Advances in dermatology
Genotypic Analysis in Primary Cutaneous Lymphomas Using the Standardized Biomed-2 Polymerase Chain Reaction Protocols
Aplicación de los Protocolos de PCR Biomed-2 en el Análisis Genotípico de los Linfomas Cutáneos Primarios
F. Gallardoa,
, B. Bellosillob, S. Serranob, R.M. Pujola
Corresponding author
FGallardo@imas.imim.es
Correspondence: Servicio de Dermatología, Hospital del Mar, IMAS, Passeig Marítim, 25-29, 08003 Barcelona, Spain.
Correspondence: Servicio de Dermatología, Hospital del Mar, IMAS, Passeig Marítim, 25-29, 08003 Barcelona, Spain.
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Pujol" "autores" => array:4 [ 0 => array:4 [ "nombre" => "F." "apellidos" => "Gallardo" "email" => array:1 [ 0 => "FGallardo@imas.imim.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "Bellosillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Serrano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "R.M." "apellidos" => "Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Servicio de Patología, Hospital del Mar, IMAS, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Laboratorio de Biología Molecular, Servicio de Patología, Hospital del Mar, IMAS, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital del Mar, IMAS, Passeig Marítim, 25-29, 08003 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aplicación de los Protocolos de PCR Biomed-2 en el Análisis Genotípico de los Linfomas Cutáneos Primarios" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-02-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84271" "palabras" => array:6 [ 0 => "cutaneous lymphoma" 1 => "gene rearrangement" 2 => "clonality" 3 => "polymerase chain reaction" 4 => "BIOMED-2" 5 => "GeneScan" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84272" "palabras" => array:6 [ 0 => "linfoma cutáneo" 1 => "reordenamiento genético" 2 => "clonalidad" 3 => "reacción en cadena de la polimerasa" 4 => "BIOMED-2" 5 => "GeneScan" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The European Biomedicine and Health (BIOMED-2) Concerted Action Project BMH4-CT98-3936 has defined standardized protocols for polymerase chain reaction (PCR) amplification of different loci of the T-cell receptor (TCR) and immunoglobulin (Ig) genes with a view to achieving greater sensitivity and specificity in the assessment of clonality of lymphoid neoplasms. To assess T-cell clonality, analysis of TCRβ gene and TCRδ rearrangements (useful in cases of Tγδ+ cell neoplasms) is proposed alongside that of TCRγ. For analysis of B-cell clonality, along with the framework (FR) III segment of the IgH gene, other segments are studied (FRI, FRII) in addition to Igγ and Igκ genes or incomplete DJ rearrangements of the IgH gene and the κ deleting element. The results of the amplification are read using automatic reading systems (GeneScan) or using a heteroduplex system.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El proyecto europeo BIOMED-2 Concerted Action BMH4-CT98-3936 describe protocolos estandarizados de amplificación por reacción en cadena de la polimerasa (PCR) de los diferentes <span class="elsevierStyleItalic">loci</span> de los genes del receptor de la célula T (TCR) e inmunoglobulinas (Ig) con el objetivo de obtener una mayor sensibilidad y especificidad en el estudio de clonalidad de las neoplasias linfoides. En el estudio de clonalidad T, además del TCRγ se propone el estudio adicional de los reordenamientos del gen TCRβ y del <span class="elsevierStyleItalic">locus</span> TCRδ (útil en casos de neoplasias de células Tγδ+). En el estudio de clonalidad B, junto al segmento FRIII del gen IgH se diseña el estudio de otros segmentos (FRI, FRII), así como de los genes Igλ e Igκ o reordenamientos incompletos DJ del gen IgH y κde (<span class="elsevierStyleItalic">kappa deleting element</span>). La lectura de los resultados de la amplificación se realiza mediante sistemas automatizados de lectura (GeneScan) o mediante el sistema heterodúplex.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">This study was partly funded by the FIS 03/394 grant from the Spanish Ministry of Health and Consumer Affairs.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:71 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 9 | 15 |
| 2024 October | 63 | 39 | 102 |
