Determinant Factors of Disease Severity for Patients With Hidradenitis Suppurativa Evaluated in a Spanish Hospital Over a 5-Year Period

array:23 ["pii" => "S0001731024005945" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.10.051" "estado" => "S200" "fechaPublicacion" => "2024-09-03" "aid" => "4023" "copyright" => "AEDV" "copyrightAnyo" => "2024" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S0001731024005994" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.06.008" "estado" => "S200" "fechaPublicacion" => "2024-09-03" "aid" => "4028" "copyright" => "AEDV" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Effects of Age, Period, and Cohort on the Incidence of Psoriasis in Spain: A 30-year Review (1990–2019)" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:3 [ 0 => "en" 1 => "en" 2 => "es" ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efecto de la edad, cohorte y periodo en la incidencia de psoriasis en España: un análisis de 30 años (1990-2019)" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0020" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 671 "Ancho" => 1333 "Tamanyo" => 159013 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Cayuela, J.J. Pereyra-Rodríguez, J.C. Hernández-Rodríguez, L. Rodríguez Fernandez-Freire, A. Cayuela" "autores" => array:5 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Cayuela" ] 1 => array:2 [ "nombre" => "J.J." "apellidos" => "Pereyra-Rodríguez" ] 2 => array:2 [ "nombre" => "J.C." "apellidos" => "Hernández-Rodríguez" ] 3 => array:2 [ "nombre" => "L." "apellidos" => "Rodríguez Fernandez-Freire" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Cayuela" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<elsevierMultimedia ident="fig0020"></elsevierMultimedia>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005994?idApp=UINPBA000044" "url" => "/00017310/unassign/S0001731024005994/v1_202409030423/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S0001731023004908" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.05.022" "estado" => "S200" "fechaPublicacion" => "2023-07-18" "aid" => "3547" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "Case and Research Letter" "titulo" => "Recalcitrant Hailey–Hailey Disease With Satisfactory Response to Apremilast" "tienePdf" => "en" "tieneTextoCompleto" => "en" "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad de Hailey-Hailey recalcitrante con respuesta satisfactoria a apremilast" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2049 "Ancho" => 1555 "Tamanyo" => 362161 ] ] "descripcion" => array:1 [ "en" => "Red-brown plaques with superficial erosions and a macerated appearance, located in the axillary folds (A) and groin (B) before the start of treatment with apremilast. Note the improvement of the lesions after 6 months of treatment with apremilast 30mg twice a day (C and D)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Mansilla-Polo, C. Abril-Pérez, M.Á. Navarro-Mira, R. Botella-Estrada" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Mansilla-Polo" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Abril-Pérez" ] 2 => array:2 [ "nombre" => "M.Á." "apellidos" => "Navarro-Mira" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Botella-Estrada" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023004908?idApp=UINPBA000044" "url" => "/00017310/unassign/S0001731023004908/v1_202307180913/en/main.assets" ] "asociados" => array:1 [ 0 => array:17 [ "pii" => "S0001731024007762" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.10.019" "estado" => "S200" "fechaPublicacion" => "2024-10-30" "aid" => "4095" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "Comunicación Breve" "titulo" => " Factores determinantes de la severidad de la enfermedad en los pacientes con hidradenitis supurativa evaluados en un hospital español durante un periodo de 5 años" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Determinant Factors of Disease Severity for Patients With Hidradenitis Suppurativa Evaluated in a Spanish Hospital Over a 5-Year Period" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F.J. Melgosa Ramos, R. García Ruíz, A. Aguado Vázquez, A. Estébanez Corrales, T. Díaz Corpas, A. Mateu Puchades" "autores" => array:6 [ 0 => array:2 [ "nombre" => "F.J." "apellidos" => "Melgosa Ramos" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "García Ruíz" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Aguado Vázquez" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Estébanez Corrales" ] 4 => array:2 [ "nombre" => "T." "apellidos" => "Díaz Corpas" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Mateu Puchades" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024007762?idApp=UINPBA000044" "url" => "/00017310/unassign/S0001731024007762/v1_202410300909/es/main.assets" ] ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "Brief Communication" "titulo" => "Determinant Factors of Disease Severity for Patients With Hidradenitis Suppurativa Evaluated in a Spanish Hospital Over a 5-Year Period" "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F.J. Melgosa Ramos, R. García Ruíz, A. Aguado Vázquez, A. Estébanez Corrales, T. Díaz Corpas, A. Mateu Puchades" "autores" => array:6 [ 0 => array:4 [ "nombre" => "F.J." "apellidos" => "Melgosa Ramos" "email" => array:1 [ 0 => "javimelgo2017@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "R." "apellidos" => "García Ruíz" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Aguado Vázquez" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Estébanez Corrales" ] 4 => array:2 [ "nombre" => "T." "apellidos" => "Díaz Corpas" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Mateu Puchades" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Dermatology, Hospital Universitario Doctor Peset, University of Valencia, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Factores determinantes de la severidad de la enfermedad en los pacientes con hidradenitis supurativa evaluados en un hospital español durante un periodo de 5 años" ] ] "textoCompleto" => "IntroductionHidradenitis suppurativa (HS) is a systemic, chronic, and recurrent inflammatory disease with a high number of associated comorbidities that worsen the prognosis of patients.<a class="elsevierStyleCrossRef" href="#bib0095">1</a> Therefore, a correct multidisciplinary approach to these associated diseases could lead to an improved prognosis.<a class="elsevierStyleCrossRef" href="#bib0100">2</a> Additionally, the hypothesis of a treatment “window of opportunity” has been raised, where certain patients may benefit more from early systemic targeted treatment.<a class="elsevierStyleCrossRefs" href="#bib0105">3,4</a> Therefore, it is necessary to identify the characteristics and risk factors<a class="elsevierStyleCrossRefs" href="#bib0115">5–12</a> that are related to a more severe disease in order to contribute to improving the patient's prognosis.Materials and methodsA retrospective, single-center observational study was conducted, including patients diagnosed with HS at the monographic unit of the Dermatology department of the tertiary hospital Doctor Peset (Valencia, Spain) between June 2015 and June 2020. The primary objective was to identify those factors related to a more severe disease. The secondary objective was to describe the baseline characteristics of the patients. Sociodemographic data (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>), disease severity measured by PGA and IHS4 scores, number of affected locations or areas, biological therapies, and comorbidities were collected and analyzed over a five-year period. Diagnosis delay (in years) was defined as the difference in time between the onset of the disease and the moment of assessment by a dermatologist. The influence of gender, family history of HS, biological treatment, smoking habit, and number of cigarettes on the age of disease onset was also determined. Quantitative variables were expressed as mean and standard deviation, and qualitative variables as percentages. A p-value<0.05 was considered statistically significant. Statistical analyses were performed using JMP statistics v17 software.