
| 2022 October | 19 | 18 | 37 |
| 2022 September | 10 | 28 | 38 |
| 2022 August | 18 | 100 | 118 |
| 2022 July | 10 | 29 | 39 |
| 2022 June | 19 | 25 | 44 |
| 2022 May | 26 | 30 | 56 |
| 2022 April | 28 | 33 | 61 |
| 2022 March | 34 | 86 | 120 |
| 2022 February | 21 | 32 | 53 |
| 2022 January | 19 | 30 | 49 |
| 2021 December | 22 | 41 | 63 |
| 2021 November | 24 | 31 | 55 |
| 2021 October | 42 | 45 | 87 |
| 2021 September | 17 | 40 | 57 |
| 2021 August | 17 | 20 | 37 |
| 2021 July | 14 | 28 | 42 |
| 2021 June | 30 | 40 | 70 |
| 2021 May | 23 | 23 | 46 |
| 2021 April | 57 | 44 | 101 |
| 2021 March | 34 | 25 | 59 |
| 2021 February | 33 | 24 | 57 |
| 2021 January | 15 | 18 | 33 |
| 2020 December | 18 | 16 | 34 |
| 2020 November | 20 | 18 | 38 |
| 2020 October | 31 | 11 | 42 |
| 2020 September | 13 | 11 | 24 |
| 2020 August | 16 | 21 | 37 |
| 2020 July | 25 | 12 | 37 |
| 2020 June | 17 | 22 | 39 |
| 2020 May | 20 | 20 | 40 |
| 2020 April | 22 | 26 | 48 |
| 2020 March | 16 | 19 | 35 |
| 2020 February | 1 | 4 | 5 |
| 2020 January | 0 | 7 | 7 |
| 2019 December | 0 | 8 | 8 |
| 2019 November | 0 | 8 | 8 |
| 2019 October | 0 | 1 | 1 |
| 2019 September | 0 | 3 | 3 |
| 2019 August | 0 | 6 | 6 |
| 2019 July | 0 | 10 | 10 |
| 2019 June | 0 | 8 | 8 |
| 2019 May | 1 | 59 | 60 |
| 2019 April | 0 | 18 | 18 |
| 2019 March | 0 | 5 | 5 |
| 2019 February | 0 | 9 | 9 |
| 2018 June | 0 | 2 | 2 |
| 2018 May | 0 | 9 | 9 |
| 2018 April | 0 | 2 | 2 |
| 2018 February | 9 | 6 | 15 |
| 2018 January | 16 | 5 | 21 |
| 2017 December | 17 | 4 | 21 |
| 2017 November | 15 | 5 | 20 |
| 2017 October | 11 | 5 | 16 |
| 2017 September | 12 | 9 | 21 |
| 2017 August | 14 | 12 | 26 |
| 2017 July | 23 | 12 | 35 |
| 2017 June | 21 | 21 | 42 |
| 2017 May | 19 | 10 | 29 |
| 2017 April | 16 | 11 | 27 |
| 2017 March | 24 | 36 | 60 |
| 2017 February | 11 | 6 | 17 |
| 2017 January | 8 | 12 | 20 |
| 2016 December | 28 | 4 | 32 |
| 2016 November | 23 | 4 | 27 |
| 2016 October | 26 | 9 | 35 |
| 2016 September | 26 | 8 | 34 |
| 2016 August | 20 | 9 | 29 |
| 2016 July | 19 | 10 | 29 |
| 2016 June | 9 | 5 | 14 |
| 2016 May | 5 | 6 | 11 |
| 2016 April | 10 | 4 | 14 |
| 2016 March | 6 | 10 | 16 |
| 2016 February | 5 | 13 | 18 |
| 2016 January | 8 | 8 | 16 |
| 2015 December | 11 | 8 | 19 |
| 2015 November | 12 | 9 | 21 |
| 2015 October | 9 | 9 | 18 |
| 2015 September | 1 | 7 | 8 |
| 2015 August | 6 | 1 | 7 |
| 2015 July | 23 | 10 | 33 |
| 2015 June | 29 | 10 | 39 |
| 2015 May | 46 | 19 | 65 |
| 2015 April | 22 | 17 | 39 |
| 2015 March | 26 | 8 | 34 |
| 2015 February | 16 | 20 | 36 |
| 2015 January | 21 | 14 | 35 |
| 2014 December | 39 | 14 | 53 |
| 2014 November | 22 | 20 | 42 |
| 2014 October | 39 | 19 | 58 |
| 2014 September | 30 | 19 | 49 |
| 2014 August | 33 | 14 | 47 |
| 2014 July | 49 | 20 | 69 |
| 2014 June | 45 | 16 | 61 |
| 2014 May | 38 | 16 | 54 |
| 2014 April | 26 | 11 | 37 |
| 2014 March | 38 | 23 | 61 |
| 2014 February | 33 | 18 | 51 |
| 2014 January | 36 | 20 | 56 |
| 2013 December | 42 | 14 | 56 |
| 2013 November | 28 | 20 | 48 |
| 2013 October | 26 | 16 | 42 |
| 2013 September | 21 | 16 | 37 |
| 2013 August | 26 | 20 | 46 |
| 2013 July | 28 | 26 | 54 |
| 2013 June | 18 | 50 | 68 |
| 2013 May | 25 | 17 | 42 |
| 2013 April | 25 | 34 | 59 |
| 2013 March | 31 | 20 | 51 |
| 2013 February | 33 | 9 | 42 |
| 2013 January | 14 | 4 | 18 |
Show all