| 2024 September | 56 | 26 | 82 |
| 2024 August | 90 | 51 | 141 |
| 2024 July | 61 | 34 | 95 |
| 2024 June | 61 | 30 | 91 |
| 2024 May | 51 | 41 | 92 |
| 2024 April | 51 | 38 | 89 |
| 2024 March | 54 | 39 | 93 |
| 2024 February | 59 | 37 | 96 |
| 2024 January | 53 | 49 | 102 |
| 2023 December | 50 | 24 | 74 |
| 2023 November | 62 | 42 | 104 |
| 2023 October | 34 | 30 | 64 |
| 2023 September | 38 | 25 | 63 |
| 2023 August | 27 | 22 | 49 |
| 2023 July | 46 | 85 | 131 |
| 2023 June | 44 | 25 | 69 |
| 2023 May | 38 | 24 | 62 |
| 2023 April | 26 | 24 | 50 |
| 2023 March | 27 | 28 | 55 |
| 2023 February | 24 | 16 | 40 |
| 2023 January | 38 | 21 | 59 |
| 2022 December | 25 | 36 | 61 |
| 2022 November | 15 | 24 | 39 |
| 2022 October | 16 | 19 | 35 |
| 2022 September | 17 | 49 | 66 |
| 2022 August | 13 | 47 | 60 |
| 2022 July | 13 | 21 | 34 |
| 2022 June | 33 | 35 | 68 |
| 2022 May | 53 | 81 | 134 |
| 2022 April | 53 | 58 | 111 |
| 2022 March | 40 | 79 | 119 |
| 2022 February | 32 | 41 | 73 |
| 2022 January | 42 | 36 | 78 |
| 2021 December | 20 | 45 | 65 |
| 2021 November | 32 | 51 | 83 |
| 2021 October | 26 | 69 | 95 |
| 2021 September | 22 | 40 | 62 |
| 2021 August | 58 | 40 | 98 |
| 2021 July | 19 | 26 | 45 |
| 2021 June | 32 | 20 | 52 |
| 2021 May | 32 | 34 | 66 |
| 2021 April | 92 | 79 | 171 |
| 2021 March | 104 | 43 | 147 |
| 2021 February | 77 | 26 | 103 |
| 2021 January | 43 | 17 | 60 |
| 2020 December | 26 | 17 | 43 |
| 2020 November | 25 | 28 | 53 |
| 2020 October | 17 | 24 | 41 |
| 2020 September | 43 | 21 | 64 |
| 2020 August | 28 | 18 | 46 |
| 2020 July | 38 | 10 | 48 |
| 2020 June | 31 | 30 | 61 |
| 2020 May | 39 | 30 | 69 |
| 2020 April | 31 | 21 | 52 |
| 2020 March | 25 | 30 | 55 |
| 2020 February | 2 | 13 | 15 |
| 2020 January | 0 | 13 | 13 |
| 2019 December | 0 | 17 | 17 |
| 2019 November | 0 | 4 | 4 |
| 2019 October | 0 | 6 | 6 |
| 2019 September | 0 | 9 | 9 |
| 2019 August | 0 | 5 | 5 |
| 2019 July | 0 | 19 | 19 |
| 2019 June | 1 | 17 | 18 |
| 2019 May | 1 | 37 | 38 |
| 2019 April | 0 | 16 | 16 |
| 2019 March | 0 | 14 | 14 |
| 2019 February | 0 | 13 | 13 |
| 2019 January | 0 | 5 | 5 |
| 2018 December | 1 | 5 | 6 |
| 2018 November | 0 | 4 | 4 |
| 2018 September | 1 | 0 | 1 |
| 2018 August | 0 | 6 | 6 |
| 2018 July | 0 | 8 | 8 |
| 2018 June | 0 | 32 | 32 |
| 2018 May | 0 | 3 | 3 |
| 2018 March | 1 | 2 | 3 |
| 2018 February | 16 | 9 | 25 |
| 2018 January | 21 | 9 | 30 |
| 2017 December | 25 | 7 | 32 |
| 2017 November | 22 | 9 | 31 |
| 2017 October | 24 | 12 | 36 |
| 2017 September | 16 | 12 | 28 |
| 2017 August | 14 | 12 | 26 |
| 2017 July | 17 | 9 | 26 |
| 2017 June | 24 | 32 | 56 |
| 2017 May | 22 | 21 | 43 |
| 2017 April | 35 | 15 | 50 |
| 2017 March | 20 | 30 | 50 |
| 2017 February | 16 | 7 | 23 |
| 2017 January | 8 | 6 | 14 |
| 2016 December | 26 | 15 | 41 |
| 2016 November | 28 | 15 | 43 |
| 2016 October | 18 | 12 | 30 |
| 2016 September | 26 | 13 | 39 |
| 2016 August | 24 | 9 | 33 |
| 2016 July | 19 | 5 | 24 |
| 2016 June | 9 | 8 | 17 |
| 2016 May | 10 | 25 | 35 |
| 2016 April | 8 | 22 | 30 |
| 2016 March | 3 | 6 | 9 |
| 2016 February | 5 | 9 | 14 |
| 2016 January | 10 | 9 | 19 |
| 2015 December | 8 | 3 | 11 |
| 2015 November | 13 | 4 | 17 |
| 2015 October | 11 | 3 | 14 |
| 2015 September | 7 | 6 | 13 |
| 2015 August | 13 | 5 | 18 |
| 2015 July | 32 | 7 | 39 |
| 2015 June | 33 | 14 | 47 |
| 2015 May | 78 | 18 | 96 |
| 2015 April | 47 | 19 | 66 |
| 2015 March | 47 | 10 | 57 |
| 2015 February | 19 | 19 | 38 |
| 2015 January | 24 | 19 | 43 |
| 2014 December | 30 | 11 | 41 |
| 2014 November | 37 | 17 | 54 |
| 2014 October | 24 | 16 | 40 |
| 2014 September | 28 | 10 | 38 |
| 2014 August | 33 | 18 | 51 |
| 2014 July | 36 | 18 | 54 |
| 2014 June | 35 | 18 | 53 |
| 2014 May | 48 | 13 | 61 |
| 2014 April | 27 | 17 | 44 |
| 2014 March | 38 | 16 | 54 |
| 2014 February | 16 | 15 | 31 |
| 2014 January | 32 | 22 | 54 |
| 2013 December | 32 | 15 | 47 |
| 2013 November | 32 | 37 | 69 |
| 2013 October | 21 | 43 | 64 |
| 2013 September | 30 | 19 | 49 |
| 2013 August | 25 | 26 | 51 |
| 2013 July | 35 | 34 | 69 |
| 2013 June | 27 | 24 | 51 |
| 2013 May | 30 | 22 | 52 |
| 2013 April | 21 | 40 | 61 |
| 2013 March | 33 | 26 | 59 |
| 2013 February | 35 | 21 | 56 |
| 2013 January | 18 | 5 | 23 |
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