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>ResultsA total of 322 patients were included. The baseline characteristics of the patients are detailed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. A slight predominance of female sex (53%) was observed, and significant differences between genders were found in the number of patients with Hurley stage III, which was higher in males (p=0.002). The median diagnostic delay was 9.5 years without finding differences between men and women. A relationship was found between diagnostic delay and a more severe and sequelae-prone disease, so there was a difference of 11.75 years in diagnostic delay between Hurley stage I and III cases, and a difference of 7.4 years between Hurley stage I and II cases with statistically significant results (p=0.001 and p=0.03 respectively). Regarding the affected areas, significant differences in distribution by sex were found. Localization in the groin area was higher in females (p=0.01), while perianal (p=0.014) and facial (p=0.002) involvement were higher in males.The comorbidities are detailed in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>. The presence of pilonidal sinus was detected in up to 52% of the patients, more frequently in males (p=0.005), and the prevalence of psychiatric disease was significantly higher in females (p=0.025). The influence of collected comorbidities on the severity of HS was also explored. It was found that the presence of acne conglobata and/or pilonidal sinus is associated with a more severe disease in terms of IHS4 index, PGA, and the number of affected areas. The presence of cardiovascular risk factors (hypertension, dyslipidemia, and/or diabetes mellitus) was also related to a more severe HS in terms of PGA and the number of affected areas. (<a class="elsevierStyleCrossRef" href="#sec0030">Supplementary Table</a>) However, no significant relationship was found between psychiatric disease and severity in the mentioned terms. Attending to locations, perianal and/or truncal involvement was observed to be significantly associated with greater severity of HS.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>It was found that female sex and the presence of family history of HS are associated with an earlier onset of the disease, with a difference of 3 and 5 years, respectively, which is statistically significant. The age of onset was lower in non-smokers (3 years), but among smokers, it was lower in those who consume a greater number of cigarettes. Patients receiving biological treatment debuted on average 2.3 years earlier, but the differences were not significant. (<a class="elsevierStyleCrossRef" href="#sec0030">Supplementary Table</a>) A total of 95 (29.5%) patients received one or more biologic treatments, mostly adalimumab (92.6%) at a dose of 80mg every 7–14 days, followed by secukinumab (13.7%) at a dose of 300mg every 14–28 days based on severity, clinical control and real-life series.<a class="elsevierStyleCrossRef" href="#bib0155">13</a> Other biologic drugs present in the patients of the cohort included certolizumab, ustekinumab, golimumab, and guselkumab, but in a smaller percentage of patients.DiscussionThe results obtained are similar to those obtained in previous reports.<a class="elsevierStyleCrossRefs" href="#bib0110">4–12</a> There were no significant differences in the delay of diagnosis between women and men, with a median of 9.5 years, which is similar to what has been published in the literature (7–8.5 years). In our series, the most frequent locations were the axillae and groins, but we wanted to highlight the high percentage of facial and beard involvement (7%), which is often underreported.<a class="elsevierStyleCrossRef" href="#bib0095">1</a> Perianal and truncal involvement in our series is associated with increased severity of HS as measured by PGA, IHS4, and the number of affected areas. This raises the question of whether more aggressive treatment should be considered for patients with severe HS and these specific locations.<a class="elsevierStyleCrossRefs" href="#bib0100">2,15</a>The smoking habit and the prevalence of cardiovascular risk factors (arterial hypertension, dyslipidemia or diabetes) in our series is similar or slightly higher than that reported in other studies,<a class="elsevierStyleCrossRefs" href="#bib0115">5,10,12</a> and it is associated with increased severity of HS. Other chronic inflammatory diseases, such as psoriasis, have been associated with cardiovascular risk factors and metabolic syndrome, suggesting possible underlying common mechanisms between both and inflammatory disorders, so controlling these risk factors or a collaborative approach involving endocrinology may have clinical benefits in HS treatment. In our series, the presence of psychiatric comorbidity was not related to a higher prevalence of cardiovascular risk factors or to a more severe HS. However, some recent studies with larger sample sizes have reported the opposite.<a class="elsevierStyleCrossRef" href="#bib0160">14</a> The autoimmune comorbidities found in our series are similar to those reported in the literature (Psoriasis, rheumatoid arthritis (RA), psoriatic arthritis, uveitis, SAPHO, among others).<a class="elsevierStyleCrossRef" href="#bib0110">4</a> The prevalence of inflammatory bowel disease (IBD) is 1.9%, mostly due to Crohn's disease. This is similar to the estimated prevalence in recent years and far from the previously suggested prevalence. We did not find any relationship between specific locations, number of cigarettes smoked per day, isolated comorbidities, and the development of IBD. The presence of sinus pilonidal<a class="elsevierStyleCrossRef" href="#bib0170">16</a> and/or acne conglobata in our series was associated with increased severity of HS in terms of IHS4, PGA, and the number of affected areas and this is consistent with recent publications. Limitations of this study include its retrospective nature, sample size, the lack of a control group and the absence of variables such as chronic kidney disease and liver dysfunction<a class="elsevierStyleCrossRefs" href="#bib0175">17,18</a>. To conclude, we conducted a unicentric retrospective study including 322 patients with HS, analyzing which disease characteristics and/or associated comorbidities are related to greater severity, with the aim of establishing a more aggressive and early approach in these patients.Conflict of interestsThe authors declare that they have no conflict of interests." "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres2233974" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1870149" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres2233973" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1870150" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Materials and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflict of interests" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2023-07-11" "fechaAceptado" => "2023-10-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1870149" "palabras" => array:5 [ 0 => "Hidradenitis suppurativa" 1 => "Disease severity" 2 => "Comorbidities" 3 => "Pilonidal sinus" 4 => "Cardiovascular risk factors" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1870150" "palabras" => array:5 [ 0 => "Hidradenitis supurativa" 1 => "Gravedad de la enfermedad" 2 => "Comorbilidades" 3 => "Sinus pilonidal" 4 => "Factores de riesgo cardiovascular" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "It is necessary to identify which factors or comorbidities are associated with more severe hidradenitis suppurativa, aiming to identify which patients may benefit more from early systemic treatment or a more aggressive approach. A retrospective study was conducted, including patients diagnosed with HS at the dermatology department of a Spanish hospital over a 5-year period. A total of 322 patients were included. A relationship was found between diagnostic delay, the presence of acne conglobata, pilonidal sinus, cardiovascular risk factors (hypertension, dyslipidemia, and/or diabetes mellitus) and more severe HS. No significant relationship was found between psychiatric comorbidities and the severity of the HS. The presence of perianal or truncal involvement was significantly associated with severe HS. Female sex and the presence of a family history of HS were associated with an earlier onset of the disease." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Es necesario identificar qué factores o comorbilidades se asocian con una hidradenitis supurativa (HS) más grave, con el objetivo de identificar qué pacientes pueden beneficiarse de un tratamiento sistémico precoz o un enfoque más agresivo. Se realizó un estudio retrospectivo que incluyó a pacientes diagnosticados de HS en el Servicio de Dermatología de un hospital español durante un periodo de cinco años. Se incluyeron 322 pacientes. Se encontró una asociación entre el retraso en el diagnóstico, la presencia de acné conglobata, sinus pilonidal y/o factores de riesgo cardiovascular (hipertensión, dislipidemia y/o diabetes mellitus) y una forma de HS más grave. No se encontró asociación estadísticamente significativa entre la presencia de comorbilidad psiquiátrica y la gravedad de la HS. La presencia de afectación perianal o troncular se asoció significativamente con HS grave. El sexo femenino y la presencia de antecedentes familiares de HS se asociaron con un inicio más temprano de la enfermedad." ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "The following are the supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0035" ] ] ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N=322 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42.1±13.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sex (female, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">173 (53%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age of disease onset (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.8±11.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Family history of HS (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">127 (42.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Smoking habit (total number, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">211 (65.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Average number of cigarette per day \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.8±9.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Body mass index (BMI) kg/m2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27.2±6.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Obesity/BMI>30kg/m2(%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">78 (25.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Average number of affected areas \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2±0.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hurley stage</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">66 (20.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">139 (43.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">117 (36.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Physicians's Global Assessment (PGA) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.3±0.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">International Hidradenitis Suppurativa Severity Score System (IHS4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.7±6.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Biological treatment (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">95 (29.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Average number of surgical interventions \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.1±1.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3641835.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Sociodemographic characteristics of patients with hidradenitis included in the cohort." ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patient's comorbidities \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Number of patients (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Acne conglobata and/or pilonidal sinus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">110 (34.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Other autoimmune diseases (psoriasis, psoriatic arthritis, SAPHO, spondyloarthropathy, etc.) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 (9.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Inflammatory bowel disease (Crohn's or UC) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (1.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cardiovascular risk factors (hypertension, diabetes mellitus, and/or dyslipidemia) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81 (25.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Psychiatric disease (depression, anxiety, and/or personality disorders) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">103 (31.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Previous history of neoplasms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 (6.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Previous history of major adverse cardiovascular events (myocardial infarction, stroke, pulmonary embolism) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (4.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HIV and/or hepatotropic viruses (HVB or HVC) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 (3.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3641836.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Comorbidities present in the patients of the cohort." ] ] 2 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.pdf" "ficheroTamanyo" => 79291 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0095" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hidradenitis suppurativa: epidemiology, clinical presentation, and pathogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.R. Goldburg" 1 => "B.E. Strober" 2 => "M.J. Payette" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2019.08.090" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2020" "volumen" => "82" "paginaInicial" => "1045" "paginaFinal" => "1058" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31604104" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0100" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Can we improve prognosis in hidradenitis suppurativa? Identifying patients in the window of opportunity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.J. Melgosa Ramos" 1 => "R. García-Ruiz" 2 => "A. Mateu Puchades" 3 => "A. Martorell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2023" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0105" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence for a ‘window of opportunity’ in hidradenitis suppurativa treated with adalimumab: a retrospective, real-life multicentre cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.V. Marzano" 1 => "G. Genovese" 2 => "G. Casazza" 3 => "C. Moltrasio" 4 => "P. Dapavo" 5 => "G. Micali" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.18983" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2021" "volumen" => "184" "paginaInicial" => "133" "paginaFinal" => "140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32119111" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0110" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Which hidradenitis suppurativa comorbidities should I take into account?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Tzellos" 1 => "C.C. Zouboulis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/exd.14633" "Revista" => array:7 [ "tituloSerie" => "Exp Dermatol" "fecha" => "2022" "volumen" => "31" "numero" => "Suppl. 1" "paginaInicial" => "29" "paginaFinal" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35737874" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0115" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Mintoff" 1 => "F. Benhadou" 2 => "N.P. Pace" 3 => "J.W. Frew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ijd.15910" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2022" "volumen" => "61" "paginaInicial" => "1175" "paginaFinal" => "1186" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34530487" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0120" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hidradenitis suppurativa and association with stroke: systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Phan" 1 => "W.H.S. Ng" 2 => "B. Lai" 3 => "A. Garg" 4 => "S.D. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dermatol Treat" "fecha" => "2022" "volumen" => "33" "paginaInicial" => "2309" "paginaFinal" => "2316" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0125" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of major adverse cardiovascular events and all-cause mortality in patients with hidradenitis suppurativa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Egeberg" 1 => "G.H. Gislason" 2 => "P.R. Hansen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2015.6264" "Revista" => array:6 [ "tituloSerie" => "JAMA Dermatol" "fecha" => "2016" "volumen" => "152" "paginaInicial" => "429" "paginaFinal" => "434" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26885728" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0130" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metformin treatment of hidradenitis suppurativa: effect on metabolic parameters, inflammation, cardiovascular risk biomarkers, and immune mediators" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Hambly" 1 => "N. Kearney" 2 => "R. Hughes" 3 => "J.M. Fletcher" 4 => "B. Kirby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3390/ijms24086969" "Revista" => array:5 [ "tituloSerie" => "Int J Mol Sci" "fecha" => "2023" "volumen" => "24" "paginaInicial" => "6969" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/37108132" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0135" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The treatment of hidradenitis suppurativa with the glucagon-like peptide-1 agonist liraglutide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Jennings" 1 => "L. Nestor" 2 => "O. Molloy" 3 => "R. Hughes" 4 => "B. Moriarty" 5 => "B. Kirby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.15233" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2017" "volumen" => "177" "paginaInicial" => "858" "paginaFinal" => "859" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27943236" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0140" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors, clinical course and long-term prognosis in hidradenitis suppurativa: a cross-sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.B. Kromann" 1 => "I.E. Deckers" 2 => "S. Esmann" 3 => "J. Boer" 4 => "E.P. Prens" 5 => "G.B. Jemec" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.13090" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2014" "volumen" => "171" "paginaInicial" => "819" "paginaFinal" => "824" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24804604" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0145" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum inflammatory markers and leukocyte profiles accurately describe hidradenitis suppurativa disease severity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T.M. Andriano" 1 => "G. Benesh" 2 => "K.M. Babbush" 3 => "H.D. Hosgood" 4 => "J. Lin" 5 => "S.R. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ijd.16244" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2022" "volumen" => "61" "paginaInicial" => "1270" "paginaFinal" => "1275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35543428" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0150" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Özkur" 1 => "A.S. Karadağ" 2 => "P. Üstüner" 3 => "B. Aksoy" 4 => "P. Eşme" 5 => "E. Çalışkan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ced.14478" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2021" "volumen" => "46" "paginaInicial" => "532" "paginaFinal" => "540" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33030217" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0155" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New treatments and new assessment instruments for Hidradenitis suppurativa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.R. van Straalen" 1 => "J.R. Ingram" 2 => "M. Augustin" 3 => "C.C. Zouboulis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Exp Dermatol" "fecha" => "2022" "volumen" => "31" "numero" => "Suppl. 1" "paginaInicial" => "33" "paginaFinal" => "39" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0160" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between depression, quality of life and clinical severity in patients with hidradenitis suppurativa" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Sampogna" 1 => "L. Fania" 2 => "S. Mastroeni" 3 => "R. Fusari" 4 => "M. Napolitano" 5 => "D. Ciccone" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-3647" "Revista" => array:5 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2020" "volumen" => "100" "paginaInicial" => "adv00319" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32985674" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0165" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed diagnosis of hidradenitis suppurativa and its effect on patients and healthcare system" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Kokolakis" 1 => "K. Wolk" 2 => "S. Schneider-Burrus" 3 => "S. Kalus" 4 => "S. Barbus" 5 => "S. Gomis-Kleindienst" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000508787" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2020" "volumen" => "236" "paginaInicial" => "421" "paginaFinal" => "430" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32610312" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0170" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association between pilonidal sinus disease and hidradenitis suppurativa: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.J.L. Wark" 1 => "S.A. Der Sarkissian" 2 => "A. Tatian" 3 => "J. Woods" 4 => "G.D. Cains" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2023" "volumen" => "188" "paginaInicial" => "673" "paginaFinal" => "675" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0175" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of liver dysfunction and non-alcoholic fatty liver diseases in people with hidradenitis suppurativa: a systematic review and meta-analysis of real-world evidences" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.Y. Gau" 1 => "Y.P. Hsiao" 2 => "W.C. Liao" 3 => "K.S. Ma" 4 => "M.C. Wu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fimmu.2022.959691" "Revista" => array:5 [ "tituloSerie" => "Front Immunol" "fecha" => "2022" "volumen" => "13" "paginaInicial" => "959691" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36591267" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0180" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased risk of renal diseases in people with hidradenitis suppurativa: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.Y. Gau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ijd.16423" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2023" "volumen" => "62" "paginaInicial" => "e4" "paginaFinal" => "e6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36040416" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/unassign/S0001731024005945/v1_202409030423/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/00017310/unassign/S0001731024005945/v1_202409030423/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005945?idApp=UINPBA000044"]

Statistics

Brief Communication

Determinant Factors of Disease Severity for Patients With Hidradenitis Suppurativa Evaluated in a Spanish Hospital Over a 5-Year Period

Factores determinantes de la severidad de la enfermedad en los pacientes con hidradenitis supurativa evaluados en un hospital español durante un periodo de 5 años

F.J. Melgosa Ramos

Corresponding author

javimelgo2017@gmail.com

Corresponding author.

, R. García Ruíz, A. Aguado Vázquez, A. Estébanez Corrales, T. Díaz Corpas, A. Mateu Puchades

Department of Dermatology, Hospital Universitario Doctor Peset, University of Valencia, Spain

Read

1019

Times
was read the article

276

Total PDF

743

Total HTML

Share statistics

 array:23 [
  "pii" => "S0001731024005945"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2023.10.051"
  "estado" => "S200"
  "fechaPublicacion" => "2024-09-03"
  "aid" => "4023"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2024"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "crp"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:17 [
    "pii" => "S0001731024005994"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2024.06.008"
    "estado" => "S200"
    "fechaPublicacion" => "2024-09-03"
    "aid" => "4028"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Effects of Age&#44; Period&#44; and Cohort on the Incidence of Psoriasis in Spain&#58; A 30-year Review &#40;1990&#8211;2019&#41;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:3 [
        0 => "en"
        1 => "en"
        2 => "es"
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Efecto de la edad&#44; cohorte y periodo en la incidencia de psoriasis en Espa&#241;a&#58; un an&#225;lisis de 30 a&#241;os &#40;1990-2019&#41;"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 1
        "multimedia" => array:5 [
          "identificador" => "fig0020"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => false
          "mostrarDisplay" => true
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "fx1.jpeg"
              "Alto" => 671
              "Ancho" => 1333
              "Tamanyo" => 159013
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46; Cayuela, J&#46;J&#46; Pereyra-Rodr&#237;guez, J&#46;C&#46; Hern&#225;ndez-Rodr&#237;guez, L&#46; Rodr&#237;guez Fernandez-Freire, A&#46; Cayuela"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Cayuela"
            ]
            1 => array:2 [
              "nombre" => "J&#46;J&#46;"
              "apellidos" => "Pereyra-Rodr&#237;guez"
            ]
            2 => array:2 [
              "nombre" => "J&#46;C&#46;"
              "apellidos" => "Hern&#225;ndez-Rodr&#237;guez"
            ]
            3 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Rodr&#237;guez Fernandez-Freire"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Cayuela"
            ]
          ]
        ]
      ]
      "resumen" => array:1 [
        0 => array:3 [
          "titulo" => "Graphical abstract"
          "clase" => "graphical"
          "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0020"></elsevierMultimedia></p></span>"
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005994?idApp=UINPBA000044"
    "url" => "/00017310/unassign/S0001731024005994/v1_202409030423/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "S0001731023004908"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2023.05.022"
    "estado" => "S200"
    "fechaPublicacion" => "2023-07-18"
    "aid" => "3547"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "crp"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Recalcitrant Hailey&#8211;Hailey Disease With Satisfactory Response to Apremilast"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Enfermedad de Hailey-Hailey recalcitrante con respuesta satisfactoria a apremilast"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2049
              "Ancho" => 1555
              "Tamanyo" => 362161
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Red-brown plaques with superficial erosions and a macerated appearance&#44; located in the axillary folds &#40;A&#41; and groin &#40;B&#41; before the start of treatment with apremilast&#46; Note the improvement of the lesions after 6 months of treatment with apremilast 30<span class="elsevierStyleHsp" style=""></span>mg twice a day &#40;C and D&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Mansilla-Polo, C&#46; Abril-P&#233;rez, M&#46;&#193;&#46; Navarro-Mira, R&#46; Botella-Estrada"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Mansilla-Polo"
            ]
            1 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Abril-P&#233;rez"
            ]
            2 => array:2 [
              "nombre" => "M&#46;&#193;&#46;"
              "apellidos" => "Navarro-Mira"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Botella-Estrada"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023004908?idApp=UINPBA000044"
    "url" => "/00017310/unassign/S0001731023004908/v1_202307180913/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:17 [
      "pii" => "S0001731024007762"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2024.10.019"
      "estado" => "S200"
      "fechaPublicacion" => "2024-10-30"
      "aid" => "4095"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "crp"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Comunicaci&#243;n Breve</span>"
        "titulo" => " Factores determinantes de la severidad de la enfermedad en los pacientes con hidradenitis supurativa evaluados en un hospital espa&#241;ol durante un periodo de 5 a&#241;os"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Determinant Factors of Disease Severity for Patients With Hidradenitis Suppurativa Evaluated in a Spanish Hospital Over a 5-Year Period"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "F&#46;J&#46; Melgosa Ramos, R&#46; Garc&#237;a Ru&#237;z, A&#46; Aguado V&#225;zquez, A&#46; Est&#233;banez Corrales, T&#46; D&#237;az Corpas, A&#46; Mateu Puchades"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "Melgosa Ramos"
              ]
              1 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Garc&#237;a Ru&#237;z"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Aguado V&#225;zquez"
              ]
              3 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Est&#233;banez Corrales"
              ]
              4 => array:2 [
                "nombre" => "T&#46;"
                "apellidos" => "D&#237;az Corpas"
              ]
              5 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Mateu Puchades"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024007762?idApp=UINPBA000044"
      "url" => "/00017310/unassign/S0001731024007762/v1_202410300909/es/main.assets"
    ]
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Brief Communication</span>"
    "titulo" => "Determinant Factors of Disease Severity for Patients With Hidradenitis Suppurativa Evaluated in a Spanish Hospital Over a 5-Year Period"
    "tieneTextoCompleto" => true
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F&#46;J&#46; Melgosa Ramos, R&#46; Garc&#237;a Ru&#237;z, A&#46; Aguado V&#225;zquez, A&#46; Est&#233;banez Corrales, T&#46; D&#237;az Corpas, A&#46; Mateu Puchades"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "F&#46;J&#46;"
            "apellidos" => "Melgosa Ramos"
            "email" => array:1 [
              0 => "javimelgo2017@gmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "R&#46;"
            "apellidos" => "Garc&#237;a Ru&#237;z"
          ]
          2 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Aguado V&#225;zquez"
          ]
          3 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Est&#233;banez Corrales"
          ]
          4 => array:2 [
            "nombre" => "T&#46;"
            "apellidos" => "D&#237;az Corpas"
          ]
          5 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Mateu Puchades"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Department of Dermatology&#44; Hospital Universitario Doctor Peset&#44; University of Valencia&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Factores determinantes de la severidad de la enfermedad en los pacientes con hidradenitis supurativa evaluados en un hospital espa&#241;ol durante un periodo de 5 a&#241;os"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Hidradenitis suppurativa &#40;HS&#41; is a systemic&#44; chronic&#44; and recurrent inflammatory disease with a high number of associated comorbidities that worsen the prognosis of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a> Therefore&#44; a correct multidisciplinary approach to these associated diseases could lead to an improved prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">2</span></a> Additionally&#44; the hypothesis of a treatment &#8220;window of opportunity&#8221; has been raised&#44; where certain patients may benefit more from early systemic targeted treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">3&#44;4</span></a> Therefore&#44; it is necessary to identify the characteristics and risk factors<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">5&#8211;12</span></a> that are related to a more severe disease in order to contribute to improving the patient&#39;s prognosis&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Materials and methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">A retrospective&#44; single-center observational study was conducted&#44; including patients diagnosed with HS at the monographic unit of the Dermatology department of the tertiary hospital Doctor Peset &#40;Valencia&#44; Spain&#41; between June 2015 and June 2020&#46; The primary objective was to identify those factors related to a more severe disease&#46; The secondary objective was to describe the baseline characteristics of the patients&#46; Sociodemographic data &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; disease severity measured by PGA and IHS4 scores&#44; number of affected locations or areas&#44; biological therapies&#44; and comorbidities were collected and analyzed over a five-year period&#46; Diagnosis delay &#40;in years&#41; was defined as the difference in time between the onset of the disease and the moment of assessment by a dermatologist&#46; The influence of gender&#44; family history of HS&#44; biological treatment&#44; smoking habit&#44; and number of cigarettes on the age of disease onset was also determined&#46; Quantitative variables were expressed as mean and standard deviation&#44; and qualitative variables as percentages&#46; A <span class="elsevierStyleItalic">p</span>-value<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered statistically significant&#46; Statistical analyses were performed using JMP statistics v17 software&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="par0015" class="elsevierStylePara elsevierViewall">A total of 322 patients were included&#46; The baseline characteristics of the patients are detailed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; A slight predominance of female sex &#40;53&#37;&#41; was observed&#44; and significant differences between genders were found in the number of patients with Hurley stage III&#44; which was higher in males &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#46; The median diagnostic delay was 9&#46;5 years without finding differences between men and women&#46; A relationship was found between diagnostic delay and a more severe and sequelae-prone disease&#44; so there was a difference of 11&#46;75 years in diagnostic delay between Hurley stage I and III cases&#44; and a difference of 7&#46;4 years between Hurley stage I and II cases with statistically significant results &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001 and <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03 respectively&#41;&#46; Regarding the affected areas&#44; significant differences in distribution by sex were found&#46; Localization in the groin area was higher in females &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#44; while perianal &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;014&#41; and facial &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41; involvement were higher in males&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The comorbidities are detailed in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; The presence of pilonidal sinus was detected in up to 52&#37; of the patients&#44; more frequently in males &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&#44; and the prevalence of psychiatric disease was significantly higher in females &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;025&#41;&#46; The influence of collected comorbidities on the severity of HS was also explored&#46; It was found that the presence of acne conglobata and&#47;or pilonidal sinus is associated with a more severe disease in terms of IHS4 index&#44; PGA&#44; and the number of affected areas&#46; The presence of cardiovascular risk factors &#40;hypertension&#44; dyslipidemia&#44; and&#47;or diabetes mellitus&#41; was also related to a more severe HS in terms of PGA and the number of affected areas&#46; &#40;<a class="elsevierStyleCrossRef" href="#sec0030">Supplementary Table</a>&#41; However&#44; no significant relationship was found between psychiatric disease and severity in the mentioned terms&#46; Attending to locations&#44; perianal and&#47;or truncal involvement was observed to be significantly associated with greater severity of HS&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">It was found that female sex and the presence of family history of HS are associated with an earlier onset of the disease&#44; with a difference of 3 and 5 years&#44; respectively&#44; which is statistically significant&#46; The age of onset was lower in non-smokers &#40;3 years&#41;&#44; but among smokers&#44; it was lower in those who consume a greater number of cigarettes&#46; Patients receiving biological treatment debuted on average 2&#46;3 years earlier&#44; but the differences were not significant&#46; &#40;<a class="elsevierStyleCrossRef" href="#sec0030">Supplementary Table</a>&#41; A total of 95 &#40;29&#46;5&#37;&#41; patients received one or more biologic treatments&#44; mostly adalimumab &#40;92&#46;6&#37;&#41; at a dose of 80<span class="elsevierStyleHsp" style=""></span>mg every 7&#8211;14 days&#44; followed by secukinumab &#40;13&#46;7&#37;&#41; at a dose of 300<span class="elsevierStyleHsp" style=""></span>mg every 14&#8211;28 days based on severity&#44; clinical control and real-life series&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">13</span></a> Other biologic drugs present in the patients of the cohort included certolizumab&#44; ustekinumab&#44; golimumab&#44; and guselkumab&#44; but in a smaller percentage of patients&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">The results obtained are similar to those obtained in previous reports&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">4&#8211;12</span></a> There were no significant differences in the delay of diagnosis between women and men&#44; with a median of 9&#46;5 years&#44; which is similar to what has been published in the literature &#40;7&#8211;8&#46;5 years&#41;&#46; In our series&#44; the most frequent locations were the axillae and groins&#44; but we wanted to highlight the high percentage of facial and beard involvement &#40;7&#37;&#41;&#44; which is often underreported&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a> Perianal and truncal involvement in our series is associated with increased severity of HS as measured by PGA&#44; IHS4&#44; and the number of affected areas&#46; This raises the question of whether more aggressive treatment should be considered for patients with severe HS and these specific locations&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2&#44;15</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The smoking habit and the prevalence of cardiovascular risk factors &#40;arterial hypertension&#44; dyslipidemia or diabetes&#41; in our series is similar or slightly higher than that reported in other studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">5&#44;10&#44;12</span></a> and it is associated with increased severity of HS&#46; Other chronic inflammatory diseases&#44; such as psoriasis&#44; have been associated with cardiovascular risk factors and metabolic syndrome&#44; suggesting possible underlying common mechanisms between both and inflammatory disorders&#44; so controlling these risk factors or a collaborative approach involving endocrinology may have clinical benefits in HS treatment&#46; In our series&#44; the presence of psychiatric comorbidity was not related to a higher prevalence of cardiovascular risk factors or to a more severe HS&#46; However&#44; some recent studies with larger sample sizes have reported the opposite&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">14</span></a> The autoimmune comorbidities found in our series are similar to those reported in the literature &#40;Psoriasis&#44; rheumatoid arthritis &#40;RA&#41;&#44; psoriatic arthritis&#44; uveitis&#44; SAPHO&#44; among others&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">4</span></a> The prevalence of inflammatory bowel disease &#40;IBD&#41; is 1&#46;9&#37;&#44; mostly due to Crohn&#39;s disease&#46; This is similar to the estimated prevalence in recent years and far from the previously suggested prevalence&#46; We did not find any relationship between specific locations&#44; number of cigarettes smoked per day&#44; isolated comorbidities&#44; and the development of IBD&#46; The presence of sinus pilonidal<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">16</span></a> and&#47;or acne conglobata in our series was associated with increased severity of HS in terms of IHS4&#44; PGA&#44; and the number of affected areas and this is consistent with recent publications&#46; Limitations of this study include its retrospective nature&#44; sample size&#44; the lack of a control group and the absence of variables such as chronic kidney disease and liver dysfunction<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">17&#44;18</span></a>&#46; To conclude&#44; we conducted a unicentric retrospective study including 322 patients with HS&#44; analyzing which disease characteristics and&#47;or associated comorbidities are related to greater severity&#44; with the aim of establishing a more aggressive and early approach in these patients&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflict of interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres2233974"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1870149"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres2233973"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1870150"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflict of interests"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2023-07-11"
    "fechaAceptado" => "2023-10-09"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1870149"
          "palabras" => array:5 [
            0 => "Hidradenitis suppurativa"
            1 => "Disease severity"
            2 => "Comorbidities"
            3 => "Pilonidal sinus"
            4 => "Cardiovascular risk factors"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1870150"
          "palabras" => array:5 [
            0 => "Hidradenitis supurativa"
            1 => "Gravedad de la enfermedad"
            2 => "Comorbilidades"
            3 => "Sinus pilonidal"
            4 => "Factores de riesgo cardiovascular"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">It is necessary to identify which factors or comorbidities are associated with more severe hidradenitis suppurativa&#44; aiming to identify which patients may benefit more from early systemic treatment or a more aggressive approach&#46; A retrospective study was conducted&#44; including patients diagnosed with HS at the dermatology department of a Spanish hospital over a 5-year period&#46; A total of 322 patients were included&#46; A relationship was found between diagnostic delay&#44; the presence of acne conglobata&#44; pilonidal sinus&#44; cardiovascular risk factors &#40;hypertension&#44; dyslipidemia&#44; and&#47;or diabetes mellitus&#41; and more severe HS&#46; No significant relationship was found between psychiatric comorbidities and the severity of the HS&#46; The presence of perianal or truncal involvement was significantly associated with severe HS&#46; Female sex and the presence of a family history of HS were associated with an earlier onset of the disease&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Es necesario identificar qu&#233; factores o comorbilidades se asocian con una hidradenitis supurativa &#40;HS&#41; m&#225;s grave&#44; con el objetivo de identificar qu&#233; pacientes pueden beneficiarse de un tratamiento sist&#233;mico precoz o un enfoque m&#225;s agresivo&#46; Se realiz&#243; un estudio retrospectivo que incluy&#243; a pacientes diagnosticados de HS en el Servicio de Dermatolog&#237;a de un hospital espa&#241;ol durante un periodo de cinco a&#241;os&#46; Se incluyeron 322 pacientes&#46; Se encontr&#243; una asociaci&#243;n entre el retraso en el diagn&#243;stico&#44; la presencia de acn&#233; conglobata&#44; sinus pilonidal y&#47;o factores de riesgo cardiovascular &#40;hipertensi&#243;n&#44; dislipidemia y&#47;o diabetes mellitus&#41; y una forma de HS m&#225;s grave&#46; No se encontr&#243; asociaci&#243;n estad&#237;sticamente significativa entre la presencia de comorbilidad psiqui&#225;trica y la gravedad de la HS&#46; La presencia de afectaci&#243;n perianal o troncular se asoci&#243; significativamente con HS grave&#46; El sexo femenino y la presencia de antecedentes familiares de HS se asociaron con un inicio m&#225;s temprano de la enfermedad&#46;</p></span>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0050" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0035"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>322&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sex &#40;female&#44; &#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">173 &#40;53&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Age of disease onset &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Family history of HS &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127 &#40;42&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Smoking habit &#40;total number&#44; &#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">211 &#40;65&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Average number of cigarette per day</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Body mass index &#40;BMI&#41; kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Obesity&#47;BMI</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#62;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">30</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78 &#40;25&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Average number of affected areas</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hurley stage</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;20&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">139 &#40;43&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117 &#40;36&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Physicians&#39;s Global Assessment &#40;PGA&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">International Hidradenitis Suppurativa Severity Score System &#40;IHS4&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Biological treatment &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95 &#40;29&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Average number of surgical interventions</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3641835.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Sociodemographic characteristics of patients with hidradenitis included in the cohort&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patient&#39;s comorbidities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Number of patients &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acne conglobata and&#47;or pilonidal sinus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">110 &#40;34&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Other autoimmune diseases &#40;psoriasis&#44; psoriatic arthritis&#44; SAPHO&#44; spondyloarthropathy&#44; etc&#46;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;9&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inflammatory bowel disease &#40;Crohn&#39;s or UC&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cardiovascular risk factors &#40;hypertension&#44; diabetes mellitus&#44; and&#47;or dyslipidemia&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81 &#40;25&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Psychiatric disease &#40;depression&#44; anxiety&#44; and&#47;or personality disorders&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">103 &#40;31&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Previous history of neoplasms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;6&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Previous history of major adverse cardiovascular events &#40;myocardial infarction&#44; stroke&#44; pulmonary embolism&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;4&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HIV and&#47;or hepatotropic viruses &#40;HVB or HVC&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;3&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3641836.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Comorbidities present in the patients of the cohort&#46;</p>"
        ]
      ]
      2 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.pdf"
          "ficheroTamanyo" => 79291
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:18 [
            0 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hidradenitis suppurativa&#58; epidemiology&#44; clinical presentation&#44; and pathogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;R&#46; Goldburg"
                            1 => "B&#46;E&#46; Strober"
                            2 => "M&#46;J&#46; Payette"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.08.090"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2020"
                        "volumen" => "82"
                        "paginaInicial" => "1045"
                        "paginaFinal" => "1058"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31604104"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Can we improve prognosis in hidradenitis suppurativa&#63; Identifying patients in the window of opportunity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46;J&#46; Melgosa Ramos"
                            1 => "R&#46; Garc&#237;a-Ruiz"
                            2 => "A&#46; Mateu Puchades"
                            3 => "A&#46; Martorell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2023"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence for a &#8216;window of opportunity&#8217; in hidradenitis suppurativa treated with adalimumab&#58; a retrospective&#44; real-life multicentre cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;V&#46; Marzano"
                            1 => "G&#46; Genovese"
                            2 => "G&#46; Casazza"
                            3 => "C&#46; Moltrasio"
                            4 => "P&#46; Dapavo"
                            5 => "G&#46; Micali"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.18983"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2021"
                        "volumen" => "184"
                        "paginaInicial" => "133"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32119111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Which hidradenitis suppurativa comorbidities should I take into account&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Tzellos"
                            1 => "C&#46;C&#46; Zouboulis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/exd.14633"
                      "Revista" => array:7 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "2022"
                        "volumen" => "31"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "29"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35737874"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic syndrome and hidradenitis suppurativa&#58; epidemiological&#44; molecular&#44; and therapeutic aspects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Mintoff"
                            1 => "F&#46; Benhadou"
                            2 => "N&#46;P&#46; Pace"
                            3 => "J&#46;W&#46; Frew"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ijd.15910"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2022"
                        "volumen" => "61"
                        "paginaInicial" => "1175"
                        "paginaFinal" => "1186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34530487"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hidradenitis suppurativa and association with stroke&#58; systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Phan"
                            1 => "W&#46;H&#46;S&#46; Ng"
                            2 => "B&#46; Lai"
                            3 => "A&#46; Garg"
                            4 => "S&#46;D&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Dermatol Treat"
                        "fecha" => "2022"
                        "volumen" => "33"
                        "paginaInicial" => "2309"
                        "paginaFinal" => "2316"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of major adverse cardiovascular events and all-cause mortality in patients with hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Egeberg"
                            1 => "G&#46;H&#46; Gislason"
                            2 => "P&#46;R&#46; Hansen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2015.6264"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2016"
                        "volumen" => "152"
                        "paginaInicial" => "429"
                        "paginaFinal" => "434"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26885728"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metformin treatment of hidradenitis suppurativa&#58; effect on metabolic parameters&#44; inflammation&#44; cardiovascular risk biomarkers&#44; and immune mediators"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Hambly"
                            1 => "N&#46; Kearney"
                            2 => "R&#46; Hughes"
                            3 => "J&#46;M&#46; Fletcher"
                            4 => "B&#46; Kirby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/ijms24086969"
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Mol Sci"
                        "fecha" => "2023"
                        "volumen" => "24"
                        "paginaInicial" => "6969"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/37108132"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The treatment of hidradenitis suppurativa with the glucagon-like peptide-1 agonist liraglutide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Jennings"
                            1 => "L&#46; Nestor"
                            2 => "O&#46; Molloy"
                            3 => "R&#46; Hughes"
                            4 => "B&#46; Moriarty"
                            5 => "B&#46; Kirby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.15233"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2017"
                        "volumen" => "177"
                        "paginaInicial" => "858"
                        "paginaFinal" => "859"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27943236"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors&#44; clinical course and long-term prognosis in hidradenitis suppurativa&#58; a cross-sectional study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;B&#46; Kromann"
                            1 => "I&#46;E&#46; Deckers"
                            2 => "S&#46; Esmann"
                            3 => "J&#46; Boer"
                            4 => "E&#46;P&#46; Prens"
                            5 => "G&#46;B&#46; Jemec"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.13090"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2014"
                        "volumen" => "171"
                        "paginaInicial" => "819"
                        "paginaFinal" => "824"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24804604"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum inflammatory markers and leukocyte profiles accurately describe hidradenitis suppurativa disease severity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46;M&#46; Andriano"
                            1 => "G&#46; Benesh"
                            2 => "K&#46;M&#46; Babbush"
                            3 => "H&#46;D&#46; Hosgood"
                            4 => "J&#46; Lin"
                            5 => "S&#46;R&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ijd.16244"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2022"
                        "volumen" => "61"
                        "paginaInicial" => "1270"
                        "paginaFinal" => "1275"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35543428"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and demographic features of hidradenitis suppurativa&#58; a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; &#214;zkur"
                            1 => "A&#46;S&#46; Karada&#287;"
                            2 => "P&#46; &#220;st&#252;ner"
                            3 => "B&#46; Aksoy"
                            4 => "P&#46; E&#351;me"
                            5 => "E&#46; &#199;al&#305;&#351;kan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.14478"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2021"
                        "volumen" => "46"
                        "paginaInicial" => "532"
                        "paginaFinal" => "540"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33030217"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New treatments and new assessment instruments for Hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;R&#46; van Straalen"
                            1 => "J&#46;R&#46; Ingram"
                            2 => "M&#46; Augustin"
                            3 => "C&#46;C&#46; Zouboulis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Dermatol"
                        "fecha" => "2022"
                        "volumen" => "31"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "33"
                        "paginaFinal" => "39"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation between depression&#44; quality of life and clinical severity in patients with hidradenitis suppurativa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Sampogna"
                            1 => "L&#46; Fania"
                            2 => "S&#46; Mastroeni"
                            3 => "R&#46; Fusari"
                            4 => "M&#46; Napolitano"
                            5 => "D&#46; Ciccone"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2340/00015555-3647"
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "2020"
                        "volumen" => "100"
                        "paginaInicial" => "adv00319"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32985674"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Delayed diagnosis of hidradenitis suppurativa and its effect on patients and healthcare system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Kokolakis"
                            1 => "K&#46; Wolk"
                            2 => "S&#46; Schneider-Burrus"
                            3 => "S&#46; Kalus"
                            4 => "S&#46; Barbus"
                            5 => "S&#46; Gomis-Kleindienst"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000508787"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2020"
                        "volumen" => "236"
                        "paginaInicial" => "421"
                        "paginaFinal" => "430"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32610312"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The association between pilonidal sinus disease and hidradenitis suppurativa&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;J&#46;L&#46; Wark"
                            1 => "S&#46;A&#46; Der Sarkissian"
                            2 => "A&#46; Tatian"
                            3 => "J&#46; Woods"
                            4 => "G&#46;D&#46; Cains"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2023"
                        "volumen" => "188"
                        "paginaInicial" => "673"
                        "paginaFinal" => "675"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of liver dysfunction and non-alcoholic fatty liver diseases in people with hidradenitis suppurativa&#58; a systematic review and meta-analysis of real-world evidences"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;Y&#46; Gau"
                            1 => "Y&#46;P&#46; Hsiao"
                            2 => "W&#46;C&#46; Liao"
                            3 => "K&#46;S&#46; Ma"
                            4 => "M&#46;C&#46; Wu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fimmu.2022.959691"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Immunol"
                        "fecha" => "2022"
                        "volumen" => "13"
                        "paginaInicial" => "959691"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36591267"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased risk of renal diseases in people with hidradenitis suppurativa&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;Y&#46; Gau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ijd.16423"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2023"
                        "volumen" => "62"
                        "paginaInicial" => "e4"
                        "paginaFinal" => "e6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36040416"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/unassign/S0001731024005945/v1_202409030423/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/00017310/unassign/S0001731024005945/v1_202409030423/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005945?idApp=UINPBA000044"
]

Article information

ISSN: 00017310
Original language: English

DOI:10.1016/j.ad.2023.10.051

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	30	8	38
2024 October	202	72	274
2024 September	233	53	286
2024 August	203	87	290
2024 July	75	56	131

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